BR9610013A - Processos para reconstituir um embrião animal e para preparar um animal, embrião de animal reconstituído, e , animal - Google Patents

Processos para reconstituir um embrião animal e para preparar um animal, embrião de animal reconstituído, e , animal

Info

Publication number
BR9610013A
BR9610013A BR9610013-3A BR9610013A BR9610013A BR 9610013 A BR9610013 A BR 9610013A BR 9610013 A BR9610013 A BR 9610013A BR 9610013 A BR9610013 A BR 9610013A
Authority
BR
Brazil
Prior art keywords
animal
embryo
reconstituted
time
activated
Prior art date
Application number
BR9610013-3A
Other languages
English (en)
Portuguese (pt)
Inventor
Keith Henry Stockman Campbell
Ian Wilmut
Original Assignee
Roslin Inst Edinburgh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10779997&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9610013(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Roslin Inst Edinburgh filed Critical Roslin Inst Edinburgh
Publication of BR9610013A publication Critical patent/BR9610013A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
    • C12N15/877—Techniques for producing new mammalian cloned embryos
    • C12N15/8773—Ovine embryos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
    • C12N15/877—Techniques for producing new mammalian cloned embryos
    • C12N15/8771—Bovine embryos

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Reproductive Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Environmental Sciences (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BR9610013-3A 1995-08-31 1996-08-30 Processos para reconstituir um embrião animal e para preparar um animal, embrião de animal reconstituído, e , animal BR9610013A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9517779.6A GB9517779D0 (en) 1995-08-31 1995-08-31 Biological manipulation
PCT/GB1996/002098 WO1997007668A1 (en) 1995-08-31 1996-08-30 Unactivated oocytes as cytoplast recipients for nuclear transfer

Publications (1)

Publication Number Publication Date
BR9610013A true BR9610013A (pt) 1999-12-21

Family

ID=10779997

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9610013-3A BR9610013A (pt) 1995-08-31 1996-08-30 Processos para reconstituir um embrião animal e para preparar um animal, embrião de animal reconstituído, e , animal

Country Status (22)

Country Link
US (12) US6252133B1 (enExample)
EP (1) EP0847237B1 (enExample)
JP (3) JP2000506721A (enExample)
KR (4) KR20060057638A (enExample)
CN (3) CN1772891A (enExample)
AT (1) ATE400176T1 (enExample)
AU (1) AU728809B2 (enExample)
BR (1) BR9610013A (enExample)
CA (1) CA2229657A1 (enExample)
CZ (1) CZ60498A3 (enExample)
DE (1) DE69637591D1 (enExample)
DK (1) DK0847237T3 (enExample)
ES (1) ES2309989T3 (enExample)
GB (1) GB9517779D0 (enExample)
HU (1) HUP9802485A3 (enExample)
IL (1) IL123417A0 (enExample)
NO (1) NO980846L (enExample)
NZ (2) NZ316148A (enExample)
PL (1) PL325336A1 (enExample)
SG (1) SG75919A1 (enExample)
WO (1) WO1997007668A1 (enExample)
ZA (1) ZA967383B (enExample)

Families Citing this family (193)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5480772A (en) 1993-02-03 1996-01-02 Brandeis University In vitro activation of a nucleus
GB9517780D0 (en) * 1995-08-31 1995-11-01 Roslin Inst Edinburgh Biological manipulation
US7307198B2 (en) 1995-08-31 2007-12-11 Roslin Institute Ungulates produced by nuclear transfer of G1 cells
GB9517779D0 (en) * 1995-08-31 1995-11-01 Roslin Inst Edinburgh Biological manipulation
US6077697A (en) * 1996-04-10 2000-06-20 Chromos Molecular Systems, Inc. Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
US6025155A (en) * 1996-04-10 2000-02-15 Chromos Molecular Systems, Inc. Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
WO1998016630A1 (en) 1996-10-11 1998-04-23 The Texas A & M University System Methods for the generation of primordial germ cells and transgenic animal species
