ATE400176T1 - Inaktivierte oozyten als zytoplasmische rezeptoren zum kern-transfer - Google Patents

Inaktivierte oozyten als zytoplasmische rezeptoren zum kern-transfer

Info

Publication number
ATE400176T1
ATE400176T1 AT96928586T AT96928586T ATE400176T1 AT E400176 T1 ATE400176 T1 AT E400176T1 AT 96928586 T AT96928586 T AT 96928586T AT 96928586 T AT96928586 T AT 96928586T AT E400176 T1 ATE400176 T1 AT E400176T1
Authority
AT
Austria
Prior art keywords
time
embryo
transfer
oocyte
nucleus
Prior art date
Application number
AT96928586T
Other languages
English (en)
Inventor
Keith Campbell
Ian Wilmut
Original Assignee
Roslin Inst Edinburgh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10779997&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE400176(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Roslin Inst Edinburgh filed Critical Roslin Inst Edinburgh
Application granted granted Critical
Publication of ATE400176T1 publication Critical patent/ATE400176T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027New or modified breeds of vertebrates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
    • C12N15/877Techniques for producing new mammalian cloned embryos
    • C12N15/8773Ovine embryos
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48Reproductive organs
    • A61K35/54Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
    • C12N15/877Techniques for producing new mammalian cloned embryos
    • C12N15/8771Bovine embryos

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Reproductive Health (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Environmental Sciences (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT96928586T 1995-08-31 1996-08-30 Inaktivierte oozyten als zytoplasmische rezeptoren zum kern-transfer ATE400176T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9517779.6A GB9517779D0 (en) 1995-08-31 1995-08-31 Biological manipulation

Publications (1)

Publication Number Publication Date
ATE400176T1 true ATE400176T1 (de) 2008-07-15

Family

ID=10779997

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96928586T ATE400176T1 (de) 1995-08-31 1996-08-30 Inaktivierte oozyten als zytoplasmische rezeptoren zum kern-transfer

Country Status (23)

Country Link
US (12) US6252133B1 (de)
EP (1) EP0847237B1 (de)
JP (3) JP2000506721A (de)
KR (4) KR100533477B1 (de)
CN (3) CN1250715C (de)
AT (1) ATE400176T1 (de)
AU (1) AU728809B2 (de)
BR (1) BR9610013A (de)
CA (1) CA2229657A1 (de)
CZ (1) CZ60498A3 (de)
DE (1) DE69637591D1 (de)
DK (1) DK0847237T3 (de)
ES (1) ES2309989T3 (de)
GB (1) GB9517779D0 (de)
HK (1) HK1004937A1 (de)
HU (1) HUP9802485A3 (de)
IL (1) IL123417A0 (de)
NO (1) NO980846L (de)
NZ (2) NZ335407A (de)
PL (1) PL325336A1 (de)
SG (1) SG75919A1 (de)
WO (1) WO1997007668A1 (de)
ZA (1) ZA967383B (de)

