ATE317908T1 - Verfahren zur herstellung von rekombinanten viren - Google Patents

Verfahren zur herstellung von rekombinanten viren

Info

Publication number
ATE317908T1
ATE317908T1 AT97947083T AT97947083T ATE317908T1 AT E317908 T1 ATE317908 T1 AT E317908T1 AT 97947083 T AT97947083 T AT 97947083T AT 97947083 T AT97947083 T AT 97947083T AT E317908 T1 ATE317908 T1 AT E317908T1
Authority
AT
Austria
Prior art keywords
producing recombinant
recombinant viruses
producing
concerns
virus
Prior art date
Application number
AT97947083T
Other languages
English (en)
Inventor
Helene Leblois-Prehaud
Michel Perricaudet
Emmanuelle Vigne
Patrice Yeh
Original Assignee
Centelion
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9497899&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE317908(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Centelion filed Critical Centelion
Application granted granted Critical
Publication of ATE317908T1 publication Critical patent/ATE317908T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/14011—Baculoviridae
    • C12N2710/14041—Use of virus, viral particle or viral elements as a vector
    • C12N2710/14043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vectore
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/14011—Baculoviridae
    • C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
    • C12N2710/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pens And Brushes (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
AT97947083T 1996-11-22 1997-11-18 Verfahren zur herstellung von rekombinanten viren ATE317908T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9614278A FR2756297B1 (fr) 1996-11-22 1996-11-22 Procede de production de virus recombinants

Publications (1)

Publication Number Publication Date
ATE317908T1 true ATE317908T1 (de) 2006-03-15

Family

ID=9497899

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97947083T ATE317908T1 (de) 1996-11-22 1997-11-18 Verfahren zur herstellung von rekombinanten viren

Country Status (18)

