BR9910298A - Novo cristal de n-[n-(3,3-dometil-butil)-l-alfa-aspartil]-l-fenil-alanin a-metil-éster, e, processo para prodição de novo cristal. - Google Patents

Novo cristal de n-[n-(3,3-dometil-butil)-l-alfa-aspartil]-l-fenil-alanin a-metil-éster, e, processo para prodição de novo cristal.

Info

Publication number
BR9910298A
BR9910298A BR9910298-6A BR9910298A BR9910298A BR 9910298 A BR9910298 A BR 9910298A BR 9910298 A BR9910298 A BR 9910298A BR 9910298 A BR9910298 A BR 9910298A
Authority
BR
Brazil
Prior art keywords
crystal
ester
new crystal
alanine
phenyl
Prior art date
Application number
BR9910298-6A
Other languages
English (en)
Inventor
Akihiro Kishishita
Kazutaka Nagashima
Hirotoshi Ishida
Takeshi Nagai
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Publication of BR9910298A publication Critical patent/BR9910298A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Seasonings (AREA)

Abstract

"NOVO CRISTAL DE N-[N-(3,3-DIMETIL-BUTIL)-L-ALFA-ASPARTIL]-L-FENIL-ALANINA- METIL-éSTER, E, PROCESSO PARA PRODUçãO DE NOVO CRISTAL". Na precipitação de N-[N-(3,3-dimetil-butil)-L-<244>-aspartil]-L-fenil-alanina-1-metil-éster de uma solução aquosa do citado éster, seu cristal é precipitado em uma temperatura de cristalização de 25°C ou menor e a solução é adicionalmente esfriada, se necessário ou se desejado, e o cristal precipitado ( cristal de tipo B) é separado por separação de sólido-líquido e depois é seco. O cristal assim seco é um novo cristal ( cristal de tipo D) do citado éster que apresenta excelente velocidade de dissolução, e este cristal quando medido por difratometria de raios X em pó, mostra picos característicos em padrão de difração de raios X em ângulos (2<SYM>, radiação CuK<244>) de pelo menos 5,4°, 8,4°, 18,8° e 17,6°.
BR9910298-6A 1998-05-08 1999-04-26 Novo cristal de n-[n-(3,3-dometil-butil)-l-alfa-aspartil]-l-fenil-alanin a-metil-éster, e, processo para prodição de novo cristal. BR9910298A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP10125992A JPH11322788A (ja) 1998-05-08 1998-05-08 新規アスパルテーム誘導体結晶及びその製造方法
PCT/JP1999/002200 WO1999058554A1 (fr) 1998-05-08 1999-04-26 Nouveau cristal de derive d'aspartame et son procede de fabrication

Publications (1)

Publication Number Publication Date
BR9910298A true BR9910298A (pt) 2001-01-30

Family

ID=14924052

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9910298-6A BR9910298A (pt) 1998-05-08 1999-04-26 Novo cristal de n-[n-(3,3-dometil-butil)-l-alfa-aspartil]-l-fenil-alanin a-metil-éster, e, processo para prodição de novo cristal.

Country Status (7)

Country Link
EP (1) EP1076064A4 (pt)
JP (1) JPH11322788A (pt)
KR (1) KR20010043389A (pt)
CN (1) CN1299372A (pt)
BR (1) BR9910298A (pt)
CA (1) CA2331810A1 (pt)
WO (1) WO1999058554A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6750324B1 (en) 1997-12-02 2004-06-15 Neuralab Limited Humanized and chimeric N-terminal amyloid beta-antibodies
US20030147882A1 (en) 1998-05-21 2003-08-07 Alan Solomon Methods for amyloid removal using anti-amyloid antibodies
US6423864B1 (en) * 1998-11-25 2002-07-23 The Nutrasweet Company Purification of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester via crystallization
WO2001009168A1 (en) * 1999-07-28 2001-02-08 The Nutrasweet Company A METHOD FOR THE PURIFICATION OF N-[N-(3,3-DIMETHYLBUTYL)-L-α-ASPARTYL]-L-PHENYLALANINE 1-METHYL ESTER
WO2001047949A1 (fr) * 1999-12-28 2001-07-05 Ajinomoto Co., Inc. Cristaux de derives d'aspartame
KR100463349B1 (ko) * 2002-01-23 2004-12-29 현대중공업 주식회사 선박 발라스트 탱크의 침전물제거장치를 이용한 선박 발라스트 탱크내의 해양자생물 제거장치

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2666452B2 (ja) * 1988-10-03 1997-10-22 味の素株式会社 溶解性の改善されたα―Ｌ―アスパルチル―Ｌ―フェニルアラニンメチルエステル乾燥結晶の製造方法
JPH0327398A (ja) * 1989-06-26 1991-02-05 Mitsui Toatsu Chem Inc α―Ｌ―アスパルチル―Ｌ―フェニルアラニンメチルエステルの晶析方法
JP2817255B2 (ja) * 1989-09-19 1998-10-30 東ソー株式会社 α―Ｌ―アスパルチル―Ｌ―フェニルアラニンメチルエステルの晶析法
JP3019519B2 (ja) * 1991-05-24 2000-03-13 味の素株式会社 α−Ｌ−アスパルチル−Ｌ−フェニルアラニンメチルエステル顆粒
JPH05286994A (ja) * 1992-04-13 1993-11-02 Tosoh Corp α−Ｌ−アスパルチル−Ｌ−フェニルアラニンメチルエステルの晶析法
FR2719590B1 (fr) * 1994-05-09 1996-07-26 Claude Nofre Procédé perfectionné de préparation d'un composé dérivé de l'aspartame utile comme agent édulcorant.

Also Published As

Publication number Publication date
EP1076064A4 (en) 2001-09-05
CA2331810A1 (en) 1999-11-18
WO1999058554A1 (fr) 1999-11-18
CN1299372A (zh) 2001-06-13
JPH11322788A (ja) 1999-11-24
EP1076064A1 (en) 2001-02-14
KR20010043389A (ko) 2001-05-25

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Legal Events

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B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE A 4A, 5A, 6A, 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1911 DE 21/08/2007.