ES2131038T1 - Procedimiento inmunologico de deteccion de anticuerpos, que estan dirigidos contra la transglutaminasa tisular (ttg), utilizacion de la ttg para el diagnostico y el control de terapias asi como agente farmaceutico oral que contiene ttg. - Google Patents
Procedimiento inmunologico de deteccion de anticuerpos, que estan dirigidos contra la transglutaminasa tisular (ttg), utilizacion de la ttg para el diagnostico y el control de terapias asi como agente farmaceutico oral que contiene ttg.Info
- Publication number
- ES2131038T1 ES2131038T1 ES97939994T ES97939994T ES2131038T1 ES 2131038 T1 ES2131038 T1 ES 2131038T1 ES 97939994 T ES97939994 T ES 97939994T ES 97939994 T ES97939994 T ES 97939994T ES 2131038 T1 ES2131038 T1 ES 2131038T1
- Authority
- ES
- Spain
- Prior art keywords
- ttg
- diagnosis
- control
- antibodies
- detection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000003745 diagnosis Methods 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 238000002560 therapeutic procedure Methods 0.000 title abstract 3
- 238000001514 detection method Methods 0.000 title abstract 2
- 108700039882 Protein Glutamine gamma Glutamyltransferase 2 Proteins 0.000 title 3
- 102100038095 Protein-glutamine gamma-glutamyltransferase 2 Human genes 0.000 title 3
- 230000001900 immune effect Effects 0.000 title 1
- 239000008177 pharmaceutical agent Substances 0.000 title 1
- 230000000890 antigenic effect Effects 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000008105 immune reaction Effects 0.000 abstract 2
- 208000015943 Coeliac disease Diseases 0.000 abstract 1
- 206010012735 Diarrhoea Diseases 0.000 abstract 1
- 108060008539 Transglutaminase Proteins 0.000 abstract 1
- 208000037976 chronic inflammation Diseases 0.000 abstract 1
- 208000037893 chronic inflammatory disorder Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 102000003601 transglutaminase Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/104—Aminoacyltransferases (2.3.2)
- C12N9/1044—Protein-glutamine gamma-glutamyltransferase (2.3.2.13), i.e. transglutaminase or factor XIII
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
LA INVENCION TRATA DE UN PROCEDIMIENTO PARA LA DETECCION DE ANTICUERPOS PROCEDENTES DE LIQUIDOS CORPORALES MEDIANTE UNA REACCION INMUNOLOGICA CON TRANSGLUTAMINASA (TTG) TISULAR, CON COMPUESTOS QUE CONTIENEN TTG, SUS ESTRUCTURAS ANTIGENICAS, SECUENCIAS INMUNORREACTIVAS O SIMILARES. EL PROCEDIMIENTO SE PUEDE UTILIZAR PARA EL DIAGNOSTICO Y TERAPIA DE ENFERMEDADES, QUE ESTAN RELACIONADAS CON UNA REACCION INMUNOLOGICA CONTRA LA TTG, COMPUESTOS QUE CONTIENEN LA TTG, SUS ESTRUCTURAS ANTIGENICAS, SECUENCIAS INMUNORREACTIVAS O SIMILARES. POR TANTO EL OBJETO DE LA INVENCION ES TAMBIEN LA UTILIZACION DE LA TTG Y DE LAS SUSTANCIAS CITADAS PARA EL DIAGNOSTICO Y CONTROL, PREFERIBLEMENTE PARA EL DIAGNOSTICO Y CONTROL DE LA TERAPIA DE ENFERMEDADES INFLAMATORIAS CRONICAS O DE ENFERMEDADES AUTOINMUNES, DE MANERA ESPECIALMENTE PREFERIDA PARA EL DIAGNOSTICO Y TERAPIA DE LA DIARREA TROPICAL O DE LA ENFERMEDAD CELIACA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19630557A DE19630557C2 (de) | 1996-07-18 | 1996-07-18 | Verfahren zum Nachweis von Antikörpern aus Körperflüssigkeiten durch eine Immunreaktion mit Gewebe-Transglutaminase (tTG) sowie die Verwendung von tTG in Diagnose und Therapie |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2131038T1 true ES2131038T1 (es) | 1999-07-16 |
ES2131038T3 ES2131038T3 (es) | 2002-09-01 |
Family
ID=7801172
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97939994T Expired - Lifetime ES2131038T3 (es) | 1996-07-18 | 1997-07-14 | Procedimiento inmunologico para detectar anticuerpos dirigidos contra la transglutaminasa tisular (ttg), utilizacion de la ttg para fines de diagnostico y de control de terapia y agente farmaceutico oral que contiene la ttg. |
