RO80082B - Procedeu pentru prepararea unor derivati de pleuromutilinglicozida - Google Patents

Procedeu pentru prepararea unor derivati de pleuromutilinglicozida

Info

Publication number
RO80082B
RO80082B RO95807A RO9580778A RO80082B RO 80082 B RO80082 B RO 80082B RO 95807 A RO95807 A RO 95807A RO 9580778 A RO9580778 A RO 9580778A RO 80082 B RO80082 B RO 80082B
Authority
RO
Romania
Prior art keywords
pleuromutilinglicoside
derivatives
preparation
vinyl
general formula
Prior art date
Application number
RO95807A
Other languages
English (en)
Other versions
RO80082A (ro
Inventor
Ramakrishnan Nagarajan
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of RO80082B publication Critical patent/RO80082B/ro
Publication of RO80082A publication Critical patent/RO80082A/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Procedeu pentru prepararea unor derivati de de pleuromutilinglicozida cu formula generala I: (vezi formula) în care R este vinil si R1 este (vezi formula) în care R3 este alcanoil (C2-C4); R4 este OR3 sau -NR7R8; R5 este H sau -CH2OR3 si R6 este -OR3sau: (vezi formula) în care R7 si R8 reprezinta independent H sau alchil (C1-C3); si R2 este H cu conditia ca R1 sa fie altul decît anomerul beta de D-xilopiranosil, caracterizat prin aceea ca, un glicozil HR1 în care R3, R4, R5 si R6 au fost defini ti mai sus, reactioneaza cu o pluromutilina cu formula generala II: (vezi formula) în care R este vinil, R2 este H si Y este iod, reactantii fiind luati în raport molar de circa 1:1 la temperatura camerei, în prezenta carbonatului de potasiu în acetona.
RO7895807A 1977-12-08 1978-12-02 Procedeu pentru prepararea unor derivati de pleuromutilinglicoida RO80082A (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/858,507 US4130709A (en) 1977-12-08 1977-12-08 Pleuromutilin glycoside derivatives

Publications (2)

Publication Number Publication Date
RO80082B true RO80082B (ro) 1983-01-30
RO80082A RO80082A (ro) 1983-02-01

Family

ID=25328471

Family Applications (3)

Application Number Title Priority Date Filing Date
RO7895807A RO80082A (ro) 1977-12-08 1978-12-02 Procedeu pentru prepararea unor derivati de pleuromutilinglicoida
RO106830A RO84426B (ro) 1977-12-08 1978-12-02 Procedeu pentru prepararea unor derivati de pleuromutiliglicozida
RO106829A RO84425B (ro) 1977-12-08 1978-12-02 Procedeu pentru prepararea unor derivati de pleuromutilinglicozida

Family Applications After (2)

Application Number Title Priority Date Filing Date
RO106830A RO84426B (ro) 1977-12-08 1978-12-02 Procedeu pentru prepararea unor derivati de pleuromutiliglicozida
RO106829A RO84425B (ro) 1977-12-08 1978-12-02 Procedeu pentru prepararea unor derivati de pleuromutilinglicozida

Country Status (28)

