BR112022000522A2 - Folha hemostática, flexível, biocompatível, embalagem vedada e método para preparar uma folha hemostática - Google Patents
Folha hemostática, flexível, biocompatível, embalagem vedada e método para preparar uma folha hemostáticaInfo
- Publication number
- BR112022000522A2 BR112022000522A2 BR112022000522A BR112022000522A BR112022000522A2 BR 112022000522 A2 BR112022000522 A2 BR 112022000522A2 BR 112022000522 A BR112022000522 A BR 112022000522A BR 112022000522 A BR112022000522 A BR 112022000522A BR 112022000522 A2 BR112022000522 A2 BR 112022000522A2
- Authority
- BR
- Brazil
- Prior art keywords
- reactive
- hemostatic sheet
- electrophilic
- blood
- groups
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/225—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/64—Use of materials characterised by their function or physical properties specially adapted to be resorbable inside the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
- A61L2300/604—Biodegradation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
Abstract
folha hemostática, flexível, biocompatível, embalagem vedada e método para preparar uma folha hemostática. a invenção refere-se a uma folha hemostática, flexível, biocompatível, que compreende: uma estrutura carreadora fibrosa coesa que compreende um espaço intersticial interconectado tridimensional; e distribuída dentro do espaço intersticial, uma pluralidade de partículas de polímero reativo compreendendo (i) um polímero eletrofílico solúvel em água que carrega pelo menos 3 grupos eletrofílicos reativos que são capazes de reagir com grupos amina no tecido e no sangue mediante a formação de uma ligação covalente e (ii) um agente reticulante nucleofílico que contém pelo menos dois grupos nucleofílicos reativos que são capazes de reagir com os grupos eletrofílicos reativos do polímero eletrofílico mediante a formação de uma ligação covalente, sendo que as ditas partículas de polímero reativo têm um diâmetro na faixa de 0,5 a 100 µm e estão presentes em uma quantidade de pelo menos 3%, em peso, da estrutura carreadora fibrosa. quando o sangue é absorvido pela folha hemostática da presente invenção, o polímero eletrofílico solúvel em água nas partículas de polímero reativo começa a se dissolver assim que essas partículas são umedecidas pelo sangue, permitindo assim que o polímero eletrofílico reaja com os grupos nucleofílicos reativos no sangue e no tecido, bem como com os grupos nucleofílicos reativos do agente reticulante nucleofílico, induzindo assim a coagulação do sangue e a vedação do tecido, ambas contribuindo para a hemostasia.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19186026 | 2019-07-12 | ||
| PCT/EP2020/069443 WO2021009015A1 (en) | 2019-07-12 | 2020-07-09 | Biocompatible, flexible, haemostatic sheet |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112022000522A2 true BR112022000522A2 (pt) | 2022-03-03 |
Family
ID=67262166
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112022000522A BR112022000522A2 (pt) | 2019-07-12 | 2020-07-09 | Folha hemostática, flexível, biocompatível, embalagem vedada e método para preparar uma folha hemostática |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20220133943A1 (pt) |
| EP (2) | EP4238590A1 (pt) |
| JP (1) | JP2022540127A (pt) |
| KR (1) | KR20220054589A (pt) |
| CN (1) | CN114096285A (pt) |
| AU (1) | AU2020313510A1 (pt) |
| BR (1) | BR112022000522A2 (pt) |
| CA (1) | CA3146724A1 (pt) |
| ES (1) | ES2962645T3 (pt) |
| WO (1) | WO2021009015A1 (pt) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20210213157A1 (en) * | 2020-01-09 | 2021-07-15 | Ethicon, Inc. | Flexible Gelatin Sealant Dressing with Reactive Components |
| JP2024506078A (ja) * | 2021-02-10 | 2024-02-08 | エシコン・インコーポレイテッド | 合成マトリクス及び生合成接着剤を含む二成分封止システム |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU215635B (hu) * | 1990-04-02 | 1999-01-28 | Procter And Gamble Co. | Eljárás részecskék közötti térhálósított aggregátumokat tartalmazó szemcsés, abszorbens polimer készítmények előállítására |
| US6833408B2 (en) | 1995-12-18 | 2004-12-21 | Cohesion Technologies, Inc. | Methods for tissue repair using adhesive materials |
| NZ583819A (en) | 2007-08-28 | 2012-08-31 | Medtronic Xomed Inc | Polymer comprising a dicarboxy-derivatised chitosan polymer cross-linked to an aldehyde-derivatised dextran polymer useful for preventing tissue adhesion and for promoting wound healing |
| US8545871B2 (en) * | 2008-11-19 | 2013-10-01 | Actamax Surgical Materials Llc | Fibrous tissue sealant and method of using same |
| PT2442835E (pt) * | 2009-06-16 | 2015-03-23 | Baxter Healthcare Sa | Esponja hemostática |
| SA111320355B1 (ar) | 2010-04-07 | 2015-01-08 | Baxter Heathcare S A | إسفنجة لايقاف النزف |
| US8273369B2 (en) * | 2010-05-17 | 2012-09-25 | Ethicon, Inc. | Reinforced absorbable synthetic matrix for hemostatic applications |
| CN103429268B (zh) | 2011-01-04 | 2015-11-25 | 本德尔分析控股有限公司 | 从亲电活化的聚噁唑啉衍生的经交联的聚合物和植入物 |
| US20130096063A1 (en) * | 2011-10-11 | 2013-04-18 | Baxter Healthcare S.A. | Hemostatic compositions |
| DE102012002209A1 (de) | 2012-02-07 | 2013-08-08 | Carl Freudenberg Kg | Biodegradierbares Vlies für medizinische Zwecke |
| ES2563246T3 (es) * | 2012-03-16 | 2016-03-11 | Bender Analytical Holding B.V. | Polímeros reticulados y productos médicos derivados de polioxazolina nucleofílicamente activada |
| EP2999491B1 (en) * | 2013-05-22 | 2020-03-18 | The Penn State Research Foundation | Wound dressings and applications thereof |
| WO2016056901A1 (en) | 2014-10-06 | 2016-04-14 | Gatt Technologies B.V. | Tissue-adhesive porous haemostatic product |
| CN105727346B (zh) * | 2016-02-04 | 2019-08-27 | 中国科学院化学研究所 | 一种止血织物及其制备方法与应用 |
| NL2016527B1 (en) | 2016-03-31 | 2017-11-02 | Polyganics Ip B V | Tissue-adhesive biomedical materials. |
| CN106390177B (zh) * | 2016-09-28 | 2020-07-14 | 深圳先进技术研究院 | 一种壳聚糖基多层纳米纤维膜敷料及其制备方法和应用 |
-
2020
- 2020-07-09 CA CA3146724A patent/CA3146724A1/en active Pending
- 2020-07-09 JP JP2022500738A patent/JP2022540127A/ja active Pending
- 2020-07-09 WO PCT/EP2020/069443 patent/WO2021009015A1/en active Application Filing
- 2020-07-09 KR KR1020227004805A patent/KR20220054589A/ko active Search and Examination
- 2020-07-09 BR BR112022000522A patent/BR112022000522A2/pt unknown
- 2020-07-09 EP EP23179003.1A patent/EP4238590A1/en active Pending
- 2020-07-09 EP EP20736384.7A patent/EP3996759B1/en active Active
- 2020-07-09 CN CN202080050544.2A patent/CN114096285A/zh active Pending
- 2020-07-09 ES ES20736384T patent/ES2962645T3/es active Active
- 2020-07-09 AU AU2020313510A patent/AU2020313510A1/en active Pending
-
2022
- 2022-01-11 US US17/573,574 patent/US20220133943A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3996759A1 (en) | 2022-05-18 |
| KR20220054589A (ko) | 2022-05-03 |
| JP2022540127A (ja) | 2022-09-14 |
| EP3996759B1 (en) | 2023-08-09 |
| WO2021009015A1 (en) | 2021-01-21 |
| US20220133943A1 (en) | 2022-05-05 |
| AU2020313510A1 (en) | 2022-02-03 |
| CN114096285A (zh) | 2022-02-25 |
| ES2962645T3 (es) | 2024-03-20 |
| EP4238590A1 (en) | 2023-09-06 |
| EP3996759C0 (en) | 2023-08-09 |
| CA3146724A1 (en) | 2021-01-21 |
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