ATE143950T1 - 2-nitroimidazolderivat, verfahren zu dessen herstellung und dieses als aktiven bestandteil enthaltender strahlungssensibilisator - Google Patents
2-nitroimidazolderivat, verfahren zu dessen herstellung und dieses als aktiven bestandteil enthaltender strahlungssensibilisatorInfo
- Publication number
- ATE143950T1 ATE143950T1 AT91902775T AT91902775T ATE143950T1 AT E143950 T1 ATE143950 T1 AT E143950T1 AT 91902775 T AT91902775 T AT 91902775T AT 91902775 T AT91902775 T AT 91902775T AT E143950 T1 ATE143950 T1 AT E143950T1
- Authority
- AT
- Austria
- Prior art keywords
- active ingredient
- production
- containing same
- nitroimidazole derivative
- radiation sensitizer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2016721A JP2626727B2 (ja) | 1990-01-26 | 1990-01-26 | 2―ニトロイミダゾール誘導体、その製造法及びこれを有効成分とする放射線増感剤 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE143950T1 true ATE143950T1 (de) | 1996-10-15 |
Family
ID=11924130
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT91902775T ATE143950T1 (de) | 1990-01-26 | 1991-01-24 | 2-nitroimidazolderivat, verfahren zu dessen herstellung und dieses als aktiven bestandteil enthaltender strahlungssensibilisator |
Country Status (10)
Country | Link |
---|---|
US (1) | US5270330A (de) |
EP (1) | EP0513351B1 (de) |
JP (1) | JP2626727B2 (de) |
KR (2) | KR927003539A (de) |
AT (1) | ATE143950T1 (de) |
CA (1) | CA2074533C (de) |
DE (1) | DE69122605T2 (de) |
DK (1) | DK0513351T3 (de) |
ES (1) | ES2094218T3 (de) |
WO (1) | WO1991011440A1 (de) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69332821T2 (de) * | 1992-12-18 | 2003-11-13 | Pola Chemical Industries, Inc. | Optisch aktives 2-nitroimidazolderivat, verfahren zu seiner herstellung und ein intermediat zu seiner herstellung |
US6060604A (en) * | 1995-03-31 | 2000-05-09 | Florida State University | Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups |
US5700825A (en) * | 1995-03-31 | 1997-12-23 | Florida State University | Radiosensitizing diamines and their pharmaceutical preparations |
US6331286B1 (en) | 1998-12-21 | 2001-12-18 | Photogen, Inc. | Methods for high energy phototherapeutics |
US5929104A (en) * | 1997-04-02 | 1999-07-27 | Pola Chemical Industries, Inc. | Method for inducing apoptosis of cancer cell |
US8974363B2 (en) | 1997-12-11 | 2015-03-10 | Provectus Pharmatech, Inc. | Topical medicaments and methods for photodynamic treatment of disease |
US8557298B2 (en) | 1998-08-06 | 2013-10-15 | Provectus Pharmatech, Inc. | Medicaments for chemotherapeutic treatment of disease |
US20020001567A1 (en) * | 1998-12-21 | 2002-01-03 | Photogen, Inc. | Intracorporeal medicaments for high energy phototherapeutic treatment of disease |
US7384623B1 (en) | 1998-12-21 | 2008-06-10 | Provectus Pharmatech, Inc. | High energy phototherapeutic agents |
US8470296B2 (en) * | 1998-12-21 | 2013-06-25 | Provectus Pharmatech, Inc. | Intracorporeal medicaments for high energy phototherapeutic treatment of disease |
EP1594459B1 (de) | 2002-12-30 | 2010-02-17 | Angiotech International Ag | Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung |
CA2514841A1 (en) * | 2003-02-02 | 2004-08-19 | Palo Alto Institute Of Molecular Medicine | Cell-killing molecules and methods of use thereof |
ZA200507752B (en) | 2003-03-28 | 2007-01-31 | Threshold Pharmaceuticals Inc | Compositions and methods for treating cancer |