US6235969B1 (en) * 1997-01-10 2001-05-22 University Of Massachusetts Cloning pigs using donor nuclei from non-quiescent differentiated cells
US5945577A (en) * 1997-01-10 1999-08-31 University Of Massachusetts As Represented By Its Amherst Campus Cloning using donor nuclei from proliferating somatic cells
US20090092588A1 (en) * 1997-01-10 2009-04-09 University Of Massachusetts As Represented By Its Amherst Campus Cloned ungulate embryos and animals, use of cells, tissues and organs thereof for transplantation therapies including parkinson's disease
US6011197A (en) 1997-03-06 2000-01-04 Infigen, Inc. Method of cloning bovines using reprogrammed non-embryonic bovine cells
DE69833545T2 (de) 1997-03-26 2006-12-14 Imperial College Innovations Ltd. In der zellmembran verankertes antikoagulant-fusionsprotein
JP2001509361A (ja) 1997-07-03 2001-07-24 ユニヴァーシティー オヴ マサチューセッツ 分化した無血清飢餓細胞からの供与核を用いるクローニング
US7923015B2 (en) 1997-08-14 2011-04-12 Institut Pasteur Methods for direct visualization of active synapses
US7923216B2 (en) 1997-08-14 2011-04-12 Institut Pasteur In vivo modulation of neuronal transport
JPH11127852A (ja) * 1997-10-28 1999-05-18 Snow Brand Milk Prod Co Ltd 上皮細胞のｇ０期同調方法
AU747070B2 (en) * 1998-01-16 2002-05-09 Agrobiogen Gmbh Efficient nuclear transfer using primordial germ cells
US7351876B2 (en) 1998-01-16 2008-04-01 Agrobiogen Gmbh Biotechnologie Efficient nuclear transfer with primordial gametes
US6600087B1 (en) * 1998-01-16 2003-07-29 Agrobiogen Gmbh Efficient nuclear transfer using fetal fibroblasts and multiple cloning procedures
US6331659B1 (en) 1998-01-21 2001-12-18 University Of Hawaii Cumulus cells as nuclear donors
CA2324009A1 (en) * 1998-03-16 1999-09-23 Relag Pty Ltd. Porcine nuclear transfer
AUPP294898A0 (en) * 1998-04-15 1998-05-07 Monash University Method of nuclear transfer
GB9808325D0 (en) * 1998-04-20 1998-06-17 Ltr Ciz Di Associazione Italia Source of nuclei for nuclear transfer
US6143564A (en) * 1998-07-07 2000-11-07 University Of Hawaii Use of the polar body chromosomes for the production of embryos and normal offspring
GB9820988D0 (en) * 1998-09-25 1998-11-18 Biotech & Biolog Scien Res Screening method
WO2000022098A1 (en) * 1998-10-12 2000-04-20 Geron Bio-Med Limited Porcine oocytes with improved developmental competence
EP1818397A1 (en) * 1998-11-02 2007-08-15 Trustees Of Tufts College Methods for cloning animals
US6781030B1 (en) 1998-11-02 2004-08-24 Trustee Of Tufts College, Ballou Hall Methods for cloning mammals using telophase oocytes
NZ511299A (en) 1998-11-19 2003-02-28 Ppl Therapeutics Scotland Ltd Stabilisation of milk from transgenic animals through expression of a serine proteinase inhibitor and optionally fibrinogen in the mammary gland
US6700037B2 (en) 1998-11-24 2004-03-02 Infigen, Inc. Method of cloning porcine animals
US6258998B1 (en) 1998-11-24 2001-07-10 Infigen, Inc. Method of cloning porcine animals
EP1141265B1 (en) * 1999-01-13 2008-09-03 Revivicor, Inc. Double nuclear transfer method and results thereof
US7531715B1 (en) * 1999-01-13 2009-05-12 Ppl Therapeutics (Scotland) Double nuclear transfer method and results thereof
WO2000044914A1 (en) 1999-01-28 2000-08-03 Medical College Of Georgia Research Institute, Inc. Composition and method for in vivo and in vitro attenuation of gene expression using double stranded rna
AU3382800A (en) 1999-02-26 2000-09-14 Millennium Pharmaceuticals, Inc. Secreted proteins and uses thereof
EP2199392A3 (en) * 1999-03-04 2010-12-15 Revivicor, Inc. Genetic modification of somatic cells and uses thereof
US20020012660A1 (en) * 1999-03-04 2002-01-31 Alan Colman Method of preparing a somatic cells for nuclear transfer
WO2001000855A1 (en) 1999-06-23 2001-01-04 Ppl Therapeutics (Scotland) Ltd. Fusion proteins incorporating lysozyme
US7291714B1 (en) 1999-06-30 2007-11-06 Millennium Pharmaceuticals, Inc. Glycoprotein VI and uses thereof
KR100368435B1 (ko) * 1999-06-30 2003-01-24 황우석 체세포 복제동물의 생산을 위한 세포융합방법
