GB9517779D0 - Biological manipulation - Google Patents

Biological manipulation

Info

Publication number
GB9517779D0
GB9517779D0 GBGB9517779.6A GB9517779A GB9517779D0 GB 9517779 D0 GB9517779 D0 GB 9517779D0 GB 9517779 A GB9517779 A GB 9517779A GB 9517779 D0 GB9517779 D0 GB 9517779D0
Authority
GB
United Kingdom
Prior art keywords
time
embryo
oocyte
nucleus
activated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
GBGB9517779.6A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roslin Institute
Original Assignee
Roslin Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10779997&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GB9517779(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Roslin Institute filed Critical Roslin Institute
Priority to GBGB9517779.6A priority Critical patent/GB9517779D0/en
Publication of GB9517779D0 publication Critical patent/GB9517779D0/en
Priority to CN2006100037660A priority patent/CN1813642B/zh
Priority to IL12341796A priority patent/IL123417A0/xx
Priority to SG1999000941A priority patent/SG75919A1/en
Priority to AT96928586T priority patent/ATE400176T1/de
Priority to CNB961978929A priority patent/CN1250715C/zh
Priority to CNA2005101270278A priority patent/CN1772891A/zh
Priority to PCT/GB1996/002098 priority patent/WO1997007668A1/en
Priority to NZ335407A priority patent/NZ335407A/en
Priority to CZ98604A priority patent/CZ60498A3/cs
Priority to HU9802485A priority patent/HUP9802485A3/hu
Priority to GB9926730A priority patent/GB2340493B/en
Priority to ZA9607383A priority patent/ZA967383B/xx
Priority to KR1019980701382A priority patent/KR100533477B1/ko
Priority to BR9610013-3A priority patent/BR9610013A/pt
Priority to CA002229657A priority patent/CA2229657A1/en
Priority to EP96928586A priority patent/EP0847237B1/en
Priority to GB9802916A priority patent/GB2318792B/en
Priority to PL96325336A priority patent/PL325336A1/xx
Priority to AU68309/96A priority patent/AU728809B2/en
Priority to KR1020067006296A priority patent/KR20060057638A/ko
Priority to KR1020057014691A priority patent/KR100743006B1/ko
Priority to KR1020077007531A priority patent/KR20070041793A/ko
Priority to NZ504101A priority patent/NZ504101A/en
Priority to DK96928586T priority patent/DK0847237T3/da
Priority to NZ316148A priority patent/NZ316148A/xx
Priority to ES96928586T priority patent/ES2309989T3/es
Priority to JP9509995A priority patent/JP2000506721A/ja
Priority to DE69637591T priority patent/DE69637591D1/de
Priority to HK98104135.1A priority patent/HK1004937B/xx
Priority to US08/803,165 priority patent/US6252133B1/en
Priority to NO980846A priority patent/NO980846L/no
Priority to HK00103527.6A priority patent/HK1024381B/xx
Priority to US09/650,285 priority patent/US6525243B1/en
Priority to US09/973,701 priority patent/US20030037352A1/en
Priority to US09/989,128 priority patent/US7307198B2/en
Priority to US09/989,126 priority patent/US7332648B2/en
Priority to US09/989,125 priority patent/US7304204B2/en
Priority to US10/190,617 priority patent/US7326824B2/en
Priority to US10/234,854 priority patent/US7321075B2/en
Priority to US10/909,845 priority patent/US7329796B2/en
Priority to US10/914,161 priority patent/US7321076B2/en
Priority to US11/068,903 priority patent/US7432415B2/en
Priority to US11/265,114 priority patent/US7524677B2/en
Priority to JP2005345998A priority patent/JP2006340710A/ja
Priority to US11/543,881 priority patent/US7326825B2/en
Priority to US11/544,038 priority patent/US20070028312A1/en
Priority to JP2008111492A priority patent/JP2008194053A/ja
Priority to US12/647,316 priority patent/US20100146654A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
    • C12N15/877—Techniques for producing new mammalian cloned embryos
    • C12N15/8773—Ovine embryos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
    • C12N15/877—Techniques for producing new mammalian cloned embryos
    • C12N15/8771—Bovine embryos