Country Link
US (1) US4130709A (ro)
EP (1) EP0002588B1 (ro)
JP (1) JPS5498751A (ro)
AT (1) AT362065B (ro)
AU (1) AU524665B2 (ro)
BE (1) BE872489A (ro)
CA (1) CA1109866A (ro)
CH (1) CH639103A5 (ro)
CS (2) CS219342B2 (ro)
DD (1) DD139858A5 (ro)
DE (1) DE2862226D1 (ro)
DK (1) DK539578A (ro)
ES (1) ES475854A1 (ro)
FI (1) FI783709A7 (ro)
FR (1) FR2411205A1 (ro)
GB (1) GB2009738B (ro)
GR (1) GR72774B (ro)
HU (1) HU181429B (ro)
IE (1) IE47533B1 (ro)
IL (1) IL56115A (ro)
IT (1) IT1160316B (ro)
LU (1) LU80619A1 (ro)
PL (1) PL123850B1 (ro)
PT (1) PT68857A (ro)
RO (3) RO80082A (ro)
SU (1) SU902666A3 (ro)
YU (1) YU281878A (ro)
ZA (1) ZA786872B (ro)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5594359A (en) * 1979-01-12 1980-07-17 Sandoz Ag Novel pleuromutilin derivatives*their manufacture and use
US5041534A (en) * 1983-03-22 1991-08-20 Merrell Dow Pharmaceuticals Process for preparing antibiotic L 17054
FR2551442B1 (fr) * 1983-09-05 1987-04-30 Centre Nat Rech Scient Nouveaux derives furaniques, leur preparation et leur application
US5077398A (en) * 1986-11-18 1991-12-31 Merck & Co., Inc. Process for isolation of avermectin B1 components with improved purity and subsequent isolaton of B2 components
US5843908A (en) * 1990-09-28 1998-12-01 Bristol-Myers Squibb Company Pradimicins l and fl, and derivatives thereof
US5696096A (en) * 1990-09-28 1997-12-09 Bristol-Myers Squibb Company Pradimicin derivatives
AT400674B (de) * 1991-07-24 1996-02-26 Biochemie Gmbh Pharmazeutische pleuromutilin-zubereitung
JP3816570B2 (ja) * 1996-02-16 2006-08-30 塩水港精糖株式会社 アシル化剤
GB9614017D0 (en) * 1996-07-04 1996-09-04 Biochemie Gmbh Organic compounds
UY25225A1 (es) 1997-10-29 2000-12-29 Smithkline Beecham Plc Derivados de pleuromutilina utiles como agentes antimicrobianos
ES2182703B1 (es) * 2001-06-18 2004-06-01 Consejo Superior De Investigaciones Cientificas Un procedimiento enzimatico para obtener 4-0-b-d-galactopiranosil-d-xilosa, 4-o-b-d-galactopiranosil-d-xilosa obtenida de acuerdo con el pr cedimiento, composiciones que la contienen y su uso en la evaluacion de la lactasa intestinal.
GB0218578D0 (en) * 2002-08-09 2002-09-18 Glaxo Group Ltd Novel method
GB0308114D0 (en) * 2003-04-08 2003-05-14 Glaxo Group Ltd Novel compounds
ATE450535T1 (de) 2003-09-03 2009-12-15 Glaxo Group Ltd Neues verfahren zur herstellung von pleuromutilinderivaten
US6838576B1 (en) 2003-10-23 2005-01-04 3M Innovative Properties Company Process for preparing functional group-containing olefinic compounds
US8268791B2 (en) * 2004-08-25 2012-09-18 Aegis Therapeutics, Llc. Alkylglycoside compositions for drug administration
US20140162965A1 (en) 2004-08-25 2014-06-12 Aegis Therapeutics, Inc. Compositions for oral drug administration
US9895444B2 (en) 2004-08-25 2018-02-20 Aegis Therapeutics, Llc Compositions for drug administration
US20060046962A1 (en) 2004-08-25 2006-03-02 Aegis Therapeutics Llc Absorption enhancers for drug administration
GB0513058D0 (en) * 2005-06-27 2005-08-03 Sandoz Ag Organic compounds
US7998927B2 (en) * 2006-06-23 2011-08-16 Aegis Therapeutics, Llc Stabilizing alkylglycoside compositions and methods thereof
US8226949B2 (en) 2006-06-23 2012-07-24 Aegis Therapeutics Llc Stabilizing alkylglycoside compositions and methods thereof
US8173594B2 (en) * 2006-06-23 2012-05-08 Aegis Therapeutics, Llc Stabilizing alkylglycoside compositions and methods thereof
US8084022B2 (en) 2006-06-23 2011-12-27 Aegis Therapeutics, Llc Stabilizing alkylglycoside compositions and methods thereof
US20090326193A1 (en) * 2006-06-23 2009-12-31 Aegis Therapeutics Llc Stabilizing alkylglycoside compositions and methods thereof
EP1972618A1 (en) * 2007-03-20 2008-09-24 Nabriva Therapeutics AG Pleuromutilin derivatives for the treatment of diseases mediated by microbes
CA2756690C (en) 2008-03-28 2016-08-16 Hale Biopharma Ventures, Llc Administration of benzodiazepine compositions
US8440631B2 (en) 2008-12-22 2013-05-14 Aegis Therapeutics, Llc Compositions for drug administration
DK3415139T3 (da) 2011-06-14 2022-06-20 Neurelis Inc Administration af benzodiazepin
WO2016044846A1 (en) * 2014-09-19 2016-03-24 Emory University Saccharide analogs and agents for the diagnosis and therapy of bacterial infections
CN107810000B (zh) 2015-06-17 2021-03-12 纳布里瓦治疗有限责任公司 来氟米林的可注射药物组合物

Also Published As

Publication number Publication date
GB2009738A (en) 1979-06-20
IE782421L (en) 1979-06-08
DE2862226D1 (en) 1983-05-11
IL56115A (en) 1984-01-31
RO84426B (ro) 1984-08-30
PT68857A (en) 1979-01-01
IL56115A0 (en) 1979-03-12
GB2009738B (en) 1982-11-10
EP0002588A1 (en) 1979-06-27
ATA871578A (de) 1980-09-15
LU80619A1 (fr) 1979-06-05
AT362065B (de) 1981-04-27
PL211492A1 (pl) 1979-11-19
RO84425A (ro) 1984-06-21
AU4216278A (en) 1979-06-14
IE47533B1 (en) 1984-04-18
CS219344B2 (en) 1983-03-25
YU281878A (en) 1983-06-30
ZA786872B (en) 1980-08-27
CS219342B2 (en) 1983-03-25
FR2411205B1 (ro) 1981-08-14
US4130709A (en) 1978-12-19
GR72774B (ro) 1983-12-05
BE872489A (fr) 1979-06-05
CH639103A5 (fr) 1983-10-31
PL123850B1 (en) 1982-12-31
RO84425B (ro) 1984-08-30
ES475854A1 (es) 1980-05-16
SU902666A3 (ru) 1982-01-30
FR2411205A1 (fr) 1979-07-06
IT1160316B (it) 1987-03-11
FI783709A7 (fi) 1979-06-09
DD139858A5 (de) 1980-01-23
IT7830657A0 (it) 1978-12-06
JPS5498751A (en) 1979-08-03
RO84426A (ro) 1984-06-21
CA1109866A (en) 1981-09-29
HU181429B (en) 1983-07-28
DK539578A (da) 1979-07-05
AU524665B2 (en) 1982-09-30
RO80082A (ro) 1983-02-01
EP0002588B1 (en) 1983-04-06

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