BR9809580A - Derivados de alquil, alquenil e alquinil g crisamina para o diagnóstico antes da morte da doença de alzheimer e diagnóstico in vivo através de imagem e prevenção de deposição de amilóide - Google Patents
Derivados de alquil, alquenil e alquinil g crisamina para o diagnóstico antes da morte da doença de alzheimer e diagnóstico in vivo através de imagem e prevenção de deposição de amilóideInfo
- Publication number
- BR9809580A BR9809580A BR9809580-3A BR9809580A BR9809580A BR 9809580 A BR9809580 A BR 9809580A BR 9809580 A BR9809580 A BR 9809580A BR 9809580 A BR9809580 A BR 9809580A
- Authority
- BR
- Brazil
- Prior art keywords
- derivatives
- diagnosis
- alzheimer
- disease
- crisamine
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/001—Acyclic or carbocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
- C07C63/66—Polycyclic acids with unsaturation outside the aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/94—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of polycyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/14—Aza-phenalenes, e.g. 1,8-naphthalimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/28—Cinnolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/02—1,2-Oxazines; Hydrogenated 1,2-oxazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
- C07D265/26—Two oxygen atoms, e.g. isatoic anhydride
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/22—Tin compounds
- C07F7/2208—Compounds having tin linked only to carbon, hydrogen and/or halogen
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/14—Styryl dyes
- C09B23/141—Bis styryl dyes containing two radicals C6H5-CH=CH-
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/837,494 US6168776B1 (en) | 1994-07-19 | 1997-04-18 | Alkyl, alkenyl and alkynyl Chrysamine G derivatives for the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
PCT/US1998/007889 WO1998047969A1 (en) | 1997-04-18 | 1998-04-20 | Alkyl, alkenyl and alkynyl chrysamine g derivatives for the antemortem diagnosis of alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9809580A true BR9809580A (pt) | 2001-06-19 |
Family
ID=25274617
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9809580-3A BR9809580A (pt) | 1997-04-18 | 1998-04-20 | Derivados de alquil, alquenil e alquinil g crisamina para o diagnóstico antes da morte da doença de alzheimer e diagnóstico in vivo através de imagem e prevenção de deposição de amilóide |
Country Status (19)
Families Citing this family (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6417178B1 (en) * | 1994-07-19 | 2002-07-09 | University Of Pittsburgh | Amyloid binding nitrogen-linked compounds for the antemortem diagnosis of alzheimer's disease, in vivo imaging and prevention of amyloid deposits |
CN1434706A (zh) * | 1999-12-23 | 2003-08-06 | 神经化学公司 | 用于调节脑淀粉状蛋白性血管病的化合物和方法 |
US7640062B2 (en) | 2000-05-08 | 2009-12-29 | Brainsgate Ltd. | Methods and systems for management of alzheimer's disease |
US7297326B2 (en) * | 2000-08-21 | 2007-11-20 | The General Hospital Corporation | Ocular diagnosis of Alzheimer's disease |
JP4853936B2 (ja) * | 2000-08-21 | 2012-01-11 | ザ ジェネラル ホスピタル コーポレイション | 神経変性状態の診断方法 |
HU230581B1 (hu) | 2000-08-24 | 2017-01-30 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Tioflavin-származékok és alkalmazásuk az Alzheimer-kór diagnózisában és kezelésében |
US7270800B2 (en) | 2000-08-24 | 2007-09-18 | University Of Pittsburgh | Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
US6589504B1 (en) | 2000-09-22 | 2003-07-08 | Pharmacia & Upjohn Company | Compounds and methods for diagnosing and treating amyloid-related conditions |
DE60128138T2 (de) * | 2000-11-02 | 2008-01-03 | Cornell Research Foundation, Inc. | In vivo multiphoton diagnostische detektion und bilddarstellung einer neurodegenerativen erkrankung |
US6379650B1 (en) | 2001-03-19 | 2002-04-30 | Wesley Scott Ashton | Technetium 99m-N2S2-congo red complexes utilizing diamide dithiolate ligand systems for radioimaging |
ES2274973T3 (es) | 2001-04-23 | 2007-06-01 | The Trustees Of The University Of Pennsylvania | Inhibidores de la agregacion de placas amiloides y agentes de obtencion de imagenes diagnosticas. |
PT1420830E (pt) * | 2001-04-27 | 2011-04-20 | Brigham & Womens Hospital | Diagnóstico ocular da doença de alzheimer |
US20030211459A1 (en) * | 2001-10-25 | 2003-11-13 | The General Hospital Corporation | Drug development by rapid neuroimaging of neural cells |
US7407778B2 (en) | 2002-02-07 | 2008-08-05 | Pettegrew Jay W | Compounds, compositions and methods for treating neuropsychiatric disorders |
US7700074B2 (en) * | 2002-02-07 | 2010-04-20 | Pettegrew Jay W | Method and system for diagnosis of neuropsychiatric disorders including chronic alcoholism |
JP4421900B2 (ja) * | 2002-04-09 | 2010-02-24 | ザ スクリップス リサーチ インスティテュート | モチーフ・グラフトされたハイブリッドポリペプチドおよびその使用 |
US7636597B2 (en) | 2002-11-14 | 2009-12-22 | Brainsgate, Ltd. | Surgical tools and techniques for stimulation |
US7684859B2 (en) | 2002-04-25 | 2010-03-23 | Brainsgate Ltd. | Stimulation of the OTIC ganglion for treating medical conditions |
DK1558585T3 (da) | 2002-10-04 | 2014-01-06 | Prana Biotechnology Ltd | Neurologisk aktive forbindelser |
TW200413009A (en) * | 2002-10-04 | 2004-08-01 | Univ Pennsylvania | Biphenyls and fluorenes as imaging agents in alzheimer's disease |
US20040204344A1 (en) * | 2003-01-22 | 2004-10-14 | Xudong Huang | Amyloid-binding, metal-chelating agents |
GB0307855D0 (en) * | 2003-04-04 | 2003-05-14 | Novartis Ag | Organic compounds |
EP1631561B1 (en) | 2003-05-07 | 2010-08-18 | General Electric Company | Compositions and methods for non-invasive imaging of soluble beta-amyloid |
US20040223912A1 (en) * | 2003-05-07 | 2004-11-11 | Montalto Michael Christopher | Compositions and methods for non-invasive imaging of soluble beta-amyloid |
WO2005040337A2 (en) * | 2003-05-20 | 2005-05-06 | The Regents Of The University Of California | METHODS FOR BINDING AGENTS TO β-AMYLOID PLAQUES |
US20060257842A1 (en) * | 2003-05-29 | 2006-11-16 | Pettegrew Jay W | Cryopreservation media and molecules |
CN1795198B (zh) * | 2003-05-29 | 2011-08-17 | 杰伊·W·佩特格尤 | 对神经精神疾病进行医学成像所用的甘油磷酸胆碱及其衍生物 |
US20060035242A1 (en) * | 2004-08-13 | 2006-02-16 | Michelitsch Melissa D | Prion-specific peptide reagents |
US20050214222A1 (en) * | 2004-02-13 | 2005-09-29 | Mckinnon Stuart J | In vivo imaging of amyloid plaques in glaucoma using intravenous injectable dyes |
US9233245B2 (en) | 2004-02-20 | 2016-01-12 | Brainsgate Ltd. | SPG stimulation |
US8055347B2 (en) | 2005-08-19 | 2011-11-08 | Brainsgate Ltd. | Stimulation for treating brain events and other conditions |
US8010189B2 (en) * | 2004-02-20 | 2011-08-30 | Brainsgate Ltd. | SPG stimulation for treating complications of subarachnoid hemorrhage |
GB0405193D0 (en) * | 2004-03-08 | 2004-04-21 | Medical Res Council | Compounds |
EP1838296B1 (en) * | 2004-10-20 | 2012-08-08 | Resverlogix Corp. | Flavanoids and isoflavanoids for the prevention and treatment of cardiovascular diseases |
WO2006076683A2 (en) * | 2005-01-13 | 2006-07-20 | Novartis Vaccines And Diagnostics Inc. | Isolation and detection of pathogenic prions |
WO2007002540A2 (en) * | 2005-06-24 | 2007-01-04 | Kung Hank F | Radiolabeled-pegylation of ligands for use as imaging agents |
US8410109B2 (en) * | 2005-07-29 | 2013-04-02 | Resverlogix Corp. | Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices |
GB2453191A (en) * | 2005-10-18 | 2009-04-01 | Brigham & Womens Hospital | Diagnosis of transmissible spongiform encephalopathy |
AU2006320556A1 (en) * | 2005-12-01 | 2007-06-07 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Isotopically-labeled benzothiazole compounds as imaging agents for amyloidogenic proteins |
ES2817950T3 (es) | 2006-04-11 | 2021-04-08 | Cognoptix Inc | Procesamiento de imágenes oculares |
EP2514423A3 (en) | 2006-04-14 | 2012-12-19 | Prana Biotechnology Ltd | Method of treatment of age-related macular degeneration (AMD) |
US7700616B2 (en) * | 2006-05-08 | 2010-04-20 | Molecular Neuroimaging, Llc. | Compounds and amyloid probes thereof for therapeutic and imaging uses |
WO2007139777A2 (en) * | 2006-05-26 | 2007-12-06 | Merck & Co., Inc. | Methods for the diagnosis and prognosis of alzheimer's disease using csf protein profiling |
US7745222B2 (en) * | 2006-10-13 | 2010-06-29 | General Electric Company | Amyloid binding assays |
US7858663B1 (en) * | 2007-10-31 | 2010-12-28 | Pisgah Laboratories, Inc. | Physical and chemical properties of thyroid hormone organic acid addition salts |
EP2103611A4 (en) | 2006-12-25 | 2010-06-30 | Univ Tohoku | benzoxazole |
JP5236664B2 (ja) | 2007-02-01 | 2013-07-17 | レスバーロジックス コーポレイション | 心血管疾患を予防および治療するための化合物 |
EP2152255A1 (en) * | 2007-05-21 | 2010-02-17 | Neuroptix Corporation | Ophthalmic formulations of amyloid- contrast agents and methods of use thereof |
JP5172229B2 (ja) * | 2007-07-04 | 2013-03-27 | 住友化学株式会社 | アゾ化合物又はその塩 |
US20100221180A1 (en) * | 2007-08-31 | 2010-09-02 | Yanming Wang | In vivo imaging of myelination |
US7860569B2 (en) | 2007-10-18 | 2010-12-28 | Brainsgate, Ltd. | Long-term SPG stimulation therapy for prevention of vascular dementia |
MX2010010314A (es) | 2008-03-21 | 2011-04-12 | Gen Hospital Corp | Compuestos y composiciones para la deteccion y el tratamiento de la enfermedad de alzheimer y trastornos relacionados. |
AU2009243060A1 (en) * | 2008-04-30 | 2009-11-05 | Novartis Ag. | Assay for pathogenic conformers |
WO2009146388A1 (en) | 2008-05-28 | 2009-12-03 | The Trustees Of Columbia University In The City Of New York | Voxel-based methods for assessing subjects using positron emission tomography |
AU2009262252B2 (en) | 2008-06-26 | 2013-05-02 | Resverlogix Corp. | Methods of preparing quinazolinone derivatives |
JP5635535B2 (ja) | 2009-01-08 | 2014-12-03 | レスバーロジックス コーポレイション | 心血管疾患の予防および治療のための化合物 |
US9925282B2 (en) | 2009-01-29 | 2018-03-27 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
NZ595747A (en) | 2009-03-18 | 2015-06-26 | Resverlogix Corp | Novel quinazolinones and related compounds for use as anti-inflammatory agents |
CU23844B1 (es) | 2009-04-17 | 2012-10-15 | Ct De Neurociencias De Cuba | Procedimiento de obtención de nuevos derivados de naftaleno para el diagnóstico in vivo de la enfermedad de alzheimer |
DK2421533T3 (en) | 2009-04-22 | 2019-01-07 | Resverlogix Corp | Hitherto unknown anti-inflammatory agents |
US8455836B2 (en) * | 2009-10-28 | 2013-06-04 | Roy Stockdale | Sensor system for constantly monitoring an irradiance level of a UV lamp and for being operated by power from a sensor thereof |
US9555130B2 (en) * | 2010-02-25 | 2017-01-31 | Case Western Reserve University | Compositions and methods for in vivo imaging of myelin in the peripheral nervous system |
NZ607257A (en) | 2010-08-16 | 2015-02-27 | Cognoptix Inc | System and method for detecting amyloid proteins |
CN103945848B (zh) | 2011-11-01 | 2016-09-07 | 雷斯韦洛吉克斯公司 | 被取代的喹唑啉酮的口服即释制剂 |
US10058530B2 (en) | 2012-10-25 | 2018-08-28 | The General Hospital Corporation | Combination therapies for the treatment of Alzheimer's disease and related disorders |
CA2889446C (en) | 2012-10-25 | 2021-05-11 | The General Hospital Corporation | Combination therapies for the treatment of alzheimer's disease and related disorders |
US9765039B2 (en) | 2012-11-21 | 2017-09-19 | Zenith Epigenetics Ltd. | Biaryl derivatives as bromodomain inhibitors |
US9073878B2 (en) | 2012-11-21 | 2015-07-07 | Zenith Epigenetics Corp. | Cyclic amines as bromodomain inhibitors |
CN105073744B (zh) | 2012-12-21 | 2019-11-08 | 齐尼思表观遗传学有限公司 | 作为溴结构域抑制剂的新型杂环化合物 |
CU20130027A7 (es) | 2013-02-28 | 2014-10-30 | Ct De Neurociencias De Cuba | Chaperoninas químicas como nuevos moduladores moleculares de la beta agregación proteica presente en las enfermedades conformacionales |
US10525005B2 (en) | 2013-05-23 | 2020-01-07 | The General Hospital Corporation | Cromolyn compositions and methods thereof |
AU2014340182B2 (en) | 2013-10-22 | 2019-05-23 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
TW201609183A (zh) | 2013-10-31 | 2016-03-16 | 康諾普堤克斯公司 | 眼用調配物之製備方法及其用途 |
EP2878335B1 (en) | 2013-11-10 | 2018-01-03 | Brainsgate Ltd. | Implant and delivery system for neural stimulator |
CN107530356A (zh) | 2015-03-13 | 2018-01-02 | 雷斯韦洛吉克斯公司 | 用于治疗补体相关疾病之组合物及治疗方法 |
US10271907B2 (en) | 2015-05-13 | 2019-04-30 | Brainsgate Ltd. | Implant and delivery system for neural stimulator |
KR101943706B1 (ko) * | 2016-08-25 | 2019-01-29 | 성균관대학교산학협력단 | 유비퀴틴 활성 저해용 조성물 |
US20190240194A1 (en) | 2016-08-31 | 2019-08-08 | The General Hospital Corporation | Macrophages/microglia in neuro-inflammation associated with neurodegenerative diseases |
MX2020000577A (es) | 2017-07-20 | 2020-09-10 | Aztherapies Inc | Formulaciones en polvo de cromolina sodica e ibuprofeno. |
AU2019299347A1 (en) | 2018-07-02 | 2021-01-21 | Aztherapies, Inc. | Powdered formulations of cromolyn sodium and alpha-lactose |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US329638A (en) | 1885-11-03 | Fabriken | ||
US394841A (en) | 1888-12-18 | Carl duisberg | ||
US401024A (en) | 1889-04-09 | Benfabriken | ||
US622961A (en) | 1899-04-11 | Ivan levinstein and carl mensching | ||
US1979534A (en) | 1931-10-15 | 1934-11-06 | Farastan Company | Disazo compound for therapeutic use |
CH513785A (de) | 1967-10-03 | 1971-10-15 | Ciba Geigy Ag | Verfahren zur Herstellung von neuen Bis-stilbenverbindungen |
CH554848A (de) | 1967-10-03 | 1974-10-15 | Ciba Geigy Ag | Verfahren zur herstellung neuer stilben-derivate. |
CH540958A (de) | 1970-07-23 | 1973-08-31 | Ciba Geigy Ag | Verwendung von Styrylverbindungen als optische Aufhellmittel für organische Materialien ausserhalb der Textilindustrie |
DE2039993A1 (de) | 1970-08-12 | 1972-02-17 | Basf Ag | Optische Aufheller der Bisstyrylbenzolreihe |
CH574950A5 (US06168776-20010102-C00075.png) | 1972-06-30 | 1976-04-30 | Ciba Geigy Ag | |
US4016156A (en) | 1972-06-30 | 1977-04-05 | Ciba-Geigy Corporation | Distyryl compounds |
DE2364396A1 (de) | 1973-12-22 | 1975-07-10 | Basf Ag | Neue bisstyrylarylverbindungen |
LU75628A1 (US06168776-20010102-C00075.png) | 1976-08-19 | 1978-04-13 | ||
US4933156A (en) | 1987-04-08 | 1990-06-12 | Salutar, Inc. | Amyloidosis and Alzheimer's disease diagnostic assay and reagents therefor |
US5039511A (en) | 1987-04-08 | 1991-08-13 | Salutar, Inc. | Amyloidosis and alzheimer's disease diagnostic assay and reagents therefor |
CA1302403C (en) | 1987-04-08 | 1992-06-02 | Steven C. Quay | Amyloidosis and alzheimer's disease diagnostic assay and reagents therefor |
US5008099A (en) | 1987-04-08 | 1991-04-16 | Salutar, Inc. | Amyloidosis and Alzheimer's disease diagnostic assay and reagents therefor |
US5231000A (en) | 1987-10-08 | 1993-07-27 | The Mclean Hospital | Antibodies to A4 amyloid peptide |
JP2641529B2 (ja) * | 1988-10-26 | 1997-08-13 | 三菱化学株式会社 | 新規有機高分子 |
AU654013B2 (en) | 1991-03-13 | 1994-10-20 | Regents Of The University Of Minnesota | 2-hydroxy-3(4-iodophenyl)-1-(4-phenylpiperidinyl) propane |
US5297562A (en) | 1991-04-01 | 1994-03-29 | President And Fellows Of Harvard College | Method for detecting and treating Alzheimer's disease |
US5434050A (en) | 1991-08-13 | 1995-07-18 | Regents Of The University Of Minnesota | Labelled β-amyloid peptide and methods of screening for Alzheimer's disease |
US5276059A (en) | 1992-07-10 | 1994-01-04 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibition of diseases associated with amyloid formation |
AU712552B2 (en) | 1995-05-01 | 1999-11-11 | University Of Pittsburgh | Azo compounds for the antemortem diagnosis of alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
-
1997
- 1997-04-18 US US08/837,494 patent/US6168776B1/en not_active Expired - Lifetime
-
1998
- 1998-04-20 TR TR1999/03115T patent/TR199903115T2/xx unknown
- 1998-04-20 IL IL13242698A patent/IL132426A0/xx unknown
- 1998-04-20 KR KR1019997009642A patent/KR20010006552A/ko not_active Application Discontinuation
- 1998-04-20 ZA ZA9803301A patent/ZA983301B/xx unknown
- 1998-04-20 JP JP54622398A patent/JP2002500634A/ja active Pending
- 1998-04-20 PL PL98336321A patent/PL336321A1/xx unknown
- 1998-04-20 CA CA002286607A patent/CA2286607A1/en not_active Abandoned
- 1998-04-20 EE EEP199900503A patent/EE9900503A/xx unknown
- 1998-04-20 HU HU0003804A patent/HUP0003804A3/hu unknown
- 1998-04-20 SK SK1440-99A patent/SK144099A3/sk unknown
- 1998-04-20 BR BR9809580-3A patent/BR9809580A/pt unknown
- 1998-04-20 CN CN98806318A patent/CN1261906A/zh active Pending
- 1998-04-20 NZ NZ500714A patent/NZ500714A/en unknown
- 1998-04-20 WO PCT/US1998/007889 patent/WO1998047969A1/en not_active Application Discontinuation
- 1998-04-20 EP EP98918448A patent/EP0977815A1/en not_active Withdrawn
- 1998-04-20 AU AU71369/98A patent/AU7136998A/en not_active Abandoned
- 1998-04-20 AR ARP980101817A patent/AR012845A1/es not_active Application Discontinuation
- 1998-11-09 US US09/188,200 patent/US6133259A/en not_active Expired - Fee Related
- 1998-11-09 US US09/188,244 patent/US6114175A/en not_active Expired - Fee Related
-
1999
- 1999-10-18 NO NO995088A patent/NO995088L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US6133259A (en) | 2000-10-17 |
NZ500714A (en) | 2001-09-28 |
TR199903115T2 (xx) | 2000-05-22 |
CA2286607A1 (en) | 1998-10-29 |
ZA983301B (en) | 1999-10-20 |
JP2002500634A (ja) | 2002-01-08 |
CN1261906A (zh) | 2000-08-02 |
IL132426A0 (en) | 2001-03-19 |
EE9900503A (et) | 2000-06-15 |
KR20010006552A (ko) | 2001-01-26 |
HUP0003804A3 (en) | 2002-09-30 |
AR012845A1 (es) | 2000-11-22 |
HUP0003804A2 (hu) | 2001-06-28 |
US6114175A (en) | 2000-09-05 |
US6168776B1 (en) | 2001-01-02 |
NO995088D0 (no) | 1999-10-18 |
SK144099A3 (en) | 2000-07-11 |
EP0977815A1 (en) | 2000-02-09 |
PL336321A1 (en) | 2000-06-19 |
WO1998047969A1 (en) | 1998-10-29 |
AU7136998A (en) | 1998-11-13 |
NO995088L (no) | 1999-12-17 |
MX9909557A (es) | 2002-12-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR9809580A (pt) | Derivados de alquil, alquenil e alquinil g crisamina para o diagnóstico antes da morte da doença de alzheimer e diagnóstico in vivo através de imagem e prevenção de deposição de amilóide | |
BR9812776A (pt) | Composto para o dignóstico antemortem de doença de alzheimer e diagnóstico por imagens in vivo e prevenção de deposição amilóide | |
FR2377376A1 (fr) | Derives d'hexahydroterphenyle et leur application en tant que cristaux liquides | |
NZ307369A (en) | Azocompounds for the antemortem diagnosis of alzheimer's disease and in vivo imaging and prevention of amyloid deposition | |
BRPI0113470B8 (pt) | composto de ligação amilóide, composição farmacêutica e métodos de síntese de composto, de detecção in vivo de depósitos amilóides num indivíduo e em tecido humano ou animal, de quantificação de depósito amilóide em tecido de biópsia ou postmortem e de distinção de um cérebro de doença de alzheimer de um cérebro normal | |
AR030816A1 (es) | Derivados de glucopiranosiloxibencilbenceno y composiciones farmaceuticas que comprenden los mismos | |
TNSN99170A1 (fr) | Derives de tetrahydroquinoleine substitues nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant | |
DE69937198D1 (de) | Behandlung der alzheimer-krankheit durch erhöhung des cytidin-spiegels in vivo | |
HUP0102909A2 (hu) | L-karnitint és alfa-liponsavat tartalmazó antioxidáns készítmény | |
TNSN01035A1 (fr) | Derives d'ethers de pyrazole nouveaux, et compositions pharmaceutiques les contenant. | |
FR2411205A1 (fr) | Derives heterosidiques de pleuromutiline et leur utilisation therapeutique | |
KR950700314A (ko) | 루이스형 당쇄 유도체(Lewis-type sugar chain derivative) | |
SI1667947T1 (sl) | Postopki 11C-radiooznačevanja fenotiazina in fenotiazinu podobnih spojin | |
BR0011728A (pt) | Método de inibir a agregação de proteìna amilóide e imagem de depósitos de amilóide | |
EA200200188A1 (ru) | Конденсированные пирролкарбоксамиды: лиганды для гамк-мозговых рецепторов | |
FR2673625B1 (fr) | Nouveaux derives d'acylaminophenol, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. | |
ES2102041T3 (es) | Tioeter-aminas fenolicas para radioformacion de imagenes y radioquimioterapia y derivados acilados de las mismas para usar en el diagnostico y el tratamiento de trastornos de la pigmentacion. | |
HUP0004667A2 (hu) | Új, optikailag aktív aminopentán-származékok | |
DK1107751T3 (da) | Lægemiddel indeholdende platinkompleksforbindelser samt anvendelse deraf | |
TNSN00105A1 (fr) | Derives de 1-trifluoromethyl-4-hydroxy-7-piperidinyl- aminomethylchromane, procede pour leur preparation et compositions pharmaceutiques les contenant | |
FR2410640A1 (fr) | Derives de phenoxyalcanolamines, leur preparation et leurs utilisations therapeutiques | |
Zimmerman et al. | Hepatic toxicity of antimicrobial agents. | |
ES2071793T3 (es) | Nuevos derivados de la pirrolidona, su procedimiento de preparacion y composiciones farmaceuticas que los contienen. | |
MA30267B1 (fr) | Derives amides en tant que ligands de canal ionique et compositions pharmaceutiques et procedes d'utilisation de tels derives | |
FR2648135B1 (fr) | Derives de phenyl-1-dihydro-1,4 amino-3 oxo-4 pyridazines, leur preparation et leur application en therapeutique |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A,6A E 7A ANUIDADES. |