BR112018010113A2 - composto, composição, e, métodos para inibir acc, para tratar uma infecção fúngica, parasítica ou bacteriana e para controlar patógenos fúngicos agrícolas - Google Patents
composto, composição, e, métodos para inibir acc, para tratar uma infecção fúngica, parasítica ou bacteriana e para controlar patógenos fúngicos agrícolasInfo
- Publication number
- BR112018010113A2 BR112018010113A2 BR112018010113A BR112018010113A BR112018010113A2 BR 112018010113 A2 BR112018010113 A2 BR 112018010113A2 BR 112018010113 A BR112018010113 A BR 112018010113A BR 112018010113 A BR112018010113 A BR 112018010113A BR 112018010113 A2 BR112018010113 A2 BR 112018010113A2
- Authority
- BR
- Brazil
- Prior art keywords
- fungal
- treating
- parasitic
- compound
- composition
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y604/00—Ligases forming carbon-carbon bonds (6.4)
- C12Y604/01—Ligases forming carbon-carbon bonds (6.4.1)
- C12Y604/01002—Acetyl-CoA carboxylase (6.4.1.2)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Microbiology (AREA)
- Environmental Sciences (AREA)
- Biotechnology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
a presente invenção provê compostos de pirazol da fórmula i inibindo acetil coa carboxilase (acc), composições e uso dos mesmos para o tratamento de obesidade ou como fungicidas.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562259973P | 2015-11-25 | 2015-11-25 | |
US62/259,973 | 2015-11-25 | ||
PCT/US2016/063386 WO2017091600A1 (en) | 2015-11-25 | 2016-11-22 | Pyrazole acc inhibitors and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112018010113A2 true BR112018010113A2 (pt) | 2018-11-21 |
BR112018010113B1 BR112018010113B1 (pt) | 2022-06-14 |
Family
ID=57543206
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018010113-3A BR112018010113B1 (pt) | 2015-11-25 | 2016-11-22 | Composto de pirazol útil como inibidor da acetil-coa carboxilase (acc) |
Country Status (18)
Country | Link |
---|---|
US (2) | US20170166582A1 (pt) |
EP (1) | EP3380480B1 (pt) |
JP (1) | JP2019502660A (pt) |
KR (1) | KR20180082556A (pt) |
CN (1) | CN108349995B (pt) |
AR (1) | AR106798A1 (pt) |
AU (1) | AU2016361412A1 (pt) |
BR (1) | BR112018010113B1 (pt) |
CA (1) | CA3004796C (pt) |
CL (1) | CL2018001356A1 (pt) |
CO (1) | CO2018005368A2 (pt) |
EA (1) | EA201890913A1 (pt) |
ES (1) | ES2939833T3 (pt) |
MX (1) | MX2018006286A (pt) |
PL (1) | PL3380480T3 (pt) |
PT (1) | PT3380480T (pt) |
SI (1) | SI3380480T1 (pt) |
WO (1) | WO2017091600A1 (pt) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL3628320T3 (pl) | 2011-11-11 | 2022-07-25 | Gilead Apollo, Llc | Inhibitory acc i ich zastosowania |
WO2015117087A1 (en) | 2014-01-31 | 2015-08-06 | Dana-Farber Cancer Institute, Inc. | Uses of diazepane derivatives |
US10150756B2 (en) | 2014-01-31 | 2018-12-11 | Dana-Farber Cancer Institute, Inc. | Diaminopyrimidine benzenesulfone derivatives and uses thereof |
RU2750164C2 (ru) | 2015-09-11 | 2021-06-22 | Дана-Фарбер Кэнсер Инститьют, Инк. | Цианотиенотриазолодиазепины и пути их применения |
MX2018003030A (es) | 2015-09-11 | 2018-04-11 | Dana Farber Cancer Inst Inc | Acetamida tienotriazolodiazepinas y usos de las mismas. |
AR106472A1 (es) | 2015-10-26 | 2018-01-17 | Gilead Apollo Llc | Inhibidores de acc y usos de los mismos |
EA201890949A1 (ru) | 2015-11-25 | 2018-12-28 | Джилид Аполло, Ллс | СЛОЖНОЭФИРНЫЕ ИНГИБИТОРЫ АЦЕТИЛ-КоА-КАРБОКСИЛАЗЫ И ВАРИАНТЫ ИХ ПРИМЕНЕНИЯ |
PT3380479T (pt) | 2015-11-25 | 2023-03-13 | Gilead Apollo Llc | Inhibidores de triazol acc e seus usos |
MX2018006499A (es) | 2015-11-25 | 2018-08-01 | Dana Farber Cancer Inst Inc | Inhibidores de bromodominio bivalentes y usos de los mismos. |
CN108347939B (zh) | 2015-11-25 | 2021-09-28 | 吉利德阿波罗公司 | 含有2,4-二氧代-1,4-二氢噻吩并[2,3-d]嘧啶的衍生物的杀真菌组合物 |
EA201890913A1 (ru) | 2015-11-25 | 2018-11-30 | Джилид Аполло, Ллс | Пиразоловые соединения в качестве ингибиторов акк и их применение |
BR112018067408A2 (pt) * | 2016-03-02 | 2018-12-26 | Gilead Apollo Llc | formas sólidas de um inibidor de acc de tienopirimidinadiona e métodos para a produção das mesmas |
US10759812B2 (en) | 2017-01-22 | 2020-09-01 | Sunshine Lake Pharma Co., Ltd. | Thienopyrimidine derivative and use thereof in medicine |
EP3589635A1 (en) | 2017-03-03 | 2020-01-08 | Gilead Apollo, LLC | Processes for the preparation of fungicidal compounds |
CN110431143B (zh) * | 2017-03-24 | 2022-08-12 | 浙江海正药业股份有限公司 | 杂芳基并嘧啶酮类衍生物及其制备方法和用途 |
CA3055581C (en) | 2017-03-28 | 2023-03-14 | Gilead Sciences, Inc. | Methods of treating liver disease |
CN110709402B (zh) * | 2017-06-15 | 2022-05-10 | 浙江海正药业股份有限公司 | 杂芳基并嘧啶酮类衍生物、其制备方法及其在医药上用途 |
CN111201234A (zh) * | 2017-07-17 | 2020-05-26 | 南京瑞捷医药科技有限公司 | 新型化合物及其作为acc抑制剂的用途 |
CN110950884B (zh) * | 2018-09-27 | 2024-03-26 | 上海翰森生物医药科技有限公司 | 含二并环类衍生物抑制剂、其制备方法和应用 |
TW202033511A (zh) | 2018-10-29 | 2020-09-16 | 美商基利阿波羅有限責任公司 | 用於製備殺真菌化合物之方法 |
CN111484504B (zh) * | 2019-01-25 | 2024-05-10 | 南京圣和药业股份有限公司 | Acc抑制剂的光学异构体及其应用 |
AR119594A1 (es) | 2019-08-09 | 2021-12-29 | Gilead Sciences Inc | Derivados de tienopirimidina como inhibidores acc y usos de los mismos |
CN110746439B (zh) * | 2019-10-18 | 2020-10-30 | 南京瑞捷医药科技有限公司 | 一种噻吩并嘧啶二酮化合物的制备方法 |
CN111039880B (zh) * | 2019-12-10 | 2022-06-21 | 河南大学 | 咪康唑及其衍生物作为tgr5激动剂的应用 |
US11478533B2 (en) | 2020-04-27 | 2022-10-25 | Novo Nordisk A/S | Semaglutide for use in medicine |
CN113968871A (zh) * | 2020-07-25 | 2022-01-25 | 南京圣和药业股份有限公司 | 苯基取代类acc抑制剂的晶型 |
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US10941158B2 (en) | 2021-03-09 |
WO2017091600A1 (en) | 2017-06-01 |
WO2017091600A9 (en) | 2018-07-19 |
CL2018001356A1 (es) | 2018-08-17 |
PT3380480T (pt) | 2023-03-14 |
EP3380480A1 (en) | 2018-10-03 |
AR106798A1 (es) | 2018-02-21 |
CO2018005368A2 (es) | 2018-05-31 |
CN108349995A (zh) | 2018-07-31 |
CA3004796A1 (en) | 2017-06-01 |
KR20180082556A (ko) | 2018-07-18 |
AU2016361412A9 (en) | 2018-12-06 |
BR112018010113B1 (pt) | 2022-06-14 |
JP2019502660A (ja) | 2019-01-31 |
PL3380480T3 (pl) | 2023-05-08 |
US20190375759A1 (en) | 2019-12-12 |
CA3004796C (en) | 2023-11-14 |
ES2939833T3 (es) | 2023-04-27 |
MX2018006286A (es) | 2018-09-07 |
AU2016361412A1 (en) | 2018-05-24 |
SI3380480T1 (sl) | 2023-04-28 |
EP3380480B1 (en) | 2022-12-14 |
EA201890913A1 (ru) | 2018-11-30 |
US20170166582A1 (en) | 2017-06-15 |
CN108349995B (zh) | 2021-08-03 |
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