Country Status (22)
Country | Link |
---|---|
US (2) | US6319726B1 (es) |
EP (1) | EP0912898B1 (es) |
CN (1) | CN1138146C (es) |
AT (1) | ATE210296T1 (es) |
AU (1) | AU718797B2 (es) |
BR (1) | BR9710500B1 (es) |
CA (1) | CA2260769C (es) |
CZ (1) | CZ291662B6 (es) |
DE (2) | DE19630557C2 (es) |
DK (1) | DK0912898T3 (es) |
ES (1) | ES2131038T3 (es) |
GR (1) | GR990300020T1 (es) |
HK (1) | HK1021025A1 (es) |
HU (1) | HU228479B1 (es) |
IL (1) | IL128042A (es) |
NO (1) | NO321466B1 (es) |
NZ (1) | NZ333744A (es) |
PL (1) | PL189091B1 (es) |
PT (1) | PT912898E (es) |
SI (1) | SI9720044B (es) |
SK (1) | SK284410B6 (es) |
WO (1) | WO1998003872A2 (es) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999056698A2 (en) * | 1998-05-06 | 1999-11-11 | Københavns Universitet | Treatment of celiac disease |
WO2001001133A2 (en) * | 1999-06-28 | 2001-01-04 | Immundiagnostik Ag | Diagnosis of gluten sensitive enteropathy and other autoimmunopathies |
US6703208B1 (en) | 1999-10-20 | 2004-03-09 | Immco Diagnostics | Immunological assay for detection of antibodies in celiac disease |
WO2001029090A1 (en) * | 1999-10-20 | 2001-04-26 | Immco Diagnostics | Immunological assay for detection of antibodies in celiac disease |
CU22968A1 (es) * | 2000-06-07 | 2004-07-14 | Ct Ingenieria Genetica Biotech | Procedimiento para la detección de anticuerpos anti transglutaminasa con utilidad en el diagnóstico de la enfermedad celíaca |
GB0103024D0 (en) * | 2001-02-07 | 2001-03-21 | Rsr Ltd | Assay for Autoantibodies to tissue transglutaminase |
FI20010868A0 (fi) | 2001-04-25 | 2001-04-25 | Markku Maeki | Menetelmä ja välineet gluteenin indusoimien tautien havaitsemiseksi |
KR100488131B1 (ko) * | 2001-07-07 | 2005-05-06 | (주)푸드바이오테크 | 알레르기 진단용 단백질 칩과 알레르기 유발원의 검출방법 및 알레르기 유발 항체의 검출 방법 |
GB0117870D0 (en) * | 2001-07-21 | 2001-09-12 | Univ Nottingham Trent | Method of diagnosis and kit of parts therefor |
ES2361993T5 (es) * | 2002-02-14 | 2014-12-09 | The Board Of Trustees Of The Leland Stanford Junior University | Tratamiento con enzimas de productos alimenticios para celiaquía |
US7320788B2 (en) * | 2002-02-14 | 2008-01-22 | The Board Of Trustees Of The Leland Stanford Junior University | Enzyme treatment of foodstuffs for Celiac Sprue |
US8143210B2 (en) * | 2002-02-14 | 2012-03-27 | The Board Of Trustees Of The Leland Stanford Junior University | Enzyme treatment of foodstuffs for celiac sprue |
US7202216B2 (en) * | 2002-05-14 | 2007-04-10 | The Board Of Trustees Of The Leland Stanford Junior University | Drug therapy for celiac sprue |
AU2003234597A1 (en) * | 2002-05-14 | 2003-12-02 | The Board Of Trustees Of The Leland Stanford Junior University | Drug therapy for celiac sprue |
US7462688B2 (en) * | 2002-05-14 | 2008-12-09 | The Board Of Trustees Of The Leland Stanford Junior University | Peptides for diagnostic and therapeutic methods for celiac sprue |
US7265093B2 (en) * | 2002-05-14 | 2007-09-04 | The Board Of Trustees Of The Leland Stanford Junior University | Drug therapy for Celiac Sprue |
EP1563300B1 (en) | 2002-11-20 | 2012-04-18 | The Board Of Trustees Of The Leland Stanford Junior University | Diagnostic method for celiac sprue |
US7579313B2 (en) | 2003-11-18 | 2009-08-25 | The Board Of Trustees Of The Leland Stanford Junior University | Transglutaminase inhibitors and methods of use thereof |
US7534426B2 (en) * | 2004-04-26 | 2009-05-19 | The Board Of Trustees Of The Leland Stanford Junior University | Glutenase enzyme assays |
US7563864B2 (en) * | 2004-04-26 | 2009-07-21 | Celiac Sprue Research Foundation | Prolyl endopeptidase mediated destruction of T cell epitopes in whole gluten |
US7628985B2 (en) * | 2004-04-26 | 2009-12-08 | The Board Of Regents Of The Leland Stanford Junior University | Therapeutic enzyme formulations and uses thereof in celiac sprue and/or dermatitis herpetoformis |
