BR112023000350A2 - Sais e formas de um inibidor de wee1 - Google Patents
Sais e formas de um inibidor de wee1Info
- Publication number
- BR112023000350A2 BR112023000350A2 BR112023000350A BR112023000350A BR112023000350A2 BR 112023000350 A2 BR112023000350 A2 BR 112023000350A2 BR 112023000350 A BR112023000350 A BR 112023000350A BR 112023000350 A BR112023000350 A BR 112023000350A BR 112023000350 A2 BR112023000350 A2 BR 112023000350A2
- Authority
- BR
- Brazil
- Prior art keywords
- forms
- salts
- wee1 inhibitor
- wee1
- free base
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Epidemiology (AREA)
Abstract
SAIS E FORMAS DE UM INIBIDOR DE WEE1. O sal, como o sal de adipato da Forma A, e as formas de base livre do Composto A, são inibidores de WEE1. Esses sais e/ou formas e formas de base livre, bem como sais farmaceuticamente aceitáveis e composições dos mesmos, são úteis para o tratamento de doenças ou condições, que incluem as condições caracterizadas por proliferação celular excessiva, como câncer de mama.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063049996P | 2020-07-09 | 2020-07-09 | |
| PCT/US2021/070851 WO2022011391A1 (en) | 2020-07-09 | 2021-07-08 | Salts and forms of a wee1 inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112023000350A2 true BR112023000350A2 (pt) | 2023-03-28 |
Family
ID=79552745
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112023000350A BR112023000350A2 (pt) | 2020-07-09 | 2021-07-08 | Sais e formas de um inibidor de wee1 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20230265097A1 (pt) |
| EP (1) | EP4178960A1 (pt) |
| JP (1) | JP2023533040A (pt) |
| KR (1) | KR20230038523A (pt) |
| CN (1) | CN116323613A (pt) |
| AU (1) | AU2021305347A1 (pt) |
| BR (1) | BR112023000350A2 (pt) |
| CA (1) | CA3188737A1 (pt) |
| MX (1) | MX2023000333A (pt) |
| TW (1) | TW202216716A (pt) |
| WO (1) | WO2022011391A1 (pt) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116462687A (zh) * | 2022-01-18 | 2023-07-21 | 江苏天士力帝益药业有限公司 | Wee1抑制剂及其制备和用途 |
| WO2024031048A1 (en) * | 2022-08-05 | 2024-02-08 | Recurium Ip Holdings, Llc | Wee1 compound for treating uterine serous carcinoma |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2020009372A (es) * | 2018-03-09 | 2020-10-14 | Recurium Ip Holdings Llc | 1,2-dihidro-3h-pirazolo[3,4-d]pirimidin-3-onas sustituidas. |
-
2021
- 2021-07-08 US US18/004,628 patent/US20230265097A1/en active Pending
- 2021-07-08 WO PCT/US2021/070851 patent/WO2022011391A1/en unknown
- 2021-07-08 CA CA3188737A patent/CA3188737A1/en active Pending
- 2021-07-08 JP JP2023501229A patent/JP2023533040A/ja active Pending
- 2021-07-08 KR KR1020237004679A patent/KR20230038523A/ko unknown
- 2021-07-08 AU AU2021305347A patent/AU2021305347A1/en active Pending
- 2021-07-08 EP EP21838389.1A patent/EP4178960A1/en active Pending
- 2021-07-08 MX MX2023000333A patent/MX2023000333A/es unknown
- 2021-07-08 CN CN202180055999.8A patent/CN116323613A/zh active Pending
- 2021-07-08 BR BR112023000350A patent/BR112023000350A2/pt unknown
- 2021-07-09 TW TW110125370A patent/TW202216716A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2023533040A (ja) | 2023-08-01 |
| US20230265097A1 (en) | 2023-08-24 |
| AU2021305347A1 (en) | 2023-02-16 |
| WO2022011391A1 (en) | 2022-01-13 |
| CN116323613A (zh) | 2023-06-23 |
| MX2023000333A (es) | 2023-03-08 |
| TW202216716A (zh) | 2022-05-01 |
| KR20230038523A (ko) | 2023-03-20 |
| CA3188737A1 (en) | 2022-01-13 |
| EP4178960A1 (en) | 2023-05-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| UY38553A (es) | Inhibidores de cdk2 | |
| CO2018009275A2 (es) | Derivados pirrolidina espiro-condensados como inhibidores de enzimas desubiquitinantes (dub) | |
| BR112018069612A2 (pt) | compostos de pirroltriazina como inibidores de tam | |
| CO2019011762A2 (es) | Compuestos que inhiben la proteína mcl-1 | |
| BR112021018303A2 (pt) | Novos inibidores de pequenas moléculas de fatores de transcrição tead | |
| DOP2018000227A (es) | Inhibidores de bromodominios | |
| EA201792116A1 (ru) | Ингибитор янус-киназы | |
| BR112017020900A2 (pt) | compostos de 1-ciano-pirrolidina como inibidores de usp30 | |
| BR112018074621A2 (pt) | derivados de pirazolopirimidina como inibidores de quinase | |
| PH12017502407B1 (en) | Fused pyrimidine compound or salt thereof | |
| CL2020001576A1 (es) | Componentes heterocíclicos bicíclicos sustituidos como inhibidores de prmt5. | |
| UY36285A (es) | Compuestos que inhiben la proteína mcl-1 | |
| EA201791576A1 (ru) | Ингибитор jak | |
| BR112015028501B8 (pt) | Compostos derivados de bipirazol, seus sais, composição compreendendo o composto ou o sal, método de inibição in vitro de uma atividade de jak1, e processo de preparação de sal de ácido fosfórico | |
| UY38471A (es) | Compuestos de azalactam como inhibidores de hpk1 | |
| BR112023000350A2 (pt) | Sais e formas de um inibidor de wee1 | |
| BR112021026498A2 (pt) | Composto, uso do composto e composição farmacêutica | |
| DOP2021000077A (es) | Derivados de quinolina como inhibidores de la integrina alfa4beta7 | |
| BR112021017620A2 (pt) | Compostos macrocíclicos | |
| PH12019550140A1 (en) | Piperidine-substituted mnk inhibitors and methods related thereto | |
| BR112018013977A2 (pt) | derivados de quinolin-2-ona | |
| UY36713A (es) | Triazoles para el tratamiento de enfermedades desmielinizantes | |
| EA202193015A1 (ru) | Ингибиторы cdk | |
| CO2021001277A2 (es) | Inhibidores de triazol glicolato oxidasa | |
| ECSP21011232A (es) | Nuevo derivado de amina heterocíclico y composición farmacéutica que lo comprende |