Families Citing this family (191)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5480772A (en) 1993-02-03 1996-01-02 Brandeis University In vitro activation of a nucleus
US7332648B2 (en) 1995-08-31 2008-02-19 Roslin Institute Unactivated oocytes in nuclear transfer to produce cultured inner cell mass cells and ungulates
GB9517779D0 (en) * 1995-08-31 1995-11-01 Roslin Inst Edinburgh Biological manipulation
GB9517780D0 (en) * 1995-08-31 1995-11-01 Roslin Inst Edinburgh Biological manipulation
US6025155A (en) * 1996-04-10 2000-02-15 Chromos Molecular Systems, Inc. Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
US6077697A (en) 1996-04-10 2000-06-20 Chromos Molecular Systems, Inc. Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
US6271436B1 (en) 1996-10-11 2001-08-07 The Texas A & M University System Cells and methods for the generation of transgenic pigs
US5945577A (en) * 1997-01-10 1999-08-31 University Of Massachusetts As Represented By Its Amherst Campus Cloning using donor nuclei from proliferating somatic cells
US20090092588A1 (en) * 1997-01-10 2009-04-09 University Of Massachusetts As Represented By Its Amherst Campus Cloned ungulate embryos and animals, use of cells, tissues and organs thereof for transplantation therapies including parkinson's disease
US6235969B1 (en) 1997-01-10 2001-05-22 University Of Massachusetts Cloning pigs using donor nuclei from non-quiescent differentiated cells
US6011197A (en) 1997-03-06 2000-01-04 Infigen, Inc. Method of cloning bovines using reprogrammed non-embryonic bovine cells
NZ500007A (en) 1997-03-26 2001-08-31 Imp College Innovations Ltd Anticoagulant fusion protein anchored to cell membrane to prevent organ rejection after a transplant
CN101003800A (zh) 1997-07-03 2007-07-25 马萨诸塞大学 使用来自无血清饥饿的分化细胞的供体细胞核进行克隆
US7923216B2 (en) 1997-08-14 2011-04-12 Institut Pasteur In vivo modulation of neuronal transport
US7923015B2 (en) 1997-08-14 2011-04-12 Institut Pasteur Methods for direct visualization of active synapses
JPH11127852A (ja) * 1997-10-28 1999-05-18 Snow Brand Milk Prod Co Ltd 上皮細胞のg0期同調方法
US7351876B2 (en) 1998-01-16 2008-04-01 Agrobiogen Gmbh Biotechnologie Efficient nuclear transfer with primordial gametes
ATE407555T1 (de) * 1998-01-16 2008-09-15 Agrobiogen Gmbh Efficienter kerntransfer mit primordialen keimzellen
US6331659B1 (en) * 1998-01-21 2001-12-18 University Of Hawaii Cumulus cells as nuclear donors
CA2324009A1 (en) * 1998-03-16 1999-09-23 Relag Pty Ltd. Porcine nuclear transfer
AUPP294898A0 (en) * 1998-04-15 1998-05-07 Monash University Method of nuclear transfer
GB9808325D0 (en) * 1998-04-20 1998-06-17 Ltr Ciz Di Associazione Italia Source of nuclei for nuclear transfer
US6143564A (en) * 1998-07-07 2000-11-07 University Of Hawaii Use of the polar body chromosomes for the production of embryos and normal offspring
GB9820988D0 (en) * 1998-09-25 1998-11-18 Biotech & Biolog Scien Res Screening method
AU6218899A (en) * 1998-10-12 2000-05-01 Geron Bio-Med Limited Porcine oocytes with improved developmental competence
EP1818397A1 (de) * 1998-11-02 2007-08-15 Trustees Of Tufts College Verfahren zur Klonierung von Tieren
US6781030B1 (en) * 1998-11-02 2004-08-24 Trustee Of Tufts College, Ballou Hall Methods for cloning mammals using telophase oocytes
EP1130961B1 (de) 1998-11-19 2009-04-08 Pharming Intellectual Property BV Stabilisierung der milch transgener tieren
US6258998B1 (en) 1998-11-24 2001-07-10 Infigen, Inc. Method of cloning porcine animals
US6700037B2 (en) 1998-11-24 2004-03-02 Infigen, Inc. Method of cloning porcine animals
EP1141265B1 (de) * 1999-01-13 2008-09-03 Revivicor, Inc. Doppelkerntransfersverfahren und dessen ergebnisse
US7531715B1 (en) * 1999-01-13 2009-05-12 Ppl Therapeutics (Scotland) Double nuclear transfer method and results thereof
WO2000044914A1 (en) 1999-01-28 2000-08-03 Medical College Of Georgia Research Institute, Inc. Composition and method for in vivo and in vitro attenuation of gene expression using double stranded rna
EP2301947A3 (de) 1999-02-26 2011-11-23 Millennium Pharmaceuticals, Inc. Sekretierte Proteine und Verwendungen dafür
PT1159415E (pt) * 1999-03-04 2010-03-31 Revivicor Inc Modificação genética de células somáticas e suas utilizações
US20020012660A1 (en) * 1999-03-04 2002-01-31 Alan Colman Method of preparing a somatic cells for nuclear transfer
EP1194570A1 (de) 1999-06-23 2002-04-10 PPL Therapeutics (Scotland) Limited Lysozym- enthaltende fusionsproteine
NZ508739A (en) * 1999-06-30 2002-11-26 Woo Suk Hwang Method for producing cloned tigers by employing inter-species nuclear transplantation technique
KR100414043B1 (ko) * 1999-06-30 2004-01-13 황우석 체세포 복제동물 및 그 생산방법
US7291714B1 (en) 1999-06-30 2007-11-06 Millennium Pharmaceuticals, Inc. Glycoprotein VI and uses thereof
RU2216591C2 (ru) * 1999-06-30 2003-11-20 Воо-Сук ХВАНГ Способ получения клонированных эмбрионов человека путем применения способа межвидовой трансплантации ядер
CA2334382A1 (en) * 1999-06-30 2001-01-04 Woo-Suk Hwang Method for producing cloned cows
