MX2022010079A - Metodos para preparar derivados quirales de benzodiazepinona. - Google Patents
Metodos para preparar derivados quirales de benzodiazepinona.Info
- Publication number
- MX2022010079A MX2022010079A MX2022010079A MX2022010079A MX2022010079A MX 2022010079 A MX2022010079 A MX 2022010079A MX 2022010079 A MX2022010079 A MX 2022010079A MX 2022010079 A MX2022010079 A MX 2022010079A MX 2022010079 A MX2022010079 A MX 2022010079A
- Authority
- MX
- Mexico
- Prior art keywords
- sup
- sub
- compound
- integer
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
- C07D243/26—Preparation from compounds already containing the benzodiazepine skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
- C07D243/30—Preparation including building-up the benzodiazepine skeleton from compounds already containing hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención proporciona métodos para preparar compuestos de Fórmula (I), en donde los compuestos están representados por la estructura de fórmula (I): (ver Fórmula) Fórmula (I) en donde: cada uno de R1 es independientemente F, Cl, Br, I, OCH3, CN o NO2; cada uno de R2 es independientemente alquilo C1-C5 idéntico o diferente; n1 es un número entero entre 1 y 5; y n2 es un número entero entre 1 y 4. Además, la presente invención proporciona un compuesto representado por las siguientes estructuras: (ver Fórmulas) en donde X comprende: cloruro, acetato, adipato, alginato, ascorbato, aspartato, benzoato, bencenosulfonato, bisulfato, borato, butirato, citrato, alcanforato, alcanforsulfonato, ciclopentanopropionato, digluconato, dodecilsulfato, etanosulfonato, fumarato, glucoheptanoato, glicerofosfato, hemisulfato, heptanoato, hexanoato, yodhidrato, maleato, 2-hidroxietanosulfonato, lactato, metanosulfonato, 2-naftalenosulfonato, nicotinato, nitrato, oxalato, pectinato, persulfato, 3-fenilpropionato, fosfato, picrato, pivalato, propionato, salicilato, succinato, sulfato, sulfonato, tartrato, tiocianato, sal de toluenosulfonato o sal de undecanoato, o cualquier combinación de los mismos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202062977316P | 2020-02-16 | 2020-02-16 | |
PCT/US2021/018137 WO2021163676A1 (en) | 2020-02-16 | 2021-02-16 | Methods of preparing chiral benzodiazepinone derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022010079A true MX2022010079A (es) | 2022-09-02 |
Family
ID=77291712
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022010079A MX2022010079A (es) | 2020-02-16 | 2021-02-16 | Metodos para preparar derivados quirales de benzodiazepinona. |
Country Status (11)
Country | Link |
---|---|
US (1) | US20230108536A1 (es) |
EP (1) | EP4107148A4 (es) |
JP (1) | JP2023513731A (es) |
KR (1) | KR20220143094A (es) |
CN (1) | CN115103836A (es) |
AU (1) | AU2021218456A1 (es) |
BR (1) | BR112022016249A2 (es) |
CA (1) | CA3171651A1 (es) |
IL (1) | IL295572A (es) |
MX (1) | MX2022010079A (es) |
WO (1) | WO2021163676A1 (es) |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010073253A1 (en) * | 2008-12-22 | 2010-07-01 | Natco Pharma Limited | Method for preparing an optically active frovatriptan |
TWI614238B (zh) * | 2012-09-21 | 2018-02-11 | 必治妥美雅史谷比公司 | 雙(氟烷基)-1,4-苯并二氮呯酮化合物及其前藥 |
CN105308030A (zh) * | 2012-09-21 | 2016-02-03 | 百时美施贵宝公司 | 烷基、氟烷基-1,4-苯并二氮杂*酮化合物 |
EP2897954B1 (en) * | 2012-09-21 | 2016-10-26 | Bristol-Myers Squibb Company | Fluoroalkyl-1,4-benzodiazepinone compounds |
WO2014047397A1 (en) * | 2012-09-21 | 2014-03-27 | Bristol-Myers Squibb Company | Fluoroalkyl and fluorocycloalkyl 1,4-benzodiazepinone compounds as notch|inhibitors |
US10479763B2 (en) * | 2015-02-17 | 2019-11-19 | Amorepacific Corporation | Chiral resolution method of N-[4-(1-aminoethyl)-phenyl]-sulfonamide derivatives |
CN105439939B (zh) * | 2015-11-12 | 2018-12-04 | 四川恒康科技发展有限公司 | 一种(S)-N-Boc-3-羟基哌啶的合成方法 |
-
2021
- 2021-02-16 JP JP2022548818A patent/JP2023513731A/ja active Pending
- 2021-02-16 CA CA3171651A patent/CA3171651A1/en active Pending
- 2021-02-16 EP EP21753186.2A patent/EP4107148A4/en active Pending
- 2021-02-16 CN CN202180014113.5A patent/CN115103836A/zh active Pending
- 2021-02-16 MX MX2022010079A patent/MX2022010079A/es unknown
- 2021-02-16 AU AU2021218456A patent/AU2021218456A1/en active Pending
- 2021-02-16 US US17/799,680 patent/US20230108536A1/en active Pending
- 2021-02-16 IL IL295572A patent/IL295572A/en unknown
- 2021-02-16 BR BR112022016249A patent/BR112022016249A2/pt unknown
- 2021-02-16 KR KR1020227032186A patent/KR20220143094A/ko unknown
- 2021-02-16 WO PCT/US2021/018137 patent/WO2021163676A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2021163676A1 (en) | 2021-08-19 |
JP2023513731A (ja) | 2023-04-03 |
AU2021218456A1 (en) | 2022-09-22 |
EP4107148A1 (en) | 2022-12-28 |
KR20220143094A (ko) | 2022-10-24 |
EP4107148A4 (en) | 2024-05-15 |
CA3171651A1 (en) | 2021-08-19 |
CN115103836A (zh) | 2022-09-23 |
US20230108536A1 (en) | 2023-04-06 |
IL295572A (en) | 2022-10-01 |
BR112022016249A2 (pt) | 2022-10-11 |
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