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Reproductive Health (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Environmental Sciences (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
GBGB9517779.6A 1995-08-31 1995-08-31 Biological manipulation Pending GB9517779D0 (en)

Priority Applications (49)

Application Number Priority Date Filing Date Title
GBGB9517779.6A GB9517779D0 (en) 1995-08-31 1995-08-31 Biological manipulation
CN2006100037660A CN1813642B (zh) 1995-08-31 1996-08-30 作为细胞核转移胞质体受体的未激活卵母细胞
IL12341796A IL123417A0 (en) 1995-08-31 1996-08-30 Unactivated oocytes as cytoplast recipients for nuclear transfer
SG1999000941A SG75919A1 (en) 1995-08-31 1996-08-30 Unactivated oocytes as cytoplast recipients for nuclear transfer
AT96928586T ATE400176T1 (de) 1995-08-31 1996-08-30 Inaktivierte oozyten als zytoplasmische rezeptoren zum kern-transfer
CNB961978929A CN1250715C (zh) 1995-08-31 1996-08-30 用分化的二倍体供体细胞的核克隆非人类动物的方法
CNA2005101270278A CN1772891A (zh) 1995-08-31 1996-08-30 作为细胞核转移胞质体受体的未激活卵母细胞
PCT/GB1996/002098 WO1997007668A1 (en) 1995-08-31 1996-08-30 Unactivated oocytes as cytoplast recipients for nuclear transfer
NZ335407A NZ335407A (en) 1995-08-31 1996-08-30 Reconstituted animal embryos prepared by using unactivated oocytes as cytoplast recipients for nuclear transfer
CZ98604A CZ60498A3 (cs) 1995-08-31 1996-08-30 Neaktivované oocyty jako cytoplastové recipienty pro přenos jádra
HU9802485A HUP9802485A3 (en) 1995-08-31 1996-08-30 Unactivated oocytes as cytoplast recipients for nuclear transfer
GB9926730A GB2340493B (en) 1995-08-31 1996-08-30 Unactivated oocytes as cytoplast recipients for nuclear transfer
ZA9607383A ZA967383B (en) 1995-08-31 1996-08-30 Unactivated oocytes as cytoplast recipients for nuclear transfer.
KR1019980701382A KR100533477B1 (ko) 1995-08-31 1996-08-30 핵이식용 세포질 수용체로서의 불활성화 난모세포
BR9610013-3A BR9610013A (pt) 1995-08-31 1996-08-30 Processos para reconstituir um embrião animal e para preparar um animal, embrião de animal reconstituído, e , animal
CA002229657A CA2229657A1 (en) 1995-08-31 1996-08-30 Unactivated oocytes as cytoplast recipients for nuclear transfer
EP96928586A EP0847237B1 (en) 1995-08-31 1996-08-30 Unactivated oocytes as cytoplast recipients for nuclear transfer
GB9802916A GB2318792B (en) 1995-08-31 1996-08-30 Unactivated oocytes as cytoplast recipients for nuclear transfer
PL96325336A PL325336A1 (en) 1995-08-31 1996-08-30 Inactivated oocytes as cytoplastic recipients for transfering cell nuclei
AU68309/96A AU728809B2 (en) 1995-08-31 1996-08-30 Unactivated oocytes as cytoplast recipients for nuclear transfer
KR1020067006296A KR20060057638A (ko) 1995-08-31 1996-08-30 핵이식용 세포질 수용체로서의 불활성화 난모 세포
KR1020057014691A KR100743006B1 (ko) 1995-08-31 1996-08-30 핵이식용 세포질 수용체로서의 불활성화 난모 세포
KR1020077007531A KR20070041793A (ko) 1995-08-31 1996-08-30 핵이식용 세포질 수용체로서의 불활성화 난모 세포
NZ504101A NZ504101A (en) 1995-08-31 1996-08-30 A method of preparing a non-human mammal comprising reconstituting a non-human mammalian embryo
DK96928586T DK0847237T3 (da) 1995-08-31 1996-08-30 Ikke-aktiverede oocytter som cytoplastrecipienter til kerneoverföring
