PT1342718E - Ureidos n-alquilados - Google Patents
Ureidos n-alquiladosInfo
- Publication number
- PT1342718E PT1342718E PT03011817T PT03011817T PT1342718E PT 1342718 E PT1342718 E PT 1342718E PT 03011817 T PT03011817 T PT 03011817T PT 03011817 T PT03011817 T PT 03011817T PT 1342718 E PT1342718 E PT 1342718E
- Authority
- PT
- Portugal
- Prior art keywords
- ureidos
- rented
- methoxymethyl
- diphenylbarbituric
- alkoxyalkylated
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
- C07D207/408—Radicals containing only hydrogen and carbon atoms attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
- C07D211/88—Oxygen atoms attached in positions 2 and 6, e.g. glutarimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/74—Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
- C07D239/62—Barbituric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/44—Two oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Catalysts (AREA)
- Pyrrole Compounds (AREA)
- Peptides Or Proteins (AREA)
- Fats And Perfumes (AREA)
- Medicines Containing Plant Substances (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/942,636 US6093820A (en) | 1997-10-02 | 1997-10-02 | Method and reagents for N-alkylating ureides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1342718E true PT1342718E (pt) | 2005-11-30 |
Family
ID=25478386
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT98949706T PT1027339E (pt) | 1997-10-02 | 1998-10-02 | Metodo e reagentes para a n-alquilacao de ureidos |
| PT03011817T PT1342718E (pt) | 1997-10-02 | 1998-10-02 | Ureidos n-alquilados |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT98949706T PT1027339E (pt) | 1997-10-02 | 1998-10-02 | Metodo e reagentes para a n-alquilacao de ureidos |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US6093820A (pt) |
| EP (2) | EP1027339B1 (pt) |
| JP (2) | JP4061018B2 (pt) |
| CN (2) | CN1699349A (pt) |
| AT (2) | ATE299500T1 (pt) |
| AU (1) | AU758506B2 (pt) |
| CA (1) | CA2304970C (pt) |
| DE (2) | DE69830860T2 (pt) |
| DK (2) | DK1027339T3 (pt) |
| ES (2) | ES2214736T3 (pt) |
| IL (2) | IL135284A (pt) |
| PT (2) | PT1027339E (pt) |
| WO (1) | WO1999018084A1 (pt) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6093820A (en) | 1997-10-02 | 2000-07-25 | Taro Pharmaceutical Industries Ltd. | Method and reagents for N-alkylating ureides |
| US6939873B2 (en) * | 2000-07-26 | 2005-09-06 | Taro Pharmaceuticals Industries Limited | Non-sedating barbituric acid derivatives |
| US6756379B2 (en) | 2001-07-26 | 2004-06-29 | Taro Pharmaceutical Industries Ltd. | Non-sedating barbiturate compounds as neuroprotective agents |
| US7683071B2 (en) * | 2000-07-26 | 2010-03-23 | Taro Pharmaceuticals Industries Ltd. | Composition and method for improved bioavailability and enhanced brain delivery of 5,5-diphenyl barbituric acid |
| WO2003063872A1 (en) * | 2002-01-30 | 2003-08-07 | Taro Pharmaceutical Industries Ltd. | Non-sedating barbituric acid derivatives |
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| WO2004052350A2 (en) * | 2002-12-11 | 2004-06-24 | Taro Pharmaceutical Industries Limited | Method of treating movement disorders using barbituric acid derivatives |
