RO84425B - Procedeu pentru prepararea unor derivati de pleuromutilinglicozida - Google Patents

Procedeu pentru prepararea unor derivati de pleuromutilinglicozida

Info

Publication number
RO84425B
RO84425B RO106829A RO10682978A RO84425B RO 84425 B RO84425 B RO 84425B RO 106829 A RO106829 A RO 106829A RO 10682978 A RO10682978 A RO 10682978A RO 84425 B RO84425 B RO 84425B
Authority
RO
Romania
Prior art keywords
derivatives
carbon
gram
general formula
pleuromutylinglycosyd
Prior art date
Application number
RO106829A
Other languages
English (en)
Other versions
RO84425A (ro
Inventor
Ramakrishnan Nagarajan
Original Assignee
Eli Lilly And Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Co filed Critical Eli Lilly And Co
Publication of RO84425A publication Critical patent/RO84425A/ro
Publication of RO84425B publication Critical patent/RO84425B/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Prezenta inventie se refera la un procedeu pentru prepararea unor derivati de pleuromutilinglicozida, cu formula generala I: (vezi formula) în care R este vinil, R1 este: (vezi formula) în care R3 este hidrogen, R4 este -OR3 sau -NR7R8, R7 si R8 reprezentînd, independent, H sau alchil continînd 1...3 atomi de carbon, R5 este H sau -CH2OR3 si R6 este -OR3 sau: (vezi formula) iar R2 este H, cu conditia ca R1 sa fie altul decît anomerul beta-D-xilopiranozil, caracterizat prin aceea ca, în scopul diversificarii gamei substantelor utilizate ca agenti în combaterea bacteriilor gram-pozitive, gram-negative si micoplasmelor, se hidrolizeaza la temperatura camerei, în mediu de etanol, la un raport în greutate apa: metanol de 1:1 si în prezenta de trietilamina, un derivat de pleurotilenglicozida cu formula generala I de mai sus, în care R1, R2, R4, R5 si R6 au aceeasi semnificatie iar R3 reprezinta un alcanoil cu 2...4 atomi de carbon.
RO106829A 1977-12-08 1978-12-02 Procedeu pentru prepararea unor derivati de pleuromutilinglicozida RO84425B (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/858,507 US4130709A (en) 1977-12-08 1977-12-08 Pleuromutilin glycoside derivatives

Publications (2)

Publication Number Publication Date
RO84425A RO84425A (ro) 1984-06-21
RO84425B true RO84425B (ro) 1984-08-30

Family

ID=25328471

Family Applications (3)

Application Number Title Priority Date Filing Date
RO106829A RO84425B (ro) 1977-12-08 1978-12-02 Procedeu pentru prepararea unor derivati de pleuromutilinglicozida
RO7895807A RO80082A (ro) 1977-12-08 1978-12-02 Procedeu pentru prepararea unor derivati de pleuromutilinglicoida
RO106830A RO84426B (ro) 1977-12-08 1978-12-02 Procedeu pentru prepararea unor derivati de pleuromutiliglicozida

Family Applications After (2)

Application Number Title Priority Date Filing Date
RO7895807A RO80082A (ro) 1977-12-08 1978-12-02 Procedeu pentru prepararea unor derivati de pleuromutilinglicoida
RO106830A RO84426B (ro) 1977-12-08 1978-12-02 Procedeu pentru prepararea unor derivati de pleuromutiliglicozida

Country Status (28)

Country Link
US (1) US4130709A (ro)
EP (1) EP0002588B1 (ro)
JP (1) JPS5498751A (ro)
AT (1) AT362065B (ro)
AU (1) AU524665B2 (ro)
BE (1) BE872489A (ro)
CA (1) CA1109866A (ro)
CH (1) CH639103A5 (ro)
CS (2) CS219344B2 (ro)
DD (1) DD139858A5 (ro)
DE (1) DE2862226D1 (ro)
DK (1) DK539578A (ro)
ES (1) ES475854A1 (ro)
FI (1) FI783709A (ro)
FR (1) FR2411205A1 (ro)
GB (1) GB2009738B (ro)
GR (1) GR72774B (ro)
HU (1) HU181429B (ro)
IE (1) IE47533B1 (ro)
IL (1) IL56115A (ro)
IT (1) IT1160316B (ro)
LU (1) LU80619A1 (ro)
PL (1) PL123850B1 (ro)
PT (1) PT68857A (ro)
RO (3) RO84425B (ro)
SU (1) SU902666A3 (ro)
YU (1) YU281878A (ro)
ZA (1) ZA786872B (ro)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5594359A (en) * 1979-01-12 1980-07-17 Sandoz Ag Novel pleuromutilin derivatives*their manufacture and use
US5041534A (en) * 1983-03-22 1991-08-20 Merrell Dow Pharmaceuticals Process for preparing antibiotic L 17054
FR2551442B1 (fr) * 1983-09-05 1987-04-30 Centre Nat Rech Scient Nouveaux derives furaniques, leur preparation et leur application
US5077398A (en) * 1986-11-18 1991-12-31 Merck & Co., Inc. Process for isolation of avermectin B1 components with improved purity and subsequent isolaton of B2 components
US5696096A (en) * 1990-09-28 1997-12-09 Bristol-Myers Squibb Company Pradimicin derivatives
US5843908A (en) * 1990-09-28 1998-12-01 Bristol-Myers Squibb Company Pradimicins l and fl, and derivatives thereof
AT400674B (de) * 1991-07-24 1996-02-26 Biochemie Gmbh Pharmazeutische pleuromutilin-zubereitung
JP3816570B2 (ja) * 1996-02-16 2006-08-30 塩水港精糖株式会社 アシル化剤
GB9614017D0 (en) * 1996-07-04 1996-09-04 Biochemie Gmbh Organic compounds
UY25225A1 (es) 1997-10-29 2000-12-29 Smithkline Beecham Plc Derivados de pleuromutilina utiles como agentes antimicrobianos
GB0218578D0 (en) * 2002-08-09 2002-09-18 Glaxo Group Ltd Novel method
GB0308114D0 (en) * 2003-04-08 2003-05-14 Glaxo Group Ltd Novel compounds
EP2181995A3 (en) 2003-09-03 2010-06-16 Glaxo Group Limited Salts and crystalline form of mutilin 14-(exo-8-methyl-8-azabicyclo[3.2.1]oct-3-yl-sufanyl)-acetate
US6838576B1 (en) 2003-10-23 2005-01-04 3M Innovative Properties Company Process for preparing functional group-containing olefinic compounds
US8268791B2 (en) * 2004-08-25 2012-09-18 Aegis Therapeutics, Llc. Alkylglycoside compositions for drug administration
US20060046962A1 (en) 2004-08-25 2006-03-02 Aegis Therapeutics Llc Absorption enhancers for drug administration
US20140162965A1 (en) 2004-08-25 2014-06-12 Aegis Therapeutics, Inc. Compositions for oral drug administration
US9895444B2 (en) 2004-08-25 2018-02-20 Aegis Therapeutics, Llc Compositions for drug administration
GB0513058D0 (en) * 2005-06-27 2005-08-03 Sandoz Ag Organic compounds
US7998927B2 (en) * 2006-06-23 2011-08-16 Aegis Therapeutics, Llc Stabilizing alkylglycoside compositions and methods thereof
US8084022B2 (en) 2006-06-23 2011-12-27 Aegis Therapeutics, Llc Stabilizing alkylglycoside compositions and methods thereof
US8173594B2 (en) * 2006-06-23 2012-05-08 Aegis Therapeutics, Llc Stabilizing alkylglycoside compositions and methods thereof
US20090326193A1 (en) * 2006-06-23 2009-12-31 Aegis Therapeutics Llc Stabilizing alkylglycoside compositions and methods thereof
US8226949B2 (en) 2006-06-23 2012-07-24 Aegis Therapeutics Llc Stabilizing alkylglycoside compositions and methods thereof
EP1972618A1 (en) * 2007-03-20 2008-09-24 Nabriva Therapeutics AG Pleuromutilin derivatives for the treatment of diseases mediated by microbes
JP5613657B2 (ja) 2008-03-28 2014-10-29 ヘイル バイオファーマ ベンチャーズ，エルエルシー ベンゾジアゼピン組成物の投与
US8440631B2 (en) 2008-12-22 2013-05-14 Aegis Therapeutics, Llc Compositions for drug administration
EP3193946A4 (en) * 2014-09-19 2018-05-23 Emory University Saccharide analogs and agents for the diagnosis and therapy of bacterial infections

Also Published As

Publication number Publication date
RO84426A (ro) 1984-06-21
FI783709A (fi) 1979-06-09
CS219342B2 (en) 1983-03-25
IL56115A0 (en) 1979-03-12
RO80082B (ro) 1983-01-30
CS219344B2 (en) 1983-03-25
GB2009738A (en) 1979-06-20
FR2411205B1 (ro) 1981-08-14
IT1160316B (it) 1987-03-11
IE782421L (en) 1979-06-08
DD139858A5 (de) 1980-01-23
ZA786872B (en) 1980-08-27
GR72774B (ro) 1983-12-05
BE872489A (fr) 1979-06-05
DE2862226D1 (en) 1983-05-11
CA1109866A (en) 1981-09-29
JPS5498751A (en) 1979-08-03
ATA871578A (de) 1980-09-15
HU181429B (en) 1983-07-28
AU4216278A (en) 1979-06-14
PT68857A (en) 1979-01-01
YU281878A (en) 1983-06-30
IE47533B1 (en) 1984-04-18
RO84425A (ro) 1984-06-21
CH639103A5 (fr) 1983-10-31
RO84426B (ro) 1984-08-30
DK539578A (da) 1979-07-05
AT362065B (de) 1981-04-27
LU80619A1 (fr) 1979-06-05
FR2411205A1 (fr) 1979-07-06
ES475854A1 (es) 1980-05-16
EP0002588B1 (en) 1983-04-06
IT7830657A0 (it) 1978-12-06
GB2009738B (en) 1982-11-10
IL56115A (en) 1984-01-31
PL123850B1 (en) 1982-12-31
EP0002588A1 (en) 1979-06-27
AU524665B2 (en) 1982-09-30
PL211492A1 (pl) 1979-11-19
US4130709A (en) 1978-12-19
RO80082A (ro) 1983-02-01
SU902666A3 (ru) 1982-01-30

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