NZ316148A NZ316148A (en) 1995-08-31 1996-08-30 Reconstituting animal embryos by transferring nuclei into unactivated oocytes
ES96928586T ES2309989T3 (es) 1995-08-31 1996-08-30 Oocitos inactivados que son receptores de citoplastos para transferencia nuclear.
JP9509995A JP2000506721A (ja) 1995-08-31 1996-08-30 核転移用レシピエント細胞質としての不活性卵母細胞
DE69637591T DE69637591D1 (de) 1995-08-31 1996-08-30 Inaktivierte oozyten als zytoplasmische rezeptoren zum kern-transfer
HK98104135.1A HK1004937B (en) 1995-08-31 1996-08-30 Unactivated oocytes as cytoplast recipients for nuclear transfer
US08/803,165 US6252133B1 (en) 1995-08-31 1997-02-19 Unactivated oocytes as cytoplast recipients of quiescent and non-quiescent cell nuclei, while maintaining correct ploidy
NO980846A NO980846L (no) 1995-08-31 1998-02-27 Uaktiverte oocytter som cytoplasmatiske mottakere for kjerneoverf÷ringer
HK00103527.6A HK1024381B (en) 1995-08-31 1998-05-13 Unactivated oocytes as cytoplast recipients for nuclear transfer
US09/650,285 US6525243B1 (en) 1995-08-31 2000-08-29 Unactivated oocytes as cytoplast recipients of quiescent cell nuclei while maintaining correct ploidy
US09/973,701 US20030037352A1 (en) 1995-08-31 2001-10-11 Unactivated oocytes as cytoplast recipients for nuclear transfer
US09/989,128 US7307198B2 (en) 1995-08-31 2001-11-21 Ungulates produced by nuclear transfer of G1 cells
US09/989,126 US7332648B2 (en) 1995-08-31 2001-11-21 Unactivated oocytes in nuclear transfer to produce cultured inner cell mass cells and ungulates
US09/989,125 US7304204B2 (en) 1995-08-31 2001-11-21 Ungulates produced by nuclear transfer of G1 cells
US10/190,617 US7326824B2 (en) 1995-08-31 2002-07-09 Unactivated ungulate oocytes to produce a transgenic ungulate by nuclear transfer
US10/234,854 US7321075B2 (en) 1995-08-31 2002-09-05 Serial nuclear transfer of ungulate embryos
US10/909,845 US7329796B2 (en) 1995-08-31 2004-08-03 Serial nuclear transfer of ungulate embryos
US10/914,161 US7321076B2 (en) 1995-08-31 2004-08-10 Unactivated ungulate oocytes to produce a cloned ungulate by nuclear transfer
US11/068,903 US7432415B2 (en) 1995-08-31 2005-03-02 Unactivated oocytes as cytoplast recipients for nonprimate mammalian and pig nuclear transfer
US11/265,114 US7524677B2 (en) 1995-08-31 2005-11-03 Mammalian cultured inner cell mass cell culture using a g1 cell as nuclear donor
JP2005345998A JP2006340710A (ja) 1995-08-31 2005-11-30 核移植用レシピエント細胞質としての不活性卵母細胞
US11/543,881 US7326825B2 (en) 1995-08-31 2006-10-06 Methods of ungulate nuclear transfer
US11/544,038 US20070028312A1 (en) 1995-08-31 2006-10-06 Unactivated oocytes as cytoplast recipients for nuclear transfer
JP2008111492A JP2008194053A (ja) 1995-08-31 2008-04-22 核移植用レシピエント細胞質としての不活性卵母細胞
US12/647,316 US20100146654A1 (en) 1995-08-31 2009-12-24 Unactivated oocytes as cytoplast recipients for nuclear transfer

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9517779.6A GB9517779D0 (en) 1995-08-31 1995-08-31 Biological manipulation

Publications (1)

Publication Number Publication Date
GB9517779D0 true GB9517779D0 (en) 1995-11-01

Family

ID=10779997

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB9517779.6A Pending GB9517779D0 (en) 1995-08-31 1995-08-31 Biological manipulation

