BR9712518A - Polipeptìdeo, molécula de dna, vetor de expressão, célula hospedeira, composição farmacêutica, vacina, proteìna de fusão, processo para detectar tuberculose em um paciente, e, kit diagnóstico - Google Patents
Polipeptìdeo, molécula de dna, vetor de expressão, célula hospedeira, composição farmacêutica, vacina, proteìna de fusão, processo para detectar tuberculose em um paciente, e, kit diagnósticoInfo
- Publication number
- BR9712518A BR9712518A BR9712518-0A BR9712518A BR9712518A BR 9712518 A BR9712518 A BR 9712518A BR 9712518 A BR9712518 A BR 9712518A BR 9712518 A BR9712518 A BR 9712518A
- Authority
- BR
- Brazil
- Prior art keywords
- vaccine
- polypeptide
- patient
- fusion protein
- expression vector
- Prior art date
Links
- 201000008827 tuberculosis Diseases 0.000 title abstract 5
- 229920001184 polypeptide Polymers 0.000 title abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 108020004414 DNA Proteins 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 229960005486 vaccine Drugs 0.000 title abstract 3
- 102000053602 DNA Human genes 0.000 title abstract 2
- 238000009007 Diagnostic Kit Methods 0.000 title abstract 2
- 239000013604 expression vector Substances 0.000 title abstract 2
- 108020001507 fusion proteins Proteins 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 102000037865 fusion proteins Human genes 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 238000003745 diagnosis Methods 0.000 abstract 1
- 230000003053 immunization Effects 0.000 abstract 1
- 238000002649 immunization Methods 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Public Health (AREA)
- Analytical Chemistry (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Plant Pathology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
Abstract
"POLIPEPTìDEO, MOLéCULA DE DNA, VETOR DE EXPRESSãO, CéLULA HOSPEDEIRA, COMPOSIçãO FARMACêUTICA, VACINA, PROTEìNA DE FUSãO, PROCESSO PARA DETECTAR TUBERCULOSE EM UM PACIENTE, E, KIT DIAGNóSTICO" Compostos e processos para induzir uma imunidade protetora contra tuberculose são descritos. Os compostos providos incluem polipeptídeos que contém pelo menos uma porção imunogênica de uma ou mais proteínas de M. tuberculosis e moléculas de DNA codificando estes polipeptídeos. Estes compostos podem ser formulados em vacinas e/ou composições farmacêuticas para imunização contra infecção por M. tuberculosis, ou podem ser usados para o diagnóstico de tuberculose.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73051096A | 1996-10-11 | 1996-10-11 | |
US08/818,112 US6290969B1 (en) | 1995-09-01 | 1997-03-13 | Compounds and methods for immunotherapy and diagnosis of tuberculosis |
PCT/US1997/018293 WO1998016646A2 (en) | 1996-10-11 | 1997-10-07 | Compounds and methods for immunotherapy and diagnosis of tuberculosis |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9712518A true BR9712518A (pt) | 2000-10-24 |
Family
ID=27112065
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9712518-0A BR9712518A (pt) | 1996-10-11 | 1997-10-07 | Polipeptìdeo, molécula de dna, vetor de expressão, célula hospedeira, composição farmacêutica, vacina, proteìna de fusão, processo para detectar tuberculose em um paciente, e, kit diagnóstico |
Country Status (14)
Country | Link |
---|---|
US (3) | US6290969B1 (pt) |
EP (1) | EP0932681A2 (pt) |
JP (1) | JP2001501832A (pt) |
KR (1) | KR20000049101A (pt) |
AU (1) | AU4814497A (pt) |
BR (1) | BR9712518A (pt) |
CA (1) | CA2268008A1 (pt) |
CZ (1) | CZ126599A3 (pt) |
IL (1) | IL129388A0 (pt) |
NO (1) | NO991694L (pt) |
PL (1) | PL332878A1 (pt) |
TR (1) | TR199901571T2 (pt) |
WO (1) | WO1998016646A2 (pt) |
ZA (1) | ZA978969B (pt) |
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US6592877B1 (en) * | 1995-09-01 | 2003-07-15 | Corixa Corporation | Compounds and methods for immunotherapy and diagnosis of tuberculosis |
US6982085B2 (en) | 1997-04-02 | 2006-01-03 | Statens Serum Institut | TB diagnostic based on antigens from M. tuberculosis |
US6613881B1 (en) * | 1997-05-20 | 2003-09-02 | Corixa Corporation | Compounds for immunotherapy and diagnosis of tuberculosis and methods of their use |
US6555653B2 (en) * | 1997-05-20 | 2003-04-29 | Corixa Corporation | Compounds for diagnosis of tuberculosis and methods for their use |
EP1003870A1 (en) * | 1997-07-16 | 2000-05-31 | Institut Pasteur | A polynucleotide functionally coding for the lhp protein from mycobacterium tuberculosis, its biologically active derivative fragments, as well as methods using the same |
EP1484405A1 (en) * | 1997-11-10 | 2004-12-08 | Statens Serum Institut | Nucleic acid fragments and polypeptide fragments derived from M. Tuberculosis |
EP1787994A1 (en) | 1998-10-08 | 2007-05-23 | Statens Serum Institut | TB vaccine and diagnostic based on antigens from M. tuberculosis cell |
EP1117683A2 (en) * | 1998-10-08 | 2001-07-25 | Statens Serum Institut | Tb vaccine and diagnostic based on antigens from the m. tuberculosis cell |
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US20030027774A1 (en) * | 1999-03-18 | 2003-02-06 | Ronald C. Hendrickson | Tuberculosis antigens and methods of use therefor |
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US7820142B2 (en) | 2004-09-30 | 2010-10-26 | Institut Pasteur | Immunogenic glycopeptides, screening, preparation and uses |
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US6350456B1 (en) * | 1997-03-13 | 2002-02-26 | Corixa Corporation | Compositions and methods for the prevention and treatment of M. tuberculosis infection |
US6355257B1 (en) * | 1997-05-08 | 2002-03-12 | Corixa Corporation | Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors |
US6113918A (en) * | 1997-05-08 | 2000-09-05 | Ribi Immunochem Research, Inc. | Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors |
US6613881B1 (en) * | 1997-05-20 | 2003-09-02 | Corixa Corporation | Compounds for immunotherapy and diagnosis of tuberculosis and methods of their use |
US6555653B2 (en) * | 1997-05-20 | 2003-04-29 | Corixa Corporation | Compounds for diagnosis of tuberculosis and methods for their use |
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US8143386B2 (en) * | 1999-04-07 | 2012-03-27 | Corixa Corporation | Fusion proteins of mycobacterium tuberculosis antigens and their uses |
WO2001024820A1 (en) * | 1999-10-07 | 2001-04-12 | Corixa Corporation | Fusion proteins of mycobacterium tuberculosis |
WO2001062893A2 (en) * | 2000-02-25 | 2001-08-30 | Corixa Corporation | Compounds and methods for diagnosis and immunotherapy of tuberculosis |
SI1542732T1 (sl) * | 2000-06-20 | 2010-01-29 | Corixa Corp Csc The United Sta | Fuzijski proteini Mycobacterium tuberculosis |
AU2003213118A1 (en) * | 2002-02-15 | 2003-09-09 | Corixa Corporation | Fusion proteins of mycobacterium tuberculosis |
-
1997
- 1997-03-13 US US08/818,112 patent/US6290969B1/en not_active Expired - Lifetime
- 1997-10-07 AU AU48144/97A patent/AU4814497A/en not_active Abandoned
- 1997-10-07 CZ CZ991265A patent/CZ126599A3/cs unknown
- 1997-10-07 CA CA002268008A patent/CA2268008A1/en not_active Abandoned
- 1997-10-07 TR TR1999/01571T patent/TR199901571T2/xx unknown
- 1997-10-07 BR BR9712518-0A patent/BR9712518A/pt unknown
- 1997-10-07 JP JP10518456A patent/JP2001501832A/ja not_active Ceased
- 1997-10-07 ZA ZA9708969A patent/ZA978969B/xx unknown
- 1997-10-07 EP EP97910873A patent/EP0932681A2/en not_active Withdrawn
- 1997-10-07 KR KR1019990703181A patent/KR20000049101A/ko not_active Application Discontinuation
- 1997-10-07 PL PL97332878A patent/PL332878A1/xx unknown
- 1997-10-07 WO PCT/US1997/018293 patent/WO1998016646A2/en not_active Application Discontinuation
- 1997-10-07 IL IL12938897A patent/IL129388A0/xx unknown
-
1999
- 1999-04-09 NO NO991694A patent/NO991694L/no not_active Application Discontinuation
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2007
- 2007-10-29 US US11/980,320 patent/US7989605B2/en not_active Expired - Fee Related
-
2011
- 2011-05-04 US US13/100,908 patent/US20110305721A1/en not_active Abandoned
Also Published As
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KR20000049101A (ko) | 2000-07-25 |
US7989605B2 (en) | 2011-08-02 |
WO1998016646A3 (en) | 1998-10-08 |
CA2268008A1 (en) | 1998-04-23 |
PL332878A1 (en) | 1999-10-25 |
ZA978969B (en) | 1998-04-20 |
IL129388A0 (en) | 2000-02-17 |
AU4814497A (en) | 1998-05-11 |
US6290969B1 (en) | 2001-09-18 |
US20110305721A1 (en) | 2011-12-15 |
NO991694L (no) | 1999-06-10 |
EP0932681A2 (en) | 1999-08-04 |
JP2001501832A (ja) | 2001-02-13 |
TR199901571T2 (xx) | 1999-10-21 |
US20090017077A1 (en) | 2009-01-15 |
NO991694D0 (no) | 1999-04-09 |
CZ126599A3 (cs) | 1999-11-17 |
WO1998016646A2 (en) | 1998-04-23 |
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