| EP1656372B1 (en) * | 2003-07-30 | 2013-04-10 | Rigel Pharmaceuticals, Inc. | 2,4-pyrimidinediamine compounds for use in the treatment or prevention of autoimmune diseases |
| EP1781624A4 (en) * | 2004-07-02 | 2010-06-23 | Taro Pharma Ind | PROCESS FOR THE PREPARATION OF 1-METHOXYMETHYL-5,5-DIPHENYLBARBITURIC ACID |
| EP1625848A1 (en) * | 2004-08-10 | 2006-02-15 | Taro Pharmaceuticals North America, Inc. | Composition and method for enhanced delivery of 5,5-diphenyl barbituric acid |
| ATE451381T1 (de) | 2005-01-19 | 2009-12-15 | Rigel Pharmaceuticals Inc | Prodrugs aus 2,4-pyrimidindiamin-verbindungen und ihre verwendungen |
| US20090318515A1 (en) * | 2005-11-21 | 2009-12-24 | Mordechai Sharir | Succinimide derivatives as ocular hypotensive agents |
| US8853257B2 (en) | 2005-11-21 | 2014-10-07 | Mordechai Sharir | Succinimide derivatives as ocular hypotensive agents |
| WO2008066704A2 (en) * | 2006-11-14 | 2008-06-05 | Taro Pharmaceuticals North America, Inc. | Method of improving bioavailability for non-sedating barbiturates |
| KR20130056912A (ko) | 2010-10-27 | 2013-05-30 | 더 질레트 컴퍼니 | 비-발포성 수화 조성물을 포함하는 조성물 분배 장치 |
| US20120278179A1 (en) * | 2011-04-28 | 2012-11-01 | Ray Campbell | Systems and methods for deducing user information from input device behavior |
| MX2014001892A (es) | 2011-08-16 | 2014-05-27 | Gillette Co | Dispositivo dispensador de composiciones que comprende una composicion hidratante. |
| EP3062973B1 (en) | 2013-11-01 | 2019-12-11 | The Gillette Company LLC | Shave care composition for a liquid dispensing razor |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2673205A (en) | 1951-02-13 | 1954-03-23 | Ciba Pharm Prod Inc | 3-disubstituted dioxopiperidines and the manufacture thereof |
| AR204518A1 (es) * | 1973-02-28 | 1976-02-12 | Kendall & Co | Procedimiento para preparar n-mono(alcoximetil)fenobarbital |
| DE2622981A1 (de) * | 1976-05-21 | 1977-12-08 | Unisearch Ltd | Verfahren zur herstellung von halogenalkylierten verbindungen |
| IL69722A (en) * | 1983-09-14 | 1986-09-30 | Taro Pharma Ind | Oxopyrimidine derivatives and pharmaceutical compositions containing them |
| DE4028040A1 (de) * | 1990-09-05 | 1992-03-12 | Chemie Linz Deutschland | Verfahren zur n-alkylierung von harnstoffen |
| DE19504623A1 (de) | 1995-02-13 | 1996-08-14 | Bayer Ag | Verfahren zur Herstellung von N-substituierten cyclischen Imiden |
| WO1998029408A1 (fr) | 1996-12-26 | 1998-07-09 | Nikken Chemicals Co., Ltd. | Derives de n-hydroxyuree et compositions medicinales a base de ces derives |
| US6093820A (en) | 1997-10-02 | 2000-07-25 | Taro Pharmaceutical Industries Ltd. | Method and reagents for N-alkylating ureides |
| DE69906960T2 (de) | 1998-05-08 | 2004-01-29 | Smithkline Beecham Plc | Phenylurea und phenylthio urea derivate |
| CA2333537A1 (en) | 1998-05-26 | 1999-12-02 | Rimma Iliinichna Ashkinazi | N-substituted derivatives of 5-oxyiminobarbituric acid |
| CA2306170A1 (en) | 2000-04-18 | 2001-10-18 | Kenneth Curry | Novel amino, carboxy derivatives of barbituric acid |
| MXPA03000824A (es) | 2000-07-26 | 2004-11-01 | Taro Pharmaceuticals Ind Ltd | Compuestos de barbiturato no sedantes como agentes neuroprotectores. |
-
1997
- 1997-10-02 US US08/942,636 patent/US6093820A/en not_active Ceased
-
1998
- 1998-10-02 ES ES98949706T patent/ES2214736T3/es not_active Expired - Lifetime
- 1998-10-02 PT PT98949706T patent/PT1027339E/pt unknown
- 1998-10-02 EP EP98949706A patent/EP1027339B1/en not_active Expired - Lifetime
- 1998-10-02 DK DK98949706T patent/DK1027339T3/da active
- 1998-10-02 IL IL13528498A patent/IL135284A/xx not_active IP Right Cessation
- 1998-10-02 WO PCT/US1998/020665 patent/WO1999018084A1/en active Application Filing
- 1998-10-02 JP JP2000514895A patent/JP4061018B2/ja not_active Expired - Fee Related
- 1998-10-02 AT AT03011817T patent/ATE299500T1/de active
- 1998-10-02 AU AU95976/98A patent/AU758506B2/en not_active Ceased
- 1998-10-02 AT AT98949706T patent/ATE257153T1/de active
- 1998-10-02 CN CNA2005100026661A patent/CN1699349A/zh active Pending
- 1998-10-02 CA CA2304970A patent/CA2304970C/en not_active Expired - Fee Related
- 1998-10-02 DE DE69830860T patent/DE69830860T2/de not_active Expired - Lifetime
- 1998-10-02 EP EP03011817A patent/EP1342718B1/en not_active Expired - Lifetime
- 1998-10-02 DK DK03011817T patent/DK1342718T3/da active
- 1998-10-02 ES ES03011817T patent/ES2243833T3/es not_active Expired - Lifetime
- 1998-10-02 DE DE69820895T patent/DE69820895T2/de not_active Expired - Lifetime
- 1998-10-02 CN CNB988098342A patent/CN1193019C/zh not_active Expired - Fee Related
- 1998-10-02 PT PT03011817T patent/PT1342718E/pt unknown
-
2002
- 2002-02-12 US US10/073,051 patent/US6664262B2/en not_active Expired - Fee Related
-
2003
- 2003-02-27 US US10/375,340 patent/USRE38934E1/en not_active Expired - Lifetime
- 2003-10-17 US US10/687,712 patent/US6906079B2/en not_active Expired - Fee Related
-
2004
- 2004-11-07 IL IL16508004A patent/IL165080A0/xx unknown
-
2007
- 2007-10-23 JP JP2007275316A patent/JP2008101002A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20030018080A1 (en) | 2003-01-23 |
| CA2304970A1 (en) | 1999-04-15 |
| ES2243833T3 (es) | 2005-12-01 |
| JP4061018B2 (ja) | 2008-03-12 |
| DE69830860T2 (de) | 2006-04-27 |
| USRE38934E1 (en) | 2006-01-10 |
| PT1027339E (pt) | 2004-05-31 |
| EP1027339B1 (en) | 2004-01-02 |
| EP1027339A1 (en) | 2000-08-16 |
| DK1027339T3 (da) | 2004-05-03 |
| US6906079B2 (en) | 2005-06-14 |
| CN1273581A (zh) | 2000-11-15 |
| US6093820A (en) | 2000-07-25 |
| WO1999018084A1 (en) | 1999-04-15 |
| ATE299500T1 (de) | 2005-07-15 |
| CA2304970C (en) | 2010-07-13 |
| IL165080A0 (en) | 2005-12-18 |
| ATE257153T1 (de) | 2004-01-15 |
| CN1193019C (zh) | 2005-03-16 |
| AU758506B2 (en) | 2003-03-20 |
| JP2008101002A (ja) | 2008-05-01 |
| EP1342718B1 (en) | 2005-07-13 |
| DE69830860D1 (de) | 2005-08-18 |
| DE69820895D1 (de) | 2004-02-05 |
| EP1342718A1 (en) | 2003-09-10 |
| CN1699349A (zh) | 2005-11-23 |
| ES2214736T3 (es) | 2004-09-16 |
| IL135284A (en) | 2005-11-20 |
| DK1342718T3 (da) | 2005-09-26 |
| AU9597698A (en) | 1999-04-27 |
| US20040167358A1 (en) | 2004-08-26 |
| JP2001519334A (ja) | 2001-10-23 |
| DE69820895T2 (de) | 2004-10-28 |
| US6664262B2 (en) | 2003-12-16 |
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