Country Status (22)

Country Link
US (12) US6252133B1 (enExample)
EP (1) EP0847237B1 (enExample)
JP (3) JP2000506721A (enExample)
KR (4) KR100533477B1 (enExample)
CN (3) CN1250715C (enExample)
AT (1) ATE400176T1 (enExample)
AU (1) AU728809B2 (enExample)
BR (1) BR9610013A (enExample)
CA (1) CA2229657A1 (enExample)
CZ (1) CZ60498A3 (enExample)
DE (1) DE69637591D1 (enExample)
DK (1) DK0847237T3 (enExample)
ES (1) ES2309989T3 (enExample)
GB (1) GB9517779D0 (enExample)
HU (1) HUP9802485A3 (enExample)
IL (1) IL123417A0 (enExample)
NO (1) NO980846L (enExample)
NZ (2) NZ316148A (enExample)
PL (1) PL325336A1 (enExample)
SG (1) SG75919A1 (enExample)
WO (1) WO1997007668A1 (enExample)
ZA (1) ZA967383B (enExample)

Families Citing this family (192)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5480772A (en) 1993-02-03 1996-01-02 Brandeis University In vitro activation of a nucleus
GB9517780D0 (en) * 1995-08-31 1995-11-01 Roslin Inst Edinburgh Biological manipulation
GB9517779D0 (en) * 1995-08-31 1995-11-01 Roslin Inst Edinburgh Biological manipulation
US7304204B2 (en) 1995-08-31 2007-12-04 Roslin Institute Ungulates produced by nuclear transfer of G1 cells
US6025155A (en) * 1996-04-10 2000-02-15 Chromos Molecular Systems, Inc. Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
US6077697A (en) * 1996-04-10 2000-06-20 Chromos Molecular Systems, Inc. Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
EP0941310A1 (en) 1996-10-11 1999-09-15 THE TEXAS A&M UNIVERSITY SYSTEM Methods for the generation of primordial germ cells and transgenic animal species
US6235969B1 (en) * 1997-01-10 2001-05-22 University Of Massachusetts Cloning pigs using donor nuclei from non-quiescent differentiated cells
US5945577A (en) * 1997-01-10 1999-08-31 University Of Massachusetts As Represented By Its Amherst Campus Cloning using donor nuclei from proliferating somatic cells
US20090092588A1 (en) * 1997-01-10 2009-04-09 University Of Massachusetts As Represented By Its Amherst Campus Cloned ungulate embryos and animals, use of cells, tissues and organs thereof for transplantation therapies including parkinson's disease
US6011197A (en) 1997-03-06 2000-01-04 Infigen, Inc. Method of cloning bovines using reprogrammed non-embryonic bovine cells
ES2513043T3 (es) 1997-03-26 2014-10-24 Imperial Innovations Limited Proteína de fusión anticoagulante anclada a membrana de la célula
IL133786A0 (en) 1997-07-03 2001-04-30 Univ Massachusetts Cloning using donor nuclei from non-serum starved, differentiated cells
US7923216B2 (en) 1997-08-14 2011-04-12 Institut Pasteur In vivo modulation of neuronal transport
US7923015B2 (en) 1997-08-14 2011-04-12 Institut Pasteur Methods for direct visualization of active synapses
JPH11127852A (ja) * 1997-10-28 1999-05-18 Snow Brand Milk Prod Co Ltd 上皮細胞のｇ０期同調方法
AU739902B2 (en) * 1998-01-16 2001-10-25 Agrobiogen Gmbh Efficient nuclear transfer using fetal fibroblasts
US7351876B2 (en) 1998-01-16 2008-04-01 Agrobiogen Gmbh Biotechnologie Efficient nuclear transfer with primordial gametes
CA2318117A1 (en) * 1998-01-16 1999-07-22 Agrobiogen Gmbh Efficient nuclear transfer using primordial germ cells
US6331659B1 (en) * 1998-01-21 2001-12-18 University Of Hawaii Cumulus cells as nuclear donors
JP2002511234A (ja) * 1998-03-16 2002-04-16 リレグ ピーティーワイ リミテッド ブタの核移植
AUPP294898A0 (en) * 1998-04-15 1998-05-07 Monash University Method of nuclear transfer
GB9808325D0 (en) * 1998-04-20 1998-06-17 Ltr Ciz Di Associazione Italia Source of nuclei for nuclear transfer
US6143564A (en) * 1998-07-07 2000-11-07 University Of Hawaii Use of the polar body chromosomes for the production of embryos and normal offspring
GB9820988D0 (en) * 1998-09-25 1998-11-18 Biotech & Biolog Scien Res Screening method
GB2365445A (en) * 1998-10-12 2002-02-20 Geron Bio Med Ltd Porcine occcytes with improved developmental competence
EP1818397A1 (en) * 1998-11-02 2007-08-15 Trustees Of Tufts College Methods for cloning animals
US6781030B1 (en) 1998-11-02 2004-08-24 Trustee Of Tufts College, Ballou Hall Methods for cloning mammals using telophase oocytes
ATE427653T1 (de) 1998-11-19 2009-04-15 Pharming Intellectual Pty Bv Stabilisierung der milch transgener tieren
US6700037B2 (en) 1998-11-24 2004-03-02 Infigen, Inc. Method of cloning porcine animals
US6258998B1 (en) 1998-11-24 2001-07-10 Infigen, Inc. Method of cloning porcine animals
CA2360549C (en) * 1999-01-13 2013-04-09 Ppl Therapeutics (Scotland) Limited Double nuclear transfer method and results thereof
US7531715B1 (en) * 1999-01-13 2009-05-12 Ppl Therapeutics (Scotland) Double nuclear transfer method and results thereof
WO2000044914A1 (en) 1999-01-28 2000-08-03 Medical College Of Georgia Research Institute, Inc. Composition and method for in vivo and in vitro attenuation of gene expression using double stranded rna
EP1179000A4 (en) 1999-02-26 2005-10-12 Millennium Pharm Inc DECISION PROTEINS AND THEIR USE
US20020012660A1 (en) * 1999-03-04 2002-01-31 Alan Colman Method of preparing a somatic cells for nuclear transfer
AU780754B2 (en) * 1999-03-04 2005-04-14 Revivicor Inc Genetic modification of somatic cells and uses thereof
WO2001000855A1 (en) 1999-06-23 2001-01-04 Ppl Therapeutics (Scotland) Ltd. Fusion proteins incorporating lysozyme
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JP2003503044A (ja) * 1999-06-30 2003-01-28 ワン，ウー−サク 種間核移植技術を用いたヒトクローン胚の作製方法
US6590139B1 (en) 1999-06-30 2003-07-08 Woo-Suk Hwang Method for producing cloned cows
KR100414043B1 (ko) * 1999-06-30 2004-01-13 황우석 체세포 복제동물 및 그 생산방법
US7291714B1 (en) 1999-06-30 2007-11-06 Millennium Pharmaceuticals, Inc. Glycoprotein VI and uses thereof
EP1210428B1 (en) 1999-08-23 2015-03-18 Dana-Farber Cancer Institute, Inc. Pd-1, a receptor for b7-4, and uses therefor
EP2275559A3 (en) 1999-09-28 2011-03-23 Shire Human Genetic Therapies, Inc. Optimized messenger RNA
WO2002064799A2 (en) 1999-09-28 2002-08-22 Transkaryotic Therapies, Inc. Optimized messenger rna
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KR100417566B1 (ko) * 1999-11-19 2004-02-05 한국생명공학연구원 체세포 핵치환 복제수정란의 대량생산방법
US7074983B2 (en) * 1999-11-19 2006-07-11 Kirin Beer Kabushiki Kaisha Transgenic bovine comprising human immunoglobulin loci and producing human immunoglobulin
US7820878B2 (en) * 1999-11-19 2010-10-26 Kyowa Hakko Kirin Co., Ltd. Production of ungulates, preferably bovines that produce human immunoglobulins
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