JP3652308B2 (ja) 1999-06-30 2005-05-25 ソウル ナショナル ユニバーシティー インダストリー ファウンデーション クローンウシの生産方法
EP1109890A4 (en) * 1999-06-30 2004-12-29 Hwang Woo Suk PROCESS FOR OBTAINING CLONED HUMAN EMBRYOS USING INTER-SPECIES TRANSPLANTATION TECHNIQUES OF CORES
AU753209B2 (en) * 1999-06-30 2002-10-10 Seoul National University Industry Foundation Method for producing cloned tigers by employing inter-species nuclear transplantation technique
KR100414043B1 (ko) * 1999-06-30 2004-01-13 황우석 체세포 복제동물 및 그 생산방법
PT1210428E (pt) 1999-08-23 2015-07-21 Genetics Inst Llc Pd-1, um recetor para b7-4 e suas utilizações
EP2275559A3 (en) 1999-09-28 2011-03-23 Shire Human Genetic Therapies, Inc. Optimized messenger RNA
WO2002064799A2 (en) 1999-09-28 2002-08-22 Transkaryotic Therapies, Inc. Optimized messenger rna
KR100417566B1 (ko) * 1999-11-19 2004-02-05 한국생명공학연구원 체세포 핵치환 복제수정란의 대량생산방법
US7820878B2 (en) * 1999-11-19 2010-10-26 Kyowa Hakko Kirin Co., Ltd. Production of ungulates, preferably bovines that produce human immunoglobulins
US7074983B2 (en) 1999-11-19 2006-07-11 Kirin Beer Kabushiki Kaisha Transgenic bovine comprising human immunoglobulin loci and producing human immunoglobulin
AU1777301A (en) * 1999-11-19 2001-05-30 Hematech, Llc Production of ungulates, preferably bovines that produce human immunoglobulins
US7253334B2 (en) * 2000-12-22 2007-08-07 Aurox, Llc Methods for cloning non-human mammals using reprogrammed donor chromatin or donor cells
US7414170B2 (en) * 1999-11-19 2008-08-19 Kirin Beer Kabushiki Kaisha Transgenic bovines capable of human antibody production
GB9927444D0 (en) * 1999-11-19 2000-01-19 Cancer Res Campaign Tech Inhibiting gene expression
CN1293188C (zh) 2000-01-04 2007-01-03 康涅狄格州大学 一种将长期培养的可包括人工诱导基因改变的雌或雄体细胞的细胞核转移到去核受体细胞中实现靶向基因改变的克隆动物的方法
US6635802B1 (en) * 2000-01-10 2003-10-21 The Texas A&M University System Nuclear transfer using cells cultured in serum starvation media containing apoptosis inhibitors
DK1248640T3 (da) 2000-01-20 2007-02-12 Diabcell Pty Ltd Xenotransplantation af svineöer og deres fremstilling
AU2001236919A1 (en) * 2000-02-09 2001-08-20 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Premeiotic and postmeiotic origin of teratomas: isolated teratoma stem cells for therapeutic uses
WO2001068831A2 (en) 2000-03-15 2001-09-20 The University Of Georgia Research Foundation, Inc. Effective nuclear reprogramming in mammals
GB2360522A (en) 2000-03-24 2001-09-26 Geron Corp A strategy for maintaining pregnancy
AU2001261650A1 (en) * 2000-05-15 2001-11-26 Geron Corporation Ovine tissue for xenotransplantation
ATE439453T1 (de) 2000-06-05 2009-08-15 Genetics Inst Llc Zusammensetzungen, testsätze und methoden zur identifizierung und modulation von typ i diabetes
EP1320599A2 (en) 2000-06-28 2003-06-25 Genetics Institute, LLC Pd-l2 molecules: pd-1 ligands and uses therefor
EP1311530A4 (en) 2000-08-03 2004-10-06 Wim-Van Schooten PRODUCTION OF HUMANIZED ANTIBODIES IN TRANSGENIC ANIMALS
US6677500B2 (en) 2000-08-15 2004-01-13 Board Of Trustees Of The University Of Illinois Ungulates expressing exogenous IGF-I in their milk
US7049480B1 (en) * 2000-09-01 2006-05-23 Avigenics, Inc. Methods of enucleating an avian oocyte or zygote using two-photon laser scanning microscopy
FR2814642B1 (fr) 2000-10-03 2005-07-01 Ass Pour Le Dev De La Rech En Souris transgenique pour la recombinaison ciblee mediee par la cre-er modifiee
CA2425076A1 (en) * 2000-10-06 2002-04-11 Advanced Cell Technology, Inc. Cloning endangered and extinct species
US6821731B2 (en) 2000-11-28 2004-11-23 Wyeth Expression analysis of FKBP nucleic acids and polypeptides useful in the diagnosis of prostate cancer
WO2002044419A2 (en) 2000-11-28 2002-06-06 Wyeth Expression analysis of kiaa nucleic acids and polypeptides useful in the diagnosis and treatment of prostate cancer
WO2002102997A2 (en) * 2000-11-30 2002-12-27 Stemron Inc. Isolated homozygous stem cells differentiated cells derived therefrom and materials and methods for making and using same