US20080038760A1 (en) * | 2004-06-08 | 2008-02-14 | Method For Decting Anti-Transglutaminase Antibodies | Method for Detecting Anti-Transglutaminase Antibodies |
US20090305303A1 (en) * | 2006-07-25 | 2009-12-10 | Cecile Besson Duvanel | immunochromatography device for the diagnosis of diseases in a sample |
AU2008209176B2 (en) * | 2007-01-26 | 2013-01-31 | Ga Generic Assays Gmbh | Method for assaying antibodies in body fluids by immune reaction with glycoprotein 2 (GP2) from zymogenic granules of the pancreas for the differential diagnosis of inflammatory intestinal diseases and chronic pancreatitis |
BRPI0808987A2 (pt) * | 2007-03-16 | 2014-09-09 | Univ Leland Stanford Junior | Terapia combinatória de enzima para digestão de glúten dietético |
ATE511651T1 (de) | 2007-04-06 | 2011-06-15 | Zedira Gmbh | Transglutaminase 6 als diagnostischer indikator für autoimmunerkrankungen |
HU0900199D0 (en) * | 2009-04-01 | 2009-06-29 | Debreceni Egyetem | Diagnosis of gluten-induced autoimmune diseases |
FR2949782B1 (fr) * | 2009-09-04 | 2015-10-16 | Isp Investments Inc | Peptide activateur de la transglutaminase et composition cosmetique ou pharmaceutique le contenant. |
WO2013119845A1 (en) | 2012-02-07 | 2013-08-15 | Vibrant Holdings, Llc | Substrates, peptide arrays, and methods |
EP2839290B1 (de) | 2012-04-17 | 2019-03-06 | Aeneas GmbH & Co. KG | Verfahren zur präsymptomatischen diagnostik von zöliakie und glutensensitivität |
DE102012007510A1 (de) | 2012-04-17 | 2013-10-17 | Aesku.Diagnostics GmbH & Co. KG | Verfahren zur Präsymptomatischen Diagnostik von Zöliakie und Glutensensitivität |
US10006909B2 (en) | 2012-09-28 | 2018-06-26 | Vibrant Holdings, Llc | Methods, systems, and arrays for biomolecular analysis |
US10286376B2 (en) | 2012-11-14 | 2019-05-14 | Vibrant Holdings, Llc | Substrates, systems, and methods for array synthesis and biomolecular analysis |
CA2923379C (en) | 2013-02-15 | 2023-01-03 | Vibrant Holdings, Llc | Methods and compositions for amplified electrochemiluminescence detection |
CN104090102B (zh) * | 2014-06-13 | 2016-08-17 | 江南大学 | 冷冻鱼糜中微生物谷氨酰胺转胺酶elisa检测方法 |
CA2960655C (en) * | 2014-09-10 | 2024-03-19 | Vibrant Holdings, Llc | Peptide microarrays and novel biomarkers for celiac disease |
US10538808B2 (en) | 2017-05-26 | 2020-01-21 | Vibrant Holdings, Llc | Photoactive compounds and methods for biomolecule detection and sequencing |
CN110055235A (zh) * | 2019-05-14 | 2019-07-26 | 深圳市亚辉龙生物科技股份有限公司 | 用于转谷氨酰胺酶抗体检测的抗原及其制备方法、试剂盒及检测方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL155894B1 (en) * | 1987-12-23 | 1992-01-31 | Przed Zagraniczne W Polsce Pla | Test for assessing gluten-dependent enteropathies |
DE3829524A1 (de) * | 1988-08-31 | 1990-03-01 | Behringwerke Ag | Verwendung von transglutaminasen als immunsuppressiva |
DE19520480C2 (de) | 1995-06-03 | 1997-04-30 | Univ Leipzig | Immunochemisches Testmaterial und Enzymimmunoassay zur Diagnostik von Zöliakie und verwandten Eiweißintoleranzen |
US5716794A (en) * | 1996-03-29 | 1998-02-10 | Xybernaut Corporation | Celiac antigen |
-
1996
- 1996-07-18 DE DE19630557A patent/DE19630557C2/de not_active Revoked
-
1997
- 1997-07-14 DE DE59705683T patent/DE59705683D1/de not_active Expired - Lifetime
- 1997-07-14 PL PL97331203A patent/PL189091B1/pl unknown
- 1997-07-14 IL IL128042A patent/IL128042A/en not_active IP Right Cessation
- 1997-07-14 BR BRPI9710500-7A patent/BR9710500B1/pt not_active IP Right Cessation
- 1997-07-14 WO PCT/EP1997/003740 patent/WO1998003872A2/de active IP Right Grant
- 1997-07-14 NZ NZ333744A patent/NZ333744A/xx not_active IP Right Cessation
- 1997-07-14 PT PT97939994T patent/PT912898E/pt unknown
- 1997-07-14 CA CA002260769A patent/CA2260769C/en not_active Expired - Lifetime
