BR112018014015A2 - derivados de tioidantoína substituídos como antagonistas do receptor de androgênio - Google Patents

derivados de tioidantoína substituídos como antagonistas do receptor de androgênio

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Publication number
BR112018014015A2
BR112018014015A2 BR112018014015A BR112018014015A BR112018014015A2 BR 112018014015 A2 BR112018014015 A2 BR 112018014015A2 BR 112018014015 A BR112018014015 A BR 112018014015A BR 112018014015 A BR112018014015 A BR 112018014015A BR 112018014015 A2 BR112018014015 A2 BR 112018014015A2
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BR
Brazil
Prior art keywords
thioidantoin
derivatives
substituted
receptor antagonists
androgen receptor
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Application number
BR112018014015A
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English (en)
Inventor
Rocaboy Christian
Bignan Gilles
Hickson Ian
Branch Jonathan
Meerpoel Lieven
B Trabalon Escolar Luis
J Connolly Peter
Pande Vineet
Zhang Zhuming
Original Assignee
Janssen Pharmaceutica Nv
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Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BR112018014015A2 publication Critical patent/BR112018014015A2/pt

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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
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Abstract

a presente invenção refere-se a compostos, composições e métodos para o tratamento de distúrbios que são afetados pelo antagonismo de um ou mais tipos de receptores androgênicos. esses compostos são representados pela fórmula (i) a seguir: fórmula (i) em que r1 e g são aqui definidos.
BR112018014015A 2016-01-11 2017-01-10 derivados de tioidantoína substituídos como antagonistas do receptor de androgênio BR112018014015A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662277009P 2016-01-11 2016-01-11
US201662363534P 2016-07-18 2016-07-18
PCT/US2017/012844 WO2017123542A1 (en) 2016-01-11 2017-01-10 Substituted thiohydantoin derivatives as androgen receptor antagonists

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BR112018014015A2 true BR112018014015A2 (pt) 2018-12-11

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US (3) US10000502B2 (pt)
EP (1) EP3402791A1 (pt)
JP (1) JP2019504836A (pt)
KR (1) KR20180100214A (pt)
CN (1) CN108473471A (pt)
AU (3) AU2017207268B2 (pt)
BR (1) BR112018014015A2 (pt)
CA (1) CA3010509A1 (pt)
CO (1) CO2018007738A2 (pt)
CR (2) CR20180352A (pt)
EA (1) EA037753B1 (pt)
EC (1) ECSP18060342A (pt)
IL (1) IL260307A (pt)
MA (1) MA43864A (pt)
MX (1) MX2018008502A (pt)
NI (1) NI201800075A (pt)
NZ (1) NZ744137A (pt)
PH (1) PH12018501413A1 (pt)
SG (1) SG11201805685PA (pt)
SV (1) SV2018005723A (pt)
TW (1) TWI726969B (pt)
WO (1) WO2017123542A1 (pt)

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WO2018009678A1 (en) * 2016-07-08 2018-01-11 Janssen Pharmaceutica Nv Substituted hydantoin and thiohydantoin derivatives as androgen receptor antagonists
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CN113582977B (zh) * 2017-08-07 2023-04-14 正大天晴药业集团股份有限公司 用作雄激素受体拮抗剂的二芳基硫代乙内酰脲化合物
CN107987055A (zh) * 2017-12-19 2018-05-04 刘秀云 硫代咪唑二酮类雄激素受体拮抗剂及其用途
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AU2019387367A1 (en) * 2018-11-30 2021-06-10 Nuvation Bio Inc. Diarylhydantoin compounds and methods of use thereof
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MX2021007475A (es) 2018-12-19 2021-08-05 Celgene Corp Compuestos de 3-((3-aminofenil)amino)piperidina-2,6-diona sustituida, composiciones de estos y metodos de tratamiento con estos.
CN113453681B (zh) 2018-12-19 2024-10-11 细胞基因公司 经取代的3-((3-氨基苯基)氨基)哌啶-2，6-二酮化合物、其组合物及使用它们的治疗方法
CN110452166A (zh) * 2019-09-06 2019-11-15 浙江朗华制药有限公司 一种5-异硫氰酰基-3-三氟甲基-2-氰基吡啶的制备方法
EP4041739A1 (en) * 2019-10-10 2022-08-17 Myovant Sciences GmbH Crystalline forms of n-(4-(1-(2,6-difluorobenzyl)-5- ((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo- 1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-n'- methoxyurea
CN114929702B (zh) * 2020-01-19 2024-05-31 正大天晴药业集团股份有限公司 作为ar拮抗剂的二芳基硫代乙内酰脲化合物
AU2021209875A1 (en) * 2020-01-21 2022-08-11 Georgia Tech Research Corporation Aryl hydantoin heterocycles and methods of use
CN115650954A (zh) * 2022-10-24 2023-01-31 江苏海悦康医药科技有限公司 阿帕他胺有关物质的制备方法
WO2024102706A1 (en) * 2022-11-09 2024-05-16 Bristol-Myers Squibb Company Combination therapy with substituted 3-((3-aminophenyl)amino)piperidine-2,6-dione compounds

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