US7491534B2 (en) 2000-12-22 2009-02-17 Kirin Holdings Kabushiki Kaisha Methods for altering cell fate to generate T-cells specific for an antigen of interest
US20020142397A1 (en) * 2000-12-22 2002-10-03 Philippe Collas Methods for altering cell fate
EP1217071B1 (en) 2000-12-22 2010-04-28 Institut National De La Recherche Agronomique Position-independent and tissue specific expression of a transgene in milk of transgenic animals
EP1860199B1 (en) 2001-01-12 2014-03-05 Exelixis, Inc. Modulating insulin receptor signaling
CA2435857A1 (en) 2001-01-30 2002-09-26 Rebholtz, Amy K. Methods for embryo recipient management
CA2369944A1 (en) 2001-01-31 2002-07-31 Nucleonics Inc. Use of post-transcriptional gene silencing for identifying nucleic acid sequences that modulate the function of a cell
JP2002262716A (ja) * 2001-03-07 2002-09-17 National Agricultural Research Organization 株化細胞を用いて家畜個体を作出する方法
US8981061B2 (en) 2001-03-20 2015-03-17 Novo Nordisk A/S Receptor TREM (triggering receptor expressed on myeloid cells) and uses thereof
US7126039B2 (en) * 2001-03-21 2006-10-24 Geron Corporation Animal tissue with carbohydrate antigens compatible for human transplantation
US7265262B2 (en) * 2001-03-21 2007-09-04 Roslin Institute (Edinburgh) Telomerizing nuclear donor cells and improving the efficiency on nuclear transfer
WO2002079499A1 (en) 2001-04-02 2002-10-10 Wyeth Pd-1, a receptor for b7-4, and uses therefor
CN1636062A (zh) 2001-04-16 2005-07-06 惠氏控股公司 编码多肽抗原的新肺炎链球菌可读框及其应用
WO2002103350A1 (en) * 2001-06-14 2002-12-27 Infigen, Inc. Methods for cloning mammals using remodeling factors
EP1406917A4 (en) * 2001-06-15 2007-11-14 New Century Pharmaceuticals HUMAN ANALYTICAL MODELS FOR THE EVALUATION OF MEDICINAL PRODUCTS AND FOR TOXICOLOGICAL AND IMMUNOGENIC EXAMINATIONS
ES2609014T3 (es) 2001-07-12 2017-04-18 University Of Massachusetts Producción in vivo de ARN de interferencia pequeños que median el silenciamiento génico
EP1900815B1 (en) 2001-07-12 2016-09-07 University of Massachusetts In vivo production of small interfering RNAs that mediate gene silencing
US20030211603A1 (en) * 2001-08-14 2003-11-13 Earp David J. Reprogramming cells for enhanced differentiation capacity using pluripotent stem cells
US20030170678A1 (en) * 2001-10-25 2003-09-11 Neurogenetics, Inc. Genetic markers for Alzheimer's disease and methods using the same
US20030224380A1 (en) * 2001-10-25 2003-12-04 The General Hospital Corporation Genes and polymorphisms on chromosome 10 associated with Alzheimer's disease and other neurodegenerative diseases
AU2002364945A1 (en) * 2001-10-25 2003-07-09 Neurogenetics, Inc. Genes and polymorphisms on chromosome 10 associated with alzheimer's disease and other neurodegenerative diseases
WO2003042362A2 (en) 2001-11-09 2003-05-22 Dana-Farber Cancer Institute, Inc. PGC-1β, A NOVEL PGC-1 HOMOLOGUE AND USES THEREFOR
WO2003046129A2 (en) * 2001-11-09 2003-06-05 Trustees Of The University Of Pennsylvania Compositions for the derivation of germ cells from stem cells and methods of use thereof
WO2003060083A2 (en) * 2002-01-15 2003-07-24 Advanced Cell Technology, Inc. Cloning b and t lymphocytes
US20050170506A1 (en) * 2002-01-16 2005-08-04 Primegen Biotech Llc Therapeutic reprogramming, hybrid stem cells and maturation
US20030134422A1 (en) * 2002-01-16 2003-07-17 Sayre Chauncey Bigelow Stem cell maturation for all tissue lines
US20050090004A1 (en) * 2003-01-16 2005-04-28 Sayre Chauncey B. Stem cell maturation for all tissue lines
CA2480802A1 (en) * 2002-04-01 2003-10-16 Gtc Biotherapeutics, Inc. A method for selecting cell lines to be used for nuclear transfer in mammalian species
US20030217378A1 (en) * 2002-04-05 2003-11-20 The University Of Georgia Research Foundation, Inc Cloning using rapidly matured oocytes
US7612250B2 (en) 2002-07-29 2009-11-03 Trustees Of Tufts College Nuclear transfer embryo formation method