KR100368435B1 (ko) * 1999-06-30 2003-01-24 황우석 체세포 복제동물의 생산을 위한 세포융합방법
IL147972A0 (en) 1999-08-23 2002-09-12 Dana Farber Cancer Inst Inc Ge Pd-1, a receptor for b7-4 and uses therefor
EP2275559A3 (de) 1999-09-28 2011-03-23 Shire Human Genetic Therapies, Inc. Optimierte Boten-RNA (mRNA)
WO2002064799A2 (en) 1999-09-28 2002-08-22 Transkaryotic Therapies, Inc. Optimized messenger rna
US7820878B2 (en) * 1999-11-19 2010-10-26 Kyowa Hakko Kirin Co., Ltd. Production of ungulates, preferably bovines that produce human immunoglobulins
GB9927444D0 (en) * 1999-11-19 2000-01-19 Cancer Res Campaign Tech Inhibiting gene expression
US7414170B2 (en) * 1999-11-19 2008-08-19 Kirin Beer Kabushiki Kaisha Transgenic bovines capable of human antibody production
WO2001035735A1 (en) * 1999-11-19 2001-05-25 Hematech, Llc Production of ungulates, preferably bovines that produce human immunoglobulins
KR100417566B1 (ko) * 1999-11-19 2004-02-05 한국생명공학연구원 체세포 핵치환 복제수정란의 대량생산방법
US7074983B2 (en) * 1999-11-19 2006-07-11 Kirin Beer Kabushiki Kaisha Transgenic bovine comprising human immunoglobulin loci and producing human immunoglobulin
WO2001049106A2 (en) 2000-01-04 2001-07-12 University Of Connecticut Method for cloning animals with targetted genetic alterations
US6635802B1 (en) * 2000-01-10 2003-10-21 The Texas A&M University System Nuclear transfer using cells cultured in serum starvation media containing apoptosis inhibitors
DK1248640T3 (da) 2000-01-20 2007-02-12 Diabcell Pty Ltd Xenotransplantation af svineöer og deres fremstilling
AU2001236919A1 (en) * 2000-02-09 2001-08-20 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Premeiotic and postmeiotic origin of teratomas: isolated teratoma stem cells for therapeutic uses
ATE517990T1 (de) 2000-03-15 2011-08-15 Univ Georgia Effektive kernumprogrammierung in säugetieren
GB2360522A (en) 2000-03-24 2001-09-26 Geron Corp A strategy for maintaining pregnancy
AU2001261650A1 (en) * 2000-05-15 2001-11-26 Geron Corporation Ovine tissue for xenotransplantation
WO2001094636A2 (en) 2000-06-05 2001-12-13 Genetics Inst Compositions, kits, and methods for identification and modulation of type i diabetes
JP2004501631A (ja) 2000-06-28 2004-01-22 ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー Pd−l2分子:新規pd−1リガンドおよびその使用
AU2001284703B2 (en) 2000-08-03 2007-03-22 Therapeutic Human Polyclonals Inc. Production of humanized antibodies in transgenic animals
WO2002014473A2 (en) 2000-08-15 2002-02-21 Board Of Trustees Of The University Of Illinois Animals expressing exogenous igf-i in their milk
FR2814642B1 (fr) 2000-10-03 2005-07-01 Ass Pour Le Dev De La Rech En Souris transgenique pour la recombinaison ciblee mediee par la cre-er modifiee
WO2002028164A2 (en) * 2000-10-06 2002-04-11 Advanced Cell Technology, Inc. Cloning endangered and extinct species
NZ526617A (en) 2000-11-28 2004-09-24 Wyeth Corp Expression analysis of KIAA nucleic acids and polypeptides useful in the diagnosis and treatment of prostate cancer
WO2002044418A2 (en) 2000-11-28 2002-06-06 Wyeth Expression analysis of fkbp nucleic acids and polypeptides useful in the diagnosis and treatment of prostate cancer
EP1395652A2 (de) * 2000-11-30 2004-03-10 Stemron, Inc. Isolierte homozygote stammzellen, davon abgeleitet differentierte zellen, und materialien und verfahren zu deren verwendung und deren herstellung
EP1356035B1 (de) * 2000-12-22 2011-03-16 Kyowa Hakko Kirin Co., Ltd. Verfahren zur klonierung von nichtmenschliche säugern unter verwendung von reprogrammiertem donorchromatin oder donorzellen
US7491534B2 (en) * 2000-12-22 2009-02-17 Kirin Holdings Kabushiki Kaisha Methods for altering cell fate to generate T-cells specific for an antigen of interest
US20020142397A1 (en) * 2000-12-22 2002-10-03 Philippe Collas Methods for altering cell fate
EP2138583A1 (de) 2000-12-22 2009-12-30 Institut National De La Recherche Agronomique Positionsunabhängige und gewebespezifische Expression eines Transgens in der Milch eines Transgen-Tieres
EP1860199B1 (de) 2001-01-12 2014-03-05 Exelixis, Inc. Modulierte Signalisierung von Insulinrezeptoren
MXPA03006751A (es) 2001-01-30 2005-04-08 Amy K Rebholtz Metodos para el manejo de recipientes para embriones.
EP1229134A3 (de) 2001-01-31 2004-01-28 Nucleonics, Inc Verwendung von post-transkriptioneller Genabschaltung zur Identifizierung von Nukleinsäuresequenzen die die Funktion einer Zelle beeinflussen
JP2002262716A (ja) * 2001-03-07 2002-09-17 National Agricultural Research Organization 株化細胞を用いて家畜個体を作出する方法
US8981061B2 (en) 2001-03-20 2015-03-17 Novo Nordisk A/S Receptor TREM (triggering receptor expressed on myeloid cells) and uses thereof
WO2002074935A2 (en) * 2001-03-21 2002-09-26 Geron Corporation Use of telomerase reverse transcriptase to create homozygous knockout animals
US7126039B2 (en) * 2001-03-21 2006-10-24 Geron Corporation Animal tissue with carbohydrate antigens compatible for human transplantation
CA2442066C (en) 2001-04-02 2005-11-01 Wyeth Pd-1, a receptor for b7-4, and uses therefor
