ES2094218T3 - Derivados de 2-nitroimidazol, su fabricacion, y agente radiosensibilizante que lo incluye como principio activo. - Google Patents

Derivados de 2-nitroimidazol, su fabricacion, y agente radiosensibilizante que lo incluye como principio activo.

Info

Publication number
ES2094218T3
ES2094218T3 ES91902775T ES91902775T ES2094218T3 ES 2094218 T3 ES2094218 T3 ES 2094218T3 ES 91902775 T ES91902775 T ES 91902775T ES 91902775 T ES91902775 T ES 91902775T ES 2094218 T3 ES2094218 T3 ES 2094218T3
Authority
ES
Spain
Prior art keywords
nitroimidazole
derivatives
manufacture
active substance
radiosensitizing agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91902775T
Other languages
English (en)
Inventor
Toshimitsu Suzuki
Masakazu Sakaguchi
Yoshiyuki Miyata
Akira Suzuki
Tomoyuki Mori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pola Chemical Industries Inc
Original Assignee
Pola Chemical Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pola Chemical Industries Inc filed Critical Pola Chemical Industries Inc
Application granted granted Critical
Publication of ES2094218T3 publication Critical patent/ES2094218T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE DESCRIBE UN DERIVADO 2-NITROIMIDAZOL REPRESENTADO POR LA FORMULA (I) Y UN RADIOSINTETIZADOR QUE CONTIENE EL MISMO COMO INGREDIENTE ACTIVO, DONDE R1, R2 Y R3 PUEDEN SER LOS MISMOS O DIFERENTES UNO DE OTRO Y CADA UNO REPRESENTA HIDROGENO O ACILO. ESTE COMPUESTO (I) TIENE UN EFECTO RADIOSINTETIZADOR TAN EXCELENTE Y TANTA SEGURIDAD QUE EL RADIOSINTETIZADOR QUE CONTIENE EL MISMO ES ALTAMENTE EFICAZ EN LA RADIOTERAPIA DE CANCERES.
ES91902775T 1990-01-26 1991-01-24 Derivados de 2-nitroimidazol, su fabricacion, y agente radiosensibilizante que lo incluye como principio activo. Expired - Lifetime ES2094218T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2016721A JP2626727B2 (ja) 1990-01-26 1990-01-26 ２―ニトロイミダゾール誘導体、その製造法及びこれを有効成分とする放射線増感剤

Publications (1)

Publication Number Publication Date
ES2094218T3 true ES2094218T3 (es) 1997-01-16

Family

ID=11924130

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91902775T Expired - Lifetime ES2094218T3 (es) 1990-01-26 1991-01-24 Derivados de 2-nitroimidazol, su fabricacion, y agente radiosensibilizante que lo incluye como principio activo.

Country Status (10)