WO2004018999A2 (en) 2002-08-20 2004-03-04 Millenium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of cervical cancer
EP1575518A4 (en) 2002-10-10 2007-08-22 Wyeth Corp COMPOSITIONS, ORGANISMS AND METHODS WITH A NEW HUMAN KINASE
AU2003286442A1 (en) * 2002-10-16 2004-05-04 Advanced Cell Technology, Inc. Methods using gene trapped stem cells for marking pathways of stem cell differentiation and making and isolating differentiated cells
US7208306B2 (en) 2002-10-24 2007-04-24 Wyeth Compositions employing a novel human protein phosphatase
JP2006505291A (ja) 2002-11-08 2006-02-16 ヘマテック，エルエルシー プリオンタンパク質活性が低減されたトランスジェニック有蹄動物及びその用途
AU2003298689A1 (en) 2002-11-21 2004-06-18 Wyeth Methods for diagnosing rcc and other solid tumors
WO2004050831A2 (en) 2002-11-27 2004-06-17 Wyeth Compositions, organisms and methodologies employing a novel human kinase
US7482117B2 (en) 2002-12-20 2009-01-27 Celera Corporation Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof
DE602004015064D1 (de) 2003-01-06 2008-08-28 Wyeth Corp Zusammensetzungen und verfahren zur diagnose und behandlung von kolonkrebs
ES2712695T3 (es) 2003-06-02 2019-05-14 Univ Massachusetts Métodos y composiciones para controlar la eficacia de la silenciación del ARN
AU2004252442B2 (en) 2003-06-02 2010-04-08 University Of Massachusetts Methods and compositions for enhancing the efficacy and specificity of FNAi
EP1654349A4 (en) 2003-08-14 2008-08-20 Exelixis Inc SULFS AS BETA-CATENIN PATH MODIFICATORS AND METHOD OF USE
CN102517381A (zh) 2003-10-07 2012-06-27 千年药品公司 用于鉴定、评价、预防和治疗卵巢癌的核酸分子和蛋白质
WO2005046450A2 (en) 2003-11-12 2005-05-26 Children's Hospital Medical Center Method for diagnosis and treatment of pulmonary disorders
CA2921196C (en) 2003-11-26 2019-03-05 Celera Corporation Single nucleotide polymorphisms associated with cardiovascular disorders and statin response, methods of detection and uses thereof
US7682828B2 (en) 2003-11-26 2010-03-23 Whitehead Institute For Biomedical Research Methods for reprogramming somatic cells
CA2563064A1 (en) 2004-04-22 2005-11-10 Kirin Beer Kabushiki Kaisha Transgenic animals and uses thereof
EP2412826B1 (en) 2004-05-07 2014-01-08 Celera Corporation Genetic polymorphism associated with liver fibrosis methods of detection and uses thereof
EP1812041A2 (en) 2004-10-22 2007-08-01 Dana-Farber Cancer Institute, Inc. Compositions and methods for modulating pgc-1 to treat lipid-related diseases and disorders
GB0426146D0 (en) 2004-11-29 2004-12-29 Bioxell Spa Therapeutic peptides and method
CN1274829C (zh) 2004-12-10 2006-09-13 四川大学华西医院 抗eb病毒所致肿瘤多肽及其应用与制备方法
WO2006099365A2 (en) 2005-03-11 2006-09-21 Applera Corporation Genetic polymorphisms associated with coronary heart disease, methods of detection and uses thereof
US20070011603A1 (en) * 2005-07-06 2007-01-11 Mikko Makela Method, system, device and software product for showing tooltips for page segments and generating content for the page segments
US20090186097A1 (en) 2005-08-09 2009-07-23 David Lee Ayares Transgenic Ungulates Expressing CTLA4-IG and Uses Thereof
AU2006287315B2 (en) 2005-09-09 2013-02-21 The Johns Hopkins University Manipulation of regulatory T cell and DC function by targeting neuritin gene using antibodies, agonists and antagonists
CA2623106C (en) 2005-09-19 2013-12-24 Histogenics Corporation Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof
US7799530B2 (en) 2005-09-23 2010-09-21 Celera Corporation Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof
US7695911B2 (en) 2005-10-26 2010-04-13 Celera Corporation Genetic polymorphisms associated with Alzheimer's Disease, methods of detection and uses thereof
ES2378407T3 (es) 2006-09-01 2012-04-12 Therapeutic Human Polyclonals, Inc. Aumento de la expresión de inmunoglobulina humana o humanizada en animales transgénicos no humanos
EP2639318B1 (en) 2006-09-11 2015-04-08 Celera Corporation Genetic polymorphisms associated with Psoriasis, methods of detection and uses thereof
