RO81622B - Procedeu de preparare a unor derivati de 4"- dezoxi - 4"- aminoeritromicina a - Google Patents

Procedeu de preparare a unor derivati de 4"- dezoxi - 4"- aminoeritromicina a

Info

Publication number
RO81622B
RO81622B RO105255A RO10525578A RO81622B RO 81622 B RO81622 B RO 81622B RO 105255 A RO105255 A RO 105255A RO 10525578 A RO10525578 A RO 10525578A RO 81622 B RO81622 B RO 81622B
Authority
RO
Romania
Prior art keywords
deoxy
aminoarithromicin
represents hydrogen
group
preparing derivatives
Prior art date
Application number
RO105255A
Other languages
English (en)
Other versions
RO81622A (ro
Inventor
Frank Christian Sciavolino
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/856,479 external-priority patent/US4150220A/en
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of RO81622A publication Critical patent/RO81622A/ro
Publication of RO81622B publication Critical patent/RO81622B/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Inventia se refera la un procedeu de preparare a unor derivati de 4''-dezoxi-4''-amino-eritromicina Acu formula generala I: (vezi form. in desc.)în care R1 reprezinta hidrogen si R2 reprezinta hidrogen sau o grupa acil cu 2 sau 3 atomi de carbon, R3 reprezinta împreuna cu o grupa carbonil, R' reprezinta oxigen si R reprezinta hidrogen sau R reprezinta o legatura la atomul de carbon de care este legat R', prin aceea ca se hidrolizeaza un compus cu formula generala II: (vezi form. in desc.) în care substituentii R, R2, R3, R' au semnificatiile de mai sus si R'1 reprezinta o grupa acil cu 2 sau 3 atomi de carbon, sub agitare cu un exces de metanol, la temperatura camerei.
RO105255A 1977-02-04 1978-02-02 Procedeu de preparare a unor derivati de 4"- dezoxi - 4"- aminoeritromicina a RO81622B (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76548077A 1977-02-04 1977-02-04
US05/856,479 US4150220A (en) 1977-02-04 1977-12-01 Semi-synthetic 4"-erythromycin A derivatives

Publications (2)

Publication Number Publication Date
RO81622A RO81622A (ro) 1983-04-29
RO81622B true RO81622B (ro) 1983-04-30

Family

ID=27117613

Family Applications (4)

Application Number Title Priority Date Filing Date
RO7893080A RO77345A (ro) 1977-02-04 1978-02-02 Procedeu pentru prepararea unor derivati de 4"-dezoxi-4"-aminoeritromicina a
RO78101650A RO79686A7 (ro) 1977-02-04 1978-02-02 Procedeu de preparare a unor derivati de 4''-dezoxi-4''-oxo-eritromicina a
RO105255A RO81622B (ro) 1977-02-04 1978-02-02 Procedeu de preparare a unor derivati de 4"- dezoxi - 4"- aminoeritromicina a
RO78101651A RO79687A7 (ro) 1977-02-04 1978-02-02 Procedeu de preparare a unor derivati de 4''-dezoxi-4''-aminoeritromicina a

Family Applications Before (2)

Application Number Title Priority Date Filing Date
RO7893080A RO77345A (ro) 1977-02-04 1978-02-02 Procedeu pentru prepararea unor derivati de 4"-dezoxi-4"-aminoeritromicina a
RO78101650A RO79686A7 (ro) 1977-02-04 1978-02-02 Procedeu de preparare a unor derivati de 4''-dezoxi-4''-oxo-eritromicina a

Family Applications After (1)

Application Number Title Priority Date Filing Date
RO78101651A RO79687A7 (ro) 1977-02-04 1978-02-02 Procedeu de preparare a unor derivati de 4''-dezoxi-4''-aminoeritromicina a

Country Status (30)

