BR112013029498A2 - “método para produzir um suíno geneticamente modificado.” - Google Patents

“método para produzir um suíno geneticamente modificado.”

Info

Publication number
BR112013029498A2
BR112013029498A2 BR112013029498A BR112013029498A BR112013029498A2 BR 112013029498 A2 BR112013029498 A2 BR 112013029498A2 BR 112013029498 A BR112013029498 A BR 112013029498A BR 112013029498 A BR112013029498 A BR 112013029498A BR 112013029498 A2 BR112013029498 A2 BR 112013029498A2
Authority
BR
Brazil
Prior art keywords
producing
genetically modified
modified pig
pig
genetically
Prior art date
Application number
BR112013029498A
Other languages
English (en)
Other versions
BR112013029498A8 (pt
Inventor
Randall S Prather
Original Assignee
Univ Missouri
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Missouri filed Critical Univ Missouri
Publication of BR112013029498A2 publication Critical patent/BR112013029498A2/pt
Publication of BR112013029498A8 publication Critical patent/BR112013029498A8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knockout animals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/108—Swine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/7056—Lectin superfamily, e.g. CD23, CD72
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/80—Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites
BR112013029498A 2011-05-16 2012-05-16 método para produzir um suíno geneticamente modificado BR112013029498A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161519076P 2011-05-16 2011-05-16
PCT/US2012/038193 WO2012158828A1 (en) 2011-05-16 2012-05-16 Porcine reproductive and respiratory syndrome virus resistant animals

Publications (2)

Publication Number Publication Date
BR112013029498A2 true BR112013029498A2 (pt) 2016-08-09
BR112013029498A8 BR112013029498A8 (pt) 2017-02-21

Family

ID=47177326

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013029498A BR112013029498A8 (pt) 2011-05-16 2012-05-16 método para produzir um suíno geneticamente modificado

Country Status (21)

Country Link
US (5) US9820475B2 (pt)
EP (2) EP3420813A1 (pt)
JP (4) JP2014519323A (pt)
KR (5) KR102428306B1 (pt)
CN (3) CN111593025A (pt)
AU (5) AU2012255744A1 (pt)
BR (1) BR112013029498A8 (pt)
CA (2) CA3184311A1 (pt)
CY (1) CY1120890T1 (pt)
DK (1) DK2709445T3 (pt)
ES (1) ES2691618T3 (pt)
HK (1) HK1215282A1 (pt)
HR (1) HRP20181729T1 (pt)
HU (1) HUE039793T2 (pt)
LT (1) LT2709445T (pt)
MX (1) MX357421B (pt)
PL (1) PL2709445T3 (pt)
PT (1) PT2709445T (pt)
RU (1) RU2644673C2 (pt)
SI (1) SI2709445T1 (pt)
WO (1) WO2012158828A1 (pt)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3184311A1 (en) * 2011-05-16 2012-11-22 The Curators Of The University Of Missouri Porcine reproductive and respiratory syndrome virus resistant animals
GB201313235D0 (en) 2013-07-24 2013-09-04 Univ Edinburgh Antiviral Compositions Methods and Animals
WO2015153647A1 (en) * 2014-03-31 2015-10-08 Mice With Horns, Llc Method of preventing or reducing virus transmission in animals
CN104593422A (zh) * 2015-01-08 2015-05-06 中国农业大学 一种抗蓝耳病克隆猪的制备方法
US11246299B2 (en) * 2015-03-04 2022-02-15 Pormedtec Co., Ltd. Disease model pig exhibiting stable phenotype, and production method thereof
US10827730B2 (en) * 2015-08-06 2020-11-10 The Curators Of The University Of Missouri Pathogen-resistant animals having modified CD163 genes
KR20240017121A (ko) * 2015-08-06 2024-02-06 더 큐레이터스 오브 더 유니버시티 오브 미주리 변형된 cd163 유전자를 갖는 병원균-내성 동물
GB201617559D0 (en) 2016-10-17 2016-11-30 University Court Of The University Of Edinburgh The Swine comprising modified cd163 and associated methods
CN107937345B (zh) * 2017-11-16 2019-01-29 山东蓝思种业股份有限公司 一种制备同时敲除cd163基因和cd13基因的猪成纤维细胞的方法
US11160260B2 (en) 2018-04-17 2021-11-02 The Curators Of The University Of Missouri Methods for protecting porcine fetuses from infection with porcine reproductive and respiratory syndrome virus (PRRSV)
AU2018419649A1 (en) * 2018-04-17 2020-10-22 The Curators Of The University Of Missouri Methods for protecting porcine fetuses from infection with virus
WO2019210175A1 (en) * 2018-04-27 2019-10-31 The Curators Of The University Of Missouri Pathogen-resistant animals having modified aminopeptidase n (anpep) genes
CN109197780A (zh) * 2018-11-26 2019-01-15 湖北天牧畜禽有限公司 一种减少仔猪生病的养殖方法
CN114245711A (zh) * 2019-08-06 2022-03-25 新诺有限公司 用于异种移植的供体猪
BR112022020072A2 (pt) 2020-05-05 2022-11-29 Genus Plc Genes cd163, células, linhagens de células, par de grnas, complexo crispr, métodos para editar um gene cd163, preparar uma célula, produzir animais e determinar a presença ou ausência de uma sequência editada, embrião, leitão ou porco adulto, iniciador de pcr, sonda de pcr, usos e método de criação de um porco resistente ao prrsv
US20240053363A1 (en) * 2021-01-05 2024-02-15 Public University Corporation Yokohama City University Biomarker for determining fertility, and determining method using same

