BR9710500A - Processo de detecção imunológico de anticorpos, que s!ao dirigidos contra transglutaminase de tecido (ttg) para a diagnose e controle de terapia, bem como agente farmacêutico oral contendo ttg. - Google Patents

Processo de detecção imunológico de anticorpos, que s!ao dirigidos contra transglutaminase de tecido (ttg) para a diagnose e controle de terapia, bem como agente farmacêutico oral contendo ttg.

Info

Publication number
BR9710500A
BR9710500A BR9710500-7A BR9710500A BR9710500A BR 9710500 A BR9710500 A BR 9710500A BR 9710500 A BR9710500 A BR 9710500A BR 9710500 A BR9710500 A BR 9710500A
Authority
BR
Brazil
Prior art keywords
ttg
diagnosis
therapy
antibodies
control
Prior art date
Application number
BR9710500-7A
Other languages
English (en)
Other versions
BR9710500B1 (pt
Inventor
Detlef Schuppan
Walburga Dieterich
Tobias Ehnis
Original Assignee
Detlef Schuppan
Walburga Dieterich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7801172&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9710500(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Detlef Schuppan, Walburga Dieterich filed Critical Detlef Schuppan
Publication of BR9710500A publication Critical patent/BR9710500A/pt
Publication of BR9710500B1 publication Critical patent/BR9710500B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/104—Aminoacyltransferases (2.3.2)
    • C12N9/1044—Protein-glutamine gamma-glutamyltransferase (2.3.2.13), i.e. transglutaminase or factor XIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Patente de Invenção: <B>''PROCESSO DE DETECçãO IMUNOLóGICO DE ANTICORPOS, QUE SãO DIRIGIDOS CONTRA TRANSGLUTAMINASE DE TECIDO (tTG) PARA A DIAGNOSE E CONTROLE DE TERAPIA, BEM COMO AGENTE FARMACêUTICO ORAL CONTENDO tTG''<D>. A invenção refere-se a um processo para a detecção de anticorpos, a partir de líquidos do corpo, por uma imuno-reação com transglutaminase de tecido (tTG), com compostos contendo tTG, suas estruturas antígenas, seq³ências imuno-reativas ou análogos. O processo pode servir para a diagnose e para os controles de terapia de enfermidades, que estão ligadas com uma imuno-reação contra tTG, compostos contendo tTG, suas estruturas antígenas, seq³ências imuno-reativas ou análogos. Desse modo, objeto da invenção também é a aplicação de tTG e das mencionadas substâncias para a diagnose e para os controles de terapia, de preferência, para a diagnose e para os controles de terapia de en-fermidades cronicamente inflamatórias ou de enfermidades auto-imunes, muito especialmente de preferência, para a diagnose e para os controle de terapia da afta e da celíaca.
BRPI9710500-7A 1996-07-18 1997-07-14 processo de detecção imunológico de anticorpos, que são dirigidos contra transglutaminase de tecido (ttg) para a diagnose e controle de terapia, bem como agente farmacêutico oral contendo ttg. BR9710500B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19630557A DE19630557C2 (de) 1996-07-18 1996-07-18 Verfahren zum Nachweis von Antikörpern aus Körperflüssigkeiten durch eine Immunreaktion mit Gewebe-Transglutaminase (tTG) sowie die Verwendung von tTG in Diagnose und Therapie
PCT/EP1997/003740 WO1998003872A2 (de) 1996-07-18 1997-07-14 IMMUNOLOGISCHES NACHWEISVERFAHREN VON ANTIKÖRPERN, DIE GEGEN GEWEBE-TRANSGLUTAMINASE (tTG) GERICHTET SIND, VERWENDUNG VON tTG ZUR DIAGNOSE UND THERAPIEKONTROLLE SOWIE ORALES PHARMAZEUTISCHES MITTEL ENTHALTEND tTG

Publications (2)

Publication Number Publication Date
BR9710500A true BR9710500A (pt) 2000-01-18
BR9710500B1 BR9710500B1 (pt) 2009-05-05

Family

ID=7801172

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9710500-7A BR9710500B1 (pt) 1996-07-18 1997-07-14 processo de detecção imunológico de anticorpos, que são dirigidos contra transglutaminase de tecido (ttg) para a diagnose e controle de terapia, bem como agente farmacêutico oral contendo ttg.