Country Link
US (1) US5270330A (es)
EP (1) EP0513351B1 (es)
JP (1) JP2626727B2 (es)
KR (2) KR927003539A (es)
AT (1) ATE143950T1 (es)
CA (1) CA2074533C (es)
DE (1) DE69122605T2 (es)
DK (1) DK0513351T3 (es)
ES (1) ES2094218T3 (es)
WO (1) WO1991011440A1 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT632028E (pt) * 1992-12-18 2003-08-29 Pola Chem Ind Inc Derivado opticamente activo do 2-nitroimidazole processo para a producao do mesmo e intermediario para a producao do mesmo
US5700825A (en) * 1995-03-31 1997-12-23 Florida State University Radiosensitizing diamines and their pharmaceutical preparations
US6060604A (en) 1995-03-31 2000-05-09 Florida State University Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups
US6331286B1 (en) 1998-12-21 2001-12-18 Photogen, Inc. Methods for high energy phototherapeutics
US5929104A (en) * 1997-04-02 1999-07-27 Pola Chemical Industries, Inc. Method for inducing apoptosis of cancer cell
US8974363B2 (en) 1997-12-11 2015-03-10 Provectus Pharmatech, Inc. Topical medicaments and methods for photodynamic treatment of disease
US8557298B2 (en) 1998-08-06 2013-10-15 Provectus Pharmatech, Inc. Medicaments for chemotherapeutic treatment of disease
US20020001567A1 (en) * 1998-12-21 2002-01-03 Photogen, Inc. Intracorporeal medicaments for high energy phototherapeutic treatment of disease
US8470296B2 (en) * 1998-12-21 2013-06-25 Provectus Pharmatech, Inc. Intracorporeal medicaments for high energy phototherapeutic treatment of disease
US7384623B1 (en) 1998-12-21 2008-06-10 Provectus Pharmatech, Inc. High energy phototherapeutic agents
AU2003300076C1 (en) 2002-12-30 2010-03-04 Angiotech International Ag Drug delivery from rapid gelling polymer composition
CA2514841A1 (en) * 2003-02-02 2004-08-19 Palo Alto Institute Of Molecular Medicine Cell-killing molecules and methods of use thereof
ZA200507752B (en) * 2003-03-28 2007-01-31 Threshold Pharmaceuticals Inc Compositions and methods for treating cancer
US20080132458A1 (en) * 2004-03-10 2008-06-05 Threshold Pharmaceuticals, Inc. Hypoxia-Activated Anti-Cancer Agents
WO2006001374A1 (ja) * 2004-06-24 2006-01-05 Toyo Suisan Kaisha, Ltd. 放射線治療増感剤
US7608612B2 (en) * 2005-01-21 2009-10-27 Richard H. Matthews Radiosensitizer formulations and methods for use
RS52505B (en) 2005-06-29 2013-04-30 Threshold Pharmaceuticals Inc. PHOSPHORAMIDATE ALKYLATER PRODUCTS
EP2114157B1 (en) * 2006-12-26 2021-05-26 ImmunoGenesis, Inc. Phosphoramidate alkylator prodrug for the treatment of cancer
KR101408677B1 (ko) 2007-01-23 2014-06-17 가부시키가이샤 폴라 파마 2-니트로이미다졸 유도체의 제조법
WO2008090732A1 (ja) 2007-01-26 2008-07-31 Pola Pharma Inc. 医薬組成物
US8258165B2 (en) 2007-06-14 2012-09-04 Pola Pharma Inc. Pharmaceutical composition
US20090118031A1 (en) * 2007-11-01 2009-05-07 Qualizza Gregory K Shaft Structure with Configurable Bending Profile
JP6082644B2 (ja) * 2013-03-22 2017-02-15 株式会社ポーラファルマ ドラニダゾール構成光学異性体の製造方法
JP6071715B2 (ja) * 2013-03-22 2017-02-01 株式会社ポーラファルマ ドラニダゾール構成光学異性体の製造方法
JP7353606B2 (ja) 2017-10-02 2023-10-02 慶應義塾 癌幹細胞インヒビター

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4462992A (en) * 1982-02-08 1984-07-31 Research Corporation Nitroimidazole radiosensitizers for hypoxic tumor cells and compositions thereof
JPS59139363A (ja) * 1983-01-31 1984-08-10 Kayaku:Kk ２−ニトロイミダゾ−ル誘導体およびその製造法
JPS6075430A (ja) * 1983-08-31 1985-04-27 Kayaku:Kk 放射線増感剤
JPH0819111B2 (ja) * 1987-10-22 1996-02-28 ポーラ化成工業株式会社 ２―ニトロイミダゾール誘導体及びこれを有効成分とする放射線増感剤
JP3291590B2 (ja) * 1992-08-26 2002-06-10 キヤノン株式会社 カラートナー、カラー現像剤及び画像形成方法

Also Published As

Publication number Publication date
JPH03223258A (ja) 1991-10-02
JP2626727B2 (ja) 1997-07-02
ATE143950T1 (de) 1996-10-15
EP0513351A4 (en) 1993-11-10
DE69122605D1 (de) 1996-11-14
DK0513351T3 (da) 1996-11-25
EP0513351B1 (en) 1996-10-09
CA2074533C (en) 2000-10-17
CA2074533A1 (en) 1991-07-27
KR0145333B1 (en) 1998-07-15
WO1991011440A1 (fr) 1991-08-08
US5270330A (en) 1993-12-14
DE69122605T2 (de) 1997-02-13
EP0513351A1 (en) 1992-11-19
KR927003539A (ko) 1992-12-18

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