Country Link
US (2) US6387670B1 (de)
EP (1) EP0946741B1 (de)
JP (1) JP4686670B2 (de)
KR (1) KR100719645B1 (de)
AT (1) ATE317908T1 (de)
AU (1) AU731106B2 (de)
BR (1) BR9713388B1 (de)
CA (1) CA2271438C (de)
CZ (1) CZ293947B6 (de)
DE (1) DE69735274T2 (de)
ES (1) ES2260803T3 (de)
FR (1) FR2756297B1 (de)
HU (1) HU224713B1 (de)
IL (1) IL129686A (de)
NO (2) NO323937B1 (de)
SK (1) SK286900B6 (de)
WO (1) WO1998022607A1 (de)
ZA (1) ZA9710516B (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6793926B1 (en) * 1999-05-27 2004-09-21 Genovo, Inc. Methods for production of a recombinant adeno-associated virus
WO2000073480A1 (en) * 1999-05-27 2000-12-07 Genovo, Incorporated Compositions and methods for production of recombinant virus using a carrier vector derived from a nonmammalian virus
WO2000073424A1 (en) * 1999-05-28 2000-12-07 Mount Sinai School Of Medicine A novel baculovirus/adenovirus hybrid vector for the rescue, production and titration of high-capacity adenovirus amplicon vectors
GB9919409D0 (en) * 1999-08-18 1999-10-20 Univ Oxford Brookes Baculovirus expression system
CA2494772C (en) 2002-08-29 2015-12-01 The Board Of Trustees Of The Leland Stanford Junior University Circular nucleic acid vectors, and methods for making and using the same
GB0702694D0 (en) * 2007-02-12 2007-03-21 Ark Therapeutics Ltd Vectors
GB0702695D0 (en) * 2007-02-12 2007-03-21 Ark Therapeutics Ltd Production of vectors
EP2019143A1 (de) 2007-07-23 2009-01-28 Genethon Gentherapie des ZNS mit peripher verabreichten AAV-Vektoren
EP2058401A1 (de) 2007-10-05 2009-05-13 Genethon Weitverbreitete Genverabreichung an Motorneuronen unter Verwendung einer peripheren Injektion von AAV-Vektoren
EP2249950B1 (de) * 2008-03-05 2014-10-15 Council of Scientific & Industrial Research Polymere hybrid membran
EP2287323A1 (de) 2009-07-31 2011-02-23 Association Institut de Myologie Weitverbreitete Genverabreichung an die Netzhaut mithilfe der systemischen Verabreichung von AAV-Vektoren
EP2292781A1 (de) 2009-08-17 2011-03-09 Genethon Baculovirus-basierte Herstellung von Biopharmazeutika ohne kontaminierende baculovirale Virionen
CN102884196B (zh) * 2010-04-01 2015-05-06 肖卫东 重组病毒载体的结构及其制备
SG184833A1 (en) 2010-04-14 2012-11-29 Emd Millipore Corp Methods of producing high titer, high purity virus stocks and methods of use thereof
EP3470523A1 (de) 2012-05-09 2019-04-17 Oregon Health & Science University Adeno-assoziierte virenplasmide und vektoren
TWI775096B (zh) 2012-05-15 2022-08-21 澳大利亞商艾佛蘭屈澳洲私營有限公司 使用腺相關病毒(aav)sflt-1治療老年性黃斑部退化(amd)
AU2013279284A1 (en) 2012-06-21 2015-01-29 Association Institut De Myologie Widespread gene delivery of gene therapy vectors
WO2015031686A1 (en) * 2013-08-30 2015-03-05 Amgen Inc. High titer recombinant aav vector production in adherent and suspension cells
WO2015142941A1 (en) 2014-03-17 2015-09-24 Avalanche Biotechnologies, Inc. Compositions and methods for enhanced gene expression in cone cells
SG11201707063TA (en) 2015-03-02 2017-09-28 Adverum Biotechnologies Inc Compositions and methods for intravitreal delivery of polynucleotides to retinal cones
GB2545763A (en) 2015-12-23 2017-06-28 Adverum Biotechnologies Inc Mutant viral capsid libraries and related systems and methods
CA3082907A1 (en) 2017-11-27 2019-05-31 Coda Biotherapeutics, Inc. Compositions and methods for neurological diseases
US10610606B2 (en) 2018-02-01 2020-04-07 Homology Medicines, Inc. Adeno-associated virus compositions for PAH gene transfer and methods of use thereof
EP3755795A4 (de) 2018-02-19 2022-07-20 Homology Medicines, Inc. Adeno-assoziierte viruszusammensetzungen zur wiederherstellung der f8-genfunktion und verfahren zur verwendung davon
US20230193315A1 (en) 2019-01-31 2023-06-22 Oregon Health & Science University Methods for using transcription-dependent directed evolution of aav capsids
CA3151920A1 (en) 2019-08-21 2021-02-25 Coda Biotherapeutics, Inc. Compositions and methods for neurological diseases
TW202140791A (zh) 2020-01-13 2021-11-01 美商霍蒙拉奇醫藥公司 治療苯酮尿症之方法
TW202208632A (zh) 2020-05-27 2022-03-01 美商同源醫藥公司 用於恢復ｐａｈ基因功能的腺相關病毒組成物及其使用方法
GB202013940D0 (en) 2020-09-04 2020-10-21 Synpromics Ltd Regulatory nucleic acid sequences
AU2021358957A1 (en) 2020-10-07 2023-06-08 Asklepios Biopharmaceutical, Inc. Therapeutic adeno-associated virus delivery of fukutin related protein (fkrp) for treating dystroglycanopathy. disorders including limb girdle 21
WO2023212298A1 (en) 2022-04-29 2023-11-02 Broadwing Bio Llc Bispecific antibodies and methods of treating ocular disease
WO2023212293A1 (en) 2022-04-29 2023-11-02 Broadwing Bio Llc Complement factor h related 4-specific antibodies and uses thereof
WO2023212294A1 (en) 2022-04-29 2023-11-02 Broadwing Bio Llc Angiopoietin-related protein 7-specific antibodies and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL92298A (en) * 1988-11-14 2001-04-30 Us Secretary U S Dept Of Comme Method for producing isolated empty b19 parvovirus capsids, introducing genes into cells utilizing the same, diagnostic assays for detecting parvovirus infection and an anti-parvovirus vaccine containing said capsids
US5559099A (en) * 1994-09-08 1996-09-24 Genvec, Inc. Penton base protein and methods of using same
CA2200835A1 (en) * 1994-09-23 1996-03-28 Frederick M. Boyce Use of a non-mammalian dna virus to express an exogenous gene in a mammalian cell

