BR112017006943A2 - produto hemostático poroso adesivo de tecido - Google Patents

produto hemostático poroso adesivo de tecido

Info

Publication number
BR112017006943A2
BR112017006943A2 BR112017006943A BR112017006943A BR112017006943A2 BR 112017006943 A2 BR112017006943 A2 BR 112017006943A2 BR 112017006943 A BR112017006943 A BR 112017006943A BR 112017006943 A BR112017006943 A BR 112017006943A BR 112017006943 A2 BR112017006943 A2 BR 112017006943A2
Authority
BR
Brazil
Prior art keywords
pox
coated
substrate
hemostatic product
coating
Prior art date
Application number
BR112017006943A
Other languages
English (en)
Other versions
BR112017006943B1 (pt
Inventor
Caspar Mathias Elizabeth Bender Johannes
Alexander Boerman Marcel
Original Assignee
Gatt Tech B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gatt Tech B V filed Critical Gatt Tech B V
Publication of BR112017006943A2 publication Critical patent/BR112017006943A2/pt
Publication of BR112017006943B1 publication Critical patent/BR112017006943B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
    • A61L15/325—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/425—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/58—Adhesives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/64—Use of materials characterised by their function or physical properties specially adapted to be resorbable inside the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Materials For Medical Uses (AREA)
  • Application Of Or Painting With Fluid Materials (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

a invenção proporciona um processo para a preparação de um produto hemostático adesivo, sendo que o dito processo compreende as etapas de: ? proporcionar um substrato sólido poroso; ? revestir o substrato com um líquido de revestimento que compreende uma polioxazolina ativada de forma eletrofílica (el-pox) e um solvente para produzir um substrato revestido, sendo que a dita el-pox contém pelo menos 2 grupos eletrofílicos reativos; ? remover o solvente a partir do substrato revestido. o presente processo permite a aplicação de um revestimento de el-pox que deixa a estrutura de poros plenamente intacta de forma que a capacidade do substrato poroso absorver fluidos, tais como sangue, permanece essencialmente inalterada. o produto hemostático revestido com el-pox obtido por meio do presente processo é dotado de excelentes propriedades adesivas devido à presença dos grupos reativos eletrofílicos que são capazes de reagir com, por exemplo, os grupos amina que estão naturalmente presentes no tecido, sob a formação de ligações covalentes. a presente invenção também proporciona um produto hemostático adesivo de tecido selecionado a partir de uma malha revestida, uma espuma revestida e um pó revestido, sendo que o dito produto hemostático compreende: ? um substrato sólido poroso que é dotado de uma porosidade de pelo menos 5%, em volume, e que compreende uma superfície externa que compreende um polímero nucleofílico que contém grupos nucleofílicos reativos; um revestimento adesivo que cobre pelo menos uma parte do substrato sólido, com o dito revestimento compreendendo uma polioxazolina ativada de forma eletrofílica (el-pox), com a dita el-pox contendo em média pelo menos 1 grupo eletrofílico reativo.
BR112017006943-1A 2014-10-06 2015-10-05 produto hemostático poroso adesivo de tecido BR112017006943B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14187781.1 2014-10-06
EP14187781 2014-10-06
PCT/NL2015/050696 WO2016056901A1 (en) 2014-10-06 2015-10-05 Tissue-adhesive porous haemostatic product

Publications (2)

Publication Number Publication Date
BR112017006943A2 true BR112017006943A2 (pt) 2018-01-09
BR112017006943B1 BR112017006943B1 (pt) 2020-12-01

Family

ID=51663058

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017006943-1A BR112017006943B1 (pt) 2014-10-06 2015-10-05 produto hemostático poroso adesivo de tecido

Country Status (10)

Country Link
US (2) US10232077B2 (pt)
EP (1) EP3204057B1 (pt)
JP (1) JP6683398B2 (pt)
KR (1) KR102514142B1 (pt)
CN (1) CN107106719B (pt)
AU (1) AU2015328825B2 (pt)
BR (1) BR112017006943B1 (pt)
CA (1) CA2963057C (pt)
RU (1) RU2704259C2 (pt)
WO (1) WO2016056901A1 (pt)

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Also Published As

Publication number Publication date
EP3204057B1 (en) 2019-12-04
US20190125922A1 (en) 2019-05-02
CA2963057C (en) 2023-08-01
CN107106719B (zh) 2021-06-01
US10751441B2 (en) 2020-08-25
RU2017115407A3 (pt) 2019-04-10
RU2017115407A (ru) 2018-11-14
KR20170066450A (ko) 2017-06-14
CN107106719A (zh) 2017-08-29
AU2015328825B2 (en) 2019-02-21
CA2963057A1 (en) 2016-04-14
US20180221531A1 (en) 2018-08-09
EP3204057A1 (en) 2017-08-16
US10232077B2 (en) 2019-03-19
AU2015328825A1 (en) 2017-04-20
KR102514142B1 (ko) 2023-03-27
RU2704259C2 (ru) 2019-10-25
BR112017006943B1 (pt) 2020-12-01
JP6683398B2 (ja) 2020-04-22
WO2016056901A1 (en) 2016-04-14
JP2017531488A (ja) 2017-10-26

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