MX9801255A - Un metodo para determinar el grado de agregacion del peptido ba4. - Google Patents

Un metodo para determinar el grado de agregacion del peptido ba4.

Info

Publication number
MX9801255A
MX9801255A MX9801255A MX9801255A MX9801255A MX 9801255 A MX9801255 A MX 9801255A MX 9801255 A MX9801255 A MX 9801255A MX 9801255 A MX9801255 A MX 9801255A MX 9801255 A MX9801255 A MX 9801255A
Authority
MX
Mexico
Prior art keywords
peptide
beta
aggregation
determining
degree
Prior art date
Application number
MX9801255A
Other languages
English (en)
Other versions
MXPA98001255A (es
Inventor
Shefali Goyal
Joseph West Paul
Norbert G Riedel
Sudhir R Sahasrabudhe
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of MX9801255A publication Critical patent/MX9801255A/es
Publication of MXPA98001255A publication Critical patent/MXPA98001255A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Se describe un método para determinar el grado de agregacion del péptido.5A4. El método comprende hacer reaccionar la proteína con un agente de union adecuado, el cual es capaz de unir el péptido betaA4 solamente en su estado no agregado para formar una cantidad de reactivo de union unido a la proteína. La cantidad de agente de union a la proteína después es medido.
MXPA/A/1998/001255A 1995-08-16 1998-02-13 Un metodo para determinar el grado de agregaciondel peptido ba4 MXPA98001255A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US51560695A 1995-08-16 1995-08-16
US515606 1995-08-16
PCT/US1996/012034 WO1997007403A1 (en) 1995-08-16 1996-07-23 A METHOD OF DETERMINING THE DEGREE OF AGGREGATION OF THE βA4 PEPTIDE

Publications (2)

Publication Number Publication Date
MX9801255A true MX9801255A (es) 1998-05-31
MXPA98001255A MXPA98001255A (es) 1998-10-23

Family

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Also Published As

Publication number Publication date
IL122759A0 (en) 1998-08-16
AU697842B2 (en) 1998-10-15
TW574503B (en) 2004-02-01
DE69630131T2 (de) 2004-07-08
IL122759A (en) 2003-05-29
ES2206586T3 (es) 2004-05-16
CA2229187C (en) 2003-03-18
AU6505296A (en) 1997-03-12
DE69630131D1 (de) 2003-10-30
ATE250766T1 (de) 2003-10-15
KR19990036439A (ko) 1999-05-25
PT846269E (pt) 2004-01-30
CA2229187A1 (en) 1997-02-27
JP3042895B2 (ja) 2000-05-22
HK1015030A1 (en) 1999-10-08
EP0846269A1 (en) 1998-06-10
WO1997007403A1 (en) 1997-02-27
AR003251A1 (es) 1998-07-08
NO980623D0 (no) 1998-02-13
EP0846269B1 (en) 2003-09-24
NZ313070A (en) 1999-01-28
JPH11501398A (ja) 1999-02-02
CN1193385A (zh) 1998-09-16
ZA966808B (en) 1997-02-19
DK0846269T3 (da) 2003-12-01
CN1107230C (zh) 2003-04-30
NO980623L (no) 1998-02-13

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