Also Published As

Publication number Publication date
ZA9710516B (en) 1998-06-10
KR20000057202A (ko) 2000-09-15
KR100719645B1 (ko) 2007-05-17
ES2260803T3 (es) 2006-11-01
NO2013009I1 (no) 2013-04-29
JP4686670B2 (ja) 2011-05-25
HU224713B1 (en) 2006-01-30
IL129686A (en) 2005-12-18
CA2271438A1 (fr) 1998-05-28
BR9713388A (pt) 2000-03-21
DE69735274T2 (de) 2006-10-12
FR2756297A1 (fr) 1998-05-29
NO323937B1 (no) 2007-07-23
SK286900B6 (sk) 2009-07-06
NO992464D0 (no) 1999-05-21
CZ182299A3 (cs) 1999-08-11
FR2756297B1 (fr) 1999-01-08
WO1998022607A1 (fr) 1998-05-28
US20030022356A1 (en) 2003-01-30
DE69735274D1 (de) 2006-04-20
NO992464L (no) 1999-06-23
AU5226198A (en) 1998-06-10
CZ293947B6 (cs) 2004-08-18
SK66699A3 (en) 2000-02-14
HUP0001762A2 (hu) 2000-09-28
JP2001503993A (ja) 2001-03-27
EP0946741A1 (de) 1999-10-06
BR9713388B1 (pt) 2009-01-13
US6387670B1 (en) 2002-05-14
IL129686A0 (en) 2000-02-29
AU731106B2 (en) 2001-03-22
EP0946741B1 (de) 2006-02-15
HUP0001762A3 (en) 2002-01-28
CA2271438C (fr) 2010-10-26

Similar Documents

Publication Publication Date Title
ATE317908T1 (de) Verfahren zur herstellung von rekombinanten viren
DK0886644T3 (da) Lang bölgelængde-modificerede fluorescerende proteiner
ITTO950367A0 (it) Proteine di prrsv ricombinanti, corredi diagnostici e vaccini contenenti tali proteine di prrsv ricombinanti.
EE9800306A (et) Isoleeritud dimeerne fibroblastide aktivatsioonivalk alfa ja selle kasutusalad
ATE481480T1 (de) Methoden und zusammensetzungen zur herstellung von polypeptiden
DE69534778D1 (en) Cathepsin-02-protease
DE59501599D1 (de) Verfahren zur Herstellung von Propandiol-1,2
ID18046A (id) Senyawa siklik campuran, pembuatan dan penngunaannya.
DE69114105D1 (de) Prozess zur Herstellung von MTBE.
EA200000196A1 (ru) Универсальная плазма крови
DE69707607D1 (de) Enzymbehandeltes Hesperidin, Verfahren zur Herstellung und Verfahren zur Verwendung von enzymbehandeltem Hesperidin
DE69842033D1 (de) Verfahren zur Herstellung einer Elektrode auf der Basis von Wiedergewinnung und Wiederverwendung von Aktivmass
ATE181549T1 (de) Verfahren zur herstellung von (s)-3-amino-1- substituiert-pirrolidine
DE69822711D1 (de) Verfarhen zur Herstellung von Dialkylnaphthalinen
DE69015945D1 (de) Verfahren zur Herstellung von p,p'-Biphenol.
PT633928E (pt) Microrganismos processo de preparacao e utilizacao
DE59811806D1 (de) Verwendung von ausgewählten phytostenolestern zur herstellung von hypocholesterinämischen mitteln
DE59104437D1 (de) Verwendung von molybdänverbindungen zur lack-koagulierung.
PE20399A1 (es) Muteina ob
ATE205176T1 (de) Verfahren zur herstellung von xylitol
DK192890D0 (da) 24r-scumnol, fremgangsmaade til fremstilling heraf samt anvendelse af samme
DE69733948D1 (de) In vivo herstellung von replicativen molekülen
ATE307201T1 (de) Srcr domäne-enthaltendes protein
DE59508975D1 (de) Verfahren zur Herstellung von substituierten Chinazolin-2,4-dionen
ATE209910T1 (de) Verwendung von 6,7-substituierter 2- aminotetraline zur behandlung von zytokin- vermittleten entzündungszuständen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties