BR9713388B1 - processos de produÇço de vÍrus e de adenovÍrus recombinantes defectivos, e baculovÍrus recombinante. - Google Patents
processos de produÇço de vÍrus e de adenovÍrus recombinantes defectivos, e baculovÍrus recombinante.Info
- Publication number
- BR9713388B1 BR9713388B1 BRPI9713388-4A BR9713388A BR9713388B1 BR 9713388 B1 BR9713388 B1 BR 9713388B1 BR 9713388 A BR9713388 A BR 9713388A BR 9713388 B1 BR9713388 B1 BR 9713388B1
- Authority
- BR
- Brazil
- Prior art keywords
- recombinant
- adenoviruses
- production processes
- defective
- baculoviruses
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 241000701447 unidentified baculovirus Species 0.000 title abstract 2
- 230000002950 deficient Effects 0.000 title 1
- 241000701161 unidentified adenovirus Species 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 230000000295 complement effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14041—Use of virus, viral particle or viral elements as a vector
- C12N2710/14043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vectore
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
- C12N2710/14141—Use of virus, viral particle or viral elements as a vector
- C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Pens And Brushes (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9614278A FR2756297B1 (fr) | 1996-11-22 | 1996-11-22 | Procede de production de virus recombinants |
| PCT/FR1997/002073 WO1998022607A1 (fr) | 1996-11-22 | 1997-11-18 | Procede de production de virus recombinants |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR9713388A BR9713388A (pt) | 2000-03-21 |
| BR9713388B1 true BR9713388B1 (pt) | 2009-01-13 |
Family
ID=9497899
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI9713388-4A BR9713388B1 (pt) | 1996-11-22 | 1997-11-18 | processos de produÇço de vÍrus e de adenovÍrus recombinantes defectivos, e baculovÍrus recombinante. |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US6387670B1 (enExample) |
| EP (1) | EP0946741B1 (enExample) |
| JP (1) | JP4686670B2 (enExample) |
| KR (1) | KR100719645B1 (enExample) |
| AT (1) | ATE317908T1 (enExample) |
| AU (1) | AU731106B2 (enExample) |
| BR (1) | BR9713388B1 (enExample) |
| CA (1) | CA2271438C (enExample) |
| CZ (1) | CZ293947B6 (enExample) |
| DE (1) | DE69735274T2 (enExample) |
| ES (1) | ES2260803T3 (enExample) |
| FR (1) | FR2756297B1 (enExample) |
| HU (1) | HU224713B1 (enExample) |
| IL (1) | IL129686A (enExample) |
| NO (2) | NO323937B1 (enExample) |
| SK (1) | SK286900B6 (enExample) |
| WO (1) | WO1998022607A1 (enExample) |
| ZA (1) | ZA9710516B (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2375119A1 (en) * | 1999-05-27 | 2000-12-07 | Genovo, Incorporated | Compositions and methods for production of recombinant virus using a carrier vector derived from a nonmammalian virus |
| US6793926B1 (en) * | 1999-05-27 | 2004-09-21 | Genovo, Inc. | Methods for production of a recombinant adeno-associated virus |
| WO2000073424A1 (en) * | 1999-05-28 | 2000-12-07 | Mount Sinai School Of Medicine | A novel baculovirus/adenovirus hybrid vector for the rescue, production and titration of high-capacity adenovirus amplicon vectors |
| GB9919409D0 (en) | 1999-08-18 | 1999-10-20 | Univ Oxford Brookes | Baculovirus expression system |
| US7897380B2 (en) | 2002-08-29 | 2011-03-01 | The Board Of Trustees Of The Leland Stanford Junior University | Circular nucleic acid vectors, and methods for making and using the same |
| GB0702694D0 (en) * | 2007-02-12 | 2007-03-21 | Ark Therapeutics Ltd | Vectors |
| GB0702695D0 (en) * | 2007-02-12 | 2007-03-21 | Ark Therapeutics Ltd | Production of vectors |
| EP2019143A1 (en) | 2007-07-23 | 2009-01-28 | Genethon | CNS gene delivery using peripheral administration of AAV vectors |
| EP2058401A1 (en) | 2007-10-05 | 2009-05-13 | Genethon | Widespread gene delivery to motor neurons using peripheral injection of AAV vectors |
