ES2063000T3 - Derivados de nitroazol que contienen fluor y radiosensibilizador que comprende los mismos. - Google Patents

Derivados de nitroazol que contienen fluor y radiosensibilizador que comprende los mismos.

Info

Publication number
ES2063000T3
ES2063000T3 ES88109316T ES88109316T ES2063000T3 ES 2063000 T3 ES2063000 T3 ES 2063000T3 ES 88109316 T ES88109316 T ES 88109316T ES 88109316 T ES88109316 T ES 88109316T ES 2063000 T3 ES2063000 T3 ES 2063000T3
Authority
ES
Spain
Prior art keywords
nitroazole
radiosensitizer
derivatives
same
contain fluoride
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88109316T
Other languages
English (en)
Inventor
Tsutomu Kagiya
Mitsuyuki Abe
Seiichi Nishimoto
Yuta Shibamoto
Kazuhiro Shimokawa
Yorisato Hisanaga
Tatsuo Nakada
Toru Yoshizawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daikin Industries Ltd
Kyoto University
Original Assignee
Daikin Industries Ltd
Kyoto University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP63020456A external-priority patent/JP2848602B2/ja
Priority claimed from JP63079230A external-priority patent/JP2602887B2/ja
Application filed by Daikin Industries Ltd, Kyoto University filed Critical Daikin Industries Ltd
Application granted granted Critical
Publication of ES2063000T3 publication Critical patent/ES2063000T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Catalysts (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

UN DERIVADO DE NITROAZOL DE LA FORMULA (I) DONDE NA ES 3-NITRO-1,2,4-TRIAZOL-1-IL O 2-NITROIMIDAZOL-1-IL Y RF ES UN GRUPO ORGANICO QUE CONTIENE FLUOR, CONSIGUEN QUE CUANDO NA ES 2-NITROIMIDAZOL-1-IL, EL GRUPO ORGANICO QUE CONTIENE FLUOR TIENE AL MENOS UN ATOMO DE FLUOR SOBRE UN ATOMO DE CARBONO QUE SE UNE AL ATOMO DE NITROGENO DEL ANILLO IMIDAZOL O UN ATOMO DE CARBONO QUE SE UNE AL DICHO ATOMO DE CARBONO, QUE ES UTIL COMO RADIOSENSIBILIZADOR.
ES88109316T 1987-06-10 1988-06-10 Derivados de nitroazol que contienen fluor y radiosensibilizador que comprende los mismos. Expired - Lifetime ES2063000T3 (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP14745987 1987-06-10
JP15678787 1987-06-24
JP24157487 1987-09-26
JP31468687 1987-12-10
JP63020456A JP2848602B2 (ja) 1987-06-24 1988-01-29 新規含フッ素２−ニトロイミダゾールおよびそれを含む放射線増感剤
JP63079230A JP2602887B2 (ja) 1987-06-10 1988-03-31 新規含フッ素３−ニトロ−１，２，４−トリアゾールおよびそれを含む放射線増感剤

Publications (1)

Publication Number Publication Date
ES2063000T3 true ES2063000T3 (es) 1995-01-01

Family

ID=27548921

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88109316T Expired - Lifetime ES2063000T3 (es) 1987-06-10 1988-06-10 Derivados de nitroazol que contienen fluor y radiosensibilizador que comprende los mismos.

Country Status (9)

Country Link
US (1) US4927941A (es)
EP (1) EP0294847B1 (es)
KR (1) KR910000236B1 (es)
AT (1) ATE101601T1 (es)
AU (2) AU614288B2 (es)
CA (2) CA1329206C (es)
DE (1) DE3887776T2 (es)
ES (1) ES2063000T3 (es)
IL (1) IL86686A (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1329206C (en) * 1987-06-10 1994-05-03 Tsutomu Kagiya Fluorine-containing nitroazole derivatives and radiosensitizer comprising the same
IL92597A0 (en) * 1988-12-14 1990-08-31 Yasunori Nishijima President K Novel fluorine-containing 2-nitroimidazole derivatives and radiosensitizer comprising the same
GB9113487D0 (en) * 1991-06-21 1991-08-07 Amersham Int Plc Agents for hypoxic cells
EP0669913B1 (en) * 1992-11-19 2003-03-05 The Trustees Of The University Of Pennsylvania Detection of hypoxia
US6252087B1 (en) 1992-11-19 2001-06-26 The Trustees Of The University Of Pennsylvania Nitroaromatic compounds for the detection of hypoxia
US6855828B1 (en) 1992-11-19 2005-02-15 The Trustees Of The University Of Pennsylvania Detection of hypoxia
US5721265A (en) * 1994-08-05 1998-02-24 Sri International Fluorinated 2-nitroimidazole analogs for detecting hypoxic tumor cells
US6060604A (en) * 1995-03-31 2000-05-09 Florida State University Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups
US20050026974A1 (en) * 1996-02-08 2005-02-03 Trustees Of The University Of Pennsylvania Detection of hypoxia
US6331286B1 (en) 1998-12-21 2001-12-18 Photogen, Inc. Methods for high energy phototherapeutics
US8974363B2 (en) * 1997-12-11 2015-03-10 Provectus Pharmatech, Inc. Topical medicaments and methods for photodynamic treatment of disease
US8557298B2 (en) * 1998-08-06 2013-10-15 Provectus Pharmatech, Inc. Medicaments for chemotherapeutic treatment of disease
US20090117199A1 (en) * 1998-08-06 2009-05-07 Scott Timothy C Method of treatment of cancer
US7384623B1 (en) 1998-12-21 2008-06-10 Provectus Pharmatech, Inc. High energy phototherapeutic agents
US8470296B2 (en) * 1998-12-21 2013-06-25 Provectus Pharmatech, Inc. Intracorporeal medicaments for high energy phototherapeutic treatment of disease
US20020001567A1 (en) * 1998-12-21 2002-01-03 Photogen, Inc. Intracorporeal medicaments for high energy phototherapeutic treatment of disease
AU2003300076C1 (en) 2002-12-30 2010-03-04 Angiotech International Ag Drug delivery from rapid gelling polymer composition
EP1590440A4 (en) * 2003-02-03 2009-03-18 Palo Alto Inst Of Molecular Me CELL-KILLING MOLECULES AND METHODS FOR THEIR USE
US7875602B2 (en) * 2005-10-21 2011-01-25 Sutter West Bay Hospitals Camptothecin derivatives as chemoradiosensitizing agents
US9056136B2 (en) * 2006-10-06 2015-06-16 Natural Pharmacia International, Inc. Weakly basic 2-nitroimidazoles for the non-invasive detection of tissue hypoxia
WO2021224186A1 (en) * 2020-05-04 2021-11-11 Institut Curie New pyridine derivatives as radiosensitizers
CN115745953A (zh) * 2022-06-29 2023-03-07 上海凌凯医药科技有限公司 一种羟基氟代试剂及羟基氟代方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE47132B1 (en) * 1977-08-19 1983-12-28 Roche Products Ltd Novel nitroimidazoles and pharmaceutical preparations containing these as well as their manufacture
ZW8781A1 (en) * 1980-05-23 1981-12-16 Hoffmann La Roche 2-nitroimidazoles and preparation thereof
DE3367092D1 (en) * 1982-05-27 1986-11-27 Nat Res Dev Improvements relating to compounds useful in radiotherapy or chemotherapy
CA1227211A (en) * 1982-05-27 1987-09-22 Israr Ahmed Nitro imidazolyl aziridino propanols
US4820844A (en) * 1985-08-15 1989-04-11 Adeka Argus Chemical Co., Ltd. Radiation sensitizer
CA1329206C (en) * 1987-06-10 1994-05-03 Tsutomu Kagiya Fluorine-containing nitroazole derivatives and radiosensitizer comprising the same

Also Published As

Publication number Publication date
US4927941A (en) 1990-05-22
EP0294847B1 (en) 1994-02-16
DE3887776D1 (de) 1994-03-24
IL86686A0 (en) 1988-11-30
AU2730788A (en) 1989-05-25
KR910000236B1 (ko) 1991-01-23
KR890000442A (ko) 1989-03-14
DE3887776T2 (de) 1994-07-07
AU614288B2 (en) 1991-08-29
CA1329207C (en) 1994-05-03
AU615700B2 (en) 1991-10-10
AU1755188A (en) 1988-12-15
EP0294847A1 (en) 1988-12-14
IL86686A (en) 1994-06-24
ATE101601T1 (de) 1994-03-15
CA1329206C (en) 1994-05-03

Similar Documents

Publication Publication Date Title
ES2063000T3 (es) Derivados de nitroazol que contienen fluor y radiosensibilizador que comprende los mismos.
ATE183182T1 (de) S-triazinderivate als lichtschutzmittel
YU47204B (sh) Derivati didehidro-vitamina d3
MX22239A (es) Derivados de n-fenilpirazol.
JPS54157503A (en) Manufacture of organic fluoro compound
ITMI931012A1 (it) Composti spiro-piranici dotati di caratteristiche fotocromatiche
ATE156486T1 (de) Fungizide 3,4-diaryl-(5h)-furan-2-onederivate
IL88665A0 (en) Fluorine-containing nitroimidazole derivatives and radiosensitizer comprising the same
ITMI930819A1 (it) Derivati eterobiciclici ad attivita' fungicida
GR3020420T3 (en) Alkyl derivatives of trazodone with cns activity.
PT713702E (pt) Agente ansiolitico
DE3264545D1 (en) 5-(4-phenyl-1-piperidinyl)methyl-2,3-dihydro-2-oxo-1h-imidazole-4-carboxylic acid derivatives
AU1446892A (en) Novel oxa- or azasteroid derivative
ITMI920225A1 (it) Derivati tiazolici di alcossiacrilati ad attivita' fungicida
ITMI920227A1 (it) Derivati acrilici di 2-tiazolilpirroli ad attivita' fungicida

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 294847

Country of ref document: ES