SG11201802989QA - Acc inhibitors and uses thereof - Google Patents
Acc inhibitors and uses thereofInfo
- Publication number
- SG11201802989QA SG11201802989QA SG11201802989QA SG11201802989QA SG11201802989QA SG 11201802989Q A SG11201802989Q A SG 11201802989QA SG 11201802989Q A SG11201802989Q A SG 11201802989QA SG 11201802989Q A SG11201802989Q A SG 11201802989QA SG 11201802989Q A SG11201802989Q A SG 11201802989QA
- Authority
- SG
- Singapore
- Prior art keywords
- acc inhibitors
- acc
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Dentistry (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562246318P | 2015-10-26 | 2015-10-26 | |
| PCT/US2016/058867 WO2017075056A1 (en) | 2015-10-26 | 2016-10-26 | Acc inhibitors and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201802989QA true SG11201802989QA (en) | 2018-05-30 |
Family
ID=57233943
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201802989QA SG11201802989QA (en) | 2015-10-26 | 2016-10-26 | Acc inhibitors and uses thereof |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US10179793B2 (en) |
| EP (1) | EP3368540A1 (en) |
| JP (1) | JP2018538246A (en) |
| KR (1) | KR20180067603A (en) |
| CN (1) | CN108368125A (en) |
| AR (1) | AR106472A1 (en) |
| AU (1) | AU2016344392A1 (en) |
| BR (1) | BR112018008227A2 (en) |
| CA (1) | CA3003275A1 (en) |
| EA (1) | EA201890749A1 (en) |
| IL (1) | IL258636A (en) |
| MX (1) | MX2018005292A (en) |
| SG (1) | SG11201802989QA (en) |
| WO (1) | WO2017075056A1 (en) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA123760C2 (en) | 2011-11-11 | 2021-06-02 | Гіліад Аполло, Ллс | COMPOUND (OPTIONS) AND COMPOSITION CONTAINING COMPOUND |
| CN107207444B (en) | 2014-11-26 | 2020-07-24 | 武田药品工业株式会社 | Bicyclic compounds |
| BR112018010113B1 (en) | 2015-11-25 | 2022-06-14 | Gilead Apollo, Llc | PYRAZOLE COMPOUND USEFUL AS INHIBITOR OF ACETYL-COA CARBOXYLASE (ACC) |
| BR112018010453B1 (en) | 2015-11-25 | 2022-06-14 | Gilead Apollo, Llc | ACETYL COA CARBOXYLASE (ACC) INHIBITOR TRIAZOLIC COMPOUNDS |
| CN108290902B (en) | 2015-11-25 | 2021-08-31 | 吉利德阿波罗公司 | Ester ACC inhibitors and uses thereof |
| KR20180086191A (en) | 2015-11-25 | 2018-07-30 | 길리어드 아폴로, 엘엘씨 | A fungicidal composition containing a 2,4-dioxo-1,4-dihydrothieno [2,3-d] pyrimidine derivative |
| EP3423456B1 (en) | 2016-03-02 | 2023-12-27 | Gilead Apollo, LLC | Solid forms of a thienopyrimidinedione acc inhibitor and methods for production thereof |
| JP2019529452A (en) | 2016-09-23 | 2019-10-17 | バイエル・アクチエンゲゼルシヤフト | N3-cyclic substituted thienouracil and uses thereof |
| CN108341830B (en) | 2017-01-22 | 2021-03-02 | 广东东阳光药业有限公司 | Thienopyrimidine derivatives and their use in medicine |
| KR20190125359A (en) * | 2017-03-03 | 2019-11-06 | 길리어드 아폴로, 엘엘씨 | Process for the preparation of fungicidal compounds |
| PT3600309T (en) | 2017-03-28 | 2022-10-03 | Gilead Sciences Inc | Therapeutic combinations for treating liver diseases |
| WO2018228369A1 (en) * | 2017-06-15 | 2018-12-20 | 浙江海正药业股份有限公司 | Heteroarylpyrimidinone derivative, method for preparation thereof, and medicinal use thereof |
| CN110959007B (en) * | 2017-07-26 | 2022-07-01 | 南京圣和药业股份有限公司 | Compounds as ACC inhibitors and uses thereof |
| CA3094988A1 (en) | 2018-03-30 | 2019-10-03 | Biotheryx, Inc. | Thienopyrimidinone compounds |
| EP3805230B1 (en) | 2018-06-05 | 2024-08-07 | Medshine Discovery Inc. | Thieno[2,3-c]pyridazin-4(1h)-one derivative and application thereof |
| CA3118422A1 (en) * | 2018-11-02 | 2020-05-07 | Dow Agrosciences Llc | Compositions comprising halauxifen and other herbicides and methods thereof |
| US20220041616A1 (en) * | 2018-11-20 | 2022-02-10 | The National Institutes of Pharmaceutical R&D Co., Ltd. | Spiro compound and medical uses thereof |
| CN111484504B (en) * | 2019-01-25 | 2024-05-10 | 南京圣和药业股份有限公司 | Optical isomer of ACC inhibitor and application thereof |
| AR119594A1 (en) | 2019-08-09 | 2021-12-29 | Gilead Sciences Inc | THIENOPYRIMIDINE DERIVATIVES AS ACC INHIBITORS AND USES THEREOF |
| CN110746439B (en) * | 2019-10-18 | 2020-10-30 | 南京瑞捷医药科技有限公司 | Preparation method of thienopyrimidinedione compound |
| WO2021112213A1 (en) * | 2019-12-05 | 2021-06-10 | 日本曹達株式会社 | 2,4-dioxo-1,4-dihydrothienopyrimidine compound, agricultural or horticultural fungicidal agent, or medical/animal antifungal agent, containing this |
| US11578081B1 (en) | 2019-12-05 | 2023-02-14 | Zhangzhou Pien Tze Huang Pharmaceutical Co., Ltd. | Crystal form as inhibitor of ACC1 and ACC2, and preparation method therefor and use thereof |
| EP4071153B1 (en) | 2019-12-05 | 2023-08-23 | Zhangzhou Pien Tze Huang Pharmaceutical Co., Ltd. | Crystal form of thieno[2,3-c]pyridazine-4(1h)-one compound, preparation method therefor and use thereof |
| US11478533B2 (en) | 2020-04-27 | 2022-10-25 | Novo Nordisk A/S | Semaglutide for use in medicine |
| CN113968871A (en) * | 2020-07-25 | 2022-01-25 | 南京圣和药业股份有限公司 | Crystalline forms of a phenyl-substituted ACC inhibitor |
| WO2022133097A1 (en) * | 2020-12-17 | 2022-06-23 | Biogen Ma Inc. | Synthesis of compounds that modulate use-dependent voltage-gated sodium channels |
| US20240083908A1 (en) | 2020-12-24 | 2024-03-14 | Modulus Discovery, Inc. | Tetrahydrothienopyrimidinesulfonamide compounds |
| WO2022268520A1 (en) * | 2021-06-21 | 2022-12-29 | Bayer Aktiengesellschaft | Use of substituted pyrrolidinones or their salts for increasing stress tolerance of plants |
| CN115677551A (en) * | 2021-12-28 | 2023-02-03 | 武汉市振邦生物科技有限公司 | Preparation process of 2-oxopyrrolidine-3-ethyl formate |
| WO2024031089A1 (en) | 2022-08-05 | 2024-02-08 | Gilead Sciences, Inc. | Sars-cov2 main protease inhibitors |
| CN115433756B (en) * | 2022-08-30 | 2024-04-09 | 山东新华制药股份有限公司 | Preparation method of prednisolone |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4670560A (en) * | 1986-04-28 | 1987-06-02 | Ortho Pharmaceutical Corporation | Thienopyrimidine-2,4-dione derivatives and intermediates thereof |
| US4835157A (en) * | 1988-03-15 | 1989-05-30 | Ortho Pharmaceutical Corporation | Thieno- and furopyrimidine-2,4-dione piperidine derivatives as serotonin antagonists and alpha adrenergic blocking agents |
| JPH02225485A (en) | 1989-02-27 | 1990-09-07 | Taiho Yakuhin Kogyo Kk | Thienopyrimidine-3-acetic acid derivative |
| JP3035745B2 (en) * | 1990-02-22 | 2000-04-24 | 武田薬品工業株式会社 | Condensed thiophene derivative |
| JP3811196B2 (en) | 1993-08-26 | 2006-08-16 | 武田薬品工業株式会社 | Endothelin antagonist, thienopyrimidine derivative and process for producing the same |
| TW276256B (en) | 1993-08-26 | 1996-05-21 | Takeda Pharm Industry Co Ltd | |
| CA2227384A1 (en) | 1995-08-17 | 1997-02-27 | Toshifumi Watanabe | Thienopyrimidine derivatives, their production and use |
| JPH09110873A (en) | 1995-08-17 | 1997-04-28 | Takeda Chem Ind Ltd | Thienopyrimidine derivative, its production and use |
| JP2007302703A (en) | 1996-04-30 | 2007-11-22 | Takeda Chem Ind Ltd | Medicinal composition |
| US6015789A (en) | 1996-04-30 | 2000-01-18 | Takeda Chemical Industries, Ltd. | Combined use of GnRH agonist and antagonist |
| SE9702001D0 (en) | 1997-05-28 | 1997-05-28 | Astra Pharma Prod | Novel compounds |
| US6984644B2 (en) | 1997-05-28 | 2006-01-10 | Astrazeneca Ab | Treatment of skin disorders using thieno[2,3-D]pyrimidinediones |
| DE19754082A1 (en) | 1997-12-05 | 1999-06-10 | Knoll Ag | Method of combating obesity |
| US6166019A (en) * | 1998-07-16 | 2000-12-26 | Abbott Laboratories | Piperazinyl pyrimidine dione compounds selective for adrenoceptors |
| EP1171442B1 (en) | 1999-04-09 | 2005-12-07 | Cell Therapeutics, Inc. | Xanthine derivatives and analogs as cell signalling inhibitors |
| WO2002064598A1 (en) * | 2001-02-14 | 2002-08-22 | Warner-Lambert Company Llc | Thieno'2,3-d pyrimidindione derivatives as matrix metalloproteinase inhibitors |
| US7655658B2 (en) | 2001-08-10 | 2010-02-02 | Palatin Technologies, Inc. | Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds |
| JP5072166B2 (en) * | 2002-01-30 | 2012-11-14 | 武田薬品工業株式会社 | Thienopyrimidine compound, production method and use thereof |
| EA200400980A1 (en) | 2002-02-27 | 2005-02-24 | Пфайзер Продактс Инк. | ACC INHIBITORS |
| AU2003253165A1 (en) | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | Pyrimidine fused bicyclic metalloproteinase inhibitors |
| WO2004060058A2 (en) | 2003-01-06 | 2004-07-22 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Herbicides inhibiting the action of plant acetyl-coa carboxylase for use as pesticides. |
| KR101074462B1 (en) | 2003-01-29 | 2011-10-18 | 다케다 야쿠힌 고교 가부시키가이샤 | Thienopyrimidine compounds and use thereof |
| WO2006014647A2 (en) | 2004-07-21 | 2006-02-09 | Athersys, Inc. | Cyclic n-hydroxy imides as inhibitors of flap endonuclease and uses thereof |
| JP2009528389A (en) | 2006-03-02 | 2009-08-06 | シーブイ・セラピューティクス・インコーポレイテッド | A2A adenosine receptor antagonist |
| US8501750B2 (en) | 2007-05-21 | 2013-08-06 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
| JP5535931B2 (en) | 2008-10-27 | 2014-07-02 | 武田薬品工業株式会社 | Bicyclic compound |
| ES2445537T3 (en) | 2009-12-29 | 2014-03-03 | Poxel | Thieno [2,3-b] pyridinedioneione activators of AMPK and therapeutic uses thereof |
| CA2799416A1 (en) * | 2010-05-14 | 2011-11-17 | University Of Rochester | Compositions and methods for targeting a3g:rna complexes |
| UA123760C2 (en) * | 2011-11-11 | 2021-06-02 | Гіліад Аполло, Ллс | COMPOUND (OPTIONS) AND COMPOSITION CONTAINING COMPOUND |
| BR112015028214A2 (en) | 2013-05-10 | 2017-07-25 | Nimbus Apollo Inc | acc inhibitors and uses thereof |
| CN105358154A (en) | 2013-05-10 | 2016-02-24 | 尼普斯阿波罗有限公司 | Acc inhibitors and uses thereof |
| AU2014262546B2 (en) | 2013-05-10 | 2018-11-08 | Gilead Apollo, Llc | ACC inhibitors and uses thereof |
| JP6417401B2 (en) | 2013-05-10 | 2018-11-07 | ギリアド アポロ， エルエルシー | ACC inhibitors and uses thereof |
| TWI652012B (en) | 2013-05-20 | 2019-03-01 | 杜邦股份有限公司 | Solid form of fungicidal pyrazole |
| WO2015007451A1 (en) * | 2013-07-15 | 2015-01-22 | Syngenta Participations Ag | Microbiocidal heterobicyclic derivatives |
| WO2015007453A1 (en) * | 2013-07-15 | 2015-01-22 | Syngenta Participations Ag | Microbiocidal heterobicyclic derivatives |
| CN108290902B (en) | 2015-11-25 | 2021-08-31 | 吉利德阿波罗公司 | Ester ACC inhibitors and uses thereof |
| KR20180086191A (en) | 2015-11-25 | 2018-07-30 | 길리어드 아폴로, 엘엘씨 | A fungicidal composition containing a 2,4-dioxo-1,4-dihydrothieno [2,3-d] pyrimidine derivative |
| BR112018010113B1 (en) | 2015-11-25 | 2022-06-14 | Gilead Apollo, Llc | PYRAZOLE COMPOUND USEFUL AS INHIBITOR OF ACETYL-COA CARBOXYLASE (ACC) |
| BR112018010453B1 (en) | 2015-11-25 | 2022-06-14 | Gilead Apollo, Llc | ACETYL COA CARBOXYLASE (ACC) INHIBITOR TRIAZOLIC COMPOUNDS |
| EP3423456B1 (en) | 2016-03-02 | 2023-12-27 | Gilead Apollo, LLC | Solid forms of a thienopyrimidinedione acc inhibitor and methods for production thereof |
-
2016
- 2016-10-25 AR ARP160103255A patent/AR106472A1/en unknown
- 2016-10-26 MX MX2018005292A patent/MX2018005292A/en unknown
- 2016-10-26 CA CA3003275A patent/CA3003275A1/en not_active Abandoned
- 2016-10-26 EP EP16791253.4A patent/EP3368540A1/en not_active Withdrawn
- 2016-10-26 AU AU2016344392A patent/AU2016344392A1/en not_active Abandoned
- 2016-10-26 CN CN201680072737.1A patent/CN108368125A/en active Pending
- 2016-10-26 SG SG11201802989QA patent/SG11201802989QA/en unknown
- 2016-10-26 US US15/334,955 patent/US10179793B2/en not_active Expired - Fee Related
- 2016-10-26 WO PCT/US2016/058867 patent/WO2017075056A1/en active Application Filing
- 2016-10-26 EA EA201890749A patent/EA201890749A1/en unknown
- 2016-10-26 BR BR112018008227A patent/BR112018008227A2/en not_active Application Discontinuation
- 2016-10-26 KR KR1020187013132A patent/KR20180067603A/en unknown
- 2016-10-26 JP JP2018521087A patent/JP2018538246A/en active Pending
-
2018
- 2018-04-11 IL IL258636A patent/IL258636A/en unknown
- 2018-11-27 US US16/201,571 patent/US20190330224A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| BR112018008227A2 (en) | 2018-10-23 |
| WO2017075056A1 (en) | 2017-05-04 |
| MX2018005292A (en) | 2018-08-01 |
| US20170145028A1 (en) | 2017-05-25 |
| US20190330224A1 (en) | 2019-10-31 |
| JP2018538246A (en) | 2018-12-27 |
| IL258636A (en) | 2018-06-28 |
| EA201890749A1 (en) | 2018-11-30 |
| CN108368125A (en) | 2018-08-03 |
| AR106472A1 (en) | 2018-01-17 |
| US10179793B2 (en) | 2019-01-15 |
| KR20180067603A (en) | 2018-06-20 |
| AU2016344392A1 (en) | 2018-05-10 |
| EP3368540A1 (en) | 2018-09-05 |
| CA3003275A1 (en) | 2017-05-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL258636A (en) | Acc inhibitors and uses thereof | |
| PL3380479T3 (en) | Triazole acc inhibitors and uses thereof | |
| PT3380480T (en) | Pyrazole acc inhibitors and uses thereof | |
| HUE053175T2 (en) | Ester acc inhibitors and uses thereof | |
| HK1256997A1 (en) | Tyk2 inhibitors and uses thereof | |
| HK1248690A1 (en) | Tyk2 inhibitors and uses thereof | |
| IL277239B (en) | Mdm2 inhibitors and combinations thereof | |
| HK1243072A1 (en) | Bromodomain inhibitors and uses thereof | |
| HK1221660A1 (en) | Acc inhibitors and uses thereof acc | |
| GB201605126D0 (en) | Inhibitors and their uses | |
| HK1221659A1 (en) | Acc inhibitors and uses thereof acc | |
| HK1221661A1 (en) | Acc inhibitors and uses thereof acc | |
| IL280863A (en) | Autotaxin inhibitors and uses thereof | |
| GB201506119D0 (en) | Systems and methods | |
| HK1221662A1 (en) | Acc inhibitors and uses thereof acc | |
| GB201617085D0 (en) | Compare and delay instructions | |
| IL263949A (en) | Complement inhibitors and uses thereof | |
| HK1249108A1 (en) | Mir-92 inhibitors and uses thereof | |
| HK1250926A1 (en) | Inhibitors and their uses | |
| IL255530A (en) | Efflux-pump inhibitors and therapeutic uses thereof | |
| IL254241A0 (en) | Etv2 and uses thereof | |
| GB201508175D0 (en) | Methods and systems | |
| EP3359151A4 (en) | Crmp2 sumoylation inhibitors and uses thereof | |
| GB201505975D0 (en) | Inhibitors and their uses | |
| GB201505971D0 (en) | Inhibitors and their uses |