BR9100519A - Composto,composicao farmaceutica,metodo para inibicao de colinesterase em um mamifero e metodo para melhorar a memoria ou tratar ou prevenir a doenca de alzheimer - Google Patents
Composto,composicao farmaceutica,metodo para inibicao de colinesterase em um mamifero e metodo para melhorar a memoria ou tratar ou prevenir a doenca de alzheimerInfo
- Publication number
- BR9100519A BR9100519A BR919100519A BR9100519A BR9100519A BR 9100519 A BR9100519 A BR 9100519A BR 919100519 A BR919100519 A BR 919100519A BR 9100519 A BR9100519 A BR 9100519A BR 9100519 A BR9100519 A BR 9100519A
- Authority
- BR
- Brazil
- Prior art keywords
- mammal
- treat
- disease
- compound
- pharmaceutical composition
- Prior art date
Links
- 208000024827 Alzheimer disease Diseases 0.000 title 1
- 206010048650 Cholinesterase inhibition Diseases 0.000 title 1
- 241000124008 Mammalia Species 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47692890A | 1990-02-08 | 1990-02-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9100519A true BR9100519A (pt) | 1991-10-29 |
Family
ID=23893824
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR919100519A BR9100519A (pt) | 1990-02-08 | 1991-02-07 | Composto,composicao farmaceutica,metodo para inibicao de colinesterase em um mamifero e metodo para melhorar a memoria ou tratar ou prevenir a doenca de alzheimer |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0441517A3 (OSRAM) |
| JP (1) | JPH07119214B2 (OSRAM) |
| KR (1) | KR950013562B1 (OSRAM) |
| CN (1) | CN1054600A (OSRAM) |
| AU (1) | AU631723B2 (OSRAM) |
| BR (1) | BR9100519A (OSRAM) |
| CA (1) | CA2035805C (OSRAM) |
| CS (1) | CS29991A2 (OSRAM) |
| DE (1) | DE9101348U1 (OSRAM) |
| EG (1) | EG19644A (OSRAM) |
| FI (1) | FI910592A7 (OSRAM) |
| HU (1) | HUT70051A (OSRAM) |
| IE (1) | IE910402A1 (OSRAM) |
| IL (1) | IL97140A (OSRAM) |
| NO (1) | NO177534C (OSRAM) |
| NZ (1) | NZ237040A (OSRAM) |
| PL (2) | PL166757B1 (OSRAM) |
| PT (1) | PT96681A (OSRAM) |
| TW (1) | TW197442B (OSRAM) |
| YU (1) | YU21391A (OSRAM) |
| ZA (1) | ZA91916B (OSRAM) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2807577B2 (ja) * | 1990-06-15 | 1998-10-08 | エーザイ株式会社 | 環状アミド誘導体 |
| EP0475908A1 (de) * | 1990-09-14 | 1992-03-18 | Ciba-Geigy Ag | Chromogene Lactamverbindungen und ihre Herstellung und Verwendung |
| TW263504B (OSRAM) * | 1991-10-03 | 1995-11-21 | Pfizer | |
| TW248556B (OSRAM) * | 1993-01-18 | 1995-06-01 | Takeda Pharm Industry Co | |
| US5620973A (en) * | 1993-11-30 | 1997-04-15 | Takeda Chemical Industries, Ltd. | Tetracyclic condensed heterocyclic compounds and their use |
| CA2344894A1 (en) | 1998-09-30 | 2000-04-06 | Takeda Chemical Industries, Ltd. | Agents for improving excretory potency of urinary bladder |
| KR20050084890A (ko) | 2002-10-30 | 2005-08-29 | 머크 프로스트 캐나다 앤드 캄파니 | 피리도피롤리진 및 피리도인돌리진 유도체 |
| US7662831B2 (en) | 2006-07-27 | 2010-02-16 | Wyeth Llc | Tetracyclic indoles as potassium channel modulators |
| US7601856B2 (en) | 2006-07-27 | 2009-10-13 | Wyeth | Benzofurans as potassium ion channel modulators |
| WO2012038966A1 (en) | 2010-09-22 | 2012-03-29 | Tyche Industries Ltd. | Process for the preparation of donepezil intermediate |
| AR112788A1 (es) * | 2017-09-07 | 2019-12-11 | Eisai R&D Man Co Ltd | Compuesto pentacíclico |
| MX2021009685A (es) | 2019-03-05 | 2021-09-10 | Eisai R&D Man Co Ltd | Compuesto heterociclo pentaciclico. |
| WO2020179781A1 (ja) | 2019-03-05 | 2020-09-10 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 五環式化合物の塩およびそれらの結晶 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3910947A (en) * | 1969-07-24 | 1975-10-07 | Sandoz Ag | Preparation of imidazo{8 2,1-a{9 isoindoles |
| IT1199076B (it) * | 1984-03-01 | 1988-12-30 | Consiglio Nazionale Ricerche | Derivati della fisostigmina con proprieta'di inibizione della aceticolinesterasi e relativo procedimento di produzione |
| US4563469A (en) * | 1984-07-20 | 1986-01-07 | Warner-Lambert Company | Derivatives of N-[2-(tetrahydro-3,5-dioxo-1H-pyrrolizin-7a(5H)-yl)ethyl]amine as cognition activators |
| EP0187619A3 (de) * | 1985-01-03 | 1987-08-26 | Ciba-Geigy Ag | 1,3-disubstituierte Tetrahydropyridine |
| US4791107A (en) * | 1986-07-16 | 1988-12-13 | Hoechst-Roussel Pharmaceuticals, Inc. | Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use |
| US4778812A (en) * | 1987-06-12 | 1988-10-18 | American Home Products Corporation | 2,3-dihydro-9-methyl-1H-pyrrolo[1,2-a]indol-1-amines and derivatives thereof |
| EP0351283A1 (fr) * | 1988-07-12 | 1990-01-17 | Synthelabo | Dérivés de [(pipéridinyl-4) méthyl]-2 dihydro-2,3 1H-isoindole et tétrahydro-2,3,4,5 1H-benzazépines, leur préparation et leur application en thérapeutique |
-
1991
- 1991-01-23 TW TW080100556A patent/TW197442B/zh active
- 1991-01-29 EP EP19910300662 patent/EP0441517A3/en not_active Withdrawn
- 1991-02-03 IL IL9714091A patent/IL97140A/en not_active IP Right Cessation
- 1991-02-06 PL PL91288977A patent/PL166757B1/pl unknown
- 1991-02-06 CA CA002035805A patent/CA2035805C/en not_active Expired - Fee Related
- 1991-02-06 DE DE9101348U patent/DE9101348U1/de not_active Expired - Lifetime
- 1991-02-06 PT PT96681A patent/PT96681A/pt unknown
- 1991-02-06 PL PL91304632A patent/PL167078B1/pl unknown
- 1991-02-07 FI FI910592A patent/FI910592A7/fi not_active Application Discontinuation
- 1991-02-07 HU HU91406A patent/HUT70051A/hu unknown
- 1991-02-07 CN CN91100860A patent/CN1054600A/zh active Pending
- 1991-02-07 BR BR919100519A patent/BR9100519A/pt not_active Application Discontinuation
- 1991-02-07 NZ NZ237040A patent/NZ237040A/xx unknown
- 1991-02-07 AU AU70879/91A patent/AU631723B2/en not_active Ceased
- 1991-02-07 YU YU21391A patent/YU21391A/sh unknown
- 1991-02-07 NO NO910473A patent/NO177534C/no unknown
- 1991-02-07 ZA ZA91916A patent/ZA91916B/xx unknown
- 1991-02-07 IE IE040291A patent/IE910402A1/en unknown
- 1991-02-07 KR KR1019910002113A patent/KR950013562B1/ko not_active Expired - Lifetime
- 1991-02-07 CS CS91299A patent/CS29991A2/cs unknown
- 1991-02-07 EG EG7591A patent/EG19644A/xx active
- 1991-02-08 JP JP3103992A patent/JPH07119214B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| KR910015580A (ko) | 1991-09-30 |
| PT96681A (pt) | 1991-10-31 |
| EP0441517A3 (en) | 1992-08-19 |
| NO177534B (no) | 1995-06-26 |
| IL97140A0 (en) | 1992-05-25 |
| EP0441517A2 (en) | 1991-08-14 |
| KR950013562B1 (ko) | 1995-11-09 |
| FI910592A0 (fi) | 1991-02-07 |
| NO177534C (no) | 1995-10-04 |
| ZA91916B (en) | 1992-09-30 |
| JPH07119214B2 (ja) | 1995-12-20 |
| HUT70051A (en) | 1995-09-28 |
| HU910406D0 (en) | 1991-08-28 |
| NZ237040A (en) | 1993-10-26 |
| PL166757B1 (pl) | 1995-06-30 |
| DE9101348U1 (de) | 1991-06-06 |
| IL97140A (en) | 1995-07-31 |
| NO910473L (no) | 1991-08-09 |
| TW197442B (OSRAM) | 1993-01-01 |
| FI910592L (fi) | 1991-08-09 |
| IE910402A1 (en) | 1991-08-14 |
| JPH04234845A (ja) | 1992-08-24 |
| NO910473D0 (no) | 1991-02-07 |
| EG19644A (en) | 1995-08-30 |
| YU21391A (sh) | 1994-01-20 |
| CS29991A2 (en) | 1991-09-15 |
| FI910592A7 (fi) | 1991-08-09 |
| CA2035805C (en) | 1995-06-27 |
| PL288977A1 (en) | 1992-01-13 |
| AU631723B2 (en) | 1992-12-03 |
| AU7087991A (en) | 1991-08-29 |
| CN1054600A (zh) | 1991-09-18 |
| PL167078B1 (pl) | 1995-07-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EG | Technical examination (opinion): publication of technical examination (opinion) | ||
| FC | Decision: refusal | ||
| FC | Decision: refusal |