BR9710115A - Processo para aplicar partìculas sólidas de um medicamento em superfìcies de mucosa das cavidade nasais, composição aquosa farmacêutica, e , processo de preparação de uma composição aquosa farmacêutica. - Google Patents
Processo para aplicar partìculas sólidas de um medicamento em superfìcies de mucosa das cavidade nasais, composição aquosa farmacêutica, e , processo de preparação de uma composição aquosa farmacêutica.Info
- Publication number
- BR9710115A BR9710115A BR9710115-0A BR9710115A BR9710115A BR 9710115 A BR9710115 A BR 9710115A BR 9710115 A BR9710115 A BR 9710115A BR 9710115 A BR9710115 A BR 9710115A
- Authority
- BR
- Brazil
- Prior art keywords
- composition
- pharmaceutical composition
- aqueous pharmaceutical
- mucosal surfaces
- preparing
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
- B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
- B05B11/1001—Piston pumps
- B05B11/1016—Piston pumps the outlet valve having a valve seat located downstream a movable valve element controlled by a pressure actuated controlling element
- B05B11/1018—Piston pumps the outlet valve having a valve seat located downstream a movable valve element controlled by a pressure actuated controlling element and the controlling element cooperating with means for opening or closing the inlet valve
Abstract
"PROCESSO PARA APLICAR PARTìCULAS SóLIDAS DE UM MEDICAMENTO EM SUPERFìCIES DE MUCOSA DAS CAVIDADES NASAIS, COMPOSIçãO AQUOSA FARMACêUTICA, E, PROCESSO DE PREPARAçãO DE UMA COMPOSIçãO AQUOSA FARMACêUTICA". Uma composição aquosa farmacêutica que é capaz de ser pulverizada dentro da cavidade nasal de um indivíduo e que compreende: (A) uma quantidade farmaceuticamente efetiva de partículas sólidas de medicamento que é efetivo no tratamento de uma condição corporal em virtude de sua presença sobre as superfícies de mucosa da cavidade nasal; e (B) um agente de suspensão em uma quantidade efetiva para manter as citadas partículas uniformemente dispersadas na composição e para fornecer à composição as seguintes propriedades tixotrópicas: (i) a viscosidade de posição na forma não-cisalhada é relativamente elevada, com a composição se apresentando na forma semelhante a gel; (ii) à medida que a composição é submetida ao cisalhamento (agitação) na preparação para pulverização, a viscosidade da composição torna-se relativamente baixa e tal que a composição na forma de uma névoa flui prontamente para dentro das passagens nasais para ser depositada sobre as superfícies de mucosa da cavidade nasal; e (iii) na forma depositada sobre as superfícies de mucosa, a viscosidade da composição é relativamente elevada e tal que ela resiste à sua remoção das superfícies de mucosa pelas forças inerentes mucocilárias que estão presentes na cavidade nasal, um processo de uso da composição e um processo de preparação da composição, incluindo na forma preferida o uso de esteróide antiinflamatório, por exemplo, triancinolona acetonida, e uma forma inodora da composição.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/678,465 US5976573A (en) | 1996-07-03 | 1996-07-03 | Aqueous-based pharmaceutical composition |
US08/678465 | 1996-07-03 | ||
PCT/US1997/011462 WO1998000178A1 (en) | 1996-07-03 | 1997-07-02 | Aqueous-based pharmaceutical composition |
Publications (2)
Publication Number | Publication Date |
---|---|
BR9710115A true BR9710115A (pt) | 2000-01-11 |
BR9710115B1 BR9710115B1 (pt) | 2010-12-14 |
Family
ID=24722901
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI9710115-0A BR9710115B1 (pt) | 1996-07-03 | 1997-07-02 | composiÇço aquosa farmacÊutica, e processo de preparaÇço de uma composiÇço aquosa farmacÊutica. |
