ATE101601T1 - Fluorhaltige nitrazol-derivate und diese umfassender strahlungssensibilisator. - Google Patents
Fluorhaltige nitrazol-derivate und diese umfassender strahlungssensibilisator.Info
- Publication number
- ATE101601T1 ATE101601T1 AT88109316T AT88109316T ATE101601T1 AT E101601 T1 ATE101601 T1 AT E101601T1 AT 88109316 T AT88109316 T AT 88109316T AT 88109316 T AT88109316 T AT 88109316T AT E101601 T1 ATE101601 T1 AT E101601T1
- Authority
- AT
- Austria
- Prior art keywords
- nitrazole
- derivatives
- fluorine containing
- radiation sensitizers
- fluorine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Catalysts (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14745987 | 1987-06-10 | ||
JP15678787 | 1987-06-24 | ||
JP24157487 | 1987-09-26 | ||
JP31468687 | 1987-12-10 | ||
JP63020456A JP2848602B2 (ja) | 1987-06-24 | 1988-01-29 | 新規含フッ素2−ニトロイミダゾールおよびそれを含む放射線増感剤 |
JP63079230A JP2602887B2 (ja) | 1987-06-10 | 1988-03-31 | 新規含フッ素3−ニトロ−1,2,4−トリアゾールおよびそれを含む放射線増感剤 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE101601T1 true ATE101601T1 (de) | 1994-03-15 |
Family
ID=27548921
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT88109316T ATE101601T1 (de) | 1987-06-10 | 1988-06-10 | Fluorhaltige nitrazol-derivate und diese umfassender strahlungssensibilisator. |
Country Status (9)
Country | Link |
---|---|
US (1) | US4927941A (de) |
EP (1) | EP0294847B1 (de) |
KR (1) | KR910000236B1 (de) |
AT (1) | ATE101601T1 (de) |
AU (2) | AU614288B2 (de) |
CA (2) | CA1329206C (de) |
DE (1) | DE3887776T2 (de) |
ES (1) | ES2063000T3 (de) |
IL (1) | IL86686A (de) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1329206C (en) * | 1987-06-10 | 1994-05-03 | Tsutomu Kagiya | Fluorine-containing nitroazole derivatives and radiosensitizer comprising the same |
IL92597A0 (en) * | 1988-12-14 | 1990-08-31 | Yasunori Nishijima President K | Novel fluorine-containing 2-nitroimidazole derivatives and radiosensitizer comprising the same |
GB9113487D0 (en) * | 1991-06-21 | 1991-08-07 | Amersham Int Plc | Agents for hypoxic cells |
US6855828B1 (en) | 1992-11-19 | 2005-02-15 | The Trustees Of The University Of Pennsylvania | Detection of hypoxia |
US6252087B1 (en) | 1992-11-19 | 2001-06-26 | The Trustees Of The University Of Pennsylvania | Nitroaromatic compounds for the detection of hypoxia |
DE69332741T2 (de) * | 1992-11-19 | 2003-10-02 | The University Of Rochester, Rochester | Nachweis von hypoxia |
US5721265A (en) * | 1994-08-05 | 1998-02-24 | Sri International | Fluorinated 2-nitroimidazole analogs for detecting hypoxic tumor cells |
US6060604A (en) | 1995-03-31 | 2000-05-09 | Florida State University | Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups |
US20050026974A1 (en) * | 1996-02-08 | 2005-02-03 | Trustees Of The University Of Pennsylvania | Detection of hypoxia |
US6331286B1 (en) | 1998-12-21 | 2001-12-18 | Photogen, Inc. | Methods for high energy phototherapeutics |
US8974363B2 (en) * | 1997-12-11 | 2015-03-10 | Provectus Pharmatech, Inc. | Topical medicaments and methods for photodynamic treatment of disease |
US20090117199A1 (en) * | 1998-08-06 | 2009-05-07 | Scott Timothy C | Method of treatment of cancer |
US8557298B2 (en) * | 1998-08-06 | 2013-10-15 | Provectus Pharmatech, Inc. | Medicaments for chemotherapeutic treatment of disease |
US7384623B1 (en) | 1998-12-21 | 2008-06-10 | Provectus Pharmatech, Inc. | High energy phototherapeutic agents |
US8470296B2 (en) * | 1998-12-21 | 2013-06-25 | Provectus Pharmatech, Inc. | Intracorporeal medicaments for high energy phototherapeutic treatment of disease |
US20020001567A1 (en) * | 1998-12-21 | 2002-01-03 | Photogen, Inc. | Intracorporeal medicaments for high energy phototherapeutic treatment of disease |
ATE457716T1 (de) | 2002-12-30 | 2010-03-15 | Angiotech Int Ag | Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung |
JP2006522021A (ja) * | 2003-02-03 | 2006-09-28 | パロ アルト インスティチュート オブ モレキュラー メディシン | 殺細胞分子およびその使用方法 |
US7875602B2 (en) | 2005-10-21 | 2011-01-25 | Sutter West Bay Hospitals | Camptothecin derivatives as chemoradiosensitizing agents |
US9056136B2 (en) * | 2006-10-06 | 2015-06-16 | Natural Pharmacia International, Inc. | Weakly basic 2-nitroimidazoles for the non-invasive detection of tissue hypoxia |
WO2021224186A1 (en) * | 2020-05-04 | 2021-11-11 | Institut Curie | New pyridine derivatives as radiosensitizers |
CN115745953B (zh) * | 2022-06-29 | 2024-06-11 | 上海凌凯医药科技有限公司 | 一种羟基氟代试剂及羟基氟代方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE47132B1 (en) * | 1977-08-19 | 1983-12-28 | Roche Products Ltd | Novel nitroimidazoles and pharmaceutical preparations containing these as well as their manufacture |
ZW8781A1 (en) * | 1980-05-23 | 1981-12-16 | Hoffmann La Roche | 2-nitroimidazoles and preparation thereof |
EP0095906B1 (de) * | 1982-05-27 | 1986-10-22 | National Research Development Corporation | Verbindungen anwendbar in Strahlentherapie und Chemotherapie |
CA1227211A (en) * | 1982-05-27 | 1987-09-22 | Israr Ahmed | Nitro imidazolyl aziridino propanols |
US4820844A (en) * | 1985-08-15 | 1989-04-11 | Adeka Argus Chemical Co., Ltd. | Radiation sensitizer |
CA1329206C (en) * | 1987-06-10 | 1994-05-03 | Tsutomu Kagiya | Fluorine-containing nitroazole derivatives and radiosensitizer comprising the same |
-
1988
- 1988-06-08 CA CA000568966A patent/CA1329206C/en not_active Expired - Fee Related
- 1988-06-09 AU AU17551/88A patent/AU614288B2/en not_active Ceased
- 1988-06-09 US US07/204,367 patent/US4927941A/en not_active Expired - Lifetime
- 1988-06-09 IL IL8668688A patent/IL86686A/en not_active IP Right Cessation
- 1988-06-10 EP EP88109316A patent/EP0294847B1/de not_active Expired - Lifetime
- 1988-06-10 ES ES88109316T patent/ES2063000T3/es not_active Expired - Lifetime
- 1988-06-10 AT AT88109316T patent/ATE101601T1/de not_active IP Right Cessation
- 1988-06-10 DE DE3887776T patent/DE3887776T2/de not_active Expired - Fee Related
- 1988-06-10 KR KR1019880007004A patent/KR910000236B1/ko not_active IP Right Cessation
- 1988-12-20 AU AU27307/88A patent/AU615700B2/en not_active Ceased
-
1989
- 1989-01-06 CA CA000587688A patent/CA1329207C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
IL86686A (en) | 1994-06-24 |
AU615700B2 (en) | 1991-10-10 |
AU614288B2 (en) | 1991-08-29 |
IL86686A0 (en) | 1988-11-30 |
DE3887776D1 (de) | 1994-03-24 |
CA1329207C (en) | 1994-05-03 |
EP0294847A1 (de) | 1988-12-14 |
US4927941A (en) | 1990-05-22 |
ES2063000T3 (es) | 1995-01-01 |
AU1755188A (en) | 1988-12-15 |
CA1329206C (en) | 1994-05-03 |
KR910000236B1 (ko) | 1991-01-23 |
AU2730788A (en) | 1989-05-25 |
DE3887776T2 (de) | 1994-07-07 |
EP0294847B1 (de) | 1994-02-16 |
KR890000442A (ko) | 1989-03-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |