NO951283L - Nye taxanderivater, deres fremstilling samt farmasöytiske preparater inneholdende derivatene - Google Patents

Nye taxanderivater, deres fremstilling samt farmasöytiske preparater inneholdende derivatene

Info

Publication number
NO951283L
NO951283L NO951283A NO951283A NO951283L NO 951283 L NO951283 L NO 951283L NO 951283 A NO951283 A NO 951283A NO 951283 A NO951283 A NO 951283A NO 951283 L NO951283 L NO 951283L
Authority
NO
Norway
Prior art keywords
residue
derivatives
general formula
preparation
well
Prior art date
Application number
NO951283A
Other languages
English (en)
Other versions
NO951283D0 (no
Inventor
Jean-Dominique Bourzat
Alain Commercon
Dominique Deprez
Jean-Pierre Pulicani
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of NO951283D0 publication Critical patent/NO951283D0/no
Publication of NO951283L publication Critical patent/NO951283L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
    • C25B3/00—Electrolytic production of organic compounds
    • C25B3/20—Processes
    • C25B3/25—Reduction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Electrochemistry (AREA)
  • Materials Engineering (AREA)
  • Metallurgy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Nye taxanderivater med den generelle formel (I): fremstilles ved elektrokjemisk reduksjon av et taxanderlvat med den HO. R generelle formel (III): OK Rl-Ot HO I formel (I) betyr et av symbolene % og R2 et hydrogenatom og det andre en hydrokfiyrest, R3 et hydrogenatom eller en rest med den generelle formel (II): der Ar betyr en arylrest, R*'N? f? fy betyr en benzylrest eller en rest R5-0-CO-der R5 betyr en alkyl-, Arx>*X!x^\. ¿¿ alkenyl-, cykloalkyl-, cykloalkenyl-, blcykloalkyl-, fenyl- eller 5H heterocyklylrest og 6° betyr en alkyl-, alkenyl-, cykloalkyl-, cykloalkenyl-, blcyklo- alkyl-, eventuelt substituert aryl- eller heterocyklylrest. Forbindelser med den generelle formel (I) der R3 betyr en rest med den generelle formel (II) oppviser bemerkelsesverdige antltumorale og antlleukemlske egenskaper.
NO951283A 1992-10-15 1995-04-03 Nye taxanderivater, deres fremstilling samt farmasöytiske preparater inneholdende derivatene NO951283L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9212331A FR2697019B1 (fr) 1992-10-15 1992-10-15 Nouveaux dérivés du taxane, leur préparation et les compositions pharmaceutiques qui les contiennent.
PCT/FR1993/001013 WO1994008984A1 (fr) 1992-10-15 1993-10-13 Nouveaux derives du taxane, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
NO951283D0 NO951283D0 (no) 1995-04-03
NO951283L true NO951283L (no) 1995-04-03

Family

ID=9434565

Family Applications (1)

Application Number Title Priority Date Filing Date
NO951283A NO951283L (no) 1992-10-15 1995-04-03 Nye taxanderivater, deres fremstilling samt farmasöytiske preparater inneholdende derivatene

Country Status (15)

Country Link
EP (1) EP0664800A1 (no)
JP (1) JPH08502280A (no)
KR (1) KR950703551A (no)
AU (1) AU5339594A (no)
CA (1) CA2146765A1 (no)
CZ (1) CZ95895A3 (no)
FI (1) FI951789A (no)
FR (1) FR2697019B1 (no)
MX (1) MX9306227A (no)
NO (1) NO951283L (no)
PL (1) PL308361A1 (no)
SK (1) SK49995A3 (no)
TW (1) TW250480B (no)
WO (1) WO1994008984A1 (no)
ZA (1) ZA937558B (no)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6495704B1 (en) 1991-09-23 2002-12-17 Florida State University 9-desoxotaxanes and process for the preparation of 9-desoxotaxanes
US6794523B2 (en) 1991-09-23 2004-09-21 Florida State University Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
US6011056A (en) 1991-09-23 2000-01-04 Florida State University C9 taxane derivatives and pharmaceutical compositions containing them
DE69432140T2 (de) * 1993-03-05 2003-07-31 Univ Florida State Verfahren zur Herstellung von 9-Desoxotaxanen
US6710191B2 (en) 1993-03-05 2004-03-23 Florida State University 9β-hydroxytetracyclic taxanes
US5703247A (en) * 1993-03-11 1997-12-30 Virginia Tech Intellectual Properties, Inc. 2-Debenzoyl-2-acyl taxol derivatives and methods for making same
US5635531A (en) * 1996-07-08 1997-06-03 Bristol-Myers Squibb Company 3'-aminocarbonyloxy paclitaxels
US5773464A (en) * 1996-09-30 1998-06-30 Bristol-Myers Squibb Company C-10 epoxy taxanes
US5977386A (en) * 1996-12-24 1999-11-02 Bristol-Myers Squibb Company 6-thio-substituted paclitaxels
US5902822A (en) * 1997-02-28 1999-05-11 Bristol-Myers Squibb Company 7-methylthiooxomethyl and 7-methylthiodioxomethyl paclitaxels
US5912264A (en) * 1997-03-03 1999-06-15 Bristol-Myers Squibb Company 6-halo-or nitrate-substituted paclitaxels
US6017935A (en) * 1997-04-24 2000-01-25 Bristol-Myers Squibb Company 7-sulfur substituted paclitaxels
EP1894921A3 (en) * 2003-09-25 2008-03-12 Tapestry Pharmaceuticals, Inc. 9, 10-Alpha, Alpha-Oh-Taxane analogs and methods for production thereof
ATE377593T1 (de) 2003-09-25 2007-11-15 Tapestry Pharmaceuticals Inc 9,10-alpha,alpha-oh-taxananaloga und verfahren zu deren herstellung
US11786504B2 (en) 2006-09-28 2023-10-17 Tapestry Pharmaceuticals, Inc. Taxane analogs for the treatment of brain cancer
WO2008106621A1 (en) 2007-02-28 2008-09-04 Tapestry Pharmaceuticals, Inc Taxane analogs for the treatment of brain cancer
US11873308B2 (en) 2006-11-06 2024-01-16 Tapestry Pharmaceuticals, Inc. Biologically active taxane analogs and methods of treatment by oral administration
WO2008121476A1 (en) 2007-03-28 2008-10-09 Tapestry Pharmaceuticals, Inc. Biologically active taxane analogs and methods of treatment by oral administration
ES2687705T3 (es) 2012-07-19 2018-10-26 Fujifilm Corporation Composición líquida que contiene un principio activo a base de taxano, proceso de producción de la misma y preparación medicinal líquida

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
US5059699A (en) * 1990-08-28 1991-10-22 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol
MX9102128A (es) * 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene

Also Published As

Publication number Publication date
FR2697019B1 (fr) 1994-11-25
ZA937558B (en) 1994-05-04
SK49995A3 (en) 1995-09-13
CZ95895A3 (en) 1995-09-13
FR2697019A1 (fr) 1994-04-22
PL308361A1 (en) 1995-07-24
EP0664800A1 (fr) 1995-08-02
FI951789A0 (fi) 1995-04-13
TW250480B (no) 1995-07-01
NO951283D0 (no) 1995-04-03
MX9306227A (es) 1994-05-31
CA2146765A1 (fr) 1994-04-28
KR950703551A (ko) 1995-09-20
JPH08502280A (ja) 1996-03-12
AU5339594A (en) 1994-05-09
WO1994008984A1 (fr) 1994-04-28
FI951789A (fi) 1995-04-13

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