KR920008028A - 피리딘 유도체, 이의 제조방법 및 용도 - Google Patents

피리딘 유도체, 이의 제조방법 및 용도 Download PDF

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Publication number
KR920008028A
KR920008028A KR1019910018297A KR910018297A KR920008028A KR 920008028 A KR920008028 A KR 920008028A KR 1019910018297 A KR1019910018297 A KR 1019910018297A KR 910018297 A KR910018297 A KR 910018297A KR 920008028 A KR920008028 A KR 920008028A
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KR
South Korea
Prior art keywords
compound
hydrogen
formula
methyl
acceptable salt
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KR1019910018297A
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English (en)
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KR100199356B1 (ko
Inventor
다까시 쇼다
노브히로 이나또미
Original Assignee
모리따 가쓰라
다께다야꾸힝고오교 가부시끼가이샤
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Publication of KR920008028A publication Critical patent/KR920008028A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

내용 없음

Description

피리딘 유도체, 이의 제조방법 및 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 하기 일반식( I )의 화합물 또는 약제학적으로 허용되는 이의 염 :
    상기식에서, R1은 벤젠환상의 치환기이고, R2는 R3은 수소 또는 메틸이며, n은 0 또는 1이다.
  2. 제1항에 있어서, R1이 수소, 히드록실시, 불소, 디플루오로메톡시 또는 트리플루오로메틸인 화합물.
  3. 제1항에 있어서, R1이 수소인 화합물.
  4. 제1항에 있어서, R2이 메틸인 화합물.
  5. 제1항에 있어서, R3이 수소인 화합물.
  6. 제1항에 있어서, n이 1인 화합물.
  7. 제1항에 있어서, 화합물이 2-[(4-디플루오로메톡시-3-메틸-2-피리딜)메틸설피닐]벤즈이미다졸인 화합물.
  8. 하기 일반식(Ⅱ)의 화합물을 클로로디플루오로메탄과 반응시키고, 경우에 따라, 반응 생성물을 산화시킴을 특징으로 하는 하기 일반식( I )의 피리딘 유도체 또는 약제학적으로 허용되는 이의 염의 제조방법 :
    상기식에서, R1및 R4는 벤젠환상의 치환기이고, R2및 R3은 각각 수소 또는 메틸이며, n은 0 또는 1이다.
  9. 제8항에 있어서, R1은 수소, 히드록실기, 불소, 디플루오로메틸 또는 트리플루오로메틸이고, R4는 수소, 히드록실기, 불소 또는 트리플루오로메틸인 방법.
  10. 유효량의 하기 일반식( I )의 화합물 또는 약제학적으로 허용되는 이의 염 및 담체를 함유함을 특징으로 하는 소화성 궤양의 예방 또는 치료용 약제학적 조성물 :
    상기식에서, R1은 벤젠환상의 치환기이고, R2및 R3은 수소 또는 메틸이며, n은 0 또는 1이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910018297A 1990-10-17 1991-10-17 피리딘유도체, 이의 제조방법 및 용도 KR100199356B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP28033190 1990-10-17
JP90-280331 1990-10-17
JP91-149045 1991-06-21
JP14904591 1991-06-21
JP91-194045 1991-06-27

Publications (2)

Publication Number Publication Date
KR920008028A true KR920008028A (ko) 1992-05-27
KR100199356B1 KR100199356B1 (ko) 1999-06-15

Family

ID=26479053

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910018297A KR100199356B1 (ko) 1990-10-17 1991-10-17 피리딘유도체, 이의 제조방법 및 용도

Country Status (6)

Country Link
US (1) US5312824A (ko)
EP (1) EP0481764B1 (ko)
KR (1) KR100199356B1 (ko)
AT (1) ATE191213T1 (ko)
CA (1) CA2053527C (ko)
DE (1) DE69132082T2 (ko)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW280770B (ko) 1993-10-15 1996-07-11 Takeda Pharm Industry Co Ltd
US5824339A (en) * 1995-09-08 1998-10-20 Takeda Chemical Industries, Ltd Effervescent composition and its production
US6544556B1 (en) * 2000-09-11 2003-04-08 Andrx Corporation Pharmaceutical formulations containing a non-steroidal antiinflammatory drug and a proton pump inhibitor
MXPA06002443A (es) * 2003-09-03 2006-08-31 Agi Therapeutics Ltd Formulaciones inhibidoras de la bomba de protones y metodos para preparar y utilizar tales formulaciones.
CA2673665C (en) 2006-12-22 2017-03-21 Ironwood Pharmaceuticals, Inc. Method and compositions for treating esophageal disorders
WO2012027331A1 (en) 2010-08-27 2012-03-01 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
CN108057028A (zh) 2013-01-15 2018-05-22 铁木医药有限公司 片剂形式的肠溶包衣的胃内滞留口服剂型及其应用和药物组合物
WO2016126625A1 (en) 2015-02-03 2016-08-11 Ironwood Pharmaceuticals, Inc. Methods of treating upper gastrointestinal disorders in ppi refractory gerd
US20170042806A1 (en) 2015-04-29 2017-02-16 Dexcel Pharma Technologies Ltd. Orally disintegrating compositions
WO2017145146A1 (en) 2016-02-25 2017-08-31 Dexcel Pharma Technologies Ltd. Compositions comprising proton pump inhibitors
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7804231L (sv) 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4472409A (en) * 1981-11-05 1984-09-18 Byk Gulden Lomberg Chemische Fabrik Gesellschaft Mit Beschrankter Haftung 2-Pyridylmethyl thio(sulfinyl)benzimidazoles with gastric acid secretion inhibiting effects
IL75400A (en) * 1984-06-16 1988-10-31 Byk Gulden Lomberg Chem Fab Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same
JPS6150978A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
JPS6150979A (ja) 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
US4738975A (en) * 1985-07-02 1988-04-19 Takeda Chemical Industries, Ltd. Pyridine derivatives, and use as anti-ulcer agents
NZ234564A (en) * 1986-11-21 1991-04-26 Haessle Ab 1-substituted benzimidazoles and pharmaceutical compositions
DK171989B1 (da) 1987-08-04 1997-09-08 Takeda Chemical Industries Ltd Fremgangsmåde til fremstilling af 2-(2-pyridylmethylsulfinyl)-benzimidazoler
JPH03504497A (ja) * 1988-05-25 1991-10-03 ビイク　グルデン　ロンベルク　ヒエーミツシエ　フアブリーク　ゲゼルシヤフト　ミツト　ベシユレンクテル　ハフツング 新規フルオルアルコキシ化合物
AU4057189A (en) * 1988-08-23 1990-03-23 Aktiebolaget Hassle Treatment of glaucoma and related disorders in the human eye with pyridinylmethyl (sulfinyl or thio)benzimidazoles

Also Published As

Publication number Publication date
US5312824A (en) 1994-05-17
EP0481764A1 (en) 1992-04-22
CA2053527C (en) 2002-03-12
EP0481764B1 (en) 2000-03-29
ATE191213T1 (de) 2000-04-15
DE69132082D1 (de) 2000-05-04
KR100199356B1 (ko) 1999-06-15
DE69132082T2 (de) 2000-08-31
CA2053527A1 (en) 1992-04-18

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