BR122018070838A8 - Compostos de amidas heterocíclicas moduladoras de sting, composição contendo ditos compostos e uso dos mesmos para tratar doença mediada por sting - Google Patents

Compostos de amidas heterocíclicas moduladoras de sting, composição contendo ditos compostos e uso dos mesmos para tratar doença mediada por sting

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Publication number
BR122018070838A8
BR122018070838A8 BR122018070838A BR122018070838A BR122018070838A8 BR 122018070838 A8 BR122018070838 A8 BR 122018070838A8 BR 122018070838 A BR122018070838 A BR 122018070838A BR 122018070838 A BR122018070838 A BR 122018070838A BR 122018070838 A8 BR122018070838 A8 BR 122018070838A8
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BR
Brazil
Prior art keywords
sting
compounds
modulating
treat
composition containing
Prior art date
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BR122018070838A
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English (en)
Other versions
BR122018070838A2 (pt
Inventor
Kenneth Charnley Adam
G Darcy Michael
W Dodson Jason
Dong Xiaoyang
V Hughes Terry
Kang Jianxing
Kathryn Leister Lara
Lian Yiqian
Li Yue
F Mehlmann John
Nevins Neysa
M Ramanjulu Joshi
J Romano Joseph
Z Wamg Gren
Ye Guosen
Zhang Daohua
Original Assignee
Glaxosmithkline Ip Dev Ltd
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Publication of BR122018070838A2 publication Critical patent/BR122018070838A2/pt
Publication of BR122018070838A8 publication Critical patent/BR122018070838A8/pt

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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P31/14—Antivirals for RNA viruses
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    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
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    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/02—Immunomodulators
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    • A—HUMAN NECESSITIES
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

São divulgados compostos que possuem a fórmula: (I-N) em que q, r, s, A, B, C, RA1, RA2, RB1, RB2, RC1, RC2, R3, R4, R5, R6, R14, R15, R16 e R17 são tal como definidos neste documento, ou um tautômero, ou um sal, particularmente um sal farmaceuticamente aceitável dos mesmos.
BR122018070838A 2016-04-07 2017-04-05 Compostos de amidas heterocíclicas moduladoras de sting, composição contendo ditos compostos e uso dos mesmos para tratar doença mediada por sting BR122018070838A8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662319358P 2016-04-07 2016-04-07
US201762461301P 2017-02-21 2017-02-21
US201762461975P 2017-02-22 2017-02-22
BR112018070655A BR112018070655A2 (pt) 2016-04-07 2017-04-05 amidas heterocíclicas úteis como moduladores de proteínas
PCT/IB2017/051945 WO2017175147A1 (en) 2016-04-07 2017-04-05 Heterocyclic amides useful as protein modulators

Publications (2)

Publication Number Publication Date
BR122018070838A2 BR122018070838A2 (pt) 2019-09-10
BR122018070838A8 true BR122018070838A8 (pt) 2022-07-19

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BR122018070836A BR122018070836A8 (pt) 2016-04-07 2017-04-05 Compostos de amidas heterocíclicas moduladoras de sting, composição contendo ditos compostos e uso dos mesmos para tratar uma doença mediada por sting
BR122018070838A BR122018070838A8 (pt) 2016-04-07 2017-04-05 Compostos de amidas heterocíclicas moduladoras de sting, composição contendo ditos compostos e uso dos mesmos para tratar doença mediada por sting
BR112018070655A BR112018070655A2 (pt) 2016-04-07 2017-04-05 amidas heterocíclicas úteis como moduladores de proteínas

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US (4) US10981901B1 (pt)
EP (2) EP3440076B1 (pt)
JP (4) JP6746712B2 (pt)
KR (2) KR102527786B1 (pt)
CN (3) CN109071514B (pt)
AU (4) AU2017247798C1 (pt)
BR (3) BR122018070836A8 (pt)
CA (1) CA3019630A1 (pt)
CL (3) CL2018002850A1 (pt)
CO (1) CO2018010727A2 (pt)
CR (2) CR20200044A (pt)
DK (1) DK3440076T3 (pt)
DO (3) DOP2018000217A (pt)
ES (1) ES2921855T3 (pt)
HR (1) HRP20220936T1 (pt)
HU (1) HUE058932T2 (pt)
IL (4) IL285702B (pt)
JO (1) JOP20170083B1 (pt)
LT (1) LT3440076T (pt)
MX (3) MX2020009947A (pt)
MY (1) MY189100A (pt)
NZ (1) NZ745957A (pt)
PE (3) PE20181920A1 (pt)
PH (3) PH12018502151B1 (pt)
PL (1) PL3440076T3 (pt)
PT (1) PT3440076T (pt)
RS (1) RS63462B1 (pt)
SG (3) SG11201808621TA (pt)
SI (1) SI3440076T1 (pt)
TW (3) TWI776806B (pt)
UA (1) UA123407C2 (pt)
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