EP2258842A1 (de) 2001-04-16 2010-12-08 Wyeth Holdings Corporation Polypeptidantigene codierende offene Leseraster aus Streptococcus Pneumoniae und Verwendungen davon
CA2450652A1 (en) * 2001-06-14 2002-12-27 Infigen, Inc. Methods for cloning mammals using remodeling factors
WO2002102830A1 (en) * 2001-06-15 2002-12-27 New Century Pharmaceuticals, Inc. Human albumin animal models for drug evaluation, toxicology and immunogenicity studies
CA2921821A1 (en) 2001-07-12 2003-01-23 University Of Massachusetts In vivo production of small interfering rnas that mediate gene silencing
EP1900815B1 (de) 2001-07-12 2016-09-07 University of Massachusetts In-vivo-Herstellung kleiner interferierender und Genverstummung vermittelnder RNAs
US20030211603A1 (en) * 2001-08-14 2003-11-13 Earp David J. Reprogramming cells for enhanced differentiation capacity using pluripotent stem cells
US20030224380A1 (en) * 2001-10-25 2003-12-04 The General Hospital Corporation Genes and polymorphisms on chromosome 10 associated with Alzheimer's disease and other neurodegenerative diseases
US20030170678A1 (en) * 2001-10-25 2003-09-11 Neurogenetics, Inc. Genetic markers for Alzheimer's disease and methods using the same
AU2002364945A1 (en) * 2001-10-25 2003-07-09 Neurogenetics, Inc. Genes and polymorphisms on chromosome 10 associated with alzheimer's disease and other neurodegenerative diseases
CA2466415C (en) 2001-11-09 2020-01-21 Dana-Farber Cancer Institute, Inc. Pgc-1.beta., a novel pgc-1 homologue and uses therefor
US7704736B2 (en) * 2001-11-09 2010-04-27 Trustees Of The University Of Pennsylvania Compositions for the derivation of germ cells from stem cells and methods of use thereof
AU2003235652A1 (en) * 2002-01-15 2003-07-30 Advanced Cell Technology, Inc. Cloning b and t lymphocytes
US20050090004A1 (en) * 2003-01-16 2005-04-28 Sayre Chauncey B. Stem cell maturation for all tissue lines
US20050170506A1 (en) * 2002-01-16 2005-08-04 Primegen Biotech Llc Therapeutic reprogramming, hybrid stem cells and maturation
US20030134422A1 (en) * 2002-01-16 2003-07-17 Sayre Chauncey Bigelow Stem cell maturation for all tissue lines
CN1650003A (zh) * 2002-04-01 2005-08-03 Gtc生物治疗学公司 选择用于哺乳动物种中核转移的细胞系的方法
US20030217378A1 (en) * 2002-04-05 2003-11-20 The University Of Georgia Research Foundation, Inc Cloning using rapidly matured oocytes
US7612250B2 (en) * 2002-07-29 2009-11-03 Trustees Of Tufts College Nuclear transfer embryo formation method
US7361511B2 (en) 2002-08-20 2008-04-22 Millenium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of cervical cancer
WO2004032877A2 (en) 2002-10-10 2004-04-22 Wyeth Compositions, organisms and methodologies employing a novel human kinase
CA2502250A1 (en) * 2002-10-16 2004-04-29 Advanced Cell Technology, Inc. Methods using gene trapped stem cells for marking pathways of stem cell differentiation and making and isolating differentiated cells
EP1554385A2 (de) 2002-10-24 2005-07-20 Wyeth Calcineurin-ähnliche menschliche phoshphoesterase
AU2003290689A1 (en) * 2002-11-08 2004-06-03 Kyowa Hakko Kirin Co., Ltd. Transgenic ungulates having reduced prion protein activity and uses thereof
CA2505416A1 (en) 2002-11-21 2004-06-10 Wyeth Methods for diagnosing rcc and other solid tumors
US7297525B2 (en) 2002-11-27 2007-11-20 Wyeth Composition employing a novel human kinase
JP5479663B2 (ja) 2002-12-20 2014-04-23 セレラ コーポレーション 心筋梗塞に関連する遺伝的多型、その検出方法および使用
CA2511907A1 (en) 2003-01-06 2004-07-22 Wyeth Compositions and methods for diagnosing and treating colon cancers
EP1633890B2 (de) 2003-06-02 2020-11-18 University of Massachusetts Verfahren und zusammensetzungen zur verbesserung der wirksamkeit und spezifität von fnai
CA2528012C (en) 2003-06-02 2015-11-24 University Of Massachusetts Methods and compositions for controlling efficacy of rna silencing
JP2007502119A (ja) 2003-08-14 2007-02-08 エクセリクシス, インク. βカテニン経路のモディファイヤーとしてのUPs及び使用方法
EP2051077A3 (de) 2003-10-07 2009-05-27 Millennium Pharmaceuticals, Inc. Nucleinsäuremoleküle und Proteine zur Identifizierung, Beurteilung, Vorbeugung und Therapie von Eierstockkrebs
WO2005046450A2 (en) 2003-11-12 2005-05-26 Children's Hospital Medical Center Method for diagnosis and treatment of pulmonary disorders
CA3048093A1 (en) 2003-11-26 2005-06-23 Celera Corporation Single nucleotide polymorphisms associated with cardiovascular disorders and statin response, methods of detection and uses thereof
US7682828B2 (en) 2003-11-26 2010-03-23 Whitehead Institute For Biomedical Research Methods for reprogramming somatic cells
US7420099B2 (en) * 2004-04-22 2008-09-02 Kirin Holdings Kabushiki Kaisha Transgenic animals and uses thereof
US7820380B2 (en) 2004-05-07 2010-10-26 Celera Corporation Genetic polymorphisms associated with liver fibrosis
EP1812041A2 (de) 2004-10-22 2007-08-01 Dana-Farber Cancer Institute, Inc. Zusammensetzungen und verfahren zur modulierung von pgc-1 zur behandlung von mit lipiden zusammenhängenden erkrankungen und störungen
GB0426146D0 (en) 2004-11-29 2004-12-29 Bioxell Spa Therapeutic peptides and method
CN1274829C (zh) 2004-12-10 2006-09-13 四川大学华西医院 抗eb病毒所致肿瘤多肽及其应用与制备方法
