BR112017001516A2 - método de ressolubilização quiral, estereoisômero, método para preparar um composto, composto, composição, e kit de ressolubilização quiral - Google Patents

método de ressolubilização quiral, estereoisômero, método para preparar um composto, composto, composição, e kit de ressolubilização quiral

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Publication number
BR112017001516A2
BR112017001516A2 BR112017001516-1A BR112017001516A BR112017001516A2 BR 112017001516 A2 BR112017001516 A2 BR 112017001516A2 BR 112017001516 A BR112017001516 A BR 112017001516A BR 112017001516 A2 BR112017001516 A2 BR 112017001516A2
Authority
BR
Brazil
Prior art keywords
chiral
resolubilization
compound
acid
preparing
Prior art date
Application number
BR112017001516-1A
Other languages
English (en)
Korean (ko)
Other versions
BR112017001516B1 (pt
Inventor
Young Woo Byoung
Lee Ki-Wha
Shin Kwang-Hyun
Park Miyoung
Jung Kyoungmi
Choi Joonho
Choi Gyeyoung
Cho Wonkyung
Park Young-Ho
Original Assignee
Amorepacific Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020150024334A external-priority patent/KR20160101554A/ko
Application filed by Amorepacific Corporation filed Critical Amorepacific Corporation
Publication of BR112017001516A2 publication Critical patent/BR112017001516A2/pt
Publication of BR112017001516B1 publication Critical patent/BR112017001516B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/42—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/42—Separation; Purification; Stabilisation; Use of additives
    • C07C303/44—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/04—Monocyclic monocarboxylic acids
    • C07C63/06—Benzoic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/56—Amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

o presente relatório descritivo refere-se a um método de ressolubilização quiral de uma mistura de estereoisômeros, compreendendo uma etapa de mistura estereoisomérica de compostos na qual um grupo amina é ligado a um átomo de carbono assimétrico, com um auxiliar quiral e um composto auxiliar formador de sal, em que o auxiliar quiral é um derivado de ácido o,o?-diaciltartárico, mais especificamente, de um ácido 2,3-dibenzoil-tartárico ou ácido o,o?di-p-toluoil tartárico, e o composto auxiliar formador de sal é ácido mandélico ou ácido canforsulfônico, e um isômero óptico contendo um alto nível de pureza óptica que pode ser obtido usando o método. portanto, de acordo com um aspecto da presente invenção, o método pode ser útil no campo farmacêutico ou cosmético quando se prepara um isômero óptico contendo uma pureza óptica alta.
BR112017001516-1A 2015-02-17 2016-02-15 Método de ressolubilização quiral, estereoisômero, método para preparar um composto, composto, composição, e kit de ressolubilização quiral BR112017001516B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
KR10-2015-0024334 2015-02-17
KR1020150024334A KR20160101554A (ko) 2015-02-17 2015-02-17 N-[4-(1-아미노에틸)-페닐]-메탄술폰아미드 유도체의 카이랄 분할 방법
EP15174617.9 2015-06-30
EP15174617 2015-06-30
PCT/KR2016/001474 WO2016133317A1 (ko) 2015-02-17 2016-02-15 Ｎ-[4-(1-아미노에틸)-페닐]-술폰아미드 유도체의 카이랄 분할 방법

Publications (2)

Publication Number Publication Date
BR112017001516A2 true BR112017001516A2 (pt) 2018-01-30
BR112017001516B1 BR112017001516B1 (pt) 2023-10-31

Family

ID=56692658

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017001516-1A BR112017001516B1 (pt) 2015-02-17 2016-02-15 Método de ressolubilização quiral, estereoisômero, método para preparar um composto, composto, composição, e kit de ressolubilização quiral

Country Status (8)

Country Link
US (1) US10479763B2 (pt)
EP (1) EP3162793B1 (pt)
JP (1) JP6687596B2 (pt)
KR (1) KR101791119B1 (pt)
CN (1) CN106660949B (pt)
BR (1) BR112017001516B1 (pt)
TW (1) TWI687396B (pt)
WO (1) WO2016133317A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102565407B1 (ko) * 2016-01-04 2023-08-10 (주)아모레퍼시픽 극성 비양자성 용매를 이용한 n-[4-(1-아미노에틸)-페닐]-술폰아미드 유도체의 카이랄 분할 방법
KR102599958B1 (ko) 2016-09-28 2023-11-09 (주)아모레퍼시픽 (r)-n-[4-(1-아미노-에틸)-2,6-다이플루오로-페닐]-메테인설폰아마이드의 제조방법
KR102587339B1 (ko) * 2016-12-22 2023-10-12 (주)아모레퍼시픽 N-[4-(1-아미노-에틸)-2,6-다이플루오로-페닐]-메테인설폰아마이드의 거울상 이성질체들의 라세미화 방법
CN109608368B (zh) * 2018-10-24 2021-03-09 常州市阳光药业有限公司 N-[4-(1-氨基乙基)-2,6-二氟苯基]甲磺酰胺的合成及拆分方法
KR20200053746A (ko) * 2018-11-09 2020-05-19 (주)아모레퍼시픽 졸-겔 조성물
MX2022010079A (es) * 2020-02-16 2022-09-02 Ayala Pharmaceuticals Inc Metodos para preparar derivados quirales de benzodiazepinona.

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JPS60152425A (ja) 1984-01-20 1985-08-10 Oyo Seikagaku Kenkyusho:Kk ラセミ体の新規な光学分割法
US4968837A (en) * 1989-07-28 1990-11-06 Ethyl Corporation Resolution of racemic mixtures
DK0418770T3 (da) 1989-09-19 1995-10-30 Hoechst Roussel Pharma Fremgangsmåde til kemisk spaltning af 5-alkoxysubstituerede (+-)-1,3-dimethyloxindolylethylaminer
US6265615B1 (en) 1998-07-01 2001-07-24 The Regents Of The University Of California Chiral recognition polymer and its use to separate enantiomers
DE19956786A1 (de) 1999-11-25 2001-05-31 Basf Ag Verfahren zur Herstellung optisch aktiver Amine
US7301023B2 (en) 2001-05-31 2007-11-27 Pfizer Inc. Chiral salt resolution
KR100927915B1 (ko) * 2005-03-17 2009-11-19 화이자 인코포레이티드 통증 치료에 유용한 ｎ-(ｎ-설폰일아미노메틸)사이클로프로판카복사마이드 유도체
US20120041225A1 (en) * 2006-02-03 2012-02-16 Vaidya Niteen A Kit for automated resolving agent selection and method thereof
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EP1862454A1 (en) * 2006-06-02 2007-12-05 Amorepacific Corporation Novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and a pharmaceutical composition containing the same
EP1882687A1 (en) * 2006-07-27 2008-01-30 Amorepacific Corporation Heterocyclic compounds useful as vanilloid receptor antagonists and pharmaceutical compositions containing the same
AR063211A1 (es) * 2006-07-27 2009-01-14 Amorepacific Corp Derivados de 3-(piridin-3-il)acrilamida y 3-(piridin-3-il)propionamida, un metodo para su preparacion, una composicion farmaceutica que los comprende y su uso en la fabricacion de medicamentos para el tratamiento de enfermedades asociadas con el receptor vaniloide.
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KR20160101554A (ko) 2015-02-17 2016-08-25 (주)아모레퍼시픽 N-[4-(1-아미노에틸)-페닐]-메탄술폰아미드 유도체의 카이랄 분할 방법

Also Published As

Publication number Publication date
EP3162793A1 (en) 2017-05-03
WO2016133317A1 (ko) 2016-08-25
EP3162793B1 (en) 2019-04-10
CN106660949A (zh) 2017-05-10
TWI687396B (zh) 2020-03-11
EP3162793A4 (en) 2018-01-03
US20170342027A1 (en) 2017-11-30
KR20170042548A (ko) 2017-04-19
US10479763B2 (en) 2019-11-19
BR112017001516B1 (pt) 2023-10-31
JP2018506503A (ja) 2018-03-08
TW201636319A (zh) 2016-10-16
KR101791119B1 (ko) 2017-11-20
CN106660949B (zh) 2020-11-13
JP6687596B2 (ja) 2020-04-22

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B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 15/02/2016, OBSERVADAS AS CONDICOES LEGAIS