US20080132458A1 (en) * | 2004-03-10 | 2008-06-05 | Threshold Pharmaceuticals, Inc. | Hypoxia-Activated Anti-Cancer Agents |
BRPI0511824A (pt) * | 2004-06-24 | 2007-12-26 | Toyo Suisan Kaisha | radiossensibilizador |
EP1838305A1 (de) * | 2005-01-21 | 2007-10-03 | Richard H. Matthews | Radiosensitizer-formulierungen mit nitrohistidinderivaten |
SI1896040T1 (sl) | 2005-06-29 | 2012-12-31 | Threshold Pharmaceuticals, Inc. | Fosforamidatna alkilatorska predzdravila |
EP2114157B1 (de) * | 2006-12-26 | 2021-05-26 | ImmunoGenesis, Inc. | Phosphoramidatalkylator-prodrug für die krebstherapie |
ATE549319T1 (de) | 2007-01-23 | 2012-03-15 | Pola Pharma Inc | Verfahren zur herstellung eines 2-nitroimidazol- derivats |
CN101621997B (zh) | 2007-01-26 | 2013-05-08 | 株式会社宝丽制药 | 医药组合物 |
US8258165B2 (en) | 2007-06-14 | 2012-09-04 | Pola Pharma Inc. | Pharmaceutical composition |
US20090118031A1 (en) * | 2007-11-01 | 2009-05-07 | Qualizza Gregory K | Shaft Structure with Configurable Bending Profile |
JP6082644B2 (ja) * | 2013-03-22 | 2017-02-15 | 株式会社ポーラファルマ | ドラニダゾール構成光学異性体の製造方法 |
JP6071715B2 (ja) * | 2013-03-22 | 2017-02-01 | 株式会社ポーラファルマ | ドラニダゾール構成光学異性体の製造方法 |
JP7353606B2 (ja) | 2017-10-02 | 2023-10-02 | 慶應義塾 | 癌幹細胞インヒビター |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4462992A (en) * | 1982-02-08 | 1984-07-31 | Research Corporation | Nitroimidazole radiosensitizers for hypoxic tumor cells and compositions thereof |
JPS59139363A (ja) * | 1983-01-31 | 1984-08-10 | Kayaku:Kk | 2−ニトロイミダゾ−ル誘導体およびその製造法 |
JPS6075430A (ja) * | 1983-08-31 | 1985-04-27 | Kayaku:Kk | 放射線増感剤 |
JPH0819111B2 (ja) * | 1987-10-22 | 1996-02-28 | ポーラ化成工業株式会社 | 2―ニトロイミダゾール誘導体及びこれを有効成分とする放射線増感剤 |
JP3291590B2 (ja) * | 1992-08-26 | 2002-06-10 | キヤノン株式会社 | カラートナー、カラー現像剤及び画像形成方法 |
-
1990
- 1990-01-26 JP JP2016721A patent/JP2626727B2/ja not_active Expired - Lifetime
- 1990-01-26 KR KR1019920701754A patent/KR927003539A/ko not_active IP Right Cessation
-
1991
- 1991-01-24 ES ES91902775T patent/ES2094218T3/es not_active Expired - Lifetime
- 1991-01-24 DE DE69122605T patent/DE69122605T2/de not_active Expired - Lifetime
- 1991-01-24 US US07/915,814 patent/US5270330A/en not_active Expired - Lifetime
- 1991-01-24 WO PCT/JP1991/000074 patent/WO1991011440A1/ja active IP Right Grant
- 1991-01-24 EP EP91902775A patent/EP0513351B1/de not_active Expired - Lifetime
- 1991-01-24 DK DK91902775.5T patent/DK0513351T3/da active
- 1991-01-24 CA CA002074533A patent/CA2074533C/en not_active Expired - Lifetime
- 1991-01-24 AT AT91902775T patent/ATE143950T1/de not_active IP Right Cessation
-
1992
- 1992-07-24 KR KR92701724A patent/KR0145333B1/ko active
Also Published As
Publication number | Publication date |
---|---|
EP0513351A4 (en) | 1993-11-10 |
EP0513351B1 (de) | 1996-10-09 |
DE69122605D1 (de) | 1996-11-14 |
US5270330A (en) | 1993-12-14 |
KR0145333B1 (en) | 1998-07-15 |
KR927003539A (ko) | 1992-12-18 |
JPH03223258A (ja) | 1991-10-02 |
EP0513351A1 (de) | 1992-11-19 |
CA2074533A1 (en) | 1991-07-27 |
WO1991011440A1 (fr) | 1991-08-08 |
DE69122605T2 (de) | 1997-02-13 |
ES2094218T3 (es) | 1997-01-16 |
CA2074533C (en) | 2000-10-17 |
JP2626727B2 (ja) | 1997-07-02 |
DK0513351T3 (da) | 1996-11-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
EELA | Cancelled due to lapse of time |