WO2006099365A2 (en) 2005-03-11 2006-09-21 Applera Corporation Genetic polymorphisms associated with coronary heart disease, methods of detection and uses thereof
US20070011603A1 (en) * 2005-07-06 2007-01-11 Mikko Makela Method, system, device and software product for showing tooltips for page segments and generating content for the page segments
CA2909775A1 (en) 2005-08-09 2007-03-29 Revivicor, Inc. Transgenic ungulates expressing ctla4-ig and uses thereof
EP1931384A4 (de) 2005-09-09 2010-03-10 Univ Johns Hopkins Manipulation der regulatorischen t-zell- und dc-funktion durch targeting des neuritin-gens mit antikörpern, agonisten und antagonisten
WO2007035778A2 (en) 2005-09-19 2007-03-29 Histogenics Corporation Cell-support matrix and a method for preparation thereof
US7799530B2 (en) 2005-09-23 2010-09-21 Celera Corporation Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof
US7695911B2 (en) 2005-10-26 2010-04-13 Celera Corporation Genetic polymorphisms associated with Alzheimer's Disease, methods of detection and uses thereof
JP5087625B2 (ja) 2006-09-01 2012-12-05 セラピューティック・ヒューマン・ポリクローナルズ・インコーポレーテッド 非ヒトトランスジェニック動物におけるヒトまたはヒト化免疫グロブリンの発現強化
EP2064345B1 (de) 2006-09-11 2013-03-13 Celera Corporation Psoriasis-assoziierte genetische polymorphismen, nachweisverfahren dafür und ihre verwendung
EP2431483B1 (de) 2006-10-20 2015-04-01 Celera Corporation Mit venöser Thrombose assoziierte genetische Polymorphismen, Nachweisverfahren und deren Verwendungen
KR101398220B1 (ko) * 2006-10-30 2014-05-22 건국대학교 산학협력단 형질전환 배아 생성방법
WO2008085891A1 (en) * 2007-01-05 2008-07-17 Worcester Polytechnic Institute Oocyte spindle-associated factors improve somatic cell cloning
JP2010523117A (ja) 2007-04-07 2010-07-15 ホワイトヘッド・インスティテュート・フォー・バイオメディカル・リサーチ 体細胞の再プログラミング
WO2008134522A1 (en) * 2007-04-26 2008-11-06 President And Fellows Of Harvard College Deriving embryonic stem cells
US7972849B2 (en) * 2007-05-17 2011-07-05 Oregon Health & Science University Primate pluripotent stem cells produced by somatic cell nuclear transfer
US20090111764A1 (en) * 2007-10-25 2009-04-30 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Mitochondrial selection
WO2009055656A2 (en) 2007-10-26 2009-04-30 Centocor, Inc. Vectors, host cells, and methods of production and uses
US8039212B2 (en) 2007-11-05 2011-10-18 Celera Corporation Genetic polymorphisms associated with liver fibrosis, methods of detection and uses thereof
US20090221620A1 (en) 2008-02-20 2009-09-03 Celera Corporation Gentic polymorphisms associated with stroke, methods of detection and uses thereof
KR100915397B1 (ko) * 2008-02-22 2009-09-03 삼성전자주식회사 커버부재, 현상 카트리지 및 화상형성장치의 현상유닛
JP5670755B2 (ja) 2008-03-12 2015-02-18 ザ ロックフェラー ユニバーシティ 翻訳プロファイリング及び分子表現型解析のための方法及び組成物
US8288094B2 (en) 2008-04-09 2012-10-16 Institut Pasteur APOBEC3 mediated DNA editing
CA3060170A1 (en) 2008-06-13 2009-12-17 Whitehead Institute For Biomedical Research Programming and reprogramming of cells
WO2010006215A1 (en) 2008-07-09 2010-01-14 Celera Corporation Genetic polymorphisms associated with cardiovascular diseases, methods of detection and uses thereof
US9181315B2 (en) 2009-01-08 2015-11-10 Dana-Farber Cancer Institute, Inc. Compositions and methods for induced brown fat differentiation
US8722964B2 (en) 2009-04-23 2014-05-13 Transposagen Biopharmaceuticals, Inc. Genetically engineered or transgenic rats exhibiting a cancer phenotype due to a disruption of germline tumor suppressor genes
CA2759608A1 (en) 2009-04-24 2010-10-28 Oregon Health & Science University Methods for mitochondrial dna replacement in oocytes
EP2267153A1 (de) 2009-05-26 2010-12-29 Université Claude Bernard Lyon 1 Identifizierung der Netrin-1-Rezeptor-unc5c-Genmutation bei festen Krebsen
US9314005B2 (en) 2009-07-01 2016-04-19 Transposagen Biopharmaceuticals, Inc. Genetically modified rat models for severe combined immunodeficiency (SCID)
WO2011011678A2 (en) 2009-07-24 2011-01-27 Transposagen Biopharmaceuticals, Inc. Genetically modified rat models for cytokine-cytokine signaling pathways
WO2011014721A2 (en) 2009-07-30 2011-02-03 Transposagen Biopharmaceuticals, Inc. Genetically modified rat models for pharmacokinetics
US20110035816A1 (en) 2009-08-05 2011-02-10 Ostertag Eric M Genetically Modified Rat Models for Drug Metabolism
US20120151609A1 (en) 2009-08-20 2012-06-14 Ostertag Eric M Genetically Modified Rat Models for Pain
US9420770B2 (en) 2009-12-01 2016-08-23 Indiana University Research & Technology Corporation Methods of modulating thrombocytopenia and modified transgenic pigs
AU2011207210A1 (en) 2010-01-22 2012-08-16 Dana-Farber Cancer Institute, Inc. Compositions,kits, and methods for identification, assessment, prevention, and therapy of metabolic disorders
TWI518325B (zh) 2010-02-04 2016-01-21 自治醫科大學 對alk抑制劑具有先抗性或後抗性癌症的識別、判斷和治療
US20150231215A1 (en) 2012-06-22 2015-08-20 Randolph J. Noelle VISTA Antagonist and Methods of Use
US10745467B2 (en) 2010-03-26 2020-08-18 The Trustees Of Dartmouth College VISTA-Ig for treatment of autoimmune, allergic and inflammatory disorders
