BR112023020554A2 - Combinações de inibidores de lsd1 para o tratamento de cânceres mieloides - Google Patents

Combinações de inibidores de lsd1 para o tratamento de cânceres mieloides

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Publication number
BR112023020554A2
BR112023020554A2 BR112023020554A BR112023020554A BR112023020554A2 BR 112023020554 A2 BR112023020554 A2 BR 112023020554A2 BR 112023020554 A BR112023020554 A BR 112023020554A BR 112023020554 A BR112023020554 A BR 112023020554A BR 112023020554 A2 BR112023020554 A2 BR 112023020554A2
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BR
Brazil
Prior art keywords
treatment
combinations
lsd1 inhibitor
myeloid cancers
inhibitor combinations
Prior art date
Application number
BR112023020554A
Other languages
English (en)
Inventor
Natalia Sacilotto
Tamara Maes
Original Assignee
Oryzon Genomics Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Oryzon Genomics Sa filed Critical Oryzon Genomics Sa
Publication of BR112023020554A2 publication Critical patent/BR112023020554A2/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Abstract

combinações de inibidores de lsd1 para o tratamento de cânceres mieloides. a presente invenção refere-se a combinações de inibidores de lsd1 (ou de sais farmaceuticamente aceitáveis dos mesmos) e de gilteritinib (ou um sal farmaceuticamente aceitável do mesmo). as combinações são particularmente úteis para o tratamento de cânceres mieloides, tais como a leucemia mieloide aguda ou a síndrome mielodisplásica.
BR112023020554A 2021-04-08 2022-03-21 Combinações de inibidores de lsd1 para o tratamento de cânceres mieloides BR112023020554A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP21382301 2021-04-08
EP21382676 2021-07-23
PCT/EP2022/057386 WO2022214303A1 (en) 2021-04-08 2022-03-21 Combinations of lsd1 inhibitors for treating myeloid cancers

Publications (1)

Publication Number Publication Date
BR112023020554A2 true BR112023020554A2 (pt) 2023-12-05

Family

ID=81327652

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112023020554A BR112023020554A2 (pt) 2021-04-08 2022-03-21 Combinações de inibidores de lsd1 para o tratamento de cânceres mieloides

Country Status (8)

Country Link
EP (1) EP4319732A1 (pt)
JP (1) JP2024513260A (pt)
KR (1) KR20230167102A (pt)
AU (1) AU2022254484A1 (pt)
BR (1) BR112023020554A2 (pt)
CA (1) CA3231846A1 (pt)
TW (1) TW202304416A (pt)
WO (1) WO2022214303A1 (pt)

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