Country Status (27)
Country | Link |
---|---|
US (8) | US5976573A (pt) |
EP (2) | EP1382330A1 (pt) |
JP (1) | JP2001501914A (pt) |
KR (1) | KR100383601B1 (pt) |
CN (1) | CN1235568C (pt) |
AP (1) | AP1045A (pt) |
AT (1) | ATE250432T1 (pt) |
AU (1) | AU737506C (pt) |
BG (1) | BG64585B1 (pt) |
BR (1) | BR9710115B1 (pt) |
CA (1) | CA2268927C (pt) |
CZ (1) | CZ299689B6 (pt) |
DE (1) | DE69725161T2 (pt) |
DK (1) | DK0938345T3 (pt) |
EA (1) | EA001406B1 (pt) |
ES (1) | ES2208931T3 (pt) |
HK (1) | HK1022652A1 (pt) |
HU (1) | HU227993B1 (pt) |
IL (1) | IL127611A0 (pt) |
NO (1) | NO318241B1 (pt) |
OA (1) | OA10950A (pt) |
PL (1) | PL194269B1 (pt) |
PT (1) | PT938345E (pt) |
SK (1) | SK284491B6 (pt) |
UA (1) | UA68337C2 (pt) |
WO (1) | WO1998000178A1 (pt) |
ZA (1) | ZA975947B (pt) |
Families Citing this family (98)
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1997
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- 1997-07-02 BR BRPI9710115-0A patent/BR9710115B1/pt not_active IP Right Cessation
- 1997-07-02 KR KR10-1999-7000006A patent/KR100383601B1/ko not_active IP Right Cessation
- 1997-07-02 SK SK1816-98A patent/SK284491B6/sk not_active IP Right Cessation
- 1997-07-02 CN CNB971974799A patent/CN1235568C/zh not_active Expired - Lifetime
- 1997-07-02 PT PT97933237T patent/PT938345E/pt unknown
- 1997-07-02 WO PCT/US1997/011462 patent/WO1998000178A1/en active IP Right Grant
- 1997-07-02 JP JP10504409A patent/JP2001501914A/ja not_active Withdrawn
- 1997-07-02 IL IL12761197A patent/IL127611A0/xx not_active IP Right Cessation
- 1997-07-02 PL PL97330936A patent/PL194269B1/pl not_active IP Right Cessation
- 1997-07-02 AU AU36471/97A patent/AU737506C/en not_active Expired
- 1997-07-02 EP EP03077914A patent/EP1382330A1/en not_active Withdrawn
- 1997-07-02 CA CA002268927A patent/CA2268927C/en not_active Expired - Fee Related
- 1997-07-02 AP APAP/P/1999/001495A patent/AP1045A/en active
- 1997-07-02 EP EP97933237A patent/EP0938345B1/en not_active Expired - Lifetime
- 1997-07-02 DK DK97933237T patent/DK0938345T3/da active
- 1997-07-02 CZ CZ0437798A patent/CZ299689B6/cs not_active IP Right Cessation
- 1997-07-02 AT AT97933237T patent/ATE250432T1/de active
- 1997-07-02 HU HU9903503A patent/HU227993B1/hu unknown
- 1997-07-02 EA EA199900080A patent/EA001406B1/ru not_active IP Right Cessation
- 1997-07-02 ES ES97933237T patent/ES2208931T3/es not_active Expired - Lifetime
- 1997-07-02 DE DE69725161T patent/DE69725161T2/de not_active Expired - Lifetime
- 1997-07-03 ZA ZA9705947A patent/ZA975947B/xx unknown
-
1998
- 1998-12-21 NO NO19986023A patent/NO318241B1/no not_active IP Right Cessation
- 1998-12-31 OA OA9800254A patent/OA10950A/en unknown
-
1999
- 1999-01-28 BG BG103127A patent/BG64585B1/bg unknown
- 1999-05-20 US US09/315,454 patent/US6143329A/en not_active Expired - Lifetime
-
2000
- 2000-03-13 HK HK00101538A patent/HK1022652A1/xx not_active IP Right Cessation
- 2000-04-28 US US09/561,371 patent/US6375984B1/en not_active Expired - Lifetime
-
2002
- 2002-04-23 US US10/128,154 patent/US7122206B2/en not_active Expired - Fee Related
-
2006
- 2006-10-16 US US11/581,565 patent/US20070031887A1/en not_active Abandoned
-
2008
- 2008-07-08 US US12/217,691 patent/US20090124586A1/en not_active Abandoned
-
2010
- 2010-03-22 US US12/728,984 patent/US7977045B2/en not_active Expired - Fee Related
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2011
- 2011-05-31 US US13/149,260 patent/US20110230455A1/en not_active Abandoned
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