BR112015029078A2 - Cola cirúrgica, poliéster reticulado preparado a partir da mesma, kit comprendendo a cola cirúrgica e um fotoiniciador, e emplastro - Google Patents

Cola cirúrgica, poliéster reticulado preparado a partir da mesma, kit comprendendo a cola cirúrgica e um fotoiniciador, e emplastro

Info

Publication number
BR112015029078A2
BR112015029078A2 BR112015029078A BR112015029078A BR112015029078A2 BR 112015029078 A2 BR112015029078 A2 BR 112015029078A2 BR 112015029078 A BR112015029078 A BR 112015029078A BR 112015029078 A BR112015029078 A BR 112015029078A BR 112015029078 A2 BR112015029078 A2 BR 112015029078A2
Authority
BR
Brazil
Prior art keywords
adhesive
prepolymers
body fluids
surgical
cutted
Prior art date
Application number
BR112015029078A
Other languages
English (en)
Other versions
BR112015029078B1 (pt
BR112015029078A8 (pt
Inventor
S Langer Robert
M Karp Jeffrey
Del Nido Pedro
LANG Nora
Jose M N Pereira Maria
LEE Yuhan
Original Assignee
Massachusetts Inst Technology
Childrens Medical Ct Corp
The Brigham And Womens Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology, Childrens Medical Ct Corp, The Brigham And Womens Hospital filed Critical Massachusetts Inst Technology
Publication of BR112015029078A2 publication Critical patent/BR112015029078A2/pt
Publication of BR112015029078A8 publication Critical patent/BR112015029078A8/pt
Publication of BR112015029078B1 publication Critical patent/BR112015029078B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/046—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/58—Adhesives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/12—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from polycarboxylic acids and polyhydroxy compounds
    • C08G63/46—Polyesters chemically modified by esterification
    • C08G63/47—Polyesters chemically modified by esterification by unsaturated monocarboxylic acids or unsaturated monohydric alcohols or reactive derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/91—Polymers modified by chemical after-treatment
    • C08G63/914—Polymers modified by chemical after-treatment derived from polycarboxylic acids and polyhydroxy compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F222/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides, or nitriles thereof
    • C08F222/10—Esters
    • C08F222/1006—Esters of polyhydric alcohols or polyhydric phenols
    • C08F222/106—Esters of polycondensation macromers
    • C08F222/1061—Esters of polycondensation macromers of alcohol terminated polyesters or polycarbonates, e.g. polyester (meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Surgery (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials For Medical Uses (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Adhesives Or Adhesive Processes (AREA)

Abstract

COLA CIRÚRGICA, POLIÉSTER RETICULADO PREPARADO A PARTIR DA MESMA, KIT COMPRENDENDO A COLA CIRÚRGICA E UM FOTOINICIADOR, E EMPLASTRO. Pré-polímeros para uso como vedantes e adesivos de tecido e métodos de fazer e usar os mesmos são providos. Os pré-polímeros têm características de fluxo tais que podem ser aplicadas através de uma seringa ou um cateter, mas são suficientemente viscosos para permanecerem no local no sítio de aplicação e não saírem do tecido. Os pré-polímeros também são suficientemente hidrofóbicos para resistir à lavagem por fluidos corporais. Os pré-polímeros são estáveis em fluidos corporais; ou seja, o pré-polímero não reticula espontaneamente em fluidos corporais sem a presença de um estímulo aplicado intencionalmente para iniciar a reticulação. Após a reticulação, o adesivo apresenta significativa resistência adesiva na presença de sangue e outros fluidos corporais. O adesivo é suficientemente elástico que é capaz de resistir ao movimento do tecido subjacente. O adesivo pode prover um selo hemostático. O adesivo é biodegradável e biocompatível, provocando resposta inflamatória mínima.
BR112015029078-7A 2013-05-24 2014-05-23 cola cirúrgica, poliéster reticulado preparado a partir da mesma, kit comprendendo a cola cirúrgica e um fotoiniciador, e emplastro BR112015029078B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361827240P 2013-05-24 2013-05-24
US61/827,240 2013-05-24
US201461924864P 2014-01-08 2014-01-08
US61/924,864 2014-01-08
PCT/US2014/039417 WO2014190302A1 (en) 2013-05-24 2014-05-23 Hydrophobic tissue adhesives

Publications (3)

Publication Number Publication Date
BR112015029078A2 true BR112015029078A2 (pt) 2017-08-22
BR112015029078A8 BR112015029078A8 (pt) 2020-03-17
BR112015029078B1 BR112015029078B1 (pt) 2020-12-08

