BR9910303A - Cristal de n-[n-(3,3-dimetil-butil)-l-alfa-aspartil]-l-fenil-alanina- metil-éster, processo para produção do cristal, e, grânulo de cristal de n-[n-(3,3-dimetil-butil)-l-alfa aspartil]-l-fenil-alanina-metil-éster. - Google Patents

Cristal de n-[n-(3,3-dimetil-butil)-l-alfa-aspartil]-l-fenil-alanina- metil-éster, processo para produção do cristal, e, grânulo de cristal de n-[n-(3,3-dimetil-butil)-l-alfa aspartil]-l-fenil-alanina-metil-éster.

Info

Publication number
BR9910303A
BR9910303A BR9910303-6A BR9910303A BR9910303A BR 9910303 A BR9910303 A BR 9910303A BR 9910303 A BR9910303 A BR 9910303A BR 9910303 A BR9910303 A BR 9910303A
Authority
BR
Brazil
Prior art keywords
crystal
alanine
butyl
methyl
ester
Prior art date
Application number
BR9910303-6A
Other languages
English (en)
Inventor
Akihiro Kishishita
Kazutaka Nagashima
Hirotoshi Ishida
Takeshi Nagai
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Publication of BR9910303A publication Critical patent/BR9910303A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Seasonings (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"CRISTAL DE N-[N-(3,3-DIMETIL-BUTIL)-L-ALFA-ASPARTIL]-L-FENIL-ALANINA- METIL-éSTER, PROCESSO PARA PRODUçãO DO CRISTAL, E, GRâNULO DE CRISTAL DE N-[N-(3,3-DIMETIL-BUTIL)-L-ALFA-ASPARTIL]-L-FENIL-ALANINA- METIL-éSTER" Por exemplo, N-[N-(3,3-dimetil-butil)-L-<244>-aspartil]-L-fenil-alanina-metil-éster ( cristal de tipo A) mostrando picos característicos de raio X difrativos em ângulos de difração de (2<SYM>, raio CuK<244>) em pelo menos 6°, 24,8°, 8,2° e 16,5° é seco para que seu teor de água seja menos do que 3% em peso. O cristal assim seco é um novo cristal ( cristal de tipo C) de N-[N-(3,3-dimetil-butil)-L-<244>-aspartil]-L-fenil-alanina-metil-éster de excelente velocidade de dissolução, e quando medido por difratometria de raios X em pó, este cristal mostra picos característicos em raios X difrativos em ângulos de difração (2<SYM>, raio CuK<244>) em pelo menos 7,1°, 19,8°, 17,3° e 17,7°. A velocidade de dissolução (solubilidade) dos cristais de tipo C é adicionalmente melhorada pela conversão dos cristais em grânulos.
BR9910303-6A 1998-05-08 1999-04-26 Cristal de n-[n-(3,3-dimetil-butil)-l-alfa-aspartil]-l-fenil-alanina- metil-éster, processo para produção do cristal, e, grânulo de cristal de n-[n-(3,3-dimetil-butil)-l-alfa aspartil]-l-fenil-alanina-metil-éster. BR9910303A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP12599198 1998-05-08
JP10207605A JP2000026496A (ja) 1998-05-08 1998-07-23 新規アスパルテーム誘導体結晶及びその製造法
PCT/JP1999/002199 WO1999058553A1 (fr) 1998-05-08 1999-04-26 Nouveau cristal de derive d'aspartame et son procede de fabrication

Publications (1)

Publication Number Publication Date
BR9910303A true BR9910303A (pt) 2001-01-30

Family

ID=26462276

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9910303-6A BR9910303A (pt) 1998-05-08 1999-04-26 Cristal de n-[n-(3,3-dimetil-butil)-l-alfa-aspartil]-l-fenil-alanina- metil-éster, processo para produção do cristal, e, grânulo de cristal de n-[n-(3,3-dimetil-butil)-l-alfa aspartil]-l-fenil-alanina-metil-éster.

Country Status (9)

Country Link
US (1) US6790470B1 (pt)
EP (1) EP1076063A4 (pt)
JP (1) JP2000026496A (pt)
KR (1) KR100583549B1 (pt)
CN (1) CN1210291C (pt)
BR (1) BR9910303A (pt)
CA (1) CA2331819A1 (pt)
RU (1) RU2219184C2 (pt)
WO (1) WO1999058553A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020001652A1 (en) * 2000-02-16 2002-01-03 Aditi Dron Process for making granulated N-[N- (3, 3-dimethylbutyl) -L-alpha -aspartyl] -L- phenylalanine 1-methyl ester
CN101448407A (zh) * 2006-05-17 2009-06-03 Wm.雷格利Jr.公司 制备食物产品的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0631312B2 (ja) * 1983-03-18 1994-04-27 味の素株式会社 ジペプチド結晶及びその製造方法
JPH0622457B2 (ja) * 1983-08-10 1994-03-30 味の素株式会社 ジペプチド甘味料含有錠剤又は顆粒及びその製造法
JPH0710878B2 (ja) * 1986-07-28 1995-02-08 東ソー株式会社 溶解性の改善されたα−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルの製造方法
JPH07103152B2 (ja) * 1986-08-12 1995-11-08 東ソー株式会社 溶解性の改善されたα−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルの製造方法
JPS63177774A (ja) * 1987-01-14 1988-07-21 Ajinomoto Co Inc アスパルテ−ム含有飲料の製造法
JP2666452B2 (ja) * 1988-10-03 1997-10-22 味の素株式会社 溶解性の改善されたα―Ｌ―アスパルチル―Ｌ―フェニルアラニンメチルエステル乾燥結晶の製造方法
JPH0327398A (ja) * 1989-06-26 1991-02-05 Mitsui Toatsu Chem Inc α―Ｌ―アスパルチル―Ｌ―フェニルアラニンメチルエステルの晶析方法
JP2671532B2 (ja) * 1989-10-20 1997-10-29 味の素株式会社 アスパルテーム顆粒
JP3019519B2 (ja) * 1991-05-24 2000-03-13 味の素株式会社 α−Ｌ−アスパルチル−Ｌ−フェニルアラニンメチルエステル顆粒
FR2697844B1 (fr) * 1992-11-12 1995-01-27 Claude Nofre Nouveaux composés dérivés de dipeptides ou d'analogues dipeptidiques utiles comme agents édulcorants, leur procédé de préparation.
FR2719590B1 (fr) * 1994-05-09 1996-07-26 Claude Nofre Procédé perfectionné de préparation d'un composé dérivé de l'aspartame utile comme agent édulcorant.

Also Published As

Publication number Publication date
WO1999058553A1 (fr) 1999-11-18
EP1076063A4 (en) 2001-09-05
KR20010043437A (ko) 2001-05-25
CA2331819A1 (en) 1999-11-18
KR100583549B1 (ko) 2006-05-26
EP1076063A1 (en) 2001-02-14
CN1210291C (zh) 2005-07-13
CN1299371A (zh) 2001-06-13
US6790470B1 (en) 2004-09-14
JP2000026496A (ja) 2000-01-25
RU2219184C2 (ru) 2003-12-20

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 11A, 12A E 13A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2143 DE 31/01/2012.