US7910303B2 (en) 2006-10-20 2011-03-22 Celera Corporation Genetic polymorphisms associated with venous thrombosis, methods of detection and uses thereof
KR101398220B1 (ko) * 2006-10-30 2014-05-22 건국대학교 산학협력단 형질전환 배아 생성방법
US20100205678A1 (en) * 2007-01-05 2010-08-12 Overstrom Eric W Oocyte spindle-associated factors improve somatic cell cloning
EP2626416A3 (en) 2007-04-07 2013-12-18 The Whitehead Institute for Biomedical Research Reprogramming of somatic cells
WO2008134522A1 (en) * 2007-04-26 2008-11-06 President And Fellows Of Harvard College Deriving embryonic stem cells
US7972849B2 (en) * 2007-05-17 2011-07-05 Oregon Health & Science University Primate pluripotent stem cells produced by somatic cell nuclear transfer
US20090111764A1 (en) * 2007-10-25 2009-04-30 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Mitochondrial selection
WO2009055656A2 (en) 2007-10-26 2009-04-30 Centocor, Inc. Vectors, host cells, and methods of production and uses
US8039212B2 (en) 2007-11-05 2011-10-18 Celera Corporation Genetic polymorphisms associated with liver fibrosis, methods of detection and uses thereof
US20090221620A1 (en) 2008-02-20 2009-09-03 Celera Corporation Gentic polymorphisms associated with stroke, methods of detection and uses thereof
KR100915397B1 (ko) * 2008-02-22 2009-09-03 삼성전자주식회사 커버부재, 현상 카트리지 및 화상형성장치의 현상유닛
WO2009114185A2 (en) 2008-03-12 2009-09-17 The Rockefeller University Methods and compositions for translational profiling and molecular phenotyping
US8288094B2 (en) 2008-04-09 2012-10-16 Institut Pasteur APOBEC3 mediated DNA editing
US9497943B2 (en) 2008-06-13 2016-11-22 Whitehead Institute For Biomedical Research Nucleic acid constructs encoding reprogramming factors linked by self-cleaving peptides
EP2878680B1 (en) 2008-07-09 2016-06-08 Celera Corporation Genetic polymorphisms associated with cardiovascular diseases, methods of detection and uses thereof
WO2010080985A1 (en) 2009-01-08 2010-07-15 Dana-Farber Cancer Institute, Inc. Compositions and methods for induced brown fat differentiation
US8722964B2 (en) 2009-04-23 2014-05-13 Transposagen Biopharmaceuticals, Inc. Genetically engineered or transgenic rats exhibiting a cancer phenotype due to a disruption of germline tumor suppressor genes
CA2759608A1 (en) 2009-04-24 2010-10-28 Oregon Health & Science University Methods for mitochondrial dna replacement in oocytes
EP2267153A1 (en) 2009-05-26 2010-12-29 Université Claude Bernard Lyon 1 Identification of netrin-1 receptor unc5c gene mutation in solid cancers
EP2449112A1 (en) 2009-07-01 2012-05-09 Transposagen Biopharmaceuticals, Inc. Genetically modified rat models for severe combined immunodeficiency (scid)
EP2456876A2 (en) 2009-07-24 2012-05-30 Transposagen Biopharmaceuticals, Inc. Genetically modified rat models for cytokine-cytokine signaling pathways
US20110145936A1 (en) 2009-07-30 2011-06-16 Ostertag Eric M Genetically Modified Rat Models for Pharmacokinetics
WO2011017518A2 (en) 2009-08-05 2011-02-10 Transposagen Biopharmaceuticals, Inc. Genetically modified rat models for drug metabolism
EP2467013A2 (en) 2009-08-20 2012-06-27 Transposagen Biopharmaceuticals, Inc. Genetically modified rat models for pain
US9420770B2 (en) 2009-12-01 2016-08-23 Indiana University Research & Technology Corporation Methods of modulating thrombocytopenia and modified transgenic pigs
WO2011091134A2 (en) 2010-01-22 2011-07-28 Dana-Farber Cancer Institute, Inc. Compositions,kits, and methods for identification, assessment, prevention, and therapy of metabolic disorders
TWI518325B (zh) 2010-02-04 2016-01-21 自治醫科大學 對ａｌｋ抑制劑具有先抗性或後抗性癌症的識別、判斷和治療
US10745467B2 (en) 2010-03-26 2020-08-18 The Trustees Of Dartmouth College VISTA-Ig for treatment of autoimmune, allergic and inflammatory disorders
MX342017B (es) 2010-03-26 2016-09-09 Dartmouth College Proteina mediadora de celula t regulatoria vista, agentes de enlace de vista y uso de los mismos.
