BR112020020957B1 - Compostos oligoméricos, população e composição farmacêutica dos mesmos e seus usos - Google Patents

Compostos oligoméricos, população e composição farmacêutica dos mesmos e seus usos Download PDF

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BR112020020957B1
BR112020020957B1 BR112020020957-0A BR112020020957A BR112020020957B1 BR 112020020957 B1 BR112020020957 B1 BR 112020020957B1 BR 112020020957 A BR112020020957 A BR 112020020957A BR 112020020957 B1 BR112020020957 B1 BR 112020020957B1
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certain embodiments
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modified
pharmaceutical composition
compound
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BR112020020957-0A
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BR112020020957A2 (pt
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Huynh-Hoa Bui
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Ionis Pharmaceuticals, Inc
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BR112020020957-0A 2018-05-09 2019-05-08 Compostos oligoméricos, população e composição farmacêutica dos mesmos e seus usos BR112020020957B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862669280P 2018-05-09 2018-05-09
US62/669,280 2018-05-09
US201862699572P 2018-07-17 2018-07-17
US62/699,572 2018-07-17
PCT/US2019/031277 WO2019217527A1 (en) 2018-05-09 2019-05-08 Compounds and methods for reducing fxi expression

Publications (2)

Publication Number Publication Date
BR112020020957A2 BR112020020957A2 (pt) 2021-03-02
BR112020020957B1 true BR112020020957B1 (pt) 2022-05-10

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BR112020020957-0A BR112020020957B1 (pt) 2018-05-09 2019-05-08 Compostos oligoméricos, população e composição farmacêutica dos mesmos e seus usos

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US (2) US20210355497A1 (https=)
EP (1) EP3799604A4 (https=)
JP (2) JP7438135B2 (https=)
KR (1) KR20210008498A (https=)
CN (1) CN112041446B (https=)
AU (1) AU2019266261A1 (https=)
BR (1) BR112020020957B1 (https=)
CA (1) CA3098136A1 (https=)
CL (2) CL2020002811A1 (https=)
CO (1) CO2020013942A2 (https=)
CR (1) CR20200605A (https=)
CU (1) CU20200082A7 (https=)
EC (1) ECSP20071129A (https=)
IL (1) IL277970B2 (https=)
JO (1) JOP20200280A1 (https=)
MX (1) MX2020011913A (https=)
MY (1) MY204000A (https=)
NI (1) NI202000079A (https=)
PE (1) PE20210393A1 (https=)
PH (1) PH12020551875A1 (https=)
SG (1) SG11202010012PA (https=)
TW (1) TWI853812B (https=)
WO (1) WO2019217527A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2011004097A (es) 2008-10-15 2011-07-28 Isis Pharmaceuticals Inc Modulacion de la expresion del factor 11.
CN115175685B (zh) 2019-12-09 2024-12-13 艾姆皮瑞克公司 用于治疗血管生成素样4(angptl4)相关疾病的寡核苷酸
JP2023554346A (ja) * 2020-12-18 2023-12-27 アイオーニス ファーマシューティカルズ， インコーポレーテッド 第ｘｉｉ因子を調節するための化合物及び方法
BR112023021231A2 (pt) 2021-04-13 2024-01-09 Sirnaomics Inc Produtos e composições
EP4493570A2 (en) 2022-03-16 2025-01-22 Empirico Inc. Galnac compositions for improving sirna bioavailability
KR20250080877A (ko) * 2022-09-26 2025-06-05 시리우스 테라퓨틱스, 인크. Fxi의 발현을 억제하기 위한 폴리핵산 분자, 약학 조성물, 및 이의 용도
WO2024140986A1 (zh) * 2022-12-30 2024-07-04 北京福元医药股份有限公司 用于抑制凝血因子xi基因表达的双链核糖核酸及其修饰物、缀合物和用途
UY40743A (es) * 2023-05-19 2024-12-13 Shanghai Argo Biopharmaceutical Co Ltd COMPOSICIONES Y MÉTODOS PARA INHIBIR LA EXPRESIÓN DEL factor de coagulación XI (FXI)
CN120173947A (zh) * 2024-03-28 2025-06-20 施能康医药科技(苏州)有限公司 靶向凝血因子xi的核酸及其用途

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