WO2016140259A3 - ポリマーおよびその架橋体 - Google Patents

ポリマーおよびその架橋体 Download PDF

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Publication number
WO2016140259A3
WO2016140259A3 PCT/JP2016/056407 JP2016056407W WO2016140259A3 WO 2016140259 A3 WO2016140259 A3 WO 2016140259A3 JP 2016056407 W JP2016056407 W JP 2016056407W WO 2016140259 A3 WO2016140259 A3 WO 2016140259A3
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WO
WIPO (PCT)
Prior art keywords
structural unit
present
copolymer
crosslinked body
substrate surface
Prior art date
Application number
PCT/JP2016/056407
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English (en)
French (fr)
Other versions
WO2016140259A9 (ja
WO2016140259A2 (ja
Inventor
石原　一彦
祐貴 井上
今日子 深澤
将 松田
山田　智
朋澄 野田
Original Assignee
国立大学法人東京大学
日油株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 国立大学法人東京大学, 日油株式会社 filed Critical 国立大学法人東京大学
Priority to CN201680004196.9A priority Critical patent/CN107108813A/zh
Priority to JP2017503682A priority patent/JP6590909B2/ja
Priority to EP16758952.2A priority patent/EP3266803B1/en
Priority to US15/554,803 priority patent/US10323132B2/en
Publication of WO2016140259A2 publication Critical patent/WO2016140259A2/ja
Publication of WO2016140259A3 publication Critical patent/WO2016140259A3/ja
Publication of WO2016140259A9 publication Critical patent/WO2016140259A9/ja

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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/507—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials for artificial blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D3/00—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials
    • B05D3/06—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by exposure to radiation
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F230/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium or a metal
    • C08F230/02—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium or a metal containing phosphorus
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D133/00—Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Coating compositions based on derivatives of such polymers
    • C09D133/04—Homopolymers or copolymers of esters
    • C09D133/06—Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, the oxygen atom being present only as part of the carboxyl radical
    • C09D133/10—Homopolymers or copolymers of methacrylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D143/00—Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing boron, silicon, phosphorus, selenium, tellurium, or a metal; Coating compositions based on derivatives of such polymers
    • C09D143/02—Homopolymers or copolymers of monomers containing phosphorus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/20—Materials or treatment for tissue regeneration for reconstruction of the heart, e.g. heart valves
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2800/00—Copolymer characterised by the proportions of the comonomers expressed
    • C08F2800/10—Copolymer characterised by the proportions of the comonomers expressed as molar percentages
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2800/00—Copolymer characterised by the proportions of the comonomers expressed
    • C08F2800/20—Copolymer characterised by the proportions of the comonomers expressed as weight or mass percentages
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2343/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing boron, silicon, phosphorus, selenium, tellurium or a metal; Derivatives of such polymers
    • C08J2343/02—Homopolymers or copolymers of monomers containing phosphorus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Materials Engineering (AREA)
  • Wood Science & Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Plasma & Fusion (AREA)
  • Physics & Mathematics (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Materials For Medical Uses (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
  • Paints Or Removers (AREA)
  • Coating Of Shaped Articles Made Of Macromolecular Substances (AREA)

Abstract

医療材料用途に用いられるに十分な生体適合性を有する共重合体と該共重合体を用いて基材表面を生体適合性に改変する架橋体形成方法を提供することであり、詳しくは、基材表面にホスホリルコリン基の特長である蛋白質吸着抑制効果と細胞接着抑制効果を与えることである。　ホスホリルコリン構成単位、疎水性構成単位、および光反応性構成単位を特定比率で含有する共重合体が、上記の課題を解決することの知見を見出し、本発明を完成した。
PCT/JP2016/056407 2015-03-03 2016-03-02 ポリマーおよびその架橋体 WO2016140259A2 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CN201680004196.9A CN107108813A (zh) 2015-03-03 2016-03-02 聚合物及其交联体
JP2017503682A JP6590909B2 (ja) 2015-03-03 2016-03-02 ポリマーおよびその架橋体
EP16758952.2A EP3266803B1 (en) 2015-03-03 2016-03-02 Polymer and crosslinked body thereof
US15/554,803 US10323132B2 (en) 2015-03-03 2016-03-02 Polymer and crosslinked body thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2015-041174 2015-03-03
JP2015041174 2015-03-03

Publications (3)

Publication Number Publication Date
WO2016140259A2 WO2016140259A2 (ja) 2016-09-09
WO2016140259A3 true WO2016140259A3 (ja) 2016-10-27
WO2016140259A9 WO2016140259A9 (ja) 2017-04-27

Family

ID=56849371

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2016/056407 WO2016140259A2 (ja) 2015-03-03 2016-03-02 ポリマーおよびその架橋体

Country Status (6)

Country Link
US (1) US10323132B2 (ja)
EP (1) EP3266803B1 (ja)
JP (1) JP6590909B2 (ja)
CN (1) CN107108813A (ja)
TW (1) TW201634501A (ja)
WO (1) WO2016140259A2 (ja)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109312246B (zh) * 2016-06-29 2021-07-06 日油株式会社 滑性赋予剂以及滑性赋予方法
TWI712621B (zh) * 2016-06-29 2020-12-11 國立大學法人東京大學 共聚物及其用途
CN106905158B (zh) * 2017-01-26 2020-01-14 中国科学院长春应用化学研究所 一种直接改性基底的二苯甲酮型分子及其应用
EP3697424A4 (en) * 2017-10-20 2021-07-07 University of Georgia Research Foundation, Inc. SURFACES AND COATING COMPOSITIONS WITH ANTI-FOULING, ANTITHROMBOTIC AND ANTIBACTERIAL PROPERTIES AND THEIR PREPARATION METHODS
JP7125751B2 (ja) * 2018-11-01 2022-08-25 学校法人 関西大学 化合物およびその合成方法ならびに重合体およびその合成方法
WO2021079610A1 (ja) * 2019-10-25 2021-04-29 国立大学法人九州大学 生体適合性接着剤
US20210346580A1 (en) * 2020-05-11 2021-11-11 Qisda Corporation Hemodialyzer and hemodialysis system
CN116003659A (zh) * 2021-10-21 2023-04-25 中国科学院过程工程研究所 疏水性聚合物及制备方法、含疏水性聚合物的涂层材料及用其构建疏水/超疏水表面的方法
CN115109188B (zh) * 2022-06-27 2023-09-15 江苏博恩尼科生物技术有限公司 一种微射流混合器-微通道反应器-管式反应器制备聚季铵盐-51的方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000001424A1 (fr) * 1998-07-07 2000-01-13 Nof Corporation Preparation et materiau pour pansement, et methode de traitement des plaies
JP2002212491A (ja) * 2001-01-15 2002-07-31 Ipposha Oil Ind Co Ltd コーティング剤及びそれを用いた構造体
JP2012046761A (ja) * 2004-03-22 2012-03-08 Abbott Cardiovascular Systems Inc ホスホリルコリンコーティング組成物
JP2013539399A (ja) * 2010-09-08 2013-10-24 バイオインタラクションズ・リミテッド 医療デバイス用潤滑性コーティング
JP2014520191A (ja) * 2011-06-24 2014-08-21 バイオインタラクションズ・リミテッド 生体適合性の生態模倣両性電解質材料

Family Cites Families (10)

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Publication number Priority date Publication date Assignee Title
US6090901A (en) * 1991-07-05 2000-07-18 Biocompatibles Limited Polymeric surface coatings
DE60041418D1 (de) * 1999-11-09 2009-03-05 Nof Corp Zusammensetzung für hydrogele, hydrogel und dessen verwendung
US8585753B2 (en) * 2006-03-04 2013-11-19 John James Scanlon Fibrillated biodegradable prosthesis
WO2009113158A1 (ja) * 2008-03-11 2009-09-17 住友ベークライト株式会社 生理活性物質の固定化方法
JP5597814B2 (ja) * 2008-09-05 2014-10-01 国立大学法人 東京大学 疎水性ポリマー材料の光表面改質法
JP5598891B2 (ja) * 2008-09-05 2014-10-01 国立大学法人 東京大学 疎水性基材の表面処理方法
AU2010339654B2 (en) * 2009-12-21 2014-07-17 Innovative Surface Technologies, Inc. Coating agents and coated articles
KR101851825B1 (ko) * 2011-06-27 2018-04-24 니치유 가부시키가이샤 폴리머 및 그 제조 방법
CN103130958A (zh) * 2011-11-23 2013-06-05 西北大学 一种光反应型仿细胞膜结构共聚物及其制备方法和应用
JP6201324B2 (ja) * 2013-01-28 2017-09-27 日油株式会社 多孔質濾過膜用ファウリング抑制剤組成物、並びに多孔質濾過膜及びその製造方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000001424A1 (fr) * 1998-07-07 2000-01-13 Nof Corporation Preparation et materiau pour pansement, et methode de traitement des plaies
JP2002212491A (ja) * 2001-01-15 2002-07-31 Ipposha Oil Ind Co Ltd コーティング剤及びそれを用いた構造体
JP2012046761A (ja) * 2004-03-22 2012-03-08 Abbott Cardiovascular Systems Inc ホスホリルコリンコーティング組成物
JP2013539399A (ja) * 2010-09-08 2013-10-24 バイオインタラクションズ・リミテッド 医療デバイス用潤滑性コーティング
JP2014520191A (ja) * 2011-06-24 2014-08-21 バイオインタラクションズ・リミテッド 生体適合性の生態模倣両性電解質材料

Also Published As

Publication number Publication date
EP3266803A2 (en) 2018-01-10
US20180051140A1 (en) 2018-02-22
EP3266803A4 (en) 2018-08-22
WO2016140259A9 (ja) 2017-04-27
EP3266803B1 (en) 2020-01-01
JP6590909B2 (ja) 2019-10-16
JPWO2016140259A1 (ja) 2018-02-01
TW201634501A (zh) 2016-10-01
US10323132B2 (en) 2019-06-18
CN107108813A (zh) 2017-08-29
WO2016140259A2 (ja) 2016-09-09

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