DE69332821D1 - Optisch aktives 2-nitroimidazolderivat, verfahren zu seiner herstellung und ein intermediat zu seiner herstellung - Google Patents

Optisch aktives 2-nitroimidazolderivat, verfahren zu seiner herstellung und ein intermediat zu seiner herstellung

Info

Publication number
DE69332821D1
DE69332821D1 DE69332821T DE69332821T DE69332821D1 DE 69332821 D1 DE69332821 D1 DE 69332821D1 DE 69332821 T DE69332821 T DE 69332821T DE 69332821 T DE69332821 T DE 69332821T DE 69332821 D1 DE69332821 D1 DE 69332821D1
Authority
DE
Germany
Prior art keywords
producing
optically active
nitroimidazole derivative
nitroimidazole
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69332821T
Other languages
English (en)
Other versions
DE69332821T2 (de
Inventor
Toshimitsu Suzuki
Azuma Nishio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pola Chemical Industries Inc
Original Assignee
Pola Chemical Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pola Chemical Industries Inc filed Critical Pola Chemical Industries Inc
Publication of DE69332821D1 publication Critical patent/DE69332821D1/de
Application granted granted Critical
Publication of DE69332821T2 publication Critical patent/DE69332821T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/63—Halogen-containing esters of saturated acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/78—Benzoic acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE69332821T 1992-12-18 1993-10-21 Optisch aktives 2-nitroimidazolderivat, verfahren zu seiner herstellung und ein intermediat zu seiner herstellung Expired - Lifetime DE69332821T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP33903592 1992-12-18
JP1653093 1993-02-03
PCT/JP1993/001519 WO1994014778A1 (en) 1992-12-18 1993-10-21 Optically active 2-nitroimidazole derivative, process for producing the same, and intermediate for producing the same

Publications (2)

Publication Number Publication Date
DE69332821D1 true DE69332821D1 (de) 2003-05-08
DE69332821T2 DE69332821T2 (de) 2003-11-13

Family

ID=26352886

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69332821T Expired - Lifetime DE69332821T2 (de) 1992-12-18 1993-10-21 Optisch aktives 2-nitroimidazolderivat, verfahren zu seiner herstellung und ein intermediat zu seiner herstellung

Country Status (9)

Country Link
US (1) US5532380A (de)
EP (1) EP0632028B1 (de)
JP (2) JP3577079B2 (de)
AT (1) ATE236131T1 (de)
DE (1) DE69332821T2 (de)
DK (1) DK0632028T3 (de)
ES (1) ES2199221T3 (de)
PT (1) PT632028E (de)
WO (1) WO1994014778A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1838305A1 (de) * 2005-01-21 2007-10-03 Richard H. Matthews Radiosensitizer-formulierungen mit nitrohistidinderivaten
EP2116241B1 (de) * 2007-01-26 2016-04-27 Pola Pharma Inc. Pharmazeutische zusammensetzung
WO2008152764A1 (ja) 2007-06-14 2008-12-18 Pola Pharma Inc. 医薬組成物
CN101642452B (zh) * 2008-08-06 2014-05-28 株式会社宝丽制药 脑肿瘤用放射线敏化剂
CN101805323B (zh) * 2010-03-23 2012-09-26 深圳万乐药业有限公司 一种合成Doranidazole中间体的非对映异构体的方法
JP6071715B2 (ja) * 2013-03-22 2017-02-01 株式会社ポーラファルマ ドラニダゾール構成光学異性体の製造方法
EP3692990A4 (de) 2017-10-02 2021-06-30 Keio University Krebsstammzellinhibitor

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2314454A (en) * 1938-08-19 1943-03-23 Gen Aniline & Film Corp Production of esters of halogen alcohols
US2377878A (en) * 1941-12-24 1945-06-12 Du Pont Dioxolane-acid halide reaction and product
US2901506A (en) * 1956-12-06 1959-08-25 American Cyanamid Co Pyrolysis of substituted carbonyloxyalkyl halides
NL292912A (de) * 1962-05-18
US3468902A (en) * 1966-06-10 1969-09-23 Hoffmann La Roche 1-substituted-2-nitroimidazole derivatives
CH526506A (de) * 1970-05-27 1972-08-15 Sandoz Ag Verfahren zur Herstellung von 2,2-Bis-(brommethyl)-propandiol-1,3-diacetat
ZW8781A1 (en) * 1980-05-23 1981-12-16 Hoffmann La Roche 2-nitroimidazoles and preparation thereof
US4462992A (en) * 1982-02-08 1984-07-31 Research Corporation Nitroimidazole radiosensitizers for hypoxic tumor cells and compositions thereof
JPS58170725A (ja) * 1982-03-31 1983-10-07 Ono Pharmaceut Co Ltd グリセリン誘導体
JPS59139363A (ja) * 1983-01-31 1984-08-10 Kayaku:Kk ２−ニトロイミダゾ−ル誘導体およびその製造法
JPS62283943A (ja) * 1986-05-30 1987-12-09 Taisho Pharmaceut Co Ltd スレイト−ル化合物およびその製造方法
JPS6330491A (ja) * 1986-07-22 1988-02-09 Sankyo Co Ltd 環状ウレタン構造を有する燐酸エステル誘導体
JPH0819111B2 (ja) * 1987-10-22 1996-02-28 ポーラ化成工業株式会社 ２―ニトロイミダゾール誘導体及びこれを有効成分とする放射線増感剤
KR927003539A (ko) * 1990-01-26 1992-12-18 스즈끼 쯔네시 2-니트로 이미다졸 유도체, 그의 제조방법 및 이를 유효성분으로 하는 방사선 증감제
JP2683613B2 (ja) * 1990-01-30 1997-12-03 出光石油化学株式会社 スチレン系樹脂から成る射出成形品

Also Published As

Publication number Publication date
EP0632028A4 (de) 1995-03-29
ES2199221T3 (es) 2004-02-16
WO1994014778A1 (en) 1994-07-07
EP0632028B1 (de) 2003-04-02
US5532380A (en) 1996-07-02
PT632028E (pt) 2003-08-29
JP2003321459A (ja) 2003-11-11
ATE236131T1 (de) 2003-04-15
JP3577079B2 (ja) 2004-10-13
DK0632028T3 (da) 2003-07-21
DE69332821T2 (de) 2003-11-13
EP0632028A1 (de) 1995-01-04

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Legal Events

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