BR112019006736A8 - Método para sintetizar derivado de 3-fenil-2,3,4,8,9,10-hexahidropirano [2,3-f]cromeneno e isômero óptico do mesmo - Google Patents

Método para sintetizar derivado de 3-fenil-2,3,4,8,9,10-hexahidropirano [2,3-f]cromeneno e isômero óptico do mesmo

Info

Publication number
BR112019006736A8
BR112019006736A8 BR112019006736A BR112019006736A BR112019006736A8 BR 112019006736 A8 BR112019006736 A8 BR 112019006736A8 BR 112019006736 A BR112019006736 A BR 112019006736A BR 112019006736 A BR112019006736 A BR 112019006736A BR 112019006736 A8 BR112019006736 A8 BR 112019006736A8
Authority
BR
Brazil
Prior art keywords
phenyl
derivative
optical isomer
synthesis
hexahydropirane
Prior art date
Application number
BR112019006736A
Other languages
English (en)
Other versions
BR112019006736A2 (pt
Inventor
Ku Yoo Sang
Wook Chung Jin
Geun Jo In
Young Kim Ji
Ho IM Jeong
Suk KANG Ku
Young Kim Jin
Original Assignee
Glaceum Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaceum Inc filed Critical Glaceum Inc
Publication of BR112019006736A2 publication Critical patent/BR112019006736A2/pt
Publication of BR112019006736A8 publication Critical patent/BR112019006736A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

A presente invenção refere-se a um método para sintetizar um derivado de 3-fenil-2,3,4,8,9,10-hexa-hidropirano [2,3-f] cromeno e um isômero óptico do mesmo, e um composto intermediário que pode ser usado para o método de síntese, e quando o método e o Composto intermediário são utilizados, o derivado 3-fenil-2,3,4,8,9,10-hexa-hidropirano[2,3-fcromeno e o seu isômero ótico podem ser efetivamente sintetizados.
BR112019006736A 2016-10-04 2017-09-27 Método para sintetizar derivado de 3-fenil-2,3,4,8,9,10-hexahidropirano [2,3-f]cromeneno e isômero óptico do mesmo BR112019006736A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20160127805 2016-10-04
PCT/KR2017/010679 WO2018066872A1 (ko) 2016-10-04 2017-09-27 3-페닐-2,3,4,8,9,10-헥사히드로피라노[2,3-f]크로멘 유도체 및 이의 광학 이성질체 합성 방법

Publications (2)

Publication Number Publication Date
BR112019006736A2 BR112019006736A2 (pt) 2019-07-23
BR112019006736A8 true BR112019006736A8 (pt) 2022-08-23

Family

ID=61831886

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019006736A BR112019006736A8 (pt) 2016-10-04 2017-09-27 Método para sintetizar derivado de 3-fenil-2,3,4,8,9,10-hexahidropirano [2,3-f]cromeneno e isômero óptico do mesmo

Country Status (19)

Country Link
US (2) US10669282B2 (pt)
EP (1) EP3524609B1 (pt)
JP (1) JP6810275B2 (pt)
KR (2) KR20180037584A (pt)
CN (1) CN109863152B (pt)
AR (1) AR109735A1 (pt)
AU (1) AU2017338514B2 (pt)
BR (1) BR112019006736A8 (pt)
CA (1) CA3039326C (pt)
DK (1) DK3524609T3 (pt)
ES (1) ES2881000T3 (pt)
HU (1) HUE055701T2 (pt)
IL (1) IL265706B (pt)
MX (1) MX2019003818A (pt)
PL (1) PL3524609T3 (pt)
PT (1) PT3524609T (pt)
TW (1) TWI641610B (pt)
WO (1) WO2018066872A1 (pt)
ZA (1) ZA201902760B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2017287746B2 (en) 2016-06-29 2020-04-09 Glaceum, Inc. Optically active pyranochromenyl phenol derivative and pharmaceutical composition comprising same
EP3524609B1 (en) * 2016-10-04 2021-05-26 Glaceum, Inc. Process for the preparation of 3-phenyl-2,3,4,8,9,10-hexahydropyrano[2,3-f]chromene derivatives, optical isomers thereof, and intermediates of the process
TWI804600B (zh) * 2018-04-03 2023-06-11 南韓商格雷森伍股份有限公司 3-苯基-2,8-二氫吡喃[2,3-ƒ]苯并哌喃衍生物的合成方法
WO2020071818A1 (ko) * 2018-10-02 2020-04-09 주식회사 글라세움 탄소 이중결합 함유 화합물의 비대칭 수소첨가 반응용 촉매
KR20200038182A (ko) * 2018-10-02 2020-04-10 주식회사 글라세움 탄소 이중결합 함유 화합물의 비대칭 수소첨가 반응용 촉매
KR20200105198A (ko) * 2019-02-28 2020-09-07 주식회사 글라세움 신경계 질환의 예방 또는 치료용 약학적 조성물
KR20210014521A (ko) 2019-07-30 2021-02-09 주식회사 글라세움 2-((6-(히드록시메틸)크로멘-5-일)옥시)-1-페닐에타논 유도체의 합성 방법

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100565423B1 (ko) 2003-10-20 2006-03-30 빅 바이오 주식회사 이소플라반 유도체 또는 이소플라벤 유도체의 제조방법
JP2006008604A (ja) * 2004-06-25 2006-01-12 Kuraray Co Ltd イソフラバン誘導体の製造方法
WO2007058480A1 (en) * 2005-11-16 2007-05-24 Md Bioalpha Co., Ltd. Composition having effect on treatment and prevention of diseases syndrome treatment with glabridin
WO2009111428A2 (en) * 2008-03-03 2009-09-11 The Administrators Of The Tulane Educational Fund Methods for synthesizing glycinols, glyceollins i and ii, compositions of selected intermediates, and therapeutic uses thereof
CN101555259B (zh) * 2009-05-15 2012-06-27 中国科学院上海有机化学研究所 螺环骨架膦噁唑啉配体、合成方法及其在不对称氢化反应中的应用
CN103030647B (zh) 2013-01-16 2014-10-29 山东省分析测试中心 一种光甘草定的合成方法
KR102344479B1 (ko) 2013-12-24 2021-12-29 주식회사 글라세움 피라노크로메닐페놀 유도체, 및 대사증후군 또는 염증 질환 치료용 약학 조성물
AU2017287746B2 (en) 2016-06-29 2020-04-09 Glaceum, Inc. Optically active pyranochromenyl phenol derivative and pharmaceutical composition comprising same
EP3524609B1 (en) * 2016-10-04 2021-05-26 Glaceum, Inc. Process for the preparation of 3-phenyl-2,3,4,8,9,10-hexahydropyrano[2,3-f]chromene derivatives, optical isomers thereof, and intermediates of the process

Also Published As

Publication number Publication date
PT3524609T (pt) 2021-07-15
AU2017338514B2 (en) 2020-05-14
CN109863152B (zh) 2021-12-03
US20200199142A1 (en) 2020-06-25
MX2019003818A (es) 2019-08-12
KR20180091803A (ko) 2018-08-16
BR112019006736A2 (pt) 2019-07-23
EP3524609A4 (en) 2020-04-08
KR101893393B1 (ko) 2018-08-30
WO2018066872A1 (ko) 2018-04-12
CN109863152A (zh) 2019-06-07
US10947250B2 (en) 2021-03-16
ZA201902760B (en) 2021-09-29
DK3524609T3 (da) 2021-07-26
AR109735A1 (es) 2019-01-16
TWI641610B (zh) 2018-11-21
PL3524609T3 (pl) 2021-12-27
CA3039326C (en) 2022-09-20
EP3524609B1 (en) 2021-05-26
IL265706B (en) 2021-06-30
HUE055701T2 (hu) 2021-12-28
KR20180037584A (ko) 2018-04-12
CA3039326A1 (en) 2018-04-12
US20200048272A1 (en) 2020-02-13
AU2017338514A1 (en) 2019-05-23
JP6810275B2 (ja) 2021-01-06
TW201813970A (zh) 2018-04-16
JP2019529577A (ja) 2019-10-17
US10669282B2 (en) 2020-06-02
EP3524609A1 (en) 2019-08-14
ES2881000T3 (es) 2021-11-26
NZ753171A (en) 2021-05-28
IL265706A (en) 2019-05-30

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Legal Events

Date Code Title Description
B350 Update of information on the portal [chapter 15.35 patent gazette]
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: AS CLASSIFICACOES ANTERIORES ERAM: C07D 493/04 , C07D 311/02

Ipc: C07D 493/04 (2006.01), C07D 311/02 (2006.01), A61P