Country Link
JP (1) JPS5827798B2 (ro)
AR (1) AR222147A1 (ro)
AU (1) AU501298B1 (ro)
BG (2) BG33159A3 (ro)
CA (1) CA1106367A (ro)
CH (1) CH628906A5 (ro)
CS (1) CS221801B2 (ro)
DD (1) DD140048A5 (ro)
DE (1) DE2804507C2 (ro)
DK (1) DK148036C (ro)
ES (2) ES466057A1 (ro)
FI (1) FI780354A (ro)
FR (2) FR2379550A1 (ro)
GB (2) GB1585315A (ro)
GR (1) GR68691B (ro)
HU (1) HU182559B (ro)
IE (1) IE46661B1 (ro)
IL (2) IL53968A0 (ro)
IT (1) IT1094209B (ro)
LU (1) LU79004A1 (ro)
NL (1) NL176174C (ro)
NO (2) NO146472C (ro)
NZ (1) NZ186385A (ro)
PH (2) PH14421A (ro)
PL (1) PL116228B1 (ro)
PT (1) PT67568B (ro)
RO (4) RO77345A (ro)
SE (2) SE445223B (ro)
SU (1) SU927122A3 (ro)
YU (3) YU40913B (ro)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4133950A (en) * 1978-01-03 1979-01-09 Pfizer Inc. 4"-Deoxy-4"-carbamate and dithiocarbamate derivatives of oleandomycin and its esters
US4124755A (en) * 1978-01-03 1978-11-07 Pfizer Inc. 11-Alkanoyl-4"-deoxy-4"-isonitrilo-oleandomycin derivatives
US4382085A (en) * 1982-03-01 1983-05-03 Pfizer Inc. 4"-Epi erythromycin A and derivatives thereof as useful antibacterial agents
US4518590A (en) * 1984-04-13 1985-05-21 Pfizer Inc. 9α-Aza-9α-homoerythromycin compounds, pharmaceutical compositions and therapeutic method
US6407074B1 (en) 1997-06-11 2002-06-18 Pfizer Inc C-4″-substituted macrolide derivatives
HN1998000074A (es) * 1997-06-11 1999-01-08 Pfizer Prod Inc Derivados de macrolidos c-4 sustituidos

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3836519A (en) * 1973-05-04 1974-09-17 Abbott Lab Sulfonyl derivatives of erythromycin
US3884903A (en) * 1973-06-21 1975-05-20 Abbott Lab 4{41 -Deoxy-4{41 -oxoerythromycin B derivatives

Also Published As

Publication number Publication date
PL204428A1 (pl) 1979-06-04
JPS5827798B2 (ja) 1983-06-11
PH16675A (en) 1983-12-13
YU40798B (en) 1986-06-30
IT1094209B (it) 1985-07-26
FR2379550B1 (ro) 1980-07-04
SE8300870D0 (sv) 1983-02-16
YU40913B (en) 1986-08-31
CH628906A5 (en) 1982-03-31
NL7801262A (nl) 1978-08-08
GB1585316A (en) 1981-02-25
NZ186385A (en) 1980-10-08
PT67568B (en) 1979-06-18
SE7800270L (sv) 1978-08-05
IL53968A0 (en) 1978-04-30
DD140048A5 (de) 1980-02-06
AR222147A1 (es) 1981-04-30
LU79004A1 (fr) 1979-09-06
RO79687A7 (ro) 1982-08-17
YU227983A (en) 1984-04-30
NL176174B (nl) 1984-10-01
YU26583A (en) 1984-02-29
NO146472C (no) 1982-10-06
BG33159A3 (en) 1982-12-15
ES472429A1 (es) 1979-04-01
YU7378A (en) 1983-04-30
YU40799B (en) 1986-06-30
CA1106367A (en) 1981-08-04
GB1585315A (en) 1981-02-25
ES466057A1 (es) 1978-10-01
BG32718A3 (en) 1982-09-15
DK148036C (da) 1985-07-15
SE457086B (sv) 1988-11-28
JPS53101337A (en) 1978-09-04
IE46661B1 (en) 1983-08-24
NO811913L (no) 1978-08-07
NO150484C (no) 1984-10-24
DE2804507C2 (de) 1982-11-04
PL116228B1 (en) 1981-05-30
DE2804507A1 (de) 1978-08-10
FR2379550A1 (fr) 1978-09-01
PT67568A (en) 1978-02-01
AU501298B1 (en) 1979-06-14
NL176174C (nl) 1985-03-01
PH14421A (en) 1981-07-10
SU927122A3 (ru) 1982-05-07
GR68691B (ro) 1982-02-01
DK148036B (da) 1985-02-11
FI780354A (fi) 1978-08-05
SE8300870L (sv) 1983-02-16
FR2385735A1 (fr) 1978-10-27
HU182559B (en) 1984-02-28
CS221801B2 (en) 1983-04-29
FR2385735B1 (ro) 1980-10-24
NO146472B (no) 1982-06-28
DK51878A (da) 1978-08-05
IE780239L (en) 1978-08-04
RO81622A (ro) 1983-04-29
NO150484B (no) 1984-07-16
RO79686A7 (ro) 1982-08-17
SE445223B (sv) 1986-06-09
IT7820005A0 (it) 1978-02-03
IL61997A0 (en) 1981-02-27
NO780389L (no) 1978-08-07
RO77345A (ro) 1981-08-17

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