DE3887776D1 - Fluorhaltige Nitrazol-Derivate und diese umfassender Strahlungssensibilisator. - Google Patents
Fluorhaltige Nitrazol-Derivate und diese umfassender Strahlungssensibilisator.Info
- Publication number
- DE3887776D1 DE3887776D1 DE88109316T DE3887776T DE3887776D1 DE 3887776 D1 DE3887776 D1 DE 3887776D1 DE 88109316 T DE88109316 T DE 88109316T DE 3887776 T DE3887776 T DE 3887776T DE 3887776 D1 DE3887776 D1 DE 3887776D1
- Authority
- DE
- Germany
- Prior art keywords
- fluorine
- nitrazol
- derivatives
- radiation sensitizer
- comprehensive radiation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14745987 | 1987-06-10 | ||
JP15678787 | 1987-06-24 | ||
JP24157487 | 1987-09-26 | ||
JP31468687 | 1987-12-10 | ||
JP63020456A JP2848602B2 (ja) | 1987-06-24 | 1988-01-29 | 新規含フッ素2−ニトロイミダゾールおよびそれを含む放射線増感剤 |
JP63079230A JP2602887B2 (ja) | 1987-06-10 | 1988-03-31 | 新規含フッ素3−ニトロ−1,2,4−トリアゾールおよびそれを含む放射線増感剤 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3887776D1 true DE3887776D1 (de) | 1994-03-24 |
DE3887776T2 DE3887776T2 (de) | 1994-07-07 |
Family
ID=27548921
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3887776T Expired - Fee Related DE3887776T2 (de) | 1987-06-10 | 1988-06-10 | Fluorhaltige Nitrazol-Derivate und diese umfassender Strahlungssensibilisator. |
Country Status (9)
Country | Link |
---|---|
US (1) | US4927941A (de) |
EP (1) | EP0294847B1 (de) |
KR (1) | KR910000236B1 (de) |
AT (1) | ATE101601T1 (de) |
AU (2) | AU614288B2 (de) |
CA (2) | CA1329206C (de) |
DE (1) | DE3887776T2 (de) |
ES (1) | ES2063000T3 (de) |
IL (1) | IL86686A (de) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1329206C (en) * | 1987-06-10 | 1994-05-03 | Tsutomu Kagiya | Fluorine-containing nitroazole derivatives and radiosensitizer comprising the same |
IL92597A0 (en) * | 1988-12-14 | 1990-08-31 | Yasunori Nishijima President K | Novel fluorine-containing 2-nitroimidazole derivatives and radiosensitizer comprising the same |
GB9113487D0 (en) * | 1991-06-21 | 1991-08-07 | Amersham Int Plc | Agents for hypoxic cells |
US6252087B1 (en) | 1992-11-19 | 2001-06-26 | The Trustees Of The University Of Pennsylvania | Nitroaromatic compounds for the detection of hypoxia |
US6855828B1 (en) | 1992-11-19 | 2005-02-15 | The Trustees Of The University Of Pennsylvania | Detection of hypoxia |
JP4169782B2 (ja) * | 1992-11-19 | 2008-10-22 | ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア | 低酸素症の検出 |
US5721265A (en) * | 1994-08-05 | 1998-02-24 | Sri International | Fluorinated 2-nitroimidazole analogs for detecting hypoxic tumor cells |
US6060604A (en) * | 1995-03-31 | 2000-05-09 | Florida State University | Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups |
US20050026974A1 (en) * | 1996-02-08 | 2005-02-03 | Trustees Of The University Of Pennsylvania | Detection of hypoxia |
US6331286B1 (en) | 1998-12-21 | 2001-12-18 | Photogen, Inc. | Methods for high energy phototherapeutics |
US8974363B2 (en) * | 1997-12-11 | 2015-03-10 | Provectus Pharmatech, Inc. | Topical medicaments and methods for photodynamic treatment of disease |
US8557298B2 (en) * | 1998-08-06 | 2013-10-15 | Provectus Pharmatech, Inc. | Medicaments for chemotherapeutic treatment of disease |
US20090117199A1 (en) * | 1998-08-06 | 2009-05-07 | Scott Timothy C | Method of treatment of cancer |
US7384623B1 (en) | 1998-12-21 | 2008-06-10 | Provectus Pharmatech, Inc. | High energy phototherapeutic agents |
US20020001567A1 (en) * | 1998-12-21 | 2002-01-03 | Photogen, Inc. | Intracorporeal medicaments for high energy phototherapeutic treatment of disease |
US8470296B2 (en) * | 1998-12-21 | 2013-06-25 | Provectus Pharmatech, Inc. | Intracorporeal medicaments for high energy phototherapeutic treatment of disease |
JP2006516548A (ja) | 2002-12-30 | 2006-07-06 | アンジオテック インターナショナル アクツィエン ゲゼルシャフト | 迅速ゲル化ポリマー組成物からの薬物送達法 |
JP2006522021A (ja) * | 2003-02-03 | 2006-09-28 | パロ アルト インスティチュート オブ モレキュラー メディシン | 殺細胞分子およびその使用方法 |
US7875602B2 (en) * | 2005-10-21 | 2011-01-25 | Sutter West Bay Hospitals | Camptothecin derivatives as chemoradiosensitizing agents |
US9056136B2 (en) * | 2006-10-06 | 2015-06-16 | Natural Pharmacia International, Inc. | Weakly basic 2-nitroimidazoles for the non-invasive detection of tissue hypoxia |
WO2021224186A1 (en) * | 2020-05-04 | 2021-11-11 | Institut Curie | New pyridine derivatives as radiosensitizers |
CN115745953A (zh) * | 2022-06-29 | 2023-03-07 | 上海凌凯医药科技有限公司 | 一种羟基氟代试剂及羟基氟代方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE47132B1 (en) * | 1977-08-19 | 1983-12-28 | Roche Products Ltd | Novel nitroimidazoles and pharmaceutical preparations containing these as well as their manufacture |
ZW8781A1 (en) * | 1980-05-23 | 1981-12-16 | Hoffmann La Roche | 2-nitroimidazoles and preparation thereof |
US4581368A (en) * | 1982-05-27 | 1986-04-08 | National Research Development Corporation | Aziridino containing nitro imidazoles and pharmaceutical compositions |
CA1227211A (en) * | 1982-05-27 | 1987-09-22 | Israr Ahmed | Nitro imidazolyl aziridino propanols |
DE3682723D1 (de) * | 1985-08-15 | 1992-01-16 | Asahi Denka Kogyo Kk | Strahlungssensibilisator. |
CA1329206C (en) * | 1987-06-10 | 1994-05-03 | Tsutomu Kagiya | Fluorine-containing nitroazole derivatives and radiosensitizer comprising the same |
-
1988
- 1988-06-08 CA CA000568966A patent/CA1329206C/en not_active Expired - Fee Related
- 1988-06-09 IL IL8668688A patent/IL86686A/en not_active IP Right Cessation
- 1988-06-09 AU AU17551/88A patent/AU614288B2/en not_active Ceased
- 1988-06-09 US US07/204,367 patent/US4927941A/en not_active Expired - Lifetime
- 1988-06-10 EP EP88109316A patent/EP0294847B1/de not_active Expired - Lifetime
- 1988-06-10 AT AT88109316T patent/ATE101601T1/de not_active IP Right Cessation
- 1988-06-10 KR KR1019880007004A patent/KR910000236B1/ko not_active IP Right Cessation
- 1988-06-10 DE DE3887776T patent/DE3887776T2/de not_active Expired - Fee Related
- 1988-06-10 ES ES88109316T patent/ES2063000T3/es not_active Expired - Lifetime
- 1988-12-20 AU AU27307/88A patent/AU615700B2/en not_active Ceased
-
1989
- 1989-01-06 CA CA000587688A patent/CA1329207C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0294847B1 (de) | 1994-02-16 |
ES2063000T3 (es) | 1995-01-01 |
CA1329207C (en) | 1994-05-03 |
ATE101601T1 (de) | 1994-03-15 |
KR890000442A (ko) | 1989-03-14 |
AU614288B2 (en) | 1991-08-29 |
KR910000236B1 (ko) | 1991-01-23 |
DE3887776T2 (de) | 1994-07-07 |
AU2730788A (en) | 1989-05-25 |
CA1329206C (en) | 1994-05-03 |
US4927941A (en) | 1990-05-22 |
AU615700B2 (en) | 1991-10-10 |
EP0294847A1 (de) | 1988-12-14 |
IL86686A0 (en) | 1988-11-30 |
IL86686A (en) | 1994-06-24 |
AU1755188A (en) | 1988-12-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |