DK0513351T3 - 2-Nitroimidazolderivat, fremstilling deraf og strålingssensibilisator indeholdende samme som aktiv bestanddel - Google Patents

2-Nitroimidazolderivat, fremstilling deraf og strålingssensibilisator indeholdende samme som aktiv bestanddel

Info

Publication number
DK0513351T3
DK0513351T3 DK91902775.5T DK91902775T DK0513351T3 DK 0513351 T3 DK0513351 T3 DK 0513351T3 DK 91902775 T DK91902775 T DK 91902775T DK 0513351 T3 DK0513351 T3 DK 0513351T3
Authority
DK
Denmark
Prior art keywords
active ingredient
preparation
containing same
nitroimidazole derivative
radiation sensitizer
Prior art date
Application number
DK91902775.5T
Other languages
English (en)
Inventor
Toshimitsu Suzuki
Masakazu Sakaguchi
Yoshiyuki Miyata
Akira Suzuki
Tomoyuki Mori
Original Assignee
Pola Chem Ind Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pola Chem Ind Inc filed Critical Pola Chem Ind Inc
Application granted granted Critical
Publication of DK0513351T3 publication Critical patent/DK0513351T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK91902775.5T 1990-01-26 1991-01-24 2-Nitroimidazolderivat, fremstilling deraf og strålingssensibilisator indeholdende samme som aktiv bestanddel DK0513351T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2016721A JP2626727B2 (ja) 1990-01-26 1990-01-26 ２―ニトロイミダゾール誘導体、その製造法及びこれを有効成分とする放射線増感剤

Publications (1)

Publication Number Publication Date
DK0513351T3 true DK0513351T3 (da) 1996-11-25

Family

ID=11924130

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91902775.5T DK0513351T3 (da) 1990-01-26 1991-01-24 2-Nitroimidazolderivat, fremstilling deraf og strålingssensibilisator indeholdende samme som aktiv bestanddel

Country Status (10)

Country Link
US (1) US5270330A (da)
EP (1) EP0513351B1 (da)
JP (1) JP2626727B2 (da)
KR (2) KR927003539A (da)
AT (1) ATE143950T1 (da)
CA (1) CA2074533C (da)
DE (1) DE69122605T2 (da)
DK (1) DK0513351T3 (da)
ES (1) ES2094218T3 (da)
WO (1) WO1991011440A1 (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0632028B1 (en) * 1992-12-18 2003-04-02 Pola Chemical Industries, Inc. Optically active 2-nitroimidazole derivative, process for producing the same, and intermediate for producing the same
US5700825A (en) * 1995-03-31 1997-12-23 Florida State University Radiosensitizing diamines and their pharmaceutical preparations
US6060604A (en) * 1995-03-31 2000-05-09 Florida State University Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups
US6331286B1 (en) 1998-12-21 2001-12-18 Photogen, Inc. Methods for high energy phototherapeutics
US5929104A (en) * 1997-04-02 1999-07-27 Pola Chemical Industries, Inc. Method for inducing apoptosis of cancer cell
US8974363B2 (en) 1997-12-11 2015-03-10 Provectus Pharmatech, Inc. Topical medicaments and methods for photodynamic treatment of disease
US8557298B2 (en) 1998-08-06 2013-10-15 Provectus Pharmatech, Inc. Medicaments for chemotherapeutic treatment of disease
US7384623B1 (en) 1998-12-21 2008-06-10 Provectus Pharmatech, Inc. High energy phototherapeutic agents
US20020001567A1 (en) * 1998-12-21 2002-01-03 Photogen, Inc. Intracorporeal medicaments for high energy phototherapeutic treatment of disease
US8470296B2 (en) * 1998-12-21 2013-06-25 Provectus Pharmatech, Inc. Intracorporeal medicaments for high energy phototherapeutic treatment of disease
JP2006516548A (ja) 2002-12-30 2006-07-06 アンジオテック インターナショナル アクツィエン ゲゼルシャフト 迅速ゲル化ポリマー組成物からの薬物送達法
JP2006522021A (ja) * 2003-02-03 2006-09-28 パロ アルト インスティチュート オブ モレキュラー メディシン 殺細胞分子およびその使用方法
ZA200507752B (en) * 2003-03-28 2007-01-31 Threshold Pharmaceuticals Inc Compositions and methods for treating cancer
WO2005086951A2 (en) * 2004-03-10 2005-09-22 Threshold Pharmaceuticals, Inc. Hypoxia-activated anti-cancer agents
EP1734046B1 (en) * 2004-06-24 2010-09-01 Toyo Suisan Kaisha, Ltd. Sulfopyranosylacylglycerol derivatives for use in combination with irradiation in an anti-tumor radiation treatment
WO2006078903A1 (en) * 2005-01-21 2006-07-27 Matthews Richard H Radiosensitizer formulations comprising nitrohistidine derivatives
PL1896040T3 (pl) 2005-06-29 2012-12-31 Threshold Pharmaceuticals Inc Proleki alkilatora fosforoamidowego
US8552048B2 (en) * 2006-12-26 2013-10-08 Threshold Pharmaceuticals, Inc. Phosphoramidate alkylator prodrugs for the treatment of cancer
JP5213178B2 (ja) 2007-01-23 2013-06-19 株式会社ポーラファルマ ２−ニトロイミダゾール誘導体の製造法
DK2116241T3 (da) 2007-01-26 2016-06-06 Pola Pharma Inc Farmaceutisk sammensætning
EP2156832B1 (en) 2007-06-14 2014-06-25 Pola Pharma Inc. Pharmaceutical composition
US20090118031A1 (en) * 2007-11-01 2009-05-07 Qualizza Gregory K Shaft Structure with Configurable Bending Profile
JP6071715B2 (ja) * 2013-03-22 2017-02-01 株式会社ポーラファルマ ドラニダゾール構成光学異性体の製造方法
JP6082644B2 (ja) * 2013-03-22 2017-02-15 株式会社ポーラファルマ ドラニダゾール構成光学異性体の製造方法
US11400076B2 (en) 2017-10-02 2022-08-02 Keio University Cancer stem cell inhibitor

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4462992A (en) * 1982-02-08 1984-07-31 Research Corporation Nitroimidazole radiosensitizers for hypoxic tumor cells and compositions thereof
JPS59139363A (ja) * 1983-01-31 1984-08-10 Kayaku:Kk ２−ニトロイミダゾ−ル誘導体およびその製造法
JPS6075430A (ja) * 1983-08-31 1985-04-27 Kayaku:Kk 放射線増感剤
JPH0819111B2 (ja) * 1987-10-22 1996-02-28 ポーラ化成工業株式会社 ２―ニトロイミダゾール誘導体及びこれを有効成分とする放射線増感剤
JP3291590B2 (ja) * 1992-08-26 2002-06-10 キヤノン株式会社 カラートナー、カラー現像剤及び画像形成方法

Also Published As

Publication number Publication date
KR0145333B1 (en) 1998-07-15
ES2094218T3 (es) 1997-01-16
CA2074533A1 (en) 1991-07-27
EP0513351A1 (en) 1992-11-19
CA2074533C (en) 2000-10-17
ATE143950T1 (de) 1996-10-15
WO1991011440A1 (fr) 1991-08-08
EP0513351B1 (en) 1996-10-09
EP0513351A4 (en) 1993-11-10
JPH03223258A (ja) 1991-10-02
DE69122605T2 (de) 1997-02-13
DE69122605D1 (de) 1996-11-14
JP2626727B2 (ja) 1997-07-02
US5270330A (en) 1993-12-14
KR927003539A (ko) 1992-12-18

Similar Documents

Publication Publication Date Title
DK0513351T3 (da) 2-Nitroimidazolderivat, fremstilling deraf og strålingssensibilisator indeholdende samme som aktiv bestanddel
DK0471236T3 (da) Imidazopyridinderivater og deres anvendelse
DK0378255T3 (da) 2-aminopyrimidinoderivater
NO180679C (no) Pyranylcyanoguanidin-derivater, preparater som inneholder dem og anvendelse derav
ES2167463T3 (es) Componentes de un compuesto medicinal que comprenden derivados n-sustituidos de la o-toluidina y preparacion percutaneamente absorbible.
HU206701B (en) Process for producing substituted flavonoid derivatives and salts and pharmaceutical compositions containing these compounds
MY103241A (en) Imidazole and 1,2,4 triazole derivatives
ES2091489T3 (es) Derivados de imidazol y composiciones farmaceuticas que los contienen.
NO961236L (no) Pyrrolodiazin-derivater som stabilisatorer for klorholdige polymerisater
TR199800813T2 (xx) Nitrik oksit sintaz�n�n �nleyicileri olarak amidin, isot�re t�revleri.
NO922151L (no) Gingerol og gingerdiolderivater som hypokolesterolemiske og antiatherosklerotiske midler
EP0266559A3 (en) Therapeutic agent for the treatment of peptic ulcer disease
NO179755C (no) Fremgangsmåte for fremstilling av deoksymulundocandin
NO832723L (no) Fremgangsmaate for oksydasjon av vinylbenzenforbindelser
NO923983D0 (no) Bisfenyletanderivater, fremgangsmaate for deres fremstilling og deres terapeutiske anvendelse
PL297368A1 (en) Novel derivatives of 2h-benzo (b) pyrane substituted with aryl or n-heteroaryl at position 4, method of obtaining them and their applications as well as preparation containing these compounds
FI854985A (fi) Foerfarande foer framstaellning av farmaceutiskt aktiva n-substituerade aziridin-2-karboxylsyraderivat.
NO932002L (no) Nye tiosemikarbazonsyreestere
ES8207542A1 (es) Un procedimiento para la preparacion de 1rs,4rs,5rs-4-(4,8 dimetil-5-hidroxi-7-nomen-1-1-il)-4-metil-3,8-dioxabiciclo(3.2.1)octano-1.aletico.
ATE163005T1 (de) Saintopin derivate
DK669388A (da) Azolderivater
SU1154907A1 (ru) Дигидрохлорид 3-(2-диэтиламиноэтилтио)-5-(2-морфолиноэтил)-1,2,4-триазино(5,6-в)индола, обладающий стресспротективной активностью
SU1573800A1 (ru) Производные о-аминобензойной кислоты, обладающие фунгицидными свойствами
SU1139143A1 (ru) Гидрохлорид 3-(2-диэтиламиноэтилтио)-9-метил-1,2,4-триазино/6,5-в/ индола, обладающий противогипоксической активностью
SU976666A1 (ru) 2,3-дифенилтиазоло /3',2',2,3/-1,2,4-триазино-/5,6-b/ индол, обладающий противовоспалительной активностью