EA202090068A1 - Соединения, влияющие на синтез пигмента и их применение для лечения бактериальных заболеваний - Google Patents
Соединения, влияющие на синтез пигмента и их применение для лечения бактериальных заболеванийInfo
- Publication number
- EA202090068A1 EA202090068A1 EA202090068A EA202090068A EA202090068A1 EA 202090068 A1 EA202090068 A1 EA 202090068A1 EA 202090068 A EA202090068 A EA 202090068A EA 202090068 A EA202090068 A EA 202090068A EA 202090068 A1 EA202090068 A1 EA 202090068A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- treatment
- compounds
- application
- bacterial diseases
- pigment synthesis
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 208000035143 Bacterial infection Diseases 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title 1
- 239000000049 pigment Substances 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 208000015181 infectious disease Diseases 0.000 abstract 3
- 230000000813 microbial effect Effects 0.000 abstract 3
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 230000001575 pathological effect Effects 0.000 abstract 2
- 230000002265 prevention Effects 0.000 abstract 2
- 206010041925 Staphylococcal infections Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
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- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
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- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
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- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
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- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
- C07C311/44—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/08—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with a hetero atom directly attached to the ring nitrogen atom
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- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
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- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyridine Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Изобретение относится к соединениям, их производным, композиции, содержащей одно или несколько из указанных соединений и производных, и их применению для предотвращения и/или лечения микробных инфекций и/или связанных с ними заболеваний или патологических состояний. Настоящие соединения и/или их производные могут быть представлены формулой (II). Настоящее применение включает в себя приготовление композиции, содержащей эффективное количество одного или нескольких соединений формулы (II) для предотвращения и/или лечения микробных инфекций и/или связанных с ними заболеваний или патологических состояний. В одном варианте осуществления изобретения указанные микробные инфекции представляют собой бактериальные инфекции. В частности, указанные бактериальные инфекции представляют собой стафилококковые инфекции.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US201762535540P | 2017-07-21 | 2017-07-21 | |
US16/041,838 US20190022038A1 (en) | 2017-07-21 | 2018-07-23 | Compounds affecting pigment production and methods for treatment of bacterial diseases |
PCT/IB2018/055459 WO2019016782A1 (en) | 2017-07-21 | 2018-07-23 | COMPOUNDS AFFECTING THE PRODUCTION OF PIGMENTS AND THEIR USE FOR THE TREATMENT OF BACTERIAL DISEASES |
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EA202090068A1 true EA202090068A1 (ru) | 2020-05-12 |
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EA202090068A EA202090068A1 (ru) | 2017-07-21 | 2018-07-23 | Соединения, влияющие на синтез пигмента и их применение для лечения бактериальных заболеваний |
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US (3) | US10471045B2 (ru) |
EP (2) | EP3655403A4 (ru) |
JP (2) | JP7348893B2 (ru) |
KR (2) | KR102655541B1 (ru) |
CN (3) | CN117486833A (ru) |
AU (4) | AU2018302790A1 (ru) |
BR (2) | BR112020001287A2 (ru) |
CA (2) | CA3070205A1 (ru) |
CL (1) | CL2020000050A1 (ru) |
EA (1) | EA202090068A1 (ru) |
IL (2) | IL271863B (ru) |
SG (1) | SG11201913817XA (ru) |
WO (2) | WO2019016781A1 (ru) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
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US11052078B2 (en) * | 2017-07-21 | 2021-07-06 | Versitech Limited | Compounds affecting pigment production and methods for treatment of bacterial diseases |
US10471045B2 (en) * | 2017-07-21 | 2019-11-12 | The University Of Hong Kong | Compounds and methods for the treatment of microbial infections |
US20210309622A1 (en) * | 2017-07-21 | 2021-10-07 | Versitech Limited | Compounds affecting pigment production and methods for treatment of bacterial diseases |
US11390604B2 (en) | 2019-03-08 | 2022-07-19 | Hoffmann-La Roche Inc. | Imidazole-pyrazole derivatives |
JP2023538969A (ja) * | 2020-08-31 | 2023-09-12 | エフ. ホフマン-ラ ロシュ アーゲー | 抗菌薬としてのイミダゾール-ピラゾール誘導体 |
CN115989227A (zh) * | 2020-09-01 | 2023-04-18 | 豪夫迈·罗氏有限公司 | 具有抗菌性的咪唑-吡唑衍生物 |
CN116096709A (zh) * | 2020-09-07 | 2023-05-09 | 豪夫迈·罗氏有限公司 | 新型杂环抗生素 |
EP4370514A1 (en) | 2021-07-15 | 2024-05-22 | F. Hoffmann-La Roche AG | Imidazole derivatives and their use as antibiotics |
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US2169971A (en) * | 1936-04-18 | 1939-08-15 | Winthrop Chem Co Inc | Sulphonic acid amide compounds |
CA2050591A1 (en) * | 1990-02-08 | 1991-08-09 | Hitoshi Oinuma | Benzenesulfonamide derivatives |
DE10348023A1 (de) * | 2003-10-15 | 2005-05-19 | Imtm Gmbh | Neue Alanyl-Aminopeptidasen-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen |
US7671077B2 (en) | 2004-07-19 | 2010-03-02 | Leu-Fen Hou Lin | Neuroprotective small organic molecules, compositions and uses related thereto |
BRPI0807014A2 (pt) * | 2007-02-09 | 2014-04-22 | Takeda Pharmaceutical | Composto, pró-droga, agente farmacêutico, métodos para melhorar a resistência a insulina em um mamífero, método para a profilaxia ou o tratamento de diabetes em um mamífero, e, uso de um composto. |
CN101429181A (zh) * | 2008-12-18 | 2009-05-13 | 毛近隆 | 对羟基苯丙烯酸衍生物及其应用 |
WO2010123599A2 (en) * | 2009-01-23 | 2010-10-28 | The Board Of Trustees Of The University Of Illinois | Anti-bacterial compositions and methods including targeting virulence factors of staphylococcus aureus |
RU2617988C2 (ru) * | 2010-09-03 | 2017-05-02 | ФОРМА ТиЭм, ЭлЭлСИ | Новые соединения и композиции для ингибирования nampt |
TW201245152A (en) * | 2011-05-04 | 2012-11-16 | Forma Tm Llc | Novel compounds and compositions for the inhibition of NAMPT |
CN102795953B (zh) * | 2012-08-17 | 2015-05-27 | 广西大学 | 以咖啡酸与磺胺类药物为原料合成咖啡酸酰胺衍生物的方法及用途 |
CN105130970B (zh) * | 2014-05-30 | 2019-06-25 | 中国人民解放军军事医学科学院毒物药物研究所 | N-磺酰基高丝氨酸内酯类衍生物、其制备方法和用途 |
US10471045B2 (en) * | 2017-07-21 | 2019-11-12 | The University Of Hong Kong | Compounds and methods for the treatment of microbial infections |
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2018
- 2018-07-22 US US16/041,836 patent/US10471045B2/en active Active
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- 2018-07-23 AU AU2018302790A patent/AU2018302790A1/en not_active Abandoned
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- 2018-07-23 CN CN202311240845.3A patent/CN117486833A/zh active Pending
- 2018-07-23 EP EP18835238.9A patent/EP3655403A4/en active Pending
- 2018-07-23 KR KR1020207003291A patent/KR102655541B1/ko active IP Right Grant
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- 2018-07-23 WO PCT/IB2018/055459 patent/WO2019016782A1/en unknown
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- 2018-07-23 KR KR1020207003292A patent/KR102655551B1/ko active IP Right Grant
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2019
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2022
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