Family

ID=50983193

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015029078-7A BR112015029078B1 (pt) 2013-05-24 2014-05-23 cola cirúrgica, poliéster reticulado preparado a partir da mesma, kit comprendendo a cola cirúrgica e um fotoiniciador, e emplastro

Country Status (9)

Country Link
US (1) US9724447B2 (pt)
EP (2) EP3950018A1 (pt)
JP (2) JP6678101B2 (pt)
CN (2) CN110051876B (pt)
BR (1) BR112015029078B1 (pt)
CA (1) CA2913338C (pt)
ES (1) ES2899023T3 (pt)
HK (1) HK1221238A1 (pt)
WO (1) WO2014190302A1 (pt)

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WO2014190302A1 (en) * 2013-05-24 2014-11-27 Massachusetts Institute Of Technology Hydrophobic tissue adhesives
HUE042067T2 (hu) 2015-02-02 2019-06-28 Coloplast As Osztómiás készülék
RU2695603C2 (ru) 2015-04-10 2019-07-24 Колопласт А/С Устройство для стомы
JP6913676B2 (ja) * 2015-06-18 2021-08-04 ティシウム ソシエテ アノニム 接着剤組成物
US11898005B2 (en) * 2015-06-18 2024-02-13 Tissium Sa Sealant composition
AU2016277798B2 (en) 2015-06-18 2020-11-26 Tissium Sa Sealant composition
CN106769502A (zh) * 2016-12-02 2017-05-31 杭州亚慧生物科技有限公司 一种外科手术封合剂胀破强度检测装置
CN107063873A (zh) * 2016-12-02 2017-08-18 杭州亚慧生物科技有限公司 一种外科手术封合剂恒温胀破强度检测装置
WO2018175619A1 (en) 2017-03-22 2018-09-27 Edwards Lifesciences Corporation System and method for implanting and securing a bioprosthetic device to wet tissue
JP7293132B2 (ja) 2017-05-25 2023-06-19 テルモ株式会社 接着閉塞システム
EP3409239A1 (en) 2017-05-29 2018-12-05 University College Dublin, National University of Ireland, Dublin An implantable active agent encapsulating device
WO2019079252A1 (en) * 2017-10-20 2019-04-25 Edwards Lifesciences Corporation LOCALIZED FUSION OF NATIVE VALVES USING AN ACTIVE ADHESIVE
EP3560427A1 (en) * 2018-04-24 2019-10-30 Gecko Biomedical Applicator for depositing a layer of adhesive or sealant composition on a biological and/or prosthetic tissue
CN112638437B (zh) 2018-07-02 2023-12-08 图拉维治疗股份有限公司 原位形成神经帽的方法和装置
JP2021006140A (ja) * 2019-06-28 2021-01-21 三洋化成工業株式会社 医療用接着剤
JP7260655B2 (ja) * 2019-09-27 2023-04-18 富士フイルム株式会社 ポリマー、硬化性組成物、硬化物
US20220380531A1 (en) 2019-10-25 2022-12-01 Tissium Sa Composition comprising activated and functionalized prepolymer
CN114980815A (zh) 2019-12-20 2022-08-30 爱德华兹生命科学创新(以色列)有限公司 植入物附着技术
KR20230133313A (ko) 2021-01-18 2023-09-19 티시움 에스에이 수술 재료
KR20230150830A (ko) 2021-02-24 2023-10-31 티시움 에스에이 활성화 및 작용화된 예비중합체를 포함하는 조성물
CN115501381B (zh) * 2022-09-23 2023-10-03 北京大学 替代可吸收缝合线的脂肪组织粘合剂、制备方法及其应用

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Also Published As

Publication number Publication date
CN110051876A (zh) 2019-07-26
JP6678101B2 (ja) 2020-04-08
JP2016526078A (ja) 2016-09-01
CN105377963A (zh) 2016-03-02
US20140348896A1 (en) 2014-11-27
JP2019081906A (ja) 2019-05-30
CA2913338A1 (en) 2014-11-27
CN105377963B (zh) 2018-11-27
BR112015029078B1 (pt) 2020-12-08
CN110051876B (zh) 2022-05-31
BR112015029078A8 (pt) 2020-03-17
ES2899023T3 (es) 2022-03-09
EP3004221A1 (en) 2016-04-13
EP3004221B1 (en) 2021-10-27
EP3950018A1 (en) 2022-02-09
US9724447B2 (en) 2017-08-08
CA2913338C (en) 2018-05-01
WO2014190302A1 (en) 2014-11-27
HK1221238A1 (zh) 2017-05-26

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 23/05/2014, OBSERVADAS AS CONDICOES LEGAIS.