US20150231215A1 (en) 2012-06-22 2015-08-20 Randolph J. Noelle VISTA Antagonist and Methods of Use
US8383793B2 (en) 2010-04-15 2013-02-26 St. Jude Children's Research Hospital Methods and compositions for the diagnosis and treatment of cancer resistant to anaplastic lymphoma kinase (ALK) kinase inhibitors
US20110269735A1 (en) 2010-04-19 2011-11-03 Celera Corporation Genetic polymorphisms associated with statin response and cardiovascular diseases, methods of detection and uses thereof
WO2012051699A1 (en) 2010-10-22 2012-04-26 Agri-Neo Inc. Synergistic activity of peracetic acid and at least one sar inducer for the control of pathogens in and onto growing plants
US20120108651A1 (en) 2010-11-02 2012-05-03 Leiden University Medical Center (LUMC) Acting on Behalf of Academic Hospital Leiden (AZL) Genetic polymorphisms associated with venous thrombosis and statin response, methods of detection and uses thereof
WO2012064090A2 (ko) 2010-11-08 2012-05-18 광주과학기술원 골격근-유래된 다능성 세포의 화학적 제조방법 및 이의 용도
CA2827348C (en) 2011-02-14 2021-02-23 Revivicor, Inc. Genetically modified pigs for xenotransplantation of vascularized xenografts and derivatives thereof
WO2012129198A1 (en) 2011-03-23 2012-09-27 Transposagen Biopharmaceuticals, Inc. Genetically modified rat models for obesity and diabetes
SI2709445T1 (sl) 2011-05-16 2018-11-30 The Curators Of The University Of Missouri Živali, odporne proti virusu prašičjega reprodukcijskega in respiratornega sindroma
US10093705B2 (en) 2011-09-13 2018-10-09 Dana-Farber Cancer Institute, Inc. Compositions and methods for brown fat induction and activity using FNDC5
LT2814842T (lt) 2012-02-15 2018-11-12 Novo Nordisk A/S Antikūnai, kurie suriša peptidoglikaną atpažįstantį baltymą 1
ES2640268T3 (es) 2012-02-15 2017-11-02 Novo Nordisk A/S Anticuerpos que se unen a y bloquean un receptor desencadenante expresado en células mieloides 1 (TREM-1)
US9550830B2 (en) 2012-02-15 2017-01-24 Novo Nordisk A/S Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1)
US9890215B2 (en) 2012-06-22 2018-02-13 King's College London Vista modulators for diagnosis and treatment of cancer
CN104619722B (zh) 2012-06-22 2022-10-04 达特茅斯大学理事会 新型vista-ig构建体和vista-ig用于治疗自身免疫性、过敏性和炎性疾病的用途
CA2884704C (en) 2012-09-07 2023-04-04 Randolph J. Noelle Vista modulators for diagnosis and treatment of cancer
EP4043493A1 (en) 2013-12-24 2022-08-17 Janssen Pharmaceutica NV Anti-vista antibodies and fragments
US11014987B2 (en) 2013-12-24 2021-05-25 Janssen Pharmaceutics Nv Anti-vista antibodies and fragments, uses thereof, and methods of identifying same
AU2015206603B9 (en) 2014-01-14 2019-07-18 Dana-Farber Cancer Institute, Inc. Compositions and methods for identification, assessment, prevention, and treatment of melanoma using PD-L1 isoforms
EP3154585B1 (en) 2014-06-11 2022-02-23 Kathy A. Green Use of vista agonists and antagonists to suppress or enhance humoral immunity
KR102641268B1 (ko) 2014-07-17 2024-02-27 노보 노르디스크 에이/에스 점도를 감소시키기 위한 trem-1 항체의 부위 지정 돌연변이유발
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
JP2018505911A (ja) 2014-12-05 2018-03-01 イミュネクスト，インコーポレーテッド 推定上のｖｉｓｔａ受容体としてのｖｓｉｇ８の同定と、ｖｉｓｔａ／ｖｓｉｇ８調節剤を産生するためのその使用
EP3808775B1 (en) 2014-12-09 2024-04-17 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized cluster of differentiation 274 gene
US10136642B2 (en) 2015-02-19 2018-11-27 Agri-Neo, Inc. Composition of peracetic acid and at least one organic fungicide for the control and/or the treatment of diseases associated with the presence of pathogens, and method, use and kit involving said composition
EP3722314A1 (en) 2015-06-24 2020-10-14 Janssen Pharmaceutica NV Anti-vista antibodies and fragments
RU2018107842A (ru) 2015-08-06 2019-09-09 Дзе Кьюрейторз Оф Дзе Юниверсити Оф Миссури Устойчивые к патогенам животные, имеющие модифицированные гены cd163
EP3368157B1 (en) 2015-10-29 2022-06-29 Dana-Farber Cancer Institute, Inc. Methods for identification, assessment, prevention, and treatment of metabolic disorders using pm20d1 and n-lipidated amino acids
TW202216201A (zh) 2016-02-12 2022-05-01 比利時商楊森製藥公司 抗vista抗體及片段、其用途及鑑定其之方法
JP7184751B2 (ja) 2016-04-15 2022-12-06 イミュネクスト インコーポレイテッド 抗ヒトｖｉｓｔａ抗体およびその使用
AU2019248547B2 (en) 2018-04-02 2025-07-17 Bristol-Myers Squibb Company Anti-TREM-1 antibodies and uses thereof