| KR101575696B1 (ko) * | 2008-03-05 | 2015-12-08 | 카운실 오브 사이언티픽 엔드 인더스트리얼 리서치 | 고분자 하이브리드막 |
| EP2287323A1 (en) | 2009-07-31 | 2011-02-23 | Association Institut de Myologie | Widespread gene delivery to the retina using systemic administration of AAV vectors |
| EP2292781A1 (en) * | 2009-08-17 | 2011-03-09 | Genethon | Baculovirus-based production of biopharmaceuticals free of contaminating baculoviral virions |
| EP2553105B1 (en) * | 2010-04-01 | 2014-12-17 | Weidong Xiao | Compositions and methods for the production of recombinant virus vectors |
| WO2011130119A2 (en) | 2010-04-14 | 2011-10-20 | Millipore Corporation | Methods of producing high titer, high purity virus stocks and methods of use thereof |
| EP3470523A1 (en) | 2012-05-09 | 2019-04-17 | Oregon Health & Science University | Adeno associated virus plasmids and vectors |
| TWI698240B (zh) | 2012-05-15 | 2020-07-11 | 澳大利亞商艾佛蘭屈澳洲私營有限公司 | 使用腺相關病毒(aav)sflt-1治療老年性黃斑部退化(amd) |
| US20150182637A1 (en) | 2012-06-21 | 2015-07-02 | Association Institut De Myologie | Widespread gene delivery of gene therapy vectors |
| US11078464B2 (en) * | 2013-08-30 | 2021-08-03 | Amgen Inc. | High titer recombinant AAV vector production in adherent and suspension cells |
| CN106414474B (zh) | 2014-03-17 | 2021-01-15 | 阿德夫拉姆生物技术股份有限公司 | 用于视锥细胞中增强的基因表达的组合物和方法 |
| CA2978068C (en) | 2015-03-02 | 2024-05-28 | Adverum Biotechnologies, Inc. | Compositions and methods for intravitreal delivery of polynucleotides to retinal cones |
| GB2545763A (en) | 2015-12-23 | 2017-06-28 | Adverum Biotechnologies Inc | Mutant viral capsid libraries and related systems and methods |
| AU2018373279B2 (en) | 2017-11-27 | 2024-07-25 | Trames Bio, Inc. | Compositions and methods for neurological diseases |
| BR112020015798A2 (pt) | 2018-02-01 | 2021-03-09 | Homology Medicines, Inc. | Composições de vírus adeno-associado para restaurar função de gene da pah e métodos de uso das mesmas |
| US10610606B2 (en) | 2018-02-01 | 2020-04-07 | Homology Medicines, Inc. | Adeno-associated virus compositions for PAH gene transfer and methods of use thereof |
| EP3755795A4 (en) | 2018-02-19 | 2022-07-20 | Homology Medicines, Inc. | Adeno-associated virus compositions for restoring f8 gene function and methods of use thereof |
| BR112020022669A2 (pt) | 2018-05-08 | 2021-02-17 | Neuracle Science Co., Ltd | distribuição de vírus adenoassociado (aav) de anticorpos anti-fam19a5 |
| JP2022523719A (ja) | 2019-01-31 | 2022-04-26 | オレゴン・ヘルス・アンド・サイエンス・ユニバーシティ | Ａａｖキャプシドの転写依存性定方向進化を使用するための方法 |
| US20220348635A1 (en) | 2019-08-21 | 2022-11-03 | Coda Biotherapeutics, Inc. | Compositions and methods for neurological diseases |
| TW202140791A (zh) | 2020-01-13 | 2021-11-01 | 美商霍蒙拉奇醫藥公司 | 治療苯酮尿症之方法 |
| TW202208632A (zh) | 2020-05-27 | 2022-03-01 | 美商同源醫藥公司 | 用於恢復ｐａｈ基因功能的腺相關病毒組成物及其使用方法 |
| GB202013940D0 (en) | 2020-09-04 | 2020-10-21 | Synpromics Ltd | Regulatory nucleic acid sequences |
| EP4225382A4 (en) | 2020-10-07 | 2025-04-23 | AskBio Inc. | ADMINISTRATION OF THERAPEUTIC ADENO-ASSOCIATED VIRUS FUKKUTIN-ASSOCIATED PROTEIN (FKRP) FOR THE TREATMENT OF DYSTROGLYCANOPATHY. DISORDERS INCLUDING LIMB GIRDLE 21 |
| EP4514845A1 (en) | 2022-04-29 | 2025-03-05 | Broadwing Bio LLC | Bispecific antibodies and methods of treating ocular disease |
| AU2023259251A1 (en) | 2022-04-29 | 2024-11-14 | Broadwing Bio Llc | Angiopoietin-related protein 7-specific antibodies and uses thereof |
| CN119365485A (zh) | 2022-04-29 | 2025-01-24 | 博闻生物有限责任公司 | 补体因子h相关4特异性抗体及其用途 |
| WO2024227154A1 (en) | 2023-04-28 | 2024-10-31 | Broadwing Bio Llc | Complement component 3 (c3)-specific antibodies and uses thereof |
| WO2025040613A1 (en) * | 2023-08-21 | 2025-02-27 | Vector Biopharma Ag | Cell line for production of helper-dependent adenoviruses |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990005538A1 (en) * | 1988-11-14 | 1990-05-31 | The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce | Parvovirus capsids |
| US5559099A (en) * | 1994-09-08 | 1996-09-24 | Genvec, Inc. | Penton base protein and methods of using same |
| EP0785803A4 (en) * | 1994-09-23 | 2000-08-02 | Gen Hospital Corp | Use of a non-mammalian dna virus to express an exogenous gene in a mammalian cell |
-
1996
- 1996-11-22 FR FR9614278A patent/FR2756297B1/fr not_active Expired - Lifetime
-
1997
- 1997-11-18 CA CA2271438A patent/CA2271438C/fr not_active Expired - Lifetime
- 1997-11-18 AT AT97947083T patent/ATE317908T1/de not_active IP Right Cessation
- 1997-11-18 SK SK666-99A patent/SK286900B6/sk not_active IP Right Cessation
- 1997-11-18 IL IL12968697A patent/IL129686A/xx not_active IP Right Cessation
- 1997-11-18 EP EP97947083A patent/EP0946741B1/fr not_active Expired - Lifetime
- 1997-11-18 US US09/308,398 patent/US6387670B1/en not_active Expired - Lifetime
- 1997-11-18 BR BRPI9713388-4A patent/BR9713388B1/pt not_active IP Right Cessation
- 1997-11-18 WO PCT/FR1997/002073 patent/WO1998022607A1/fr not_active Ceased
- 1997-11-18 DE DE69735274T patent/DE69735274T2/de not_active Expired - Lifetime
- 1997-11-18 KR KR1019997004531A patent/KR100719645B1/ko not_active Expired - Lifetime
- 1997-11-18 ES ES97947083T patent/ES2260803T3/es not_active Expired - Lifetime
- 1997-11-18 HU HU0001762A patent/HU224713B1/hu active Protection Beyond IP Right Term
- 1997-11-18 CZ CZ19991822A patent/CZ293947B6/cs not_active IP Right Cessation
- 1997-11-18 AU AU52261/98A patent/AU731106B2/en not_active Expired
- 1997-11-18 JP JP52328298A patent/JP4686670B2/ja not_active Expired - Lifetime
- 1997-11-21 ZA ZA9710516A patent/ZA9710516B/xx unknown
-
1999
- 1999-05-21 NO NO19992464A patent/NO323937B1/no not_active IP Right Cessation
-
2002
- 2002-05-09 US US10/141,491 patent/US20030022356A1/en not_active Abandoned
-
2013
- 2013-04-15 NO NO2013009C patent/NO2013009I1/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR100719645B1 (ko) | 2007-05-17 |
| KR20000057202A (ko) | 2000-09-15 |
| NO2013009I1 (no) | 2013-04-29 |
| HUP0001762A3 (en) | 2002-01-28 |
| IL129686A0 (en) | 2000-02-29 |
| NO992464D0 (no) | 1999-05-21 |
| CA2271438A1 (fr) | 1998-05-28 |
| US20030022356A1 (en) | 2003-01-30 |
| CA2271438C (fr) | 2010-10-26 |
| ZA9710516B (en) | 1998-06-10 |
| DE69735274T2 (de) | 2006-10-12 |
| NO992464L (no) | 1999-06-23 |
| EP0946741A1 (fr) | 1999-10-06 |
| ES2260803T3 (es) | 2006-11-01 |
| WO1998022607A1 (fr) | 1998-05-28 |
| CZ293947B6 (cs) | 2004-08-18 |
| IL129686A (en) | 2005-12-18 |
| FR2756297B1 (fr) | 1999-01-08 |
| DE69735274D1 (de) | 2006-04-20 |
| ATE317908T1 (de) | 2006-03-15 |
| AU5226198A (en) | 1998-06-10 |
| AU731106B2 (en) | 2001-03-22 |
| SK286900B6 (sk) | 2009-07-06 |
| JP4686670B2 (ja) | 2011-05-25 |
| HU224713B1 (en) | 2006-01-30 |
| FR2756297A1 (fr) | 1998-05-29 |
| CZ182299A3 (cs) | 1999-08-11 |
| EP0946741B1 (fr) | 2006-02-15 |
| SK66699A3 (en) | 2000-02-14 |
| HUP0001762A2 (hu) | 2000-09-28 |
| JP2001503993A (ja) | 2001-03-27 |
| US6387670B1 (en) | 2002-05-14 |
| BR9713388A (pt) | 2000-03-21 |
| NO323937B1 (no) | 2007-07-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25D | Requested change of name of applicant approved | ||
| B25A | Requested transfer of rights approved |
Free format text: GENCELL S.A. (FR) |
|
| B25D | Requested change of name of applicant approved |
Owner name: GENCELL SAS (FR) Free format text: ALTERADO DE: GENCELL S.A. |
|
| B25D | Requested change of name of applicant approved |
Owner name: CENTELION (FR) Free format text: ALTERADO DE: GENCELL SAS |
|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 10/03/2009, OBSERVADAS AS CONDICOES LEGAIS. |
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| B21A | Patent or certificate of addition expired [chapter 21.1 patent gazette] |
Free format text: PATENTE EXTINTA EM 10.03.2019 |