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CN1054840C (zh) 1993-12-16 2000-07-26 普罗格特-甘布尔公司 制备磺化脂肪酸烷酯表面活性剂的方法
GB9417831D0 (en) 1994-09-05 1994-10-26 Biotech & Biolog Scien Res Biological manipulation
US5683993A (en) 1995-06-22 1997-11-04 Ciba Vision Corporation Compositions and methods for stabilizing polymers
AU715468B2 (en) 1995-06-22 2000-02-03 Minnesota Mining And Manufacturing Company Stable hydroalcoholic compositions
GB9517779D0 (en) 1995-08-31 1995-11-01 Roslin Inst Edinburgh Biological manipulation
GB9517780D0 (en) 1995-08-31 1995-11-01 Roslin Inst Edinburgh Biological manipulation
JPH09298981A (ja) * 1996-05-16 1997-11-25 Y S New Technol Kenkyusho:Kk トランスジェニックブタ
US5945577A (en) 1997-01-10 1999-08-31 University Of Massachusetts As Represented By Its Amherst Campus Cloning using donor nuclei from proliferating somatic cells
US5995577A (en) 1997-02-10 1999-11-30 General Electric Company Optimized steam vent locations for a nuclear fuel bundle
WO1998057538A1 (en) 1997-06-18 1998-12-23 The Curators Of The University Of Missouri Complete activation of mammalian oocytes
US6740490B2 (en) * 2001-01-29 2004-05-25 Kansas State University Research Foundation Identification and applications of porcine reproductive and respiratory syndrome virus host susceptibility factor(s) for improved swine breeding
EP1465481A4 (en) 2001-12-21 2007-09-12 Univ Missouri KNOCK-OUT PORK AND METHODS OF MAKING THE SAME
NZ549953A (en) * 2004-03-17 2010-11-26 Revivicor Inc Tissue products derived from animals lacking any expression of functional alpha 1,3 galactosyltransferase
JP2007533328A (ja) 2004-04-22 2007-11-22 キリンホールディングス株式会社 トランスジェニック動物及びその用途
CA2651866C (en) 2006-05-11 2014-10-28 Universiteit Gent Sialoadhesin-related compositions and methods
WO2008109237A2 (en) * 2007-02-13 2008-09-12 Washington State University Research Foundation Macrophage cell-lines for propagation of porcine reproductive and respiratory syndrome virus
US20100122356A1 (en) * 2007-03-07 2010-05-13 Aarhus Universitet Pig model for psoriasis
US8912386B2 (en) 2007-03-28 2014-12-16 University Of Iowa Research Foundation Transgenic pig model of cystic fibrosis
US8420373B2 (en) 2007-07-27 2013-04-16 Universiteit Gent Permissive cells and uses thereof
US20110016543A1 (en) * 2008-12-04 2011-01-20 Sigma-Aldrich Co. Genomic editing of genes involved in inflammation
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Also Published As

Publication number Publication date
PT2709445T (pt) 2018-11-27
CN111593025A (zh) 2020-08-28
AU2023219858A1 (en) 2023-09-28
EP2709445A4 (en) 2015-03-25
US11019809B2 (en) 2021-06-01
KR20230132606A (ko) 2023-09-15
JP2017158579A (ja) 2017-09-14
EP3420813A1 (en) 2019-01-02
US20180368374A1 (en) 2018-12-27
AU2018256670B2 (en) 2020-09-24
RU2644673C2 (ru) 2018-02-13
JP6970525B2 (ja) 2021-11-24
PL2709445T3 (pl) 2019-01-31
US9820475B2 (en) 2017-11-21
KR102574897B1 (ko) 2023-09-06
HRP20181729T1 (hr) 2018-12-28
MX357421B (es) 2018-07-09
US20210259219A1 (en) 2021-08-26
HK1215282A1 (zh) 2016-08-19
RU2013155677A (ru) 2015-06-27
KR20200063264A (ko) 2020-06-04
JP2014519323A (ja) 2014-08-14
KR102627319B1 (ko) 2024-01-23
KR102428306B1 (ko) 2022-08-03
US20140096275A1 (en) 2014-04-03
ES2691618T3 (es) 2018-11-28
DK2709445T3 (en) 2018-11-19
WO2012158828A1 (en) 2012-11-22
AU2017202540A1 (en) 2017-05-18
US10080353B2 (en) 2018-09-25
CA2836288A1 (en) 2012-11-22
EP2709445B1 (en) 2018-10-03
JP2019193660A (ja) 2019-11-07
AU2017202540B2 (en) 2018-08-09
MX2013013427A (es) 2014-09-04
HUE039793T2 (hu) 2019-02-28
CN103687482A (zh) 2014-03-26
CN105112450A (zh) 2015-12-02
KR20140034229A (ko) 2014-03-19
KR20240014587A (ko) 2024-02-01
BR112013029498A8 (pt) 2017-02-21
US10405526B2 (en) 2019-09-10
CA3184311A1 (en) 2012-11-22
EP2709445A1 (en) 2014-03-26
AU2018256670A1 (en) 2018-12-06
LT2709445T (lt) 2018-11-12
US20200137992A1 (en) 2020-05-07
AU2012255744A1 (en) 2014-01-09
AU2020294305A1 (en) 2021-02-11
CY1120890T1 (el) 2019-12-11
JP2022081637A (ja) 2022-05-31
US20180027783A1 (en) 2018-02-01
KR20220111739A (ko) 2022-08-09
SI2709445T1 (sl) 2018-11-30

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]