US11160260B2 (en) 2018-04-17 2021-11-02 The Curators Of The University Of Missouri Methods for protecting porcine fetuses from infection with porcine reproductive and respiratory syndrome virus (PRRSV)
CN117279502A (zh) 2020-11-20 2023-12-22 雷维维科公司 用于异种移植的生长激素受体敲除的多转基因猪
EP4404740A1 (en) 2021-09-20 2024-07-31 Revivicor Inc. Multitransgenic pigs comprising ten genetic modifications for xenotransplantation

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ224241A (en) * 1987-04-14 1991-03-26 Bresatec Ltd Method of producing new animal breeds using plasmid expression vectors; plasmid expression vectors
US5057420A (en) 1987-06-05 1991-10-15 Granada Biosciences, Inc. Bovine nuclear transplantation
CA2059199A1 (en) 1992-01-10 1993-07-11 Steen Willadsen Method for producing mature reconstituted mammalian eggs by nuclear transplantation
GB2265909B (en) 1992-04-01 1996-03-20 Inst Of Animal Physiology And Fusion of donor nucleus with recipient cytoplast in the absence of calcium ion
AU680441B2 (en) * 1992-09-22 1997-07-31 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Use of taxol for treating lymphomas and breast cancer
CA2092258A1 (en) 1992-12-30 1994-07-01 Steven L. Stice Synchronized donor cells for bovine nuclear transfer
US5480772A (en) 1993-02-03 1996-01-02 Brandeis University In vitro activation of a nucleus
US5496720A (en) 1993-02-10 1996-03-05 Susko-Parrish; Joan L. Parthenogenic oocyte activation
US5523226A (en) 1993-05-14 1996-06-04 Biotechnology Research And Development Corp. Transgenic swine compositions and methods
US5333948A (en) 1993-06-22 1994-08-02 Tekonsha Engineering Company Multiple-gain electronic brake actuator with trigger point inertial sensor
ES2255477T5 (es) * 1993-07-29 2010-04-08 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Uso de paclitaxel y sus derivados en la fabricacion de un medicamento para el tratamiento de reestenosis.
AU1595195A (en) 1993-12-23 1995-07-10 Abs Global, Inc. Embryonic stem cells as nuclear donors and nuclear transfer techniques to produce chimeric and transgenic animals
GB9417831D0 (en) * 1994-09-05 1994-10-26 Biotech & Biolog Scien Res Biological manipulation
US7307198B2 (en) * 1995-08-31 2007-12-11 Roslin Institute Ungulates produced by nuclear transfer of G1 cells
GB9517779D0 (en) * 1995-08-31 1995-11-01 Roslin Inst Edinburgh Biological manipulation
GB9517780D0 (en) * 1995-08-31 1995-11-01 Roslin Inst Edinburgh Biological manipulation
US6215041B1 (en) 1997-01-10 2001-04-10 University Of Mmassachusetts Cloning using donor nuclei from a non-quiesecent somatic cells
US5945577A (en) 1997-01-10 1999-08-31 University Of Massachusetts As Represented By Its Amherst Campus Cloning using donor nuclei from proliferating somatic cells
US7291764B1 (en) * 1997-01-10 2007-11-06 University of Massachusetts, a Public Institution of Higher Education of the Commonwealth of Massachusetts, as Represented by its Amherst Campus, Office of Vice Chancellor for Research at Amherst Cloning pigs using non-quiescent differentiated donor cells or nuclei
US6235969B1 (en) 1997-01-10 2001-05-22 University Of Massachusetts Cloning pigs using donor nuclei from non-quiescent differentiated cells
US7361804B1 (en) * 1997-02-19 2008-04-22 Roslin Institute (Edinburgh) Unactivated oocytes in nuclear transfer to produce ungulates
US6011197A (en) 1997-03-06 2000-01-04 Infigen, Inc. Method of cloning bovines using reprogrammed non-embryonic bovine cells
US6600087B1 (en) 1998-01-16 2003-07-29 Agrobiogen Gmbh Efficient nuclear transfer using fetal fibroblasts and multiple cloning procedures
JP3573964B2 (ja) * 1998-06-17 2004-10-06 三洋電機株式会社 アルカリ電池用水素吸蔵合金電極及びアルカリ蓄電池用水素吸蔵合金電極の製造方法
WO2000022098A1 (en) * 1998-10-12 2000-04-20 Geron Bio-Med Limited Porcine oocytes with improved developmental competence
US6700037B2 (en) * 1998-11-24 2004-03-02 Infigen, Inc. Method of cloning porcine animals
US20050156424A1 (en) * 2000-02-29 2005-07-21 Thyssenkrupp Presta Ag Steering column and manufacturing method thereof
US8302202B2 (en) * 2005-08-03 2012-10-30 International Business Machines Corporation Transportable computing environment apparatus system and method

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