Country Status (22)

Country Link
US (2) US6319726B1 (pt)
EP (1) EP0912898B1 (pt)
CN (1) CN1138146C (pt)
AT (1) ATE210296T1 (pt)
AU (1) AU718797B2 (pt)
BR (1) BR9710500B1 (pt)
CA (1) CA2260769C (pt)
CZ (1) CZ291662B6 (pt)
DE (2) DE19630557C2 (pt)
DK (1) DK0912898T3 (pt)
ES (1) ES2131038T3 (pt)
GR (1) GR990300020T1 (pt)
HK (1) HK1021025A1 (pt)
HU (1) HU228479B1 (pt)
IL (1) IL128042A (pt)
NO (1) NO321466B1 (pt)
NZ (1) NZ333744A (pt)
PL (1) PL189091B1 (pt)
PT (1) PT912898E (pt)
SI (1) SI9720044B (pt)
SK (1) SK284410B6 (pt)
WO (1) WO1998003872A2 (pt)

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WO1999056698A2 (en) * 1998-05-06 1999-11-11 Københavns Universitet Treatment of celiac disease
WO2001001133A2 (en) * 1999-06-28 2001-01-04 Immundiagnostik Ag Diagnosis of gluten sensitive enteropathy and other autoimmunopathies
US6703208B1 (en) 1999-10-20 2004-03-09 Immco Diagnostics Immunological assay for detection of antibodies in celiac disease
WO2001029090A1 (en) * 1999-10-20 2001-04-26 Immco Diagnostics Immunological assay for detection of antibodies in celiac disease
CU22968A1 (es) * 2000-06-07 2004-07-14 Ct Ingenieria Genetica Biotech Procedimiento para la detección de anticuerpos anti transglutaminasa con utilidad en el diagnóstico de la enfermedad celíaca
GB0103024D0 (en) * 2001-02-07 2001-03-21 Rsr Ltd Assay for Autoantibodies to tissue transglutaminase
FI20010868A0 (fi) 2001-04-25 2001-04-25 Markku Maeki Menetelmä ja välineet gluteenin indusoimien tautien havaitsemiseksi
KR100488131B1 (ko) * 2001-07-07 2005-05-06 (주)푸드바이오테크 알레르기 진단용 단백질 칩과 알레르기 유발원의 검출방법 및 알레르기 유발 항체의 검출 방법
GB0117870D0 (en) * 2001-07-21 2001-09-12 Univ Nottingham Trent Method of diagnosis and kit of parts therefor
ES2361993T5 (es) * 2002-02-14 2014-12-09 The Board Of Trustees Of The Leland Stanford Junior University Tratamiento con enzimas de productos alimenticios para celiaquía
US7320788B2 (en) * 2002-02-14 2008-01-22 The Board Of Trustees Of The Leland Stanford Junior University Enzyme treatment of foodstuffs for Celiac Sprue
US8143210B2 (en) * 2002-02-14 2012-03-27 The Board Of Trustees Of The Leland Stanford Junior University Enzyme treatment of foodstuffs for celiac sprue
US7202216B2 (en) * 2002-05-14 2007-04-10 The Board Of Trustees Of The Leland Stanford Junior University Drug therapy for celiac sprue
AU2003234597A1 (en) * 2002-05-14 2003-12-02 The Board Of Trustees Of The Leland Stanford Junior University Drug therapy for celiac sprue
US7462688B2 (en) * 2002-05-14 2008-12-09 The Board Of Trustees Of The Leland Stanford Junior University Peptides for diagnostic and therapeutic methods for celiac sprue
US7265093B2 (en) * 2002-05-14 2007-09-04 The Board Of Trustees Of The Leland Stanford Junior University Drug therapy for Celiac Sprue
EP1563300B1 (en) 2002-11-20 2012-04-18 The Board Of Trustees Of The Leland Stanford Junior University Diagnostic method for celiac sprue
US7579313B2 (en) 2003-11-18 2009-08-25 The Board Of Trustees Of The Leland Stanford Junior University Transglutaminase inhibitors and methods of use thereof
US7534426B2 (en) * 2004-04-26 2009-05-19 The Board Of Trustees Of The Leland Stanford Junior University Glutenase enzyme assays
US7563864B2 (en) * 2004-04-26 2009-07-21 Celiac Sprue Research Foundation Prolyl endopeptidase mediated destruction of T cell epitopes in whole gluten
US7628985B2 (en) * 2004-04-26 2009-12-08 The Board Of Regents Of The Leland Stanford Junior University Therapeutic enzyme formulations and uses thereof in celiac sprue and/or dermatitis herpetoformis
US20080038760A1 (en) * 2004-06-08 2008-02-14 Method For Decting Anti-Transglutaminase Antibodies Method for Detecting Anti-Transglutaminase Antibodies
US20090305303A1 (en) * 2006-07-25 2009-12-10 Cecile Besson Duvanel immunochromatography device for the diagnosis of diseases in a sample
AU2008209176B2 (en) * 2007-01-26 2013-01-31 Ga Generic Assays Gmbh Method for assaying antibodies in body fluids by immune reaction with glycoprotein 2 (GP2) from zymogenic granules of the pancreas for the differential diagnosis of inflammatory intestinal diseases and chronic pancreatitis
BRPI0808987A2 (pt) * 2007-03-16 2014-09-09 Univ Leland Stanford Junior Terapia combinatória de enzima para digestão de glúten dietético
ATE511651T1 (de) 2007-04-06 2011-06-15 Zedira Gmbh Transglutaminase 6 als diagnostischer indikator für autoimmunerkrankungen
HU0900199D0 (en) * 2009-04-01 2009-06-29 Debreceni Egyetem Diagnosis of gluten-induced autoimmune diseases
FR2949782B1 (fr) * 2009-09-04 2015-10-16 Isp Investments Inc Peptide activateur de la transglutaminase et composition cosmetique ou pharmaceutique le contenant.
WO2013119845A1 (en) 2012-02-07 2013-08-15 Vibrant Holdings, Llc Substrates, peptide arrays, and methods
EP2839290B1 (de) 2012-04-17 2019-03-06 Aeneas GmbH & Co. KG Verfahren zur präsymptomatischen diagnostik von zöliakie und glutensensitivität
DE102012007510A1 (de) 2012-04-17 2013-10-17 Aesku.Diagnostics GmbH & Co. KG Verfahren zur Präsymptomatischen Diagnostik von Zöliakie und Glutensensitivität
US10006909B2 (en) 2012-09-28 2018-06-26 Vibrant Holdings, Llc Methods, systems, and arrays for biomolecular analysis
US10286376B2 (en) 2012-11-14 2019-05-14 Vibrant Holdings, Llc Substrates, systems, and methods for array synthesis and biomolecular analysis
CA2923379C (en) 2013-02-15 2023-01-03 Vibrant Holdings, Llc Methods and compositions for amplified electrochemiluminescence detection
CN104090102B (zh) * 2014-06-13 2016-08-17 江南大学 冷冻鱼糜中微生物谷氨酰胺转胺酶elisa检测方法
CA2960655C (en) * 2014-09-10 2024-03-19 Vibrant Holdings, Llc Peptide microarrays and novel biomarkers for celiac disease
US10538808B2 (en) 2017-05-26 2020-01-21 Vibrant Holdings, Llc Photoactive compounds and methods for biomolecule detection and sequencing
CN110055235A (zh) * 2019-05-14 2019-07-26 深圳市亚辉龙生物科技股份有限公司 用于转谷氨酰胺酶抗体检测的抗原及其制备方法、试剂盒及检测方法