EP2552947A4 (de) 2010-03-26 2013-11-13 Dartmouth College Vista-regulatorisches t-zellen-mediator-protein, vista-bindende wirkstoffe und verwendung davon
US8383793B2 (en) 2010-04-15 2013-02-26 St. Jude Children's Research Hospital Methods and compositions for the diagnosis and treatment of cancer resistant to anaplastic lymphoma kinase (ALK) kinase inhibitors
US20110269735A1 (en) 2010-04-19 2011-11-03 Celera Corporation Genetic polymorphisms associated with statin response and cardiovascular diseases, methods of detection and uses thereof
EP2629620A4 (de) 2010-10-22 2014-04-30 Agri Neo Inc Synergistische wirkung von peressigsäure und mindestens einem sar-induktor für die bekämpfung von krankheitserregern bei und auf pflanzenzucht
US20120108651A1 (en) 2010-11-02 2012-05-03 Leiden University Medical Center (LUMC) Acting on Behalf of Academic Hospital Leiden (AZL) Genetic polymorphisms associated with venous thrombosis and statin response, methods of detection and uses thereof
KR101352641B1 (ko) 2010-11-08 2014-01-17 광주과학기술원 골격근-유래된 다능성 세포의 화학적 제조방법 및 이의 용도
ES2680636T3 (es) 2011-02-14 2018-09-10 Revivicor Inc. Cerdos genéticamente modificados para xenotrasplante de xenoinjertos vascularizados y derivados de los mismos
WO2012129198A1 (en) 2011-03-23 2012-09-27 Transposagen Biopharmaceuticals, Inc. Genetically modified rat models for obesity and diabetes
SI2709445T1 (sl) 2011-05-16 2018-11-30 The Curators Of The University Of Missouri Živali, odporne proti virusu prašičjega reprodukcijskega in respiratornega sindroma
US10093705B2 (en) 2011-09-13 2018-10-09 Dana-Farber Cancer Institute, Inc. Compositions and methods for brown fat induction and activity using FNDC5
US9550830B2 (en) 2012-02-15 2017-01-24 Novo Nordisk A/S Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1)
EP2814844B1 (de) 2012-02-15 2017-08-02 Novo Nordisk A/S Antikörper, die den auslösenden rezeptor binden und blockieren, der auf myeloid-zellen-1 (trem-1) exprimiert ist
EP2814842B1 (de) 2012-02-15 2018-08-22 Novo Nordisk A/S Antikörper die das peptidoglycan-erkennungs-protein erkennen
WO2013192504A1 (en) 2012-06-22 2013-12-27 The Trustees Of Dartmouth College Novel vista-ig constructs and the use of vista-ig for treatment of autoimmune, allergic and inflammatory disorders
US9890215B2 (en) 2012-06-22 2018-02-13 King's College London Vista modulators for diagnosis and treatment of cancer
CA2884704C (en) 2012-09-07 2023-04-04 Randolph J. Noelle Vista modulators for diagnosis and treatment of cancer
CN106661107B (zh) 2013-12-24 2021-12-24 杨森制药公司 抗vista抗体及片段
US11014987B2 (en) 2013-12-24 2021-05-25 Janssen Pharmaceutics Nv Anti-vista antibodies and fragments, uses thereof, and methods of identifying same
CA2935804A1 (en) 2014-01-14 2015-07-23 Dana-Farber Cancer Institute, Inc. Compositions and methods for identification, assessment, prevention, and treatment of melanoma using pd-l1 isoforms
WO2015191881A2 (en) 2014-06-11 2015-12-17 Green Kathy A Use of vista agonists and antagonists to suppress or enhance humoral immunity
CN106536559B (zh) 2014-07-17 2021-04-27 诺和诺德股份有限公司 定点诱变trem-1抗体以降低黏度
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
CN107405398A (zh) 2014-12-05 2017-11-28 伊穆奈克斯特股份有限公司 鉴定vsig8作为推定vista受体及其用以产生vista/vsig8激动剂和拮抗剂的用途
RU2711729C2 (ru) 2014-12-09 2020-01-21 Регенерон Фармасьютикалз, Инк. Не относящиеся к человеку животные, имеющие гуманизированный ген кластера дифференцировки 274
US10136642B2 (en) 2015-02-19 2018-11-27 Agri-Neo, Inc. Composition of peracetic acid and at least one organic fungicide for the control and/or the treatment of diseases associated with the presence of pathogens, and method, use and kit involving said composition
DK3313882T3 (da) 2015-06-24 2020-05-11 Janssen Pharmaceutica Nv Anti-VISTA antistoffer og fragmenter
LT3331355T (lt) 2015-08-06 2024-07-25 The Curators Of The University Of Missouri Kiaulių reprodukcinio ir respiracinio sindromo virusui (prrsv) atsparios kiaulės ir ląstelės, turinčios modifikuotus cd163 genus
WO2017075329A2 (en) 2015-10-29 2017-05-04 Dana-Farber Cancer Institute, Inc. Methods for identification, assessment, prevention, and treatment of metabolic disorders using pm20d1 and n-lipidated amino acids
CA3014013A1 (en) 2016-02-12 2017-08-17 Janssen Pharmaceutica Nv Anti-vista (b7h5) antibodies
CR20180537A (es) 2016-04-15 2019-03-04 Immunext Inc Anticuerpos vista antihumanos y su uso
MX2020010204A (es) 2018-04-02 2021-01-29 Bristol Myers Squibb Co Anticuerpos anti-trem-1 y usos de los mismos.
US11160260B2 (en) 2018-04-17 2021-11-02 The Curators Of The University Of Missouri Methods for protecting porcine fetuses from infection with porcine reproductive and respiratory syndrome virus (PRRSV)
IL302983A (en) 2020-11-20 2023-07-01 Revivicor Inc Multitransgenic pigs with growth hormone receptor silencing for xenotransplantation
AU2022347161A1 (en) 2021-09-20 2024-04-04 Revivicor, Inc. Multitransgenic pigs comprising ten genetic modifications for xenotransplantation