- 1997-07-14 AT AT97939994T patent/ATE210296T1/de active
- 1997-07-14 AU AU42011/97A patent/AU718797B2/en not_active Expired
- 1997-07-14 CN CNB971965269A patent/CN1138146C/zh not_active Expired - Lifetime
- 1997-07-14 SI SI9720044A patent/SI9720044B/sl unknown
- 1997-07-14 EP EP97939994A patent/EP0912898B1/de not_active Expired - Lifetime
- 1997-07-14 DK DK97939994T patent/DK0912898T3/da active
- 1997-07-14 HU HU0202779A patent/HU228479B1/hu unknown
- 1997-07-14 ES ES97939994T patent/ES2131038T3/es not_active Expired - Lifetime
- 1997-07-14 SK SK67-99A patent/SK284410B6/sk not_active IP Right Cessation
- 1997-07-14 CZ CZ1999117A patent/CZ291662B6/cs not_active IP Right Cessation
-
1999
- 1999-01-01 GR GR990300020T patent/GR990300020T1/el unknown
- 1999-01-13 US US09/229,716 patent/US6319726B1/en not_active Expired - Lifetime
- 1999-01-15 NO NO19990190A patent/NO321466B1/no not_active IP Right Cessation
- 1999-12-22 HK HK99106049A patent/HK1021025A1/xx not_active IP Right Cessation
-
2001
- 2001-08-08 US US09/925,076 patent/US20020076834A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2131038T1 (es) | Procedimiento inmunologico de deteccion de anticuerpos, que estan dirigidos contra la transglutaminasa tisular (ttg), utilizacion de la ttg para el diagnostico y el control de terapias asi como agente farmaceutico oral que contiene ttg. | |
DK0458079T3 (da) | Ultralyd-kontrastmidler, fremgangsmåde til deres fremstilling og deres anvendelse som diagnostika og terapeutika | |
NO934130L (no) | Tumoravvisningsantigenforloepere, tumoravvisningsantigener samt anvendelse derav | |
ES2065303T5 (es) | Procedimiento de diagnosis y vacuna especifica. | |
ES2166352T3 (es) | Dominio externo de c-erbb-2:gp75. | |
ES2161246T3 (es) | Factor transformante de crecimiento alfa h1. | |
ES2169159T3 (es) | Montaje para tratar vasos sanguineos. | |
BR9912007A (pt) | Composições e métodos para terapia e diagnóstico de câncer de próstata | |
CY1108906T1 (el) | Θεραπειες συνδυασμου για λεμφωματα β-κυτταρου που περιλαμβανουν χορηγηση anti-cd20 αντισωματος | |
NO20010922D0 (no) | FremgangsmÕte for DNA vaksinering | |
AR046068A1 (es) | Anticuerpos de factor tisular y uso de los mismos | |
BR0009537A (pt) | Composições para tratamento e diagnóstico de câncer de mama e métodos para seu uso | |
HUP0301740A2 (hu) | Emlőrák kezelésére és diagnosztizálására szolgáló készítmények és eljárások | |
AR046970A1 (es) | Esteres de fosfato de florfenicol | |
BR0113213A (pt) | Método para diagnosticar uma doença auto-imune, anticorpo, composição de diagnóstico, e, uso do anticorpo | |
BR9812438A (pt) | Dispositivo de demonstração na forma de um organismo vivo | |
DE59608213D1 (de) | Arzneimittel zur immuntherapie, enthaltend antikörper, die spezifisch das mhcii-antigen eines zu behandelnden patienten erkennen | |
TR200000181T2 (tr) | Antikorların dahil olduğu, endokrin hücrelerine karşı aktivite gösteren ligandlar. | |
ES2114615T3 (es) | Nueva sonda para el diagnostico de tumores o la terapia de tumores. | |
AU2001290242A1 (en) | Beta-catenin nuclear localized protein | |
ES2074983T3 (es) | Procedimieto para el aislamiento de proteinas de membranas basales a partir de tejidos humanos y animales. | |
WO2001021653A3 (en) | Ovarian tumor antigen and methods of use therefor | |
ES2093135T3 (es) | Anticuerpos monoclonales contra el complejo plasmina-antiplasmina, procedimiento para su preparacion asi como su utilizacion. | |
ES2149155T3 (es) | Peptidos sinteticos que contienen secuencias de factor viia y su utilizacion. | |
IT8205203A0 (it) | Strumento medicale monouso atto per determinare la natura delle affezioni allergiche, tramite cutireazione. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 912898 Country of ref document: ES |