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Also Published As

Publication number Publication date
SI9720044A (sl) 1999-08-31
HUP0202779A3 (en) 2009-07-28
NO990190D0 (no) 1999-01-15
HUP0202779A2 (hu) 2002-12-28
US20020076834A1 (en) 2002-06-20
IL128042A0 (en) 1999-11-30
AU4201197A (en) 1998-02-10
CN1225723A (zh) 1999-08-11
EP0912898B1 (de) 2001-12-05
CN1138146C (zh) 2004-02-11
EP0912898A2 (de) 1999-05-06
SK284410B6 (sk) 2005-03-04
NO990190L (no) 1999-03-15
AU718797B2 (en) 2000-04-20
SI9720044B (sl) 2003-02-28
DE19630557A1 (de) 1998-01-29
PL331203A1 (en) 1999-07-05
US6319726B1 (en) 2001-11-20
HU228479B1 (en) 2013-03-28
CA2260769C (en) 2005-09-06
HK1021025A1 (en) 2000-05-26
NO321466B1 (no) 2006-05-15
IL128042A (en) 2007-06-17
CA2260769A1 (en) 1998-01-29
ES2131038T3 (es) 2002-09-01
ATE210296T1 (de) 2001-12-15
CZ291662B6 (cs) 2003-04-16
BR9710500B1 (pt) 2009-05-05
NZ333744A (en) 2000-03-27
WO1998003872A2 (de) 1998-01-29
PL189091B1 (pl) 2005-06-30
SK6799A3 (en) 2000-05-16
DE59705683D1 (de) 2002-01-17
WO1998003872A3 (de) 1998-03-12
PT912898E (pt) 2002-05-31
ES2131038T1 (es) 1999-07-16
GR990300020T1 (en) 1999-06-30
CZ11799A3 (cs) 1999-07-14
DE19630557C2 (de) 1998-07-02
DK0912898T3 (da) 2002-04-08

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B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 19/05/2009, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time
B24D Patent annual fee: restoration after fee payment