BR112019006987A2 - inibidores de receptor de glicocorticoide - Google Patents

inibidores de receptor de glicocorticoide

Info

Publication number
BR112019006987A2
BR112019006987A2 BR112019006987A BR112019006987A BR112019006987A2 BR 112019006987 A2 BR112019006987 A2 BR 112019006987A2 BR 112019006987 A BR112019006987 A BR 112019006987A BR 112019006987 A BR112019006987 A BR 112019006987A BR 112019006987 A2 BR112019006987 A2 BR 112019006987A2
Authority
BR
Brazil
Prior art keywords
compositions
glucocorticoid receptor
compounds
receptor inhibitors
useful
Prior art date
Application number
BR112019006987A
Other languages
English (en)
Other versions
BR112019006987B1 (pt
Inventor
Sun Daqing
Zhou Haiying
Eksterowicz John
C Medina Julio
R Mcgee Lawrence
Zhu Liusheng
Delarae Balbas Minna
R Fantin Valeria
Du Xiaohui
Yan Xuelei
Rew Yosup
Original Assignee
Oric Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oric Pharmaceuticals Inc filed Critical Oric Pharmaceuticals Inc
Publication of BR112019006987A2 publication Critical patent/BR112019006987A2/pt
Publication of BR112019006987B1 publication Critical patent/BR112019006987B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/008—Ketals at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

a presente invenção se refere, em geral, a composições e métodos para tratar câncer e hipercortisolismo. são fornecidos no presente documento compostos de derivado esteroidal substituído e composições farmacêuticas que compreendem os ditos compostos. os compostos e composições individuais são úteis para a inibição de receptores de glicocorticoide. adicionalmente, os compostos e composições individuais são úteis para o tratamento de câncer.
BR112019006987-9A 2016-10-07 2017-10-06 compostos inibidores de receptor de glicocorticoide, composição farmacêutica e usos dos referidos compostos BR112019006987B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662405801P 2016-10-07 2016-10-07
US62/405,801 2016-10-07
US201762526331P 2017-06-28 2017-06-28
US62/526,331 2017-06-28
PCT/US2017/055660 WO2018068021A1 (en) 2016-10-07 2017-10-06 Inhibitors of glucocorticoid receptor

Publications (2)

Publication Number Publication Date
BR112019006987A2 true BR112019006987A2 (pt) 2019-06-25
BR112019006987B1 BR112019006987B1 (pt) 2021-05-04

Family

ID=61832215

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019006987-9A BR112019006987B1 (pt) 2016-10-07 2017-10-06 compostos inibidores de receptor de glicocorticoide, composição farmacêutica e usos dos referidos compostos

Country Status (20)

Country Link
US (5) US10472387B2 (pt)
EP (2) EP3851444A1 (pt)
JP (2) JP6801093B2 (pt)
KR (2) KR20210039001A (pt)
CN (2) CN111690031B (pt)
AU (3) AU2017339510B2 (pt)
BR (1) BR112019006987B1 (pt)
CA (1) CA3039636C (pt)
DK (1) DK3523315T3 (pt)
ES (1) ES2867853T3 (pt)
HU (1) HUE054542T2 (pt)
IL (2) IL265835B (pt)
MX (2) MX2019004030A (pt)
NZ (1) NZ753142A (pt)
PL (1) PL3523315T3 (pt)
PT (1) PT3523315T (pt)
SG (1) SG11201903055UA (pt)
SI (1) SI3523315T1 (pt)
WO (1) WO2018068021A1 (pt)
ZA (1) ZA202004440B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3009525A1 (en) 2015-12-23 2017-06-29 Oric Pharmaceuticals, Inc. Inhibitors of glucocorticoid receptor
WO2017112904A1 (en) 2015-12-23 2017-06-29 Oric Pharmaceuticals, Inc. Inhibitors of glucocorticoid receptor
WO2017112902A1 (en) 2015-12-23 2017-06-29 Oric Pharmaceuticals, Inc. Inhibitors of glucocorticoid receptor
NZ753142A (en) 2016-10-07 2020-08-28 Oric Pharmaceuticals Inc Inhibitors of glucocorticoid receptor
CN112272552A (zh) * 2018-04-11 2021-01-26 欧瑞克制药公司 包含糖皮质激素受体拮抗剂的固体形式和制剂及其用途
WO2021163273A1 (en) * 2020-02-12 2021-08-19 Oric Pharmaceuticals, Inc. Uses of glucocorticoid receptor antagonists
US20230212215A1 (en) * 2020-05-08 2023-07-06 Trustees Of Dartmouth College Glucocorticoid receptor modulators
CN115915529A (zh) * 2021-09-30 2023-04-04 赛万特科技有限责任公司 发光控制方法、发光控制装置及发光装置
CN114230627B (zh) * 2021-12-31 2023-09-15 湖南新合新生物医药有限公司 一种倍他米松环氧水解物中间体的制备方法

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FR2528434B1 (fr) 1982-06-11 1985-07-19 Roussel Uclaf Nouveaux 19-nor steroides substitues en 11b et eventuellement en 2, leur procede de preparation et leur application comme medicament
ZA8231B (en) * 1981-01-09 1982-11-24 Roussel Uclaf New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
FR2522328B1 (fr) 1982-03-01 1986-02-14 Roussel Uclaf Nouveaux produits derives de la structure 3-ceto 4,9 19-nor steroides, leur procede de preparation et leur application comme medicaments
JP2785023B2 (ja) 1987-12-30 1998-08-13 ルセル―ユクラフ １７α位置を置換された１７β―ＯＨ―１９―ノルステロイドの新誘導体、その製造方法、その薬剤としての使用及びそれを含有する製薬組成物
JPH02188599A (ja) 1988-11-16 1990-07-24 Roussel Uclaf ３―ケト―デルタ―４，９―１９―ノルステロイドから誘導される新物質及びそれらよりなる薬剤
DE3921059A1 (de) 1989-06-23 1991-01-10 Schering Ag 11(beta)-aryl-4-estrene, verfahren zu ihrer herstellung sowie deren verwendung als arzneimittel
FR2651435A1 (fr) 1989-09-07 1991-03-08 Roussel Uclaf Nouvelle utilisation de composes anti-progestomimetiques.
DE4018167A1 (de) * 1990-06-01 1991-12-05 Schering Ag Verfahren zur herstellung von 10(beta)-h-steroiden
DE4042007A1 (de) * 1990-12-22 1992-06-25 Schering Ag 6,7-modifizierte-11(beta)-aryl-4-estrene
DE69413829T2 (de) 1993-08-04 1999-04-15 Akzo Nobel N.V., Arnheim/Arnhem Antiglucocorticoidsteroide zur behandlung von angststörungen
WO1995017192A1 (en) 1993-12-22 1995-06-29 The Salk Institute For Biological Studies Methods for reducing multidrug resistance
PT806952E (pt) 1995-02-02 2003-08-29 Schering Ag Antagonistas da progesterona para a preparacao de medicamentos para o tratamento de hemorragias uterinas disfuncionais
IL118974A (en) * 1995-08-17 2001-09-13 Akzo Nobel Nv History 11 - (Transformed Phenyl) - Astra - 4, 9 - Diane, their preparation and pharmaceutical preparations containing them
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EP1285927A3 (de) * 2001-08-16 2005-06-29 Schering Aktiengesellschaft Verwendung von Glucocorticoid-Rezeptorantagonisten zur Vorbeugung und Behandlung von Erkrankungen des männlichen Reproduktionssystems
US7250408B2 (en) * 2002-12-16 2007-07-31 Bayer Schering Pharma Ag Glucocorticoid receptor antagonists for prophylaxis and therapy of glucocorticoid-mediated hypogonadism, of sexual dysfunction and/or infertility
PT1989218E (pt) 2006-02-17 2010-02-01 Janssen Pharmactuica N V Derivados de 17-fósforo esteróides úteis como moduladores do receptor da progesterona
EP2439196A1 (en) 2006-03-29 2012-04-11 The Regents of The University of California Diarylthiohydantoin compounds for use in a method for the treatment of a hyperproliferative disorder
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US8658128B2 (en) 2011-02-03 2014-02-25 Pop Test Cortisol Llc System and method for diagnosis and treatment
EP2545922A1 (en) 2011-07-12 2013-01-16 PregLem S.A. Treatment of excessive menstrual bleeding associated with uterine fibroids
US20130029953A1 (en) 2011-07-28 2013-01-31 Klaus Nickisch Progesterone antagonists
EP2817019A4 (en) 2012-02-24 2016-04-06 Univ Chicago METHODS AND COMPOSITIONS ASSOCIATED WITH GLUCOCORTICOID RECEPTOR ANTAGONISM AND PROSTATE CANCER
EP2641602A1 (en) 2012-03-23 2013-09-25 PregLem S.A. Method for treating gynecological diseases
US9096641B2 (en) * 2013-06-05 2015-08-04 Evestra, Inc. Imidazolyl progesterone antagonists
EP3079475B1 (en) * 2013-12-11 2020-10-07 Sloan-kettering Institute For Cancer Research Glucocorticoid inhibitors for treatment of prostate cancer
CN104530166B (zh) 2014-12-04 2016-08-24 陕西汉江药业集团股份有限公司 选择性还原4,6-共轭双烯-3-酮甾体化合物的方法
WO2017112902A1 (en) * 2015-12-23 2017-06-29 Oric Pharmaceuticals, Inc. Inhibitors of glucocorticoid receptor
WO2017112904A1 (en) 2015-12-23 2017-06-29 Oric Pharmaceuticals, Inc. Inhibitors of glucocorticoid receptor
CA3009525A1 (en) * 2015-12-23 2017-06-29 Oric Pharmaceuticals, Inc. Inhibitors of glucocorticoid receptor
NZ753142A (en) 2016-10-07 2020-08-28 Oric Pharmaceuticals Inc Inhibitors of glucocorticoid receptor
US20200179404A1 (en) 2017-06-09 2020-06-11 Regents Of The University Of Minnesota Skin care formulations and skin cancer treatment
CN112272552A (zh) 2018-04-11 2021-01-26 欧瑞克制药公司 包含糖皮质激素受体拮抗剂的固体形式和制剂及其用途

Also Published As

Publication number Publication date
AU2017339510A1 (en) 2019-05-23
CN111690031B (zh) 2021-06-01
KR20210039001A (ko) 2021-04-08
US20200291058A1 (en) 2020-09-17
SI3523315T1 (sl) 2021-08-31
HUE054542T2 (hu) 2021-09-28
US10472387B2 (en) 2019-11-12
PL3523315T3 (pl) 2021-10-18
US20200055892A1 (en) 2020-02-20
WO2018068021A1 (en) 2018-04-12
ES2867853T3 (es) 2021-10-21
SG11201903055UA (en) 2019-05-30
BR112019006987B1 (pt) 2021-05-04
AU2021202016B2 (en) 2022-01-06
MX2019004030A (es) 2019-09-16
NZ753142A (en) 2020-08-28
JP2019533651A (ja) 2019-11-21
US10836789B2 (en) 2020-11-17
IL265835A (en) 2019-06-30
MX2021010252A (es) 2021-09-21
AU2017339510B2 (en) 2020-07-30
AU2020213316A1 (en) 2020-08-27
AU2021202016C1 (en) 2022-06-09
US20190218246A1 (en) 2019-07-18
IL265835B (en) 2021-06-30
KR102237916B1 (ko) 2021-04-09
EP3851444A1 (en) 2021-07-21
CN110099915A (zh) 2019-08-06
DK3523315T3 (da) 2021-05-03
EP3523315B1 (en) 2021-03-24
US20210017219A1 (en) 2021-01-21
EP3523315A1 (en) 2019-08-14
US20230096870A1 (en) 2023-03-30
CA3039636C (en) 2023-04-11
IL284005A (en) 2021-07-29
JP6801093B2 (ja) 2020-12-16
CN111690031A (zh) 2020-09-22
JP2021046409A (ja) 2021-03-25
ZA202004440B (en) 2022-07-27
US10723759B2 (en) 2020-07-28
AU2021202016A1 (en) 2021-04-29
AU2020213316B2 (en) 2021-03-11
KR20190083651A (ko) 2019-07-12
EP3523315A4 (en) 2020-04-15
CA3039636A1 (en) 2018-04-12
PT3523315T (pt) 2021-04-29

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Legal Events

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 06/10/2017, OBSERVADAS AS CONDICOES LEGAIS.