AU1755188A - Fluorine-containing nitrotriazole derivatives and radiosensitizer comprising the same - Google Patents

Fluorine-containing nitrotriazole derivatives and radiosensitizer comprising the same

Info

Publication number
AU1755188A
AU1755188A AU17551/88A AU1755188A AU1755188A AU 1755188 A AU1755188 A AU 1755188A AU 17551/88 A AU17551/88 A AU 17551/88A AU 1755188 A AU1755188 A AU 1755188A AU 1755188 A AU1755188 A AU 1755188A
Authority
AU
Australia
Prior art keywords
fluorine
radiosensitizer
same
carbon atom
nitrotriazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU17551/88A
Other versions
AU614288B2 (en
Inventor
Mitsuyuki Abe
Yorisato Hisanaga
Tsutomu Kagiya
Tatsuo Nakada
Seiichi Nishimoto
Yuta Shibamoto
Kazuhiro Shimokawa
Toru Yoshizawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daikin Industries Ltd
Original Assignee
YASUNORI NISHIJIMA PRESIDENT K
Kyoto University NUC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP63020456A external-priority patent/JP2848602B2/en
Priority claimed from JP63079230A external-priority patent/JP2602887B2/en
Application filed by YASUNORI NISHIJIMA PRESIDENT K, Kyoto University NUC filed Critical YASUNORI NISHIJIMA PRESIDENT K
Publication of AU1755188A publication Critical patent/AU1755188A/en
Application granted granted Critical
Publication of AU614288B2 publication Critical patent/AU614288B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Catalysts (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

A nitroazole derivative of the formula: NA-Rf (I) wherein NA is 3-nitro-1,2,4-triazol-1-yl or 2-nitroimidazol-1-yl and Rf is a fluorine-containing organic group provide that when NA is 2-nitroimidazol-1-yl, the fluorine-containing organic group has at least one fluorine atom on a carbon atom which bonds to the nitrogen atom of the imidazole ring or a carbon atom which bonds to said carbon atom, which is useful as a raiosensitizer.
AU17551/88A 1987-06-10 1988-06-09 Fluorine-containing nitrotriazole derivatives and radiosensitizer comprising the same Ceased AU614288B2 (en)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
JP62-147459 1987-06-10
JP14745987 1987-06-10
JP15678787 1987-06-24
JP62-156787 1987-06-24
JP62-241574 1987-09-26
JP24157487 1987-09-26
JP31468687 1987-12-10
JP62-314686 1987-12-10
JP63020456A JP2848602B2 (en) 1987-06-24 1988-01-29 New fluorine-containing 2-nitroimidazole and radiosensitizer containing the same
JP63-20456 1988-01-29
JP63079230A JP2602887B2 (en) 1987-06-10 1988-03-31 New fluorine-containing 3-nitro-1,2,4-triazole and radiosensitizer containing the same
JP63-79230 1988-03-31

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU27307/88A Division AU615700B2 (en) 1987-06-10 1988-12-20 Fluorine-containing nitroimidazole derivatives and radiosensitizer comprising the same

Publications (2)

Publication Number Publication Date
AU1755188A true AU1755188A (en) 1988-12-15
AU614288B2 AU614288B2 (en) 1991-08-29

Family

ID=27548921

Family Applications (2)

Application Number Title Priority Date Filing Date
AU17551/88A Ceased AU614288B2 (en) 1987-06-10 1988-06-09 Fluorine-containing nitrotriazole derivatives and radiosensitizer comprising the same
AU27307/88A Ceased AU615700B2 (en) 1987-06-10 1988-12-20 Fluorine-containing nitroimidazole derivatives and radiosensitizer comprising the same

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU27307/88A Ceased AU615700B2 (en) 1987-06-10 1988-12-20 Fluorine-containing nitroimidazole derivatives and radiosensitizer comprising the same

Country Status (9)

Country Link
US (1) US4927941A (en)
EP (1) EP0294847B1 (en)
KR (1) KR910000236B1 (en)
AT (1) ATE101601T1 (en)
AU (2) AU614288B2 (en)
CA (2) CA1329206C (en)
DE (1) DE3887776T2 (en)
ES (1) ES2063000T3 (en)
IL (1) IL86686A (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1329206C (en) * 1987-06-10 1994-05-03 Tsutomu Kagiya Fluorine-containing nitroazole derivatives and radiosensitizer comprising the same
IL92597A0 (en) * 1988-12-14 1990-08-31 Yasunori Nishijima President K Novel fluorine-containing 2-nitroimidazole derivatives and radiosensitizer comprising the same
GB9113487D0 (en) * 1991-06-21 1991-08-07 Amersham Int Plc Agents for hypoxic cells
JP4169782B2 (en) * 1992-11-19 2008-10-22 ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア Detection of hypoxia
US6252087B1 (en) 1992-11-19 2001-06-26 The Trustees Of The University Of Pennsylvania Nitroaromatic compounds for the detection of hypoxia
US6855828B1 (en) 1992-11-19 2005-02-15 The Trustees Of The University Of Pennsylvania Detection of hypoxia
US5721265A (en) * 1994-08-05 1998-02-24 Sri International Fluorinated 2-nitroimidazole analogs for detecting hypoxic tumor cells
US6060604A (en) * 1995-03-31 2000-05-09 Florida State University Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups
US20050026974A1 (en) * 1996-02-08 2005-02-03 Trustees Of The University Of Pennsylvania Detection of hypoxia
US6331286B1 (en) 1998-12-21 2001-12-18 Photogen, Inc. Methods for high energy phototherapeutics
US8974363B2 (en) * 1997-12-11 2015-03-10 Provectus Pharmatech, Inc. Topical medicaments and methods for photodynamic treatment of disease
US20090117199A1 (en) * 1998-08-06 2009-05-07 Scott Timothy C Method of treatment of cancer
US8557298B2 (en) * 1998-08-06 2013-10-15 Provectus Pharmatech, Inc. Medicaments for chemotherapeutic treatment of disease
US8470296B2 (en) * 1998-12-21 2013-06-25 Provectus Pharmatech, Inc. Intracorporeal medicaments for high energy phototherapeutic treatment of disease
US20020001567A1 (en) * 1998-12-21 2002-01-03 Photogen, Inc. Intracorporeal medicaments for high energy phototherapeutic treatment of disease
US7384623B1 (en) 1998-12-21 2008-06-10 Provectus Pharmatech, Inc. High energy phototherapeutic agents
WO2004060346A2 (en) 2002-12-30 2004-07-22 Angiotech International Ag Drug delivery from rapid gelling polymer composition
CA2514841A1 (en) * 2003-02-02 2004-08-19 Palo Alto Institute Of Molecular Medicine Cell-killing molecules and methods of use thereof
US7875602B2 (en) 2005-10-21 2011-01-25 Sutter West Bay Hospitals Camptothecin derivatives as chemoradiosensitizing agents
US9056136B2 (en) * 2006-10-06 2015-06-16 Natural Pharmacia International, Inc. Weakly basic 2-nitroimidazoles for the non-invasive detection of tissue hypoxia
WO2021224186A1 (en) * 2020-05-04 2021-11-11 Institut Curie New pyridine derivatives as radiosensitizers
CN115745953B (en) * 2022-06-29 2024-06-11 上海凌凯医药科技有限公司 Hydroxyl fluoro reagent and hydroxyl fluoro method

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE47132B1 (en) * 1977-08-19 1983-12-28 Roche Products Ltd Novel nitroimidazoles and pharmaceutical preparations containing these as well as their manufacture
ZW8781A1 (en) * 1980-05-23 1981-12-16 Hoffmann La Roche 2-nitroimidazoles and preparation thereof
CA1227211A (en) * 1982-05-27 1987-09-22 Israr Ahmed Nitro imidazolyl aziridino propanols
US4581368A (en) * 1982-05-27 1986-04-08 National Research Development Corporation Aziridino containing nitro imidazoles and pharmaceutical compositions
US4820844A (en) * 1985-08-15 1989-04-11 Adeka Argus Chemical Co., Ltd. Radiation sensitizer
CA1329206C (en) * 1987-06-10 1994-05-03 Tsutomu Kagiya Fluorine-containing nitroazole derivatives and radiosensitizer comprising the same

Also Published As

Publication number Publication date
DE3887776D1 (en) 1994-03-24
DE3887776T2 (en) 1994-07-07
CA1329207C (en) 1994-05-03
ATE101601T1 (en) 1994-03-15
KR890000442A (en) 1989-03-14
IL86686A (en) 1994-06-24
AU615700B2 (en) 1991-10-10
EP0294847B1 (en) 1994-02-16
ES2063000T3 (en) 1995-01-01
AU2730788A (en) 1989-05-25
IL86686A0 (en) 1988-11-30
KR910000236B1 (en) 1991-01-23
AU614288B2 (en) 1991-08-29
EP0294847A1 (en) 1988-12-14
CA1329206C (en) 1994-05-03
US4927941A (en) 1990-05-22

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired