BR112018008227A2 - ?composto, composição, e, métodos para inibir acc, para tratar um distúrbio metabólico, um câncer ou outro distúrbio proliferativo, uma infecção fúngica, parasítica ou bacteriana e para controlar patógenos fúngicos agrícolas? - Google Patents
?composto, composição, e, métodos para inibir acc, para tratar um distúrbio metabólico, um câncer ou outro distúrbio proliferativo, uma infecção fúngica, parasítica ou bacteriana e para controlar patógenos fúngicos agrícolas?Info
- Publication number
- BR112018008227A2 BR112018008227A2 BR112018008227A BR112018008227A BR112018008227A2 BR 112018008227 A2 BR112018008227 A2 BR 112018008227A2 BR 112018008227 A BR112018008227 A BR 112018008227A BR 112018008227 A BR112018008227 A BR 112018008227A BR 112018008227 A2 BR112018008227 A2 BR 112018008227A2
- Authority
- BR
- Brazil
- Prior art keywords
- fungal
- methods
- parasitic
- cancer
- treating
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Plant Pathology (AREA)
- Environmental Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
a presente invenção provê os compostos i e ii úteis como inibidores de acetil coa carboxilase (acc), composições dos mesmos e métodos para utilização dos mesmos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562246318P | 2015-10-26 | 2015-10-26 | |
PCT/US2016/058867 WO2017075056A1 (en) | 2015-10-26 | 2016-10-26 | Acc inhibitors and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112018008227A2 true BR112018008227A2 (pt) | 2018-10-23 |
Family
ID=57233943
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018008227A BR112018008227A2 (pt) | 2015-10-26 | 2016-10-26 | ?composto, composição, e, métodos para inibir acc, para tratar um distúrbio metabólico, um câncer ou outro distúrbio proliferativo, uma infecção fúngica, parasítica ou bacteriana e para controlar patógenos fúngicos agrícolas? |
Country Status (14)
Country | Link |
---|---|
US (2) | US10179793B2 (pt) |
EP (1) | EP3368540A1 (pt) |
JP (1) | JP2018538246A (pt) |
KR (1) | KR20180067603A (pt) |
CN (1) | CN108368125A (pt) |
AR (1) | AR106472A1 (pt) |
AU (1) | AU2016344392A1 (pt) |
BR (1) | BR112018008227A2 (pt) |
CA (1) | CA3003275A1 (pt) |
EA (1) | EA201890749A1 (pt) |
IL (1) | IL258636A (pt) |
MX (1) | MX2018005292A (pt) |
SG (1) | SG11201802989QA (pt) |
WO (1) | WO2017075056A1 (pt) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LT3329919T (lt) | 2011-11-11 | 2020-02-10 | Gilead Apollo, Llc | Acc inhibitoriai ir jų panaudojimas |
EP3225618B1 (en) | 2014-11-26 | 2020-05-06 | Takeda Pharmaceutical Company Limited | Bicyclic compound |
BR112018009212B1 (pt) | 2015-11-25 | 2022-06-14 | Gilead Apollo, Llc | Método para controlar patógenos fúngicos agrícolas |
MX2018006287A (es) | 2015-11-25 | 2018-09-07 | Gilead Apollo Llc | Inhibidores de acc de triazol y usos de los mismos. |
PT3380480T (pt) | 2015-11-25 | 2023-03-14 | Gilead Apollo Llc | Inibidores de pirazol acc e seus usos |
MX2018006288A (es) | 2015-11-25 | 2018-09-07 | Gilead Apollo Llc | Inhibidores de acc tipo ester y usos de los mismos. |
KR102622161B1 (ko) * | 2016-03-02 | 2024-01-09 | 길리어드 아폴로, 엘엘씨 | 티에노피리미딘디온 acc 억제제의 고체 형태 및 그의 제조 방법 |
RU2019111357A (ru) | 2016-09-23 | 2020-10-23 | Байер Акциенгезельшафт | N3-циклически замещенные тиеноурацилы и их применение |
WO2018133858A1 (en) | 2017-01-22 | 2018-07-26 | Sunshine Lake Pharma Co., Ltd. | Thienopyrimidine derivative and use thereof in medicine |
WO2018161008A1 (en) * | 2017-03-03 | 2018-09-07 | Gilead Apollo, Llc | Processes for the preparation of fungicidal compounds |
JP6906626B2 (ja) | 2017-03-28 | 2021-07-21 | ギリアード サイエンシーズ, インコーポレイテッド | 肝疾患を処置するための治療的組み合わせ |
CN110709402B (zh) * | 2017-06-15 | 2022-05-10 | 浙江海正药业股份有限公司 | 杂芳基并嘧啶酮类衍生物、其制备方法及其在医药上用途 |
EP3660023B1 (en) * | 2017-07-26 | 2023-03-08 | Nanjing Sanhome Pharmaceutical Co., Ltd. | Thienopyrimidinedione compounds as acc inhibitors and use thereof |
CN112313236A (zh) | 2018-03-30 | 2021-02-02 | 拜欧斯瑞克斯公司 | 噻吩并嘧啶酮化合物 |
JP7275444B2 (ja) * | 2018-06-05 | 2023-05-18 | メッドシャイン ディスカバリー インコーポレイテッド | チエノ[2,3-c]ピリダジン-4(1H)-オン系誘導体及びその使用 |
US20220015361A1 (en) * | 2018-11-02 | 2022-01-20 | Dow Agrosciences Llc | Compositions comprising halauxifen and other herbicides and methods thereof |
US20220041616A1 (en) * | 2018-11-20 | 2022-02-10 | The National Institutes of Pharmaceutical R&D Co., Ltd. | Spiro compound and medical uses thereof |
CN111484504B (zh) * | 2019-01-25 | 2024-05-10 | 南京圣和药业股份有限公司 | Acc抑制剂的光学异构体及其应用 |
AR119594A1 (es) | 2019-08-09 | 2021-12-29 | Gilead Sciences Inc | Derivados de tienopirimidina como inhibidores acc y usos de los mismos |
CN110746439B (zh) * | 2019-10-18 | 2020-10-30 | 南京瑞捷医药科技有限公司 | 一种噻吩并嘧啶二酮化合物的制备方法 |
JP7265681B2 (ja) * | 2019-12-05 | 2023-04-26 | ▲ザン▼州片仔▲ファン▼薬業股▲フン▼有限公司 | Acc1及びacc2阻害剤としての結晶形及びその製造方法並びに使用 |
WO2021112213A1 (ja) * | 2019-12-05 | 2021-06-10 | 日本曹達株式会社 | 2,4-ジオキソ-1,4-ジヒドロチエノピリミジン化合物、及びそれを含有する農園芸用殺菌剤又は医療用・動物用抗真菌剤 |
ES2960703T3 (es) * | 2019-12-05 | 2024-03-06 | Zhangzhou Pien Tze Huang Pharm | Forma cristalina del compuesto de tieno[2,3-c]piridazina-4(1H)-ona, método de preparación de la misma y uso de la misma |
US11478533B2 (en) | 2020-04-27 | 2022-10-25 | Novo Nordisk A/S | Semaglutide for use in medicine |
CN113968871A (zh) * | 2020-07-25 | 2022-01-25 | 南京圣和药业股份有限公司 | 苯基取代类acc抑制剂的晶型 |
WO2022133097A1 (en) * | 2020-12-17 | 2022-06-23 | Biogen Ma Inc. | Synthesis of compounds that modulate use-dependent voltage-gated sodium channels |
EP4269415A1 (en) | 2020-12-24 | 2023-11-01 | Modulus Discovery, Inc. | Tetrahydro thienopyridine sulfonamide compound |
WO2022268520A1 (de) * | 2021-06-21 | 2022-12-29 | Bayer Aktiengesellschaft | Verwendung von substituierten pyrrolidinonen oder deren salzen zur steigerung der stresstoleranz in pflanzen. |
CN115677551A (zh) * | 2021-12-28 | 2023-02-03 | 武汉市振邦生物科技有限公司 | 一种2-氧代吡咯烷-3-甲酸乙酯的制备工艺 |
CN115433756B (zh) * | 2022-08-30 | 2024-04-09 | 山东新华制药股份有限公司 | 一种泼尼松龙的制备方法 |
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AU2004207706B2 (en) | 2003-01-29 | 2010-03-04 | Takeda Pharmaceutical Company Limited | Thienopyrimidine compounds and use thereof |
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EP2519527B1 (en) | 2009-12-29 | 2013-12-18 | Poxel | Thieno[2,3-b]pyridinedione activators of ampk and therapeutic uses thereof |
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LT3329919T (lt) | 2011-11-11 | 2020-02-10 | Gilead Apollo, Llc | Acc inhibitoriai ir jų panaudojimas |
JP6417402B2 (ja) | 2013-05-10 | 2018-11-07 | ギリアド アポロ, エルエルシー | Acc阻害剤及びその使用 |
CA2911932A1 (en) | 2013-05-10 | 2014-11-13 | Nimbus Apollo, Inc. | Acc inhibitors and uses thereof |
JP6417403B2 (ja) | 2013-05-10 | 2018-11-07 | ギリアド アポロ, エルエルシー | Acc阻害剤及びその使用 |
JP6417401B2 (ja) | 2013-05-10 | 2018-11-07 | ギリアド アポロ, エルエルシー | Acc阻害剤及びその使用 |
TWI652012B (zh) | 2013-05-20 | 2019-03-01 | 杜邦股份有限公司 | 殺真菌吡唑的固態形式 |
WO2015007453A1 (en) * | 2013-07-15 | 2015-01-22 | Syngenta Participations Ag | Microbiocidal heterobicyclic derivatives |
WO2015007451A1 (en) * | 2013-07-15 | 2015-01-22 | Syngenta Participations Ag | Microbiocidal heterobicyclic derivatives |
BR112018009212B1 (pt) | 2015-11-25 | 2022-06-14 | Gilead Apollo, Llc | Método para controlar patógenos fúngicos agrícolas |
MX2018006288A (es) | 2015-11-25 | 2018-09-07 | Gilead Apollo Llc | Inhibidores de acc tipo ester y usos de los mismos. |
PT3380480T (pt) | 2015-11-25 | 2023-03-14 | Gilead Apollo Llc | Inibidores de pirazol acc e seus usos |
MX2018006287A (es) | 2015-11-25 | 2018-09-07 | Gilead Apollo Llc | Inhibidores de acc de triazol y usos de los mismos. |
KR102622161B1 (ko) | 2016-03-02 | 2024-01-09 | 길리어드 아폴로, 엘엘씨 | 티에노피리미딘디온 acc 억제제의 고체 형태 및 그의 제조 방법 |
-
2016
- 2016-10-25 AR ARP160103255A patent/AR106472A1/es unknown
- 2016-10-26 EP EP16791253.4A patent/EP3368540A1/en not_active Withdrawn
- 2016-10-26 BR BR112018008227A patent/BR112018008227A2/pt not_active Application Discontinuation
- 2016-10-26 WO PCT/US2016/058867 patent/WO2017075056A1/en active Application Filing
- 2016-10-26 JP JP2018521087A patent/JP2018538246A/ja active Pending
- 2016-10-26 CA CA3003275A patent/CA3003275A1/en not_active Abandoned
- 2016-10-26 CN CN201680072737.1A patent/CN108368125A/zh active Pending
- 2016-10-26 AU AU2016344392A patent/AU2016344392A1/en not_active Abandoned
- 2016-10-26 SG SG11201802989QA patent/SG11201802989QA/en unknown
- 2016-10-26 EA EA201890749A patent/EA201890749A1/ru unknown
- 2016-10-26 MX MX2018005292A patent/MX2018005292A/es unknown
- 2016-10-26 KR KR1020187013132A patent/KR20180067603A/ko unknown
- 2016-10-26 US US15/334,955 patent/US10179793B2/en not_active Expired - Fee Related
-
2018
- 2018-04-11 IL IL258636A patent/IL258636A/en unknown
- 2018-11-27 US US16/201,571 patent/US20190330224A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20170145028A1 (en) | 2017-05-25 |
US10179793B2 (en) | 2019-01-15 |
AR106472A1 (es) | 2018-01-17 |
CN108368125A (zh) | 2018-08-03 |
EA201890749A1 (ru) | 2018-11-30 |
EP3368540A1 (en) | 2018-09-05 |
US20190330224A1 (en) | 2019-10-31 |
JP2018538246A (ja) | 2018-12-27 |
CA3003275A1 (en) | 2017-05-04 |
SG11201802989QA (en) | 2018-05-30 |
AU2016344392A1 (en) | 2018-05-10 |
IL258636A (en) | 2018-06-28 |
KR20180067603A (ko) | 2018-06-20 |
WO2017075056A1 (en) | 2017-05-04 |
MX2018005292A (es) | 2018-08-01 |
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