FR2411205A1 - Derives heterosidiques de pleuromutiline et leur utilisation therapeutique - Google Patents

Derives heterosidiques de pleuromutiline et leur utilisation therapeutique

Info

Publication number
FR2411205A1
FR2411205A1 FR7834109A FR7834109A FR2411205A1 FR 2411205 A1 FR2411205 A1 FR 2411205A1 FR 7834109 A FR7834109 A FR 7834109A FR 7834109 A FR7834109 A FR 7834109A FR 2411205 A1 FR2411205 A1 FR 2411205A1
Authority
FR
France
Prior art keywords
derivatives
heterosidic
pleuromutiline
therapeutic use
pentopyranoses
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7834109A
Other languages
English (en)
Other versions
FR2411205B1 (fr
Inventor
Ramakrishnan Nagarajan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of FR2411205A1 publication Critical patent/FR2411205A1/fr
Application granted granted Critical
Publication of FR2411205B1 publication Critical patent/FR2411205B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'INVENTION CONCERNE DES DERIVES HETEROSIDIQUES DE PLEUROMUTILINE DE FORMULE: (CF DESSIN DANS BOPI) DANS LAQUELLE R EST UN GROUPEMENT ETHYLE OU VINYLE; R EST CHOISI PARMI DIVERS SUCRES, ENTRE AUTRES, LES ANOMERES A ET B D'HEXOPYRANOSES ET D'HEXOFURANOSES, DE PENTOPYRANOSES ET PENTOFURANOSES, D'AMINO-SUCRES, DE DISSACHARIDES ET TRISACCHARIDES ET DE CERTAINS RADICAUX HETEROSYLE, AINSI QUE LEURS DERIVES PER-O-ACYLES OU PER-O-BENZYLES; ET R EST H OU LES GROUPEMENTS ACYLE OU BENZYLE DANS LE CAS DES DERNIERS DERIVES. CES COMPOSES ONT UNE ACTIVITE ANTIBACTERIENNE.
FR7834109A 1977-12-08 1978-12-04 Derives heterosidiques de pleuromutiline et leur utilisation therapeutique Granted FR2411205A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/858,507 US4130709A (en) 1977-12-08 1977-12-08 Pleuromutilin glycoside derivatives

Publications (2)

Publication Number Publication Date
FR2411205A1 true FR2411205A1 (fr) 1979-07-06
FR2411205B1 FR2411205B1 (fr) 1981-08-14

Family

ID=25328471

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7834109A Granted FR2411205A1 (fr) 1977-12-08 1978-12-04 Derives heterosidiques de pleuromutiline et leur utilisation therapeutique

Country Status (28)

Country Link
US (1) US4130709A (fr)
EP (1) EP0002588B1 (fr)
JP (1) JPS5498751A (fr)
AT (1) AT362065B (fr)
AU (1) AU524665B2 (fr)
BE (1) BE872489A (fr)
CA (1) CA1109866A (fr)
CH (1) CH639103A5 (fr)
CS (2) CS219342B2 (fr)
DD (1) DD139858A5 (fr)
DE (1) DE2862226D1 (fr)
DK (1) DK539578A (fr)
ES (1) ES475854A1 (fr)
FI (1) FI783709A (fr)
FR (1) FR2411205A1 (fr)
GB (1) GB2009738B (fr)
GR (1) GR72774B (fr)
HU (1) HU181429B (fr)
IE (1) IE47533B1 (fr)
IL (1) IL56115A (fr)
IT (1) IT1160316B (fr)
LU (1) LU80619A1 (fr)
PL (1) PL123850B1 (fr)
PT (1) PT68857A (fr)
RO (3) RO80082A (fr)
SU (1) SU902666A3 (fr)
YU (1) YU281878A (fr)
ZA (1) ZA786872B (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA80175B (en) * 1979-01-12 1981-08-26 Sandoz Ltd New pleuromutilin derivatives, their production and use
US5041534A (en) * 1983-03-22 1991-08-20 Merrell Dow Pharmaceuticals Process for preparing antibiotic L 17054
FR2551442B1 (fr) * 1983-09-05 1987-04-30 Centre Nat Rech Scient Nouveaux derives furaniques, leur preparation et leur application
US5077398A (en) * 1986-11-18 1991-12-31 Merck & Co., Inc. Process for isolation of avermectin B1 components with improved purity and subsequent isolaton of B2 components
US5843908A (en) * 1990-09-28 1998-12-01 Bristol-Myers Squibb Company Pradimicins l and fl, and derivatives thereof
US5696096A (en) * 1990-09-28 1997-12-09 Bristol-Myers Squibb Company Pradimicin derivatives
AT400674B (de) * 1991-07-24 1996-02-26 Biochemie Gmbh Pharmazeutische pleuromutilin-zubereitung
JP3816570B2 (ja) * 1996-02-16 2006-08-30 塩水港精糖株式会社 アシル化剤
GB9614017D0 (en) * 1996-07-04 1996-09-04 Biochemie Gmbh Organic compounds
UY25225A1 (es) 1997-10-29 2000-12-29 Smithkline Beecham Plc Derivados de pleuromutilina utiles como agentes antimicrobianos
GB0218578D0 (en) * 2002-08-09 2002-09-18 Glaxo Group Ltd Novel method
GB0308114D0 (en) * 2003-04-08 2003-05-14 Glaxo Group Ltd Novel compounds
EP2181995A3 (fr) 2003-09-03 2010-06-16 Glaxo Group Limited Sels et forme crystalline de mutilin 14-(exo-8-methyl-8-azabicyclo[3.2.1]oct-3-yl-sufanyl)-acetate
US6838576B1 (en) 2003-10-23 2005-01-04 3M Innovative Properties Company Process for preparing functional group-containing olefinic compounds
US9895444B2 (en) 2004-08-25 2018-02-20 Aegis Therapeutics, Llc Compositions for drug administration
US20140162965A1 (en) 2004-08-25 2014-06-12 Aegis Therapeutics, Inc. Compositions for oral drug administration
US20060046962A1 (en) 2004-08-25 2006-03-02 Aegis Therapeutics Llc Absorption enhancers for drug administration
US8268791B2 (en) * 2004-08-25 2012-09-18 Aegis Therapeutics, Llc. Alkylglycoside compositions for drug administration
GB0513058D0 (en) * 2005-06-27 2005-08-03 Sandoz Ag Organic compounds
US8084022B2 (en) 2006-06-23 2011-12-27 Aegis Therapeutics, Llc Stabilizing alkylglycoside compositions and methods thereof
US20090326193A1 (en) * 2006-06-23 2009-12-31 Aegis Therapeutics Llc Stabilizing alkylglycoside compositions and methods thereof
US8173594B2 (en) * 2006-06-23 2012-05-08 Aegis Therapeutics, Llc Stabilizing alkylglycoside compositions and methods thereof
US8226949B2 (en) 2006-06-23 2012-07-24 Aegis Therapeutics Llc Stabilizing alkylglycoside compositions and methods thereof
US7998927B2 (en) * 2006-06-23 2011-08-16 Aegis Therapeutics, Llc Stabilizing alkylglycoside compositions and methods thereof
EP1972618A1 (fr) * 2007-03-20 2008-09-24 Nabriva Therapeutics AG Dérivés de pleuromutilin pour le traitement des maladies médiées par des microbes
DK2271347T3 (en) 2008-03-28 2016-08-15 Hale Biopharma Ventures Llc Administration of benzodiazepine compositions
US8440631B2 (en) 2008-12-22 2013-05-14 Aegis Therapeutics, Llc Compositions for drug administration
CA2961672A1 (fr) * 2014-09-19 2016-03-24 Emory University Analogues de saccharide et agents pour le diagnostic et la therapie d'infections bacteriennes

Also Published As

Publication number Publication date
HU181429B (en) 1983-07-28
GR72774B (fr) 1983-12-05
IE47533B1 (en) 1984-04-18
JPS5498751A (en) 1979-08-03
PT68857A (en) 1979-01-01
IL56115A (en) 1984-01-31
AU524665B2 (en) 1982-09-30
CS219342B2 (en) 1983-03-25
IL56115A0 (en) 1979-03-12
BE872489A (fr) 1979-06-05
SU902666A3 (ru) 1982-01-30
AT362065B (de) 1981-04-27
ZA786872B (en) 1980-08-27
RO84426A (fr) 1984-06-21
GB2009738A (en) 1979-06-20
YU281878A (en) 1983-06-30
IT1160316B (it) 1987-03-11
RO80082B (ro) 1983-01-30
CS219344B2 (en) 1983-03-25
RO84425B (ro) 1984-08-30
RO84425A (fr) 1984-06-21
EP0002588A1 (fr) 1979-06-27
GB2009738B (en) 1982-11-10
DD139858A5 (de) 1980-01-23
PL123850B1 (en) 1982-12-31
ATA871578A (de) 1980-09-15
RO84426B (ro) 1984-08-30
IT7830657A0 (it) 1978-12-06
US4130709A (en) 1978-12-19
AU4216278A (en) 1979-06-14
DK539578A (da) 1979-07-05
RO80082A (fr) 1983-02-01
PL211492A1 (pl) 1979-11-19
FR2411205B1 (fr) 1981-08-14
EP0002588B1 (fr) 1983-04-06
CH639103A5 (fr) 1983-10-31
CA1109866A (fr) 1981-09-29
ES475854A1 (es) 1980-05-16
IE782421L (en) 1979-06-08
FI783709A (fi) 1979-06-09
DE2862226D1 (en) 1983-05-11
LU80619A1 (fr) 1979-06-05

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Legal Events

Date Code Title Description
ST Notification of lapse