ATE143950T1 - 2-nitroimidazolderivat, verfahren zu dessen herstellung und dieses als aktiven bestandteil enthaltender strahlungssensibilisator - Google Patents

2-nitroimidazolderivat, verfahren zu dessen herstellung und dieses als aktiven bestandteil enthaltender strahlungssensibilisator

Info

Publication number
ATE143950T1
ATE143950T1 AT91902775T AT91902775T ATE143950T1 AT E143950 T1 ATE143950 T1 AT E143950T1 AT 91902775 T AT91902775 T AT 91902775T AT 91902775 T AT91902775 T AT 91902775T AT E143950 T1 ATE143950 T1 AT E143950T1
Authority
AT
Austria
Prior art keywords
active ingredient
production
containing same
nitroimidazole derivative
radiation sensitizer
Prior art date
Application number
AT91902775T
Other languages
English (en)
Inventor
Toshimitsu Suzuki
Masakazu Sakaguchi
Yoshiyuki Miyata
Akira Suzuki
Tomoyuki Mori
Original Assignee
Pola Chem Ind Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pola Chem Ind Inc filed Critical Pola Chem Ind Inc
Application granted granted Critical
Publication of ATE143950T1 publication Critical patent/ATE143950T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT91902775T 1990-01-26 1991-01-24 2-nitroimidazolderivat, verfahren zu dessen herstellung und dieses als aktiven bestandteil enthaltender strahlungssensibilisator ATE143950T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2016721A JP2626727B2 (ja) 1990-01-26 1990-01-26 ２―ニトロイミダゾール誘導体、その製造法及びこれを有効成分とする放射線増感剤

Publications (1)

Publication Number Publication Date
ATE143950T1 true ATE143950T1 (de) 1996-10-15

Family

ID=11924130

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91902775T ATE143950T1 (de) 1990-01-26 1991-01-24 2-nitroimidazolderivat, verfahren zu dessen herstellung und dieses als aktiven bestandteil enthaltender strahlungssensibilisator

Country Status (10)

Country Link
US (1) US5270330A (de)
EP (1) EP0513351B1 (de)
JP (1) JP2626727B2 (de)
KR (2) KR927003539A (de)
AT (1) ATE143950T1 (de)
CA (1) CA2074533C (de)
DE (1) DE69122605T2 (de)
DK (1) DK0513351T3 (de)
ES (1) ES2094218T3 (de)
WO (1) WO1991011440A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69332821T2 (de) * 1992-12-18 2003-11-13 Pola Chemical Industries, Inc. Optisch aktives 2-nitroimidazolderivat, verfahren zu seiner herstellung und ein intermediat zu seiner herstellung
US6060604A (en) * 1995-03-31 2000-05-09 Florida State University Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups
US5700825A (en) * 1995-03-31 1997-12-23 Florida State University Radiosensitizing diamines and their pharmaceutical preparations
US6331286B1 (en) 1998-12-21 2001-12-18 Photogen, Inc. Methods for high energy phototherapeutics
US5929104A (en) * 1997-04-02 1999-07-27 Pola Chemical Industries, Inc. Method for inducing apoptosis of cancer cell
US8974363B2 (en) 1997-12-11 2015-03-10 Provectus Pharmatech, Inc. Topical medicaments and methods for photodynamic treatment of disease
US8557298B2 (en) 1998-08-06 2013-10-15 Provectus Pharmatech, Inc. Medicaments for chemotherapeutic treatment of disease
US20020001567A1 (en) * 1998-12-21 2002-01-03 Photogen, Inc. Intracorporeal medicaments for high energy phototherapeutic treatment of disease
US7384623B1 (en) 1998-12-21 2008-06-10 Provectus Pharmatech, Inc. High energy phototherapeutic agents
US8470296B2 (en) * 1998-12-21 2013-06-25 Provectus Pharmatech, Inc. Intracorporeal medicaments for high energy phototherapeutic treatment of disease
EP1594459B1 (de) 2002-12-30 2010-02-17 Angiotech International Ag Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung
CA2514841A1 (en) * 2003-02-02 2004-08-19 Palo Alto Institute Of Molecular Medicine Cell-killing molecules and methods of use thereof
ZA200507752B (en) 2003-03-28 2007-01-31 Threshold Pharmaceuticals Inc Compositions and methods for treating cancer
US20080132458A1 (en) * 2004-03-10 2008-06-05 Threshold Pharmaceuticals, Inc. Hypoxia-Activated Anti-Cancer Agents
BRPI0511824A (pt) * 2004-06-24 2007-12-26 Toyo Suisan Kaisha radiossensibilizador
EP1838305A1 (de) * 2005-01-21 2007-10-03 Richard H. Matthews Radiosensitizer-formulierungen mit nitrohistidinderivaten
SI1896040T1 (sl) 2005-06-29 2012-12-31 Threshold Pharmaceuticals, Inc. Fosforamidatna alkilatorska predzdravila
EP2114157B1 (de) * 2006-12-26 2021-05-26 ImmunoGenesis, Inc. Phosphoramidatalkylator-prodrug für die krebstherapie
ATE549319T1 (de) 2007-01-23 2012-03-15 Pola Pharma Inc Verfahren zur herstellung eines 2-nitroimidazol- derivats
CN101621997B (zh) 2007-01-26 2013-05-08 株式会社宝丽制药 医药组合物
US8258165B2 (en) 2007-06-14 2012-09-04 Pola Pharma Inc. Pharmaceutical composition
US20090118031A1 (en) * 2007-11-01 2009-05-07 Qualizza Gregory K Shaft Structure with Configurable Bending Profile
JP6082644B2 (ja) * 2013-03-22 2017-02-15 株式会社ポーラファルマ ドラニダゾール構成光学異性体の製造方法
JP6071715B2 (ja) * 2013-03-22 2017-02-01 株式会社ポーラファルマ ドラニダゾール構成光学異性体の製造方法
JP7353606B2 (ja) 2017-10-02 2023-10-02 慶應義塾 癌幹細胞インヒビター

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4462992A (en) * 1982-02-08 1984-07-31 Research Corporation Nitroimidazole radiosensitizers for hypoxic tumor cells and compositions thereof
JPS59139363A (ja) * 1983-01-31 1984-08-10 Kayaku:Kk ２−ニトロイミダゾ−ル誘導体およびその製造法
JPS6075430A (ja) * 1983-08-31 1985-04-27 Kayaku:Kk 放射線増感剤
JPH0819111B2 (ja) * 1987-10-22 1996-02-28 ポーラ化成工業株式会社 ２―ニトロイミダゾール誘導体及びこれを有効成分とする放射線増感剤
JP3291590B2 (ja) * 1992-08-26 2002-06-10 キヤノン株式会社 カラートナー、カラー現像剤及び画像形成方法

Also Published As

Publication number Publication date
EP0513351A4 (en) 1993-11-10
EP0513351B1 (de) 1996-10-09
DE69122605D1 (de) 1996-11-14
US5270330A (en) 1993-12-14
KR0145333B1 (en) 1998-07-15
KR927003539A (ko) 1992-12-18
JPH03223258A (ja) 1991-10-02
EP0513351A1 (de) 1992-11-19
CA2074533A1 (en) 1991-07-27
WO1991011440A1 (fr) 1991-08-08
DE69122605T2 (de) 1997-02-13
ES2094218T3 (es) 1997-01-16
CA2074533C (en) 2000-10-17
JP2626727B2 (ja) 1997-07-02
DK0513351T3 (da) 1996-11-25

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time