PT632028E - Derivado opticamente activo do 2-nitroimidazole processo para a producao do mesmo e intermediario para a producao do mesmo - Google Patents

Derivado opticamente activo do 2-nitroimidazole processo para a producao do mesmo e intermediario para a producao do mesmo

Info

Publication number
PT632028E
PT632028E PT93923039T PT93923039T PT632028E PT 632028 E PT632028 E PT 632028E PT 93923039 T PT93923039 T PT 93923039T PT 93923039 T PT93923039 T PT 93923039T PT 632028 E PT632028 E PT 632028E
Authority
PT
Portugal
Prior art keywords
same
production
optically active
nitroimidazole
intermediary
Prior art date
Application number
PT93923039T
Other languages
English (en)
Inventor
Toshimitsu Suzuki
Azuma Nishio
Original Assignee
Pola Chem Ind Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pola Chem Ind Inc filed Critical Pola Chem Ind Inc
Publication of PT632028E publication Critical patent/PT632028E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/63—Halogen-containing esters of saturated acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/78—Benzoic acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PT93923039T 1992-12-18 1993-10-21 Derivado opticamente activo do 2-nitroimidazole processo para a producao do mesmo e intermediario para a producao do mesmo PT632028E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP33903592 1992-12-18
JP1653093 1993-02-03

Publications (1)

Publication Number Publication Date
PT632028E true PT632028E (pt) 2003-08-29

Family

ID=26352886

Family Applications (1)

Application Number Title Priority Date Filing Date
PT93923039T PT632028E (pt) 1992-12-18 1993-10-21 Derivado opticamente activo do 2-nitroimidazole processo para a producao do mesmo e intermediario para a producao do mesmo

Country Status (9)

Country Link
US (1) US5532380A (pt)
EP (1) EP0632028B1 (pt)
JP (2) JP3577079B2 (pt)
AT (1) ATE236131T1 (pt)
DE (1) DE69332821T2 (pt)
DK (1) DK0632028T3 (pt)
ES (1) ES2199221T3 (pt)
PT (1) PT632028E (pt)
WO (1) WO1994014778A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006078903A1 (en) * 2005-01-21 2006-07-27 Matthews Richard H Radiosensitizer formulations comprising nitrohistidine derivatives
DK2116241T3 (en) * 2007-01-26 2016-06-06 Pola Pharma Inc pharmaceutical composition
WO2008152764A1 (ja) 2007-06-14 2008-12-18 Pola Pharma Inc. 医薬組成物
CN101642452B (zh) * 2008-08-06 2014-05-28 株式会社宝丽制药 脑肿瘤用放射线敏化剂
CN101805323B (zh) * 2010-03-23 2012-09-26 深圳万乐药业有限公司 一种合成Doranidazole中间体的非对映异构体的方法
JP6071715B2 (ja) * 2013-03-22 2017-02-01 株式会社ポーラファルマ ドラニダゾール構成光学異性体の製造方法
JP7353606B2 (ja) 2017-10-02 2023-10-02 慶應義塾 癌幹細胞インヒビター

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2314454A (en) * 1938-08-19 1943-03-23 Gen Aniline & Film Corp Production of esters of halogen alcohols
US2377878A (en) * 1941-12-24 1945-06-12 Du Pont Dioxolane-acid halide reaction and product
US2901506A (en) * 1956-12-06 1959-08-25 American Cyanamid Co Pyrolysis of substituted carbonyloxyalkyl halides
NL292912A (pt) * 1962-05-18
US3468902A (en) * 1966-06-10 1969-09-23 Hoffmann La Roche 1-substituted-2-nitroimidazole derivatives
CH526506A (de) * 1970-05-27 1972-08-15 Sandoz Ag Verfahren zur Herstellung von 2,2-Bis-(brommethyl)-propandiol-1,3-diacetat
ZW8781A1 (en) * 1980-05-23 1981-12-16 Hoffmann La Roche 2-nitroimidazoles and preparation thereof
US4462992A (en) * 1982-02-08 1984-07-31 Research Corporation Nitroimidazole radiosensitizers for hypoxic tumor cells and compositions thereof
JPS58170725A (ja) * 1982-03-31 1983-10-07 Ono Pharmaceut Co Ltd グリセリン誘導体
JPS59139363A (ja) * 1983-01-31 1984-08-10 Kayaku:Kk ２−ニトロイミダゾ−ル誘導体およびその製造法
JPS62283943A (ja) * 1986-05-30 1987-12-09 Taisho Pharmaceut Co Ltd スレイト−ル化合物およびその製造方法
JPS6330491A (ja) * 1986-07-22 1988-02-09 Sankyo Co Ltd 環状ウレタン構造を有する燐酸エステル誘導体
JPH0819111B2 (ja) * 1987-10-22 1996-02-28 ポーラ化成工業株式会社 ２―ニトロイミダゾール誘導体及びこれを有効成分とする放射線増感剤
KR927003539A (ko) * 1990-01-26 1992-12-18 스즈끼 쯔네시 2-니트로 이미다졸 유도체, 그의 제조방법 및 이를 유효성분으로 하는 방사선 증감제
JP2683613B2 (ja) * 1990-01-30 1997-12-03 出光石油化学株式会社 スチレン系樹脂から成る射出成形品

Also Published As

Publication number Publication date
WO1994014778A1 (en) 1994-07-07
JP2003321459A (ja) 2003-11-11
US5532380A (en) 1996-07-02
EP0632028A4 (en) 1995-03-29
ATE236131T1 (de) 2003-04-15
DK0632028T3 (da) 2003-07-21
ES2199221T3 (es) 2004-02-16
JP3577079B2 (ja) 2004-10-13
DE69332821T2 (de) 2003-11-13
EP0632028B1 (en) 2003-04-02
EP0632028A1 (en) 1995-01-04
DE69332821D1 (de) 2003-05-08

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