PL2709445T3 - Zwierzęta odporne na wirus zespołu rozrodczo-oddechowego świń - Google Patents

Zwierzęta odporne na wirus zespołu rozrodczo-oddechowego świń

Info

Publication number
PL2709445T3
PL2709445T3 PL12785983T PL12785983T PL2709445T3 PL 2709445 T3 PL2709445 T3 PL 2709445T3 PL 12785983 T PL12785983 T PL 12785983T PL 12785983 T PL12785983 T PL 12785983T PL 2709445 T3 PL2709445 T3 PL 2709445T3
Authority
PL
Poland
Prior art keywords
respiratory syndrome
syndrome virus
porcine reproductive
virus resistant
resistant animals
Prior art date
Application number
PL12785983T
Other languages
English (en)
Inventor
Randall S. Prather
Kevin D. Wells
Kristin M. Whitworth
Original Assignee
The Curators Of The University Of Missouri
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Curators Of The University Of Missouri filed Critical The Curators Of The University Of Missouri
Publication of PL2709445T3 publication Critical patent/PL2709445T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027New or modified breeds of vertebrates
    • A01K67/0275Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276Knock-out vertebrates
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027New or modified breeds of vertebrates
    • A01K67/0275Genetically modified vertebrates, e.g. transgenic
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10Cells modified by introduction of foreign genetic material
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/07Animals genetically altered by homologous recombination
    • A01K2217/075Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/15Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00Animals characterised by species
    • A01K2227/10Mammal
    • A01K2227/108Swine
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/02Animal zootechnically ameliorated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/7056Lectin superfamily, e.g. CD23, CD72
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596Molecules with a "CD"-designation not provided for elsewhere
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00Nucleic acids vectors
    • C12N2800/80Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
PL12785983T 2011-05-16 2012-05-16 Zwierzęta odporne na wirus zespołu rozrodczo-oddechowego świń PL2709445T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161519076P 2011-05-16 2011-05-16
PCT/US2012/038193 WO2012158828A1 (en) 2011-05-16 2012-05-16 Porcine reproductive and respiratory syndrome virus resistant animals
EP12785983.3A EP2709445B1 (en) 2011-05-16 2012-05-16 Porcine reproductive and respiratory syndrome virus resistant animals

Publications (1)

Publication Number Publication Date
PL2709445T3 true PL2709445T3 (pl) 2019-01-31

Family

ID=47177326

Family Applications (1)

Application Number Title Priority Date Filing Date
PL12785983T PL2709445T3 (pl) 2011-05-16 2012-05-16 Zwierzęta odporne na wirus zespołu rozrodczo-oddechowego świń

Country Status (21)

Country Link
US (5) US9820475B2 (pl)
EP (2) EP2709445B1 (pl)
JP (5) JP2014519323A (pl)
KR (5) KR20240014587A (pl)
CN (3) CN105112450A (pl)
AU (5) AU2012255744A1 (pl)
BR (1) BR112013029498A8 (pl)
CA (2) CA2836288A1 (pl)
CY (1) CY1120890T1 (pl)
DK (1) DK2709445T3 (pl)
ES (1) ES2691618T3 (pl)
HK (1) HK1215282A1 (pl)
HR (1) HRP20181729T1 (pl)
HU (1) HUE039793T2 (pl)
LT (1) LT2709445T (pl)
MX (1) MX357421B (pl)
PL (1) PL2709445T3 (pl)
PT (1) PT2709445T (pl)
RU (1) RU2644673C2 (pl)
SI (1) SI2709445T1 (pl)
WO (1) WO2012158828A1 (pl)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012255744A1 (en) 2011-05-16 2014-01-09 The Curators Of The University Of Missouri Porcine reproductive and respiratory syndrome virus resistant animals
GB201313235D0 (en) 2013-07-24 2013-09-04 Univ Edinburgh Antiviral Compositions Methods and Animals
US20150275231A1 (en) * 2014-03-31 2015-10-01 Mice With Horns, Llc Method of Preventing or Reducing Virus Transmission in Animals
CN104593422A (zh) * 2015-01-08 2015-05-06 中国农业大学 一种抗蓝耳病克隆猪的制备方法
WO2016140353A1 (ja) * 2015-03-04 2016-09-09 株式会社 医療実験用大動物供給事業準備会社 安定した表現型を示す疾患モデルブタおよびその作製方法
EP4361279A3 (en) * 2015-08-06 2024-07-17 The Curators of the University of Missouri Pathogen-resistant animals having modified cd163 genes
AU2015404563B2 (en) * 2015-08-06 2022-11-17 The Curators Of The University Of Missouri Pathogen-resistant animals having modified CD163 genes
GB201617559D0 (en) 2016-10-17 2016-11-30 University Court Of The University Of Edinburgh The Swine comprising modified cd163 and associated methods
CN107937345B (zh) * 2017-11-16 2019-01-29 山东蓝思种业股份有限公司 一种制备同时敲除cd163基因和cd13基因的猪成纤维细胞的方法
US11160260B2 (en) 2018-04-17 2021-11-02 The Curators Of The University Of Missouri Methods for protecting porcine fetuses from infection with porcine reproductive and respiratory syndrome virus (PRRSV)
CA3096022A1 (en) * 2018-04-17 2019-10-24 The Curators Of The University Of Missouri Methods for protecting porcine fetuses from infection with virus
WO2019210175A1 (en) * 2018-04-27 2019-10-31 The Curators Of The University Of Missouri Pathogen-resistant animals having modified aminopeptidase n (anpep) genes
CN109197780A (zh) * 2018-11-26 2019-01-15 湖北天牧畜禽有限公司 一种减少仔猪生病的养殖方法
WO2021024123A1 (en) * 2019-08-06 2021-02-11 Nzeno Limited Donor pigs for xenotransplantation
AU2021268263A1 (en) 2020-05-05 2022-10-27 Genus Plc Methods for improving the health of porcine species by targeted inactivation of CD163
US20240053363A1 (en) * 2021-01-05 2024-02-15 Public University Corporation Yokohama City University Biomarker for determining fertility, and determining method using same

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GB9417831D0 (en) 1994-09-05 1994-10-26 Biotech & Biolog Scien Res Biological manipulation
US5683993A (en) 1995-06-22 1997-11-04 Ciba Vision Corporation Compositions and methods for stabilizing polymers
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GB9517779D0 (en) 1995-08-31 1995-11-01 Roslin Inst Edinburgh Biological manipulation
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US5945577A (en) 1997-01-10 1999-08-31 University Of Massachusetts As Represented By Its Amherst Campus Cloning using donor nuclei from proliferating somatic cells
US5995577A (en) 1997-02-10 1999-11-30 General Electric Company Optimized steam vent locations for a nuclear fuel bundle
AU7979098A (en) 1997-06-18 1999-01-04 Curators Of The University Of Missouri, The Complete activation of mammalian oocytes
US6740490B2 (en) * 2001-01-29 2004-05-25 Kansas State University Research Foundation Identification and applications of porcine reproductive and respiratory syndrome virus host susceptibility factor(s) for improved swine breeding
EP1465481A4 (en) 2001-12-21 2007-09-12 Univ Missouri KNOCK-OUT PORK AND METHODS OF MAKING THE SAME
US8106251B2 (en) * 2002-08-21 2012-01-31 Revivicor, Inc. Tissue products derived from porcine animals lacking any expression of functional alpha 1,3 galactosyltransferase
NZ550106A (en) 2004-04-22 2009-06-26 Kyowa Hakko Kirin Co Ltd Transgenic animals and uses thereof
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Also Published As

Publication number Publication date
EP2709445A4 (en) 2015-03-25
CY1120890T1 (el) 2019-12-11
AU2018256670A1 (en) 2018-12-06
JP2022081637A (ja) 2022-05-31
DK2709445T3 (en) 2018-11-19
MX2013013427A (es) 2014-09-04
JP2014519323A (ja) 2014-08-14
AU2017202540A1 (en) 2017-05-18
AU2018256670B2 (en) 2020-09-24
WO2012158828A1 (en) 2012-11-22
CA3184311A1 (en) 2012-11-22
CN105112450A (zh) 2015-12-02
CN111593025A (zh) 2020-08-28
BR112013029498A8 (pt) 2017-02-21
US11019809B2 (en) 2021-06-01
JP2017158579A (ja) 2017-09-14
CN103687482A (zh) 2014-03-26
SI2709445T1 (sl) 2018-11-30
BR112013029498A2 (pt) 2016-08-09
KR20240014587A (ko) 2024-02-01
US20140096275A1 (en) 2014-04-03
AU2023219858A1 (en) 2023-09-28
HUE039793T2 (hu) 2019-02-28
RU2644673C2 (ru) 2018-02-13
US10405526B2 (en) 2019-09-10
US20200137992A1 (en) 2020-05-07
EP2709445A1 (en) 2014-03-26
KR20140034229A (ko) 2014-03-19
LT2709445T (lt) 2018-11-12
EP2709445B1 (en) 2018-10-03
US9820475B2 (en) 2017-11-21
KR20200063264A (ko) 2020-06-04
JP2024069309A (ja) 2024-05-21
PT2709445T (pt) 2018-11-27
KR102428306B1 (ko) 2022-08-03
AU2012255744A1 (en) 2014-01-09
KR102627319B1 (ko) 2024-01-23
US10080353B2 (en) 2018-09-25
KR20230132606A (ko) 2023-09-15
EP3420813A1 (en) 2019-01-02
HRP20181729T1 (hr) 2018-12-28
US20180368374A1 (en) 2018-12-27
RU2013155677A (ru) 2015-06-27
ES2691618T3 (es) 2018-11-28
US20180027783A1 (en) 2018-02-01
AU2020294305A1 (en) 2021-02-11
KR20220111739A (ko) 2022-08-09
US20210259219A1 (en) 2021-08-26
JP2019193660A (ja) 2019-11-07
CA2836288A1 (en) 2012-11-22
AU2017202540B2 (en) 2018-08-09
MX357421B (es) 2018-07-09
JP6970525B2 (ja) 2021-11-24
KR102574897B1 (ko) 2023-09-06
HK1215282A1 (zh) 2016-08-19

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