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1030255A (zh) * 1987-04-14 1989-01-11 路明尼斯有限公司 转移基因的动物
US5057420A (en) 1987-06-05 1991-10-15 Granada Biosciences, Inc. Bovine nuclear transplantation
CA2059199A1 (en) 1992-01-10 1993-07-11 Steen Willadsen Method for producing mature reconstituted mammalian eggs by nuclear transplantation
GB2265909B (en) 1992-04-01 1996-03-20 Inst Of Animal Physiology And Fusion of donor nucleus with recipient cytoplast in the absence of calcium ion
CA2145190A1 (en) * 1992-09-22 1994-03-31 The Government Of The United States Of America As Represented By The Sec Retary, Department Of Health And Human Services Use of taxol for treating lymphomas and breast cancer
CA2092258A1 (en) 1992-12-30 1994-07-01 Steven L. Stice Synchronized donor cells for bovine nuclear transfer
US5480772A (en) 1993-02-03 1996-01-02 Brandeis University In vitro activation of a nucleus
US5496720A (en) 1993-02-10 1996-03-05 Susko-Parrish; Joan L. Parthenogenic oocyte activation
US5523226A (en) 1993-05-14 1996-06-04 Biotechnology Research And Development Corp. Transgenic swine compositions and methods
US5333948A (en) 1993-06-22 1994-08-02 Tekonsha Engineering Company Multiple-gain electronic brake actuator with trigger point inertial sensor
EP1118325B2 (de) * 1993-07-29 2010-01-06 The United States of America, represented by the Secretary, Department of Health and Human Services Verwendung von Paclitaxel und seinen Derivaten zur Herstellung eines Medikaments für die Behandlung von Restenose
EP1149898A2 (de) 1993-12-23 2001-10-31 Infigen, Inc. Embryonale Stammzellen von Huftieren als Kerndonatoren und Kerntransfertechniken zur Herstellung chimärer und transgener Tiere
GB9417831D0 (en) * 1994-09-05 1994-10-26 Biotech & Biolog Scien Res Biological manipulation
GB9517780D0 (en) * 1995-08-31 1995-11-01 Roslin Inst Edinburgh Biological manipulation
US7332648B2 (en) * 1995-08-31 2008-02-19 Roslin Institute Unactivated oocytes in nuclear transfer to produce cultured inner cell mass cells and ungulates
GB9517779D0 (en) * 1995-08-31 1995-11-01 Roslin Inst Edinburgh Biological manipulation
US7291764B1 (en) * 1997-01-10 2007-11-06 University of Massachusetts, a Public Institution of Higher Education of the Commonwealth of Massachusetts, as Represented by its Amherst Campus, Office of Vice Chancellor for Research at Amherst Cloning pigs using non-quiescent differentiated donor cells or nuclei
US5945577A (en) 1997-01-10 1999-08-31 University Of Massachusetts As Represented By Its Amherst Campus Cloning using donor nuclei from proliferating somatic cells
US6215041B1 (en) 1997-01-10 2001-04-10 University Of Mmassachusetts Cloning using donor nuclei from a non-quiesecent somatic cells
US6235969B1 (en) 1997-01-10 2001-05-22 University Of Massachusetts Cloning pigs using donor nuclei from non-quiescent differentiated cells
US7361804B1 (en) * 1997-02-19 2008-04-22 Roslin Institute (Edinburgh) Unactivated oocytes in nuclear transfer to produce ungulates
US6011197A (en) 1997-03-06 2000-01-04 Infigen, Inc. Method of cloning bovines using reprogrammed non-embryonic bovine cells
US6600087B1 (en) 1998-01-16 2003-07-29 Agrobiogen Gmbh Efficient nuclear transfer using fetal fibroblasts and multiple cloning procedures
JP3573964B2 (ja) * 1998-06-17 2004-10-06 三洋電機株式会社 アルカリ電池用水素吸蔵合金電極及びアルカリ蓄電池用水素吸蔵合金電極の製造方法
AU6218899A (en) * 1998-10-12 2000-05-01 Geron Bio-Med Limited Porcine oocytes with improved developmental competence
US6700037B2 (en) * 1998-11-24 2004-03-02 Infigen, Inc. Method of cloning porcine animals
US20050156424A1 (en) * 2000-02-29 2005-07-21 Thyssenkrupp Presta Ag Steering column and manufacturing method thereof
US8302202B2 (en) * 2005-08-03 2012-10-30 International Business Machines Corporation Transportable computing environment apparatus system and method

Also Published As

Publication number Publication date
US20030037352A1 (en) 2003-02-20
SG75919A1 (en) 2000-10-24
BR9610013A (pt) 1999-12-21
US20070028312A1 (en) 2007-02-01
JP2006340710A (ja) 2006-12-21
CZ60498A3 (cs) 1998-07-15
CN1772891A (zh) 2006-05-17
US7321076B2 (en) 2008-01-22
EP0847237A1 (de) 1998-06-17
US6252133B1 (en) 2001-06-26
US20030101468A1 (en) 2003-05-29
US7326825B2 (en) 2008-02-05
KR20070041793A (ko) 2007-04-19
JP2000506721A (ja) 2000-06-06
US20050172347A1 (en) 2005-08-04
NZ335407A (en) 2000-06-23
KR19990044149A (ko) 1999-06-25
DK0847237T3 (da) 2008-11-10
EP0847237B1 (de) 2008-07-09
US20030106081A1 (en) 2003-06-05
US20050034181A1 (en) 2005-02-10
HUP9802485A3 (en) 2000-03-28
JP2008194053A (ja) 2008-08-28
KR100743006B1 (ko) 2007-07-27
AU728809B2 (en) 2001-01-18
KR20060057638A (ko) 2006-05-26
US20070033665A1 (en) 2007-02-08
CN1202085A (zh) 1998-12-16
CN1813642B (zh) 2012-01-18
US6525243B1 (en) 2003-02-25
KR20050088162A (ko) 2005-09-01
US7524677B2 (en) 2009-04-28
IL123417A0 (en) 1998-09-24
CN1250715C (zh) 2006-04-12
US7432415B2 (en) 2008-10-07
US20100146654A1 (en) 2010-06-10
WO1997007668A1 (en) 1997-03-06
CN1813642A (zh) 2006-08-09
HK1004937A1 (en) 1998-12-18
US7326824B2 (en) 2008-02-05
US20050120399A1 (en) 2005-06-02
PL325336A1 (en) 1998-07-20
NZ316148A (en) 2000-01-28
ZA967383B (en) 1998-03-02
HUP9802485A2 (hu) 1999-02-01
NO980846D0 (no) 1998-02-27
CA2229657A1 (en) 1997-03-06
US20060064763A1 (en) 2006-03-23
NO980846L (no) 1998-04-29
US7329796B2 (en) 2008-02-12
GB9517779D0 (en) 1995-11-01
ES2309989T3 (es) 2008-12-16
KR100533477B1 (ko) 2006-04-28
DE69637591D1 (de) 2008-08-21
US7321075B2 (en) 2008-01-22
AU6830996A (en) 1997-03-19

Similar Documents

Publication Publication Date Title
ATE400176T1 (de) Inaktivierte oozyten als zytoplasmische rezeptoren zum kern-transfer
GB2318578A (en) Quiescent cell populations for nuclear transfer
AU2002361327A1 (en) Exogenous protein expression system in an avian system
WO1999005266B1 (en) Trans-species nuclear transfer
ES2246227T8 (es) Moléculas de ácido nucleico que codifican alternansacarasa
CY1105006T1 (el) Μεθοδος παραγωγης και ανατροφης πουλερικων, οπως επισης και διαταξη εκκολαψεως και φαρμα πουλερικων για την εκτελεση της μεθοδου
NZ336493A (en) A method of oocyte enucleation and production of reconstituted embryos
GB2340493B (en) Unactivated oocytes as cytoplast recipients for nuclear transfer
Miki et al. Cytoplasmic asters are required for progression past the first cell cycle in cloned mouse embryos
WO2001049106A3 (en) Method for cloning animals with targetted genetic alterations
GB2331751B (en) Quiescent cell populations for nuclear transfer
DE60041771D1 (de) Verfahren zum transferieren von spermatonialen keimzellen bei hähnen
ATE407555T1 (de) Efficienter kerntransfer mit primordialen keimzellen
Latham et al. Modelling Habituation of Introduced Predators to Unrewarding Bird Odors for Conservation of Ground-Nesting Shorebirds
Dean et al. Relocalization of small ribonucleoprotein particles (snRNPs) during the first cell cycle of mouse embryo development is independent of RNA synthesis, DNA synthesis and cytokinesis
RU98105617A (ru) Инактивированные ооциты как цитопласты-реципиенты для ядерного переноса
O'Day et al. Gamete formation reflects the sexual pheromone hierarchy of Dictyostelium giganteum
Irving Caution Again: Need to Use Newer URL's for Carnegie Stages for Issues Concerning the Early Human Embryo
WO2002045490A3 (en) Method of cloning animals
WO2002062131A8 (en) Method of cloning transgenic mammalian animals using pseudonuclei
BR0014451A (pt) Método de reconstituição in vitro de um embrião de mamìfero não humano

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties