ES8207542A1 - Un procedimiento para la preparacion de 1rs,4rs,5rs-4-(4,8 dimetil-5-hidroxi-7-nomen-1-1-il)-4-metil-3,8-dioxabiciclo(3.2.1)octano-1.aletico. - Google Patents
Un procedimiento para la preparacion de 1rs,4rs,5rs-4-(4,8 dimetil-5-hidroxi-7-nomen-1-1-il)-4-metil-3,8-dioxabiciclo(3.2.1)octano-1.aletico.Info
- Publication number
- ES8207542A1 ES8207542A1 ES501775A ES501775A ES8207542A1 ES 8207542 A1 ES8207542 A1 ES 8207542A1 ES 501775 A ES501775 A ES 501775A ES 501775 A ES501775 A ES 501775A ES 8207542 A1 ES8207542 A1 ES 8207542A1
- Authority
- ES
- Spain
- Prior art keywords
- nonen
- dioxabicyclo
- octane
- hydroxy
- dimethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- GHVNFZFCNZKVNT-UHFFFAOYSA-N Decanoic acid Natural products CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 title 1
- 238000006257 total synthesis reaction Methods 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/32—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by aldehydo- or ketonic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Epoxy Compounds (AREA)
Abstract
UN PROCEDIMIENTO PARA LA PREPARACION DE 1RS, 4SR, 5RS-4(4, 8-DIMETIL-5-HIDROXI-7-NOMEN-1-IL)-4METIL-3, 8-DIXOABICICLO 3.2.1'' OCTANO-1ACETICO. CONSTA DE LAS SIGUENTES OPERACIONES: 1. REACCION DEL COMPUESTO (I) CON TRIMETILSILLILO. 2. REACCION DEL ENOL-SILIL-ESTER OBTENIDO CON UN AGENTE BROMANTE. 3. REACCION DEL BROMURO OBTENIDO CON UN PEROXIACIDO PARA OBTENER EL EPOXIDO CORRESPONDIENTE. 4. REACCION DEL EPOXIDO CON ACIDO PERYODICO. 5. REACCION DEL ALDEHIDO OBTENIDO CON UN AGENTE OXIDANTE. 6. REACCION DEL ACIDO FORMADO CON UN PERXOACIDO. 7. REACCION DE LA GAMMA-LACTONA DE BROMO-HEMICETAL OBTENIDA CON UN ORTOFORMIATO DE TRIALIQUILO, PARA FORMAR UNA MEZCLA DE LACTONAS DE CIS/TRANSBROMOCETAL. 8. CICLAR LA LACTONA PARA FORMAR UN CETAL-ACIDO BICICLICLO. 9. REDUCCION DEL CETAL-ACIDO OBTENIDO. 10. REACCION DEL ALCOHOL OBTENIDO CON CLORURO DE METANOSULFONILO. 11. REACCION DEL MESILATO CON EL COMPUESTO (II). 12. HIDROLIZAR Y DESCARBOXILAR EL ESTER CARBOXILICO. 13. REDUCIR LA CETONA FORMADA. 14. ESTERIFICAR EL ALCOHOL OBTENIDO. 15. REACCION DEL CETAL CON UN ACIDO. 16. REACCION DEL HEMICETAL CON (CARBETOXIMETILEN) TRIFENILOSFORANO. 17 ISOMERIZAR EL ESTER 8-NONENILICO PARA FORMAR EL ESTER 7-NONELILICO. 17. HIDROLISIS DEL ESTER OBTENIDO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/146,538 US4284565A (en) | 1980-05-02 | 1980-05-02 | Total synthesis of 1RS,4SR,5RS-4-(4,8-dimethyl)-5-hydroxy-7-nonen-1-yl)-4-methyl-3,8-dioxabicyclo[3.2.1]octane-1-acetic acid and related compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES501775A0 ES501775A0 (es) | 1982-09-16 |
| ES8207542A1 true ES8207542A1 (es) | 1982-09-16 |
Family
ID=22517836
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES501775A Expired ES8207542A1 (es) | 1980-05-02 | 1981-04-29 | Un procedimiento para la preparacion de 1rs,4rs,5rs-4-(4,8 dimetil-5-hidroxi-7-nomen-1-1-il)-4-metil-3,8-dioxabiciclo(3.2.1)octano-1.aletico. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4284565A (es) |
| EP (2) | EP0116375B1 (es) |
| JP (1) | JPS56169692A (es) |
| KR (1) | KR850000046B1 (es) |
| AU (1) | AU536915B2 (es) |
| CA (1) | CA1170266A (es) |
| DE (1) | DE3169505D1 (es) |
| DK (1) | DK151966B (es) |
| ES (1) | ES8207542A1 (es) |
| FI (1) | FI74708C (es) |
| GR (1) | GR67294B (es) |
| IE (1) | IE52148B1 (es) |
| IL (1) | IL62768A (es) |
| NO (1) | NO152415C (es) |
| NZ (1) | NZ196835A (es) |
| PH (1) | PH16215A (es) |
| YU (1) | YU112281A (es) |
| ZA (1) | ZA812923B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4603213A (en) * | 1984-09-27 | 1986-07-29 | Ortho Pharmaceutical Corporation | Total synthesis of 1RS,4SR,5RS-4-(4,8-dimethyl-5-hydroxy-7-nonen-1-yl)-4-methyl-3,8-dioxabicyclo[3.2.1]octane-1-acetic acid |
| GB2348879B (en) | 1999-04-16 | 2004-03-31 | Hydron Ltd | Process |
| US7905183B2 (en) * | 2008-01-29 | 2011-03-15 | Gibson Daniel J | Structural cardboard runner, pallet, shipping article |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2322821A (en) * | 1940-06-22 | 1943-06-29 | Atlas Powder Co | Partial esters of ethers of polyhydroxylic compounds |
| US2771471A (en) * | 1950-12-01 | 1956-11-20 | Petrolite Corp | Polycarboxy acid esters of oxypropylated hexides |
| US4102895A (en) * | 1976-11-18 | 1978-07-25 | Ortho Pharmaceutical Corporation | Oxepanes |
| US4237055A (en) * | 1979-06-18 | 1980-12-02 | Ortho Pharmaceutical Corporation | Synthesis of 1RS,4SR,5RS-4-(4,8-dimethyl-5-hydroxy-7-nonen-1-yl)-4-methyl-3,8-dioxabicyclo[3.2.1]octane-1-acetic acid |
-
1980
- 1980-05-02 US US06/146,538 patent/US4284565A/en not_active Expired - Lifetime
-
1981
- 1981-04-02 CA CA000374497A patent/CA1170266A/en not_active Expired
- 1981-04-13 PH PH25494A patent/PH16215A/en unknown
- 1981-04-14 KR KR1019810001261A patent/KR850000046B1/ko active IP Right Grant
- 1981-04-15 NZ NZ196835A patent/NZ196835A/xx unknown
- 1981-04-21 JP JP5932581A patent/JPS56169692A/ja active Pending
- 1981-04-28 AU AU69903/81A patent/AU536915B2/en not_active Ceased
- 1981-04-29 GR GR64810A patent/GR67294B/el unknown
- 1981-04-29 ES ES501775A patent/ES8207542A1/es not_active Expired
- 1981-04-29 FI FI811351A patent/FI74708C/fi not_active IP Right Cessation
- 1981-04-30 NO NO811475A patent/NO152415C/no unknown
- 1981-04-30 IE IE965/81A patent/IE52148B1/en unknown
- 1981-04-30 IL IL62768A patent/IL62768A/xx unknown
- 1981-04-30 YU YU01122/81A patent/YU112281A/xx unknown
- 1981-05-01 EP EP84200026A patent/EP0116375B1/en not_active Expired
- 1981-05-01 EP EP81301934A patent/EP0039595B1/en not_active Expired
- 1981-05-01 DE DE8181301934T patent/DE3169505D1/de not_active Expired
- 1981-05-01 ZA ZA00812923A patent/ZA812923B/xx unknown
- 1981-05-01 DK DK195381AA patent/DK151966B/da not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| FI74708C (fi) | 1988-03-10 |
| YU112281A (en) | 1983-09-30 |
| IL62768A0 (en) | 1981-06-29 |
| EP0116375B1 (en) | 1986-11-12 |
| ZA812923B (en) | 1982-12-29 |
| GR67294B (es) | 1981-06-29 |
| KR850000046B1 (ko) | 1985-02-14 |
| ES501775A0 (es) | 1982-09-16 |
| AU6990381A (en) | 1981-11-05 |
| US4284565A (en) | 1981-08-18 |
| NO811475L (no) | 1981-11-03 |
| IE52148B1 (en) | 1987-07-08 |
| FI811351L (fi) | 1981-11-03 |
| DE3169505D1 (en) | 1985-05-02 |
| AU536915B2 (en) | 1984-05-31 |
| CA1170266A (en) | 1984-07-03 |
| NO152415C (no) | 1985-09-25 |
| EP0116375A1 (en) | 1984-08-22 |
| FI74708B (fi) | 1987-11-30 |
| EP0039595A1 (en) | 1981-11-11 |
| EP0039595B1 (en) | 1985-03-27 |
| NZ196835A (en) | 1983-11-18 |
| IL62768A (en) | 1984-03-30 |
| IE810965L (en) | 1981-11-02 |
| DK195381A (da) | 1981-11-03 |
| JPS56169692A (en) | 1981-12-26 |
| PH16215A (en) | 1983-08-05 |
| DK151966B (da) | 1988-01-18 